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2026

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Novel Technique For Enhancing The Therapeutic Efficacy Of Coenzyme Q10 In Transdermal Drug Delivery Systems For Skin Rejuvenation, L. M. Hettihewa, K. G. P. Wasana, Y. M. Imendra, G. P. C. Weerasooriya, W. M. K. M. Rathnayake Feb 2026

Novel Technique For Enhancing The Therapeutic Efficacy Of Coenzyme Q10 In Transdermal Drug Delivery Systems For Skin Rejuvenation, L. M. Hettihewa, K. G. P. Wasana, Y. M. Imendra, G. P. C. Weerasooriya, W. M. K. M. Rathnayake

Journal of Innovation in Science, Engineering and Technology

Coenzyme Q10 (CoQ10) is a very imperative compound for electron transport chain in mitochondria and exerts its effects as cutaneous antioxidant. All human cells have CoQ10, and sometime deficiency had been identified due to genetic defects or with ageing. Supplements with COQ 10 are commonly used enteral and dermal application for the prevention and treatment of aging. Delivery of dermal CoQ10 is very limited due to its poor penetration and unstable compounds. systematic review was conducted by our research group through electronic databases using preclinical and randomized controlled trials to evaluate the efficacy and stability of improved delivery systems of …


Assessment Of Antioxidant Retention Of Boiled And Non-Boiled Aqueous Extracts Of Broccoli, Cabbage, Kohlrabi And Cauliflower In Sri Lanka, D. M. S. S. Dassanayake, B. C. K. Kumari, P. R. H. Perera, G. M. Yasasvi, L. M. Hettihewa, W. M. K. M. Ratnayake Feb 2026

Assessment Of Antioxidant Retention Of Boiled And Non-Boiled Aqueous Extracts Of Broccoli, Cabbage, Kohlrabi And Cauliflower In Sri Lanka, D. M. S. S. Dassanayake, B. C. K. Kumari, P. R. H. Perera, G. M. Yasasvi, L. M. Hettihewa, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

The comparison of antioxidant activities between non-boiled and boiled aqueous extracts of selected vegetables from the Brassica oleracea L. species is an interesting study topic, particularly in a context like Sri Lanka, where traditional and modern medicinal practices often emphasize the role of dietary plants in health. Hence, this was aimed to evaluate the antioxidant potential of boiled and non-boiled aqueous extracts (BAE and NBAE respectively) of selected vegetables belonging to the Brassica oleracea L species, which are commonly consumed as a raw vegetable in fresh salads as well as a cooked vegetable in curry or fried form i.e. Brassica …


Assessment Of In-Vitro Anti-Diabetic And Antioxidant Activities Of Selected Edible Mushrooms, Agaricus Bisporus (Button Mushroom), Pleurotus Cystidiosus (Abalone) And Pleurotus Ostreatus (American Oyster) In Sri Lanka, E. J. Siriwardene, G. S. D. Nawaruwan, A. H. M. A. N. Abesinghe, H. D. Dedigama, K. H. E. Fernando, K. D. K. P. Kumari, W. M. K. M. Ratnayake Feb 2026

Assessment Of In-Vitro Anti-Diabetic And Antioxidant Activities Of Selected Edible Mushrooms, Agaricus Bisporus (Button Mushroom), Pleurotus Cystidiosus (Abalone) And Pleurotus Ostreatus (American Oyster) In Sri Lanka, E. J. Siriwardene, G. S. D. Nawaruwan, A. H. M. A. N. Abesinghe, H. D. Dedigama, K. H. E. Fernando, K. D. K. P. Kumari, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Mushrooms are a valuable source of proteins and vitamins as well as a food source with several pharmacological values. Hence, Higher mushroom consumption can lower the risk of certain diseases. However, a literature survey revealed that published scientific information on the therapeutic potential of some edible mushrooms is still being determined. Hence, this study evaluated and compared the antioxidant and α -amylase potential of some of the three commonly used mushroom varieties in Sri Lanka i.e. Agaricus bisporus (Button mushroom), Pleurotus cystidiosus (Abalone mushroom) and Pleurotus ostreatus (American oyster). The antioxidant activity of hot aqueous extracts of the above three …


