Digital Commons Network^™

Why General Ai Inherited The Body: A Structural Account Of Embodied Modulation Under Monolithic Imitation, Griselda Poe

Publications and Research

General AI has pursued the replication of human-level intelligence without first decomposing human cognition into structurally distinct components. Human cognition, however, is shaped by embodied constraints such as mortality, survival pressures, finite lifespan, and physiological states. This paper argues that when cognition is treated as a single undifferentiated whole, embodied modulation is not accidentally introduced into AI systems but structurally entailed. Any attempt to imitate “human intelligence” under a monolithic model necessarily incorporates variability shaped by mortal embodiment. The tensions observed in contemporary AI systems are better understood as consequences of copying an undecomposed target rather than isolated implementation errors. …