Body Mass Index And Clinical Phenotypes Of Primary Dysmenorrhea In Female University Students: Evidence From Sri Lanka Using Walidd Scoring, H. K. A. N. Senanayake, K. L. A. S. I. Liyanarachchi, J. K. M. Jagoda, S. A. S. A. Maheepala, L. C. Mallawa, P. W. T. M. Dayarathne, Y. T. R. Somisena, L. M. Hettihewa Feb 2026

Body Mass Index And Clinical Phenotypes Of Primary Dysmenorrhea In Female University Students: Evidence From Sri Lanka Using Walidd Scoring, H. K. A. N. Senanayake, K. L. A. S. I. Liyanarachchi, J. K. M. Jagoda, S. A. S. A. Maheepala, L. C. Mallawa, P. W. T. M. Dayarathne, Y. T. R. Somisena, L. M. Hettihewa

Journal of Innovation in Science, Engineering and Technology

This research investigates the relationship between body weight and the severity and characteristics of primary dysmenorrhea among female undergraduates in Sri Lanka, using the WaLIDD Score as an evaluative tool. The study aims to assess the practicality of the WaLIDD Score in native settings, examining its correlation with pain intensity, pain location, and common medication patterns, while addressing gaps in previous research conducted in Sri Lanka. A quantitative cross-sectional study was conducted among 389 female university students aged 19–27 years from both state and non-state universities in Sri Lanka, selected through stratified random sampling. Participants with chronic or menstrual diseases, …


Conceptual Analysis Of Ārthavavaha Srotas (Female Reproductive System): A Review Of The Theories And Literature, Pushpa Kulanatha, H. L. M. G. Sajeewani Feb 2026

Conceptual Analysis Of Ārthavavaha Srotas (Female Reproductive System): A Review Of The Theories And Literature, Pushpa Kulanatha, H. L. M. G. Sajeewani

Journal of Innovation in Science, Engineering and Technology

The reproductive health of females during their fertile years is foundational for individual well-being and societal prosperity. The purpose of this study was to bridge the analytical and epistemological gaps currently existing in the literature regarding Ārthavavaha Srotas (ĀvS), the Ayurvedic concept of the female reproductive system. A comprehensive literature review was conducted using forward and backward searches to analyse authentic Ayurvedic texts (Caraka and Sushruta Samhitas) alongside contemporary research articles published between 2014 and 2024. The analysis identified ten specific aspects of the ĀvS where prior interpretations were superficial or unclear. The results of this study epistemologically validate ancient …


Strspy2.0: Unlocking The Potential Of Long Reads For Forensic Dna Profiling, Courtney L Hall, Rupesh K Kesharwani, Katherine E Mcbroom Henson, Bupe Kapema, Nicole R Phillips, Fritz J Sedlazeck, Roxanne R Zascavage Feb 2026

Strspy2.0: Unlocking The Potential Of Long Reads For Forensic Dna Profiling, Courtney L Hall, Rupesh K Kesharwani, Katherine E Mcbroom Henson, Bupe Kapema, Nicole R Phillips, Fritz J Sedlazeck, Roxanne R Zascavage

Faculty, Staff and Students Publications

Forensic human identification relies on length-based differences in short tandem repeats (STRs) across autosomal and Y chromosomes, which require separate reactions and provide limited resolution. While next-generation sequencing offers greater discriminatory power, most platforms are expensive and restricted to traditional lab settings. Nanopore sequencing has the potential to change this with the real-time, portable MinION sequencer. However, forensic-specific tools that generate STR profiles compatible with established length-based databases are lacking. To address this, we developed STRspy2.0, which simultaneously profiles autosomal and Y-STRs using nanopore reads. STRspy2.0 produced accurate profiles for 54 multiplexed control libraries and 41 mock casework samples (blood, …


Modeling Spasticity: A Systematic Review, Gaby Gonzalez Chan, Jonathan Marsden, Alexander Besinis, Pablo Borja, Hilary Gunn Feb 2026

Modeling Spasticity: A Systematic Review, Gaby Gonzalez Chan, Jonathan Marsden, Alexander Besinis, Pablo Borja, Hilary Gunn

School of Health Professions

Spasticity, a type of hypertonia characterized by a velocity-dependent increase in muscle tone, is associated with damage to the brain and/or spinal cord in different neurological conditions. However, secondary non-neurological factors, such as soft tissue changes, can complicate the assessment and differentiation of the underlying causes. Accurate assessment is crucial for effective treatment planning, with clinicians relying on passive movement to grade the ‘feel’ of the spastic limb. This review aims to identify and evaluate the feasibility of spasticity models or simulations for clinical teaching. Models based on human spastic limbs were examined, with no restrictions on specific conditions or …


Myelodysplastic Syndrome Secondary To Chimeric Antigen Receptor T-Cell (Car-T) Therapy For The Treatment Of Relapsed/Refractory Multiple Myeloma, Waqqas Tai, Daniel Kim, Joe Dib, Jessica Thomas, Swathi Gopishetty, Precious Idogun, Afoma Anyadibe, Anuoluwa Ayetoran, Syed Zaidi, Savitha Balaraman, Ishmael Jaiyesimi Feb 2026

Myelodysplastic Syndrome Secondary To Chimeric Antigen Receptor T-Cell (Car-T) Therapy For The Treatment Of Relapsed/Refractory Multiple Myeloma, Waqqas Tai, Daniel Kim, Joe Dib, Jessica Thomas, Swathi Gopishetty, Precious Idogun, Afoma Anyadibe, Anuoluwa Ayetoran, Syed Zaidi, Savitha Balaraman, Ishmael Jaiyesimi

Student Publications

We present the case of a 65-year-old man with relapsed/refractory multiple myeloma (RRMM) who developed therapy-related myelodysplastic syndrome (MDS) following chimeric antigen receptor T-cell (CAR-T) therapy with idecabtagene vicleucel (ide-cel). The patient, initially diagnosed in 2019, underwent multiple lines of therapy, including high-dose melphalan with autologous stem cell transplantation, before receiving ide-cel for progressive disease. Despite initial remission, a day 100 bone marrow biopsy revealed MDS with a 7q deletion, a cytogenetic abnormality not present on prior marrow evaluations. While CAR-T therapy has revolutionized RRMM treatment, long-term complications such as therapy-related hematologic malignancy remain under-recognized.

The temporal relationship between CAR-T …


Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi Feb 2026

Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi

Karbala International Journal of Modern Science

Background: A biofilm is a collection of the microbial cells attached to the surface that are encased in a matrix of extracellular polymers. Biofilm formation creates a physical and chemical barrier that prevents antibiotics from reaching bacterial cells, resulting in treatment failure and reinfection. The present study aimed to investigate the biofilm formation in bacteria isolated from the oral cavity of patients.

Methods: In this study, 150 bacterial isolates were obtained from tooth and gum surface swabs of male and female patients of different ages who visited specialized centers and dental clinics in Babylon City after they were clinically diagnosed …


Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons Feb 2026

Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons

Journal of Counselor Preparation and Supervision

Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …


Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook Feb 2026

Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook

Journal of Counselor Preparation and Supervision

No person is without biases, even the most culturally adept among us. Managing biases is critical to counselors’ continued journey of understanding clients contextually and holistically. In this article, we describe two novel bias management concepts: A specific type of bias called saintly corrections and the more clinically fruitful approach of realistic corrections. We define and illustrate saintly and realistic corrections, outline a multifold approach (i.e., cognitive complexity, cultural identity development, and the multicultural orientation model) for remediating saintly corrections, and offer recommendations counselor educators can use during planned and contextual learning opportunities, including an example of a contextual …


Holy Cross Magazine, Vol. 60 No. 1, Winter 2026, College Of The Holy Cross Feb 2026

Holy Cross Magazine, Vol. 60 No. 1, Winter 2026, College Of The Holy Cross

Holy Cross Magazine

The Bell Was Stolen By 3
What the legendary, unsolved theft of the Fenwick Bell tells us about art, crime and absence.
Story by Marybeth Reilly-McGreen ’89
Photography by Michael Ivins

College Tradition Lives on in an Unexpected Place
How necessity, sustainability, happenstance and Jesuit identity converge in the office of Rev. Keith Maczkiewicz, S.J.
Story by Abby Riviello
Photography by Michael Ivins

What Good Can Come From Grief? Quite a Lot, It Turns Out.
Rev. James Hayes, S.J., ’72 has spent more than 50 years engaged in a ministry of consolation, a calling rooted in his own experience of …


Green Roofs For Grey Water Treatment – Comparative Study Of Economic And Environmental Impacts, Shaden S. Attia Feb 2026

Green Roofs For Grey Water Treatment – Comparative Study Of Economic And Environmental Impacts, Shaden S. Attia

Theses and Dissertations

Cities are under more pressure than ever to use sustainable methods for managing water and other resources because of urbanization, climate change, and a lack of water. Standard greywater treatment systems (SGTSs) work well, but they use a lot of resources and don't provide a lot of ecosystem services. Greywater-treating green roofs (GTGRs) have emerged as a promising Nature-Based Solution (NBS), combining wastewater recycling with benefits like regulating temperature, reducing greenhouse gas (GHG) emissions, and reducing the urban heat island (UHI) effect. Even with this potential, there is still not enough real-world research on how GTGRs affect both the economy …


Neuproio: A Dual-Action Solid Drug Nanoparticle Topical Formulation For Simultaneous Intraocular Pressure Reduction And Neuroprotection For Glaucoma, Lei Xu, Mu Li, Lin Qi, Tzu Chen Wang, Dong Liu, Vimalin Jeyalatha Mani, Hsin Yin Chuang, Qingbo Yang, Ruipu Mu, Samira Mahdi, Da Huang, Honglan Shi, Yang Hu, Hu Yang Feb 2026

Neuproio: A Dual-Action Solid Drug Nanoparticle Topical Formulation For Simultaneous Intraocular Pressure Reduction And Neuroprotection For Glaucoma, Lei Xu, Mu Li, Lin Qi, Tzu Chen Wang, Dong Liu, Vimalin Jeyalatha Mani, Hsin Yin Chuang, Qingbo Yang, Ruipu Mu, Samira Mahdi, Da Huang, Honglan Shi, Yang Hu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glaucoma is a leading cause of irreversible blindness, primarily due to elevated intraocular pressure (IOP) that damages the retina and optic nerve. Most topical glaucoma treatments focus solely on IOP-lowering without direct neuroprotection, as drug delivery to the posterior eye is challenging. Here, we developed NeuProIO, a dual-action solid drug nanoparticle (NP) eye drop for simultaneous IOP reduction and neuroprotection. Using flash nanoprecipitation in a multi-inlet vortex mixer, we fabricated the first NeuProIO solid drug NPs incorporating the repurposed neuroprotective agent maprotiline (MAP) and the IOP-lowering agent betaxolol (BX), forming MAP/BX NPs for synergistic glaucoma treatment. The NeuProIO improved stability …


Adolescent Math Anxiety: Teachers' Grouping Approach At The Intersection Of Multiple Student Identities, Dara Shifrer, Hannah Sean Ellefritz, David Hernandez-Saca, Allison Roda, Karla Santana Martinez Feb 2026

Adolescent Math Anxiety: Teachers' Grouping Approach At The Intersection Of Multiple Student Identities, Dara Shifrer, Hannah Sean Ellefritz, David Hernandez-Saca, Allison Roda, Karla Santana Martinez

Sociology Faculty Publications and Presentations

Math anxiety represents a substantial barrier to many students’ math learning. In this paper, we apply interdisciplinary perspectives to data on over 13,200 ninth graders and their math teachers from the High School Longitudinal Study. Results suggest that being perceived as dis/abled relates to heightened math anxiety regardless of adolescents’ gender, or race and ethnicity. Our intersectional approach reveals that adolescents’ expressions of math anxiety do not always correspond with gender, racial, and ethnic stereotypes, with Black girls, Black boys, and Latine boys expressing relatively low levels of math anxiety. Finally, consistent with the principles of inclusion and universal design, …


Exogenous Myrosinase From Mustard Seed Increases Bioavailability Of Sulforaphane From A Glucoraphanin-Rich Broccoli Seed Extract In A Randomized Clinical Study, Angela Mastaloudis, Lola Holcomb, Jed W. Fahey, Camila Olson, David C. Nieman, Colin Kay, Robert O'Donnell, Alessandra Pecorelli, Marissa Kinney, Yanyan Li, Suzanne L. Ishaq, Giuseppe Valacchi Feb 2026

Exogenous Myrosinase From Mustard Seed Increases Bioavailability Of Sulforaphane From A Glucoraphanin-Rich Broccoli Seed Extract In A Randomized Clinical Study, Angela Mastaloudis, Lola Holcomb, Jed W. Fahey, Camila Olson, David C. Nieman, Colin Kay, Robert O'Donnell, Alessandra Pecorelli, Marissa Kinney, Yanyan Li, Suzanne L. Ishaq, Giuseppe Valacchi

Pharmacy Faculty Scholarship

Inactive glucoraphanin (GR) in broccoli is converted to the antioxidant, anti-inflammatory, and anti-bacterial sulforaphane (SF) by cruciferous vegetable enzyme myrosinase (Myr), or similar enzymes from specific gut bacteria; both sources have variable efficiency. The effects of exogenous Myr on the conversion efficiency of GR to SF was compared to gut microbial Myr-like activity. In a randomized, double-blind, crossover study, sixteen subjects (9 F: 7 M) received a single oral dose of GR in broccoli seed extract with Myr-containing mustard seed powder, or broccoli seed extract alone, both with ascorbic acid. GR + Myr, on average, doubled the bioavailability of SF …


Observations Of Puddling Butterflies In Maryland, Usa, Aydin Örstan Feb 2026

Observations Of Puddling Butterflies In Maryland, Usa, Aydin Örstan

The Taxonomic Report of the International Lepidoptera Survey

Six butterfly species in four families were observed puddling on damp soil, scat and carrion in various locations in Montgomery County, Maryland and on small islands in the Potomac River. Four species preferred damp soil to nearby mud, but the reason for this behavior is unknown. The presence of butterflies on small islands in the Potomac River is documented for the first time.


The Impact Of Sleep On Physical Performance And Behavior In Adolescent Athletes: A Study In High School Strength And Conditioning Program, Daniel Higgins Feb 2026

The Impact Of Sleep On Physical Performance And Behavior In Adolescent Athletes: A Study In High School Strength And Conditioning Program, Daniel Higgins

Doctorate in Kinesiology

This study examined the relationship between sleep behaviors and strength performance in adolescent students enrolled in a high school strength and conditioning course. Participants included 112 students, ages 15–19, who completed daily self-reported sleep logs over an eight-week period assessing sleep duration, sleep quality, and pre-sleep technology use. Strength performance was measured through repeated assessments of the bench press, squat, and power clean. Data were analyzed using descriptive statistics, Pearson correlations, and linear regression. Results indicated that sleep duration and sleep quality did not significantly predict overall strength gains across the training period. However, strong relationships were observed among sleep-related …


A Damaging Mutation In Col6a3 Alters The Mechanobiologic Response Of Chondrocytes Derived From Human Induced Pluripotent Stem Cells, Zainab Harissa, Niek Bloks, Nancy Steward, Sara F Tufa, Douglas R Keene, Yolande F M Ramos, Ingrid Meulenbelt, Farshid Guilak Feb 2026

A Damaging Mutation In Col6a3 Alters The Mechanobiologic Response Of Chondrocytes Derived From Human Induced Pluripotent Stem Cells, Zainab Harissa, Niek Bloks, Nancy Steward, Sara F Tufa, Douglas R Keene, Yolande F M Ramos, Ingrid Meulenbelt, Farshid Guilak

2020-Current year OA Pubs

Osteoarthritis (OA) is a complex disease associated with genetic, biological, and mechanical risk factors that act, in part, to alter chondrocyte homeostasis. Our recent exome sequencing studies identified a damaging genetic variant in COL6A3, a monomeric unit of collagen type VI and a distinguishing component of the pericellular matrix (PCM) of articular cartilage, a transducer of mechanical and biochemical signals for the chondrocyte. To study the effect of this genetic variant, human induced pluripotent stem cell (hiPSC)-derived chondrocytes, genetically edited to harbor the COL6A3 mutation, were used as an in vitro model to investigate chondrocyte mechanobiology and pathobiology. The COL6A3 …


Evolving Strategies In Prostate Cancer: Emerging Approaches And Unmet Needs From The Bridging The Gaps In Prostate Cancer Expert Panel, Rana Mckay, Benjamin Maughan, Alicia Morgans, Neal Shore, Evan Yu, Ravi Madan, Jacob Berchuck, Bradley Carthon, Steven Finkelstein, Leonard Gomella, Michael Gorin, Andrew Hahn, Stacy Loeb, Vivek Narayan, Daniel Petrylak, Charles Ryan, Karine Tawagi, Phuoc Tran, Tanya Dorff Feb 2026

Evolving Strategies In Prostate Cancer: Emerging Approaches And Unmet Needs From The Bridging The Gaps In Prostate Cancer Expert Panel, Rana Mckay, Benjamin Maughan, Alicia Morgans, Neal Shore, Evan Yu, Ravi Madan, Jacob Berchuck, Bradley Carthon, Steven Finkelstein, Leonard Gomella, Michael Gorin, Andrew Hahn, Stacy Loeb, Vivek Narayan, Daniel Petrylak, Charles Ryan, Karine Tawagi, Phuoc Tran, Tanya Dorff

Department of Urology Faculty Papers

BACKGROUND: The expansion of treatment options for prostate cancer (PC) has improved disease-specific and overall survival outcomes but has also raised questions about the optimal level of treatment needed for patients based on their individual prognosis and accounting for potential toxicity, incorporating quality of life considerations.

METHODS: A panel of experts met to discuss current controversies in the care of patients with PC across the disease continuum. Multidisciplinary experts review advances and persistent uncertainties in biomarker-guided assessment, imaging, and systemic therapy for prostate cancer. The discussion outlines priority gaps in evidence that must be addressed to optimize individualized patient care. …


P-15 Peptide Enhanced Bone Graft In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study Demonstrating Improved Composite Clinical Success, James Harrop, John E. O'Toole, Michael P. Steinmetz, Rick C. Sasso, Christopher D. Chaput, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold Feb 2026

P-15 Peptide Enhanced Bone Graft In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study Demonstrating Improved Composite Clinical Success, James Harrop, John E. O'Toole, Michael P. Steinmetz, Rick C. Sasso, Christopher D. Chaput, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, controlled pivotal study.

OBJECTIVE: To evaluate whether P-15L (PearlMatrix P-15 Peptide Enhanced Bone Graft) is noninferior in effectiveness to local autograft when applied in single-level instrumented transforaminal lumbar interbody fusion (TLIF).

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated Breakthrough Drug-Device, is a composite drug-device combination bone graft containing P-15, a 15-amino acid polypeptide, which enhances cell binding, proliferation, and differentiation, resulting in bone formation.

MATERIALS AND METHODS: Skeletally mature patients, aged 22 to 80 years, with degenerative disc disease (DDD) were randomized 1:1 to P-15L (investigational) or to the local autograft (control) during single-level …


Global Public Health Feasibility: Digital Dentistry In Geriatric Population, Merna Amr Saleh Feb 2026

Global Public Health Feasibility: Digital Dentistry In Geriatric Population, Merna Amr Saleh

Theses and Dissertations

Oral health is a critical yet often overlooked determinant of well-being among older adults in Egypt, where mobility limitations, geographic barriers, and low awareness of preventive practices exacerbate dental disparities. DentalPal, a teledentistry-based mobile application, was developed to provide older adults with remote dental consultations, oral hygiene advice, and triage guidance. The platform enables users to submit oral photographs or radiographs for assessment, seek second opinions, and initiate follow-up chats directly with the healthcare provider. This flexible design allows users to access dental consultations on demand while ensuring continuity of care The question that guided this study was how older …


Facebook Interaction As A Potential Marker Of Cognitive Decline: Pilot Study, Esraa M. Qansuwa Feb 2026

Facebook Interaction As A Potential Marker Of Cognitive Decline: Pilot Study, Esraa M. Qansuwa

Theses and Dissertations

One of the critical challenges in brain disorder research is the early identification of individuals with mild cognitive impairment (MCI) who may later develop Alzheimer’s disease (AD) or other dementias. MCI in older adults is frequently associated with diminished social engagement and observable behavioral changes. With the rapid expansion of social media platforms and advances in Machine Learning (ML), digital traces from online activity present a novel and scalable avenue for mental health screening. In particular, predictive ML approaches have demonstrated strong potential in building reliable classifiers for early detection of neurocognitive decline. This study introduces an innovative framework that …


Artemisinin Partial Resistance Mutations In Zanzibar And Tanzania Suggest Regional Spread And African Origins, 2023, Sean V. Connelly, Julia G. Muller, Mohamed Ali, Billy E. Ngasala, Wahida Hassan, Bakari Mohamed, Kyaw L. Thwai, Jacob M. Sadler, Jacob Marglous, Abebe A. Fola, Abdallah Zacharia, Shija J. Shija, Safia Mohammed, Dominick C. Msolo, Hamza Said, Editruda E. Peter, Melic Odas, Isaack J. Rutha, Mwanaidi Nwange, Karamoko Naire, Shazia Ruybal-Pesántez, Robert Verity, Rebecca Crudale, Varun Goel, Barbara B. Choloi, Anders Björkman, Jeffrey A. Bailey, Jessica T. Lin, Jonathan J. Juliano Feb 2026

Artemisinin Partial Resistance Mutations In Zanzibar And Tanzania Suggest Regional Spread And African Origins, 2023, Sean V. Connelly, Julia G. Muller, Mohamed Ali, Billy E. Ngasala, Wahida Hassan, Bakari Mohamed, Kyaw L. Thwai, Jacob M. Sadler, Jacob Marglous, Abebe A. Fola, Abdallah Zacharia, Shija J. Shija, Safia Mohammed, Dominick C. Msolo, Hamza Said, Editruda E. Peter, Melic Odas, Isaack J. Rutha, Mwanaidi Nwange, Karamoko Naire, Shazia Ruybal-Pesántez, Robert Verity, Rebecca Crudale, Varun Goel, Barbara B. Choloi, Anders Björkman, Jeffrey A. Bailey, Jessica T. Lin, Jonathan J. Juliano

Faculty Publications

Artemisinin partial resistance, driven by Plasmodium falciparum K13 mutations, threatens malaria control. Zanzibar is vulnerable to artemisinin partial resistance spread but lacks recent molecular surveillance. We sequenced samples in Zanzibar and mainland Tanzania collected from 2022 to 2024. K13 mutations were found in 2 of 1440 participants (P441L, A675V) in Zanzibar and 6 of 3762 (R561H, P441L) in mainland Tanzania. Based on whole genome sequencing data, K13 mutations appear to be of African origin with regional spread. Frequent parasite importation appears to maintain partner drug mutation frequencies similar to the mainland, where artemether-lumefantrine selects for mutations favoring artesunate-amodiaquine sensitivity. Ongoing …


Comparative Evaluation Of Conventional And Sustainable Concrete Protective Coatings: Performance, Economic, And Environmental, Andro Ebrahim Feb 2026

Comparative Evaluation Of Conventional And Sustainable Concrete Protective Coatings: Performance, Economic, And Environmental, Andro Ebrahim

Theses and Dissertations

Concrete structures are highly susceptible to deterioration from environmental, chemical, and mechanical factors, making protective coatings essential for ensuring durability and reducing maintenance demands. This study aims to compare and evaluate conventional and innovative coating systems for concrete protection across three dimensions—technical performance, environmental sustainability, and life cycle cost efficiency—and to assess whether coatings often regarded or marketed as sustainable genuinely achieve sustainability across these three pillars. Four representative coatings were selected for assessment: epoxy solvent-based, epoxy solvent-free, acrylic water-based, and cementitious. Technical performance was examined through laboratory testing, expert interviews, and multiple real project cases, providing a comprehensive understanding …


Uncovering Potential Therapeutic Targets For Spinal Cord Injury; Insights From Single-Cell And Cross-Species Transcriptomics, Sara Samy Abouzekry Feb 2026

Uncovering Potential Therapeutic Targets For Spinal Cord Injury; Insights From Single-Cell And Cross-Species Transcriptomics, Sara Samy Abouzekry

Theses and Dissertations

Central nervous system (CNS) injury remains a devastating healthcare problem. Despite years of research, it remains almost impossible to achieve meaningful functional repair following traumatic brain injury (TBI) and spinal cord injury (SCI). Spinal cord injury (SCI), a highly devastating subset of CNS trauma, is considered a challenge due to the extremely limited regenerative capacity of the nervous system in adult mammals. In contrast, certain species display remarkable repair abilities followed by moderate regenerative ability in neonatal mammals, indicating that regeneration is shaped by the evolutionary context as well as the developmental age.

To uncover the core molecular mediators of …


Human Versus Machine: Can Generative Ai Anticipate Insect Biological Control Outcomes?, Kris A.G. Wyckhuys, Komivi S. Akutse, Divina M. Amalin, Salah Eddin Araj, Marie Joy B. Beltran, Ibtissem Ben Fekih, Paul André Calatayud, Lizette Cicero, Marcellin C. Cokola, Yelitza C. Colmenarez, Kenza Dessauvages, Thomas Dubois, Léna Durocher-Granger, José L. Fernández-Triana, Frederic Francis, Khalid Haddi, Rhett D. Harrison, Muhammad Haseeb, Natasha S.A. Iwanicki Feb 2026

Human Versus Machine: Can Generative Ai Anticipate Insect Biological Control Outcomes?, Kris A.G. Wyckhuys, Komivi S. Akutse, Divina M. Amalin, Salah Eddin Araj, Marie Joy B. Beltran, Ibtissem Ben Fekih, Paul André Calatayud, Lizette Cicero, Marcellin C. Cokola, Yelitza C. Colmenarez, Kenza Dessauvages, Thomas Dubois, Léna Durocher-Granger, José L. Fernández-Triana, Frederic Francis, Khalid Haddi, Rhett D. Harrison, Muhammad Haseeb, Natasha S.A. Iwanicki

All Peer-Reviewed Publications

Generative artificial intelligence (AI) could transform evidence synthesis and revolutionize the global scientific enterprise, yet its agricultural applications are understudied. Here, we systematically assess the performance of three web-grounded AI engines (ChatGPT, ScholarAI and DeepSeek) in synthesizing the global literature on biological control of the fall armyworm Spodoptera frugiperda, and benchmark their outputs against a recent, near-exhaustive human review. Though all engines rapidly screened vast literature corpora, they exhibited shortcomings in factual accuracy, reporting reliability and data consistency. In machine-run syntheses, natural enemy prevalence and performance data often diverged from published records while the level of agreement in enumerating top-performing …


Clear And Concise: Technical Writing For Biological Engineers, Abigail S. Engelberth Feb 2026

Clear And Concise: Technical Writing For Biological Engineers, Abigail S. Engelberth

Purdue University Press Books

Clear and Concise: Technical Writing for Biological Engineers is a practical guide designed to help students and early career engineers communicate their work with clarity and confidence. Drawing on years of teaching experience, Abigail S. Engelberth breaks down the essentials of technical writing into approachable steps, showing readers how to organize ideas, present data effectively, and write reports that meet professional standards.

Rather than overwhelming readers with theory, the book focuses on real-world application. It includes examples, checklists, and strategies for common engineering documents including formal and memo-style lab reports. Special attention is given to visuals, formatting, and the role …


Mechanized Tube Well Installation, Robert M. Stwalley Iii, Grace L. Baldwin Kan-Uge, Roger Tormoehlen Feb 2026

Mechanized Tube Well Installation, Robert M. Stwalley Iii, Grace L. Baldwin Kan-Uge, Roger Tormoehlen

Purdue University Press Books

Mechanized Tube Well Installation provides detailed information on the design development of a mechanized means to install shallow tube wells using a hydraulic driver attached to a small vehicle. This book explores the creation of this technique through the merging of available components, selection of the components, testing of the assembly, and the driving of wells. It also provides comprehensive coverage of state-of-the-art engineering, technology, and best practices as they relate to driving water wells for human consumption, animal care, and irrigation. Mechanized Tube Well Installation is well-aligned with collegiate humanitarian aid, environmental and natural resources engineering, and agricultural equipment …


Teaching Integrated Stem In Middle School, S. Selcen Guzey Feb 2026

Teaching Integrated Stem In Middle School, S. Selcen Guzey

Purdue University Press Books

Teaching Integrated STEM in Middle School is a valuable resource for educators, researchers, and policymakers who are committed to furthering integrated STEM education. Through a review of the literature on the topic, the volume offers a clear understanding of the impact of integrated STEM education on instructors’ teaching practices and student outcomes. The book presents a framework and instructional guide that educators can utilize to develop new curricular materials. Two sample units—focused on designing a two-stage water filter and formulating sunscreen—provide step-by-step guidance for lesson implementation and offer strategies for assisting students as they use engineering models to devise design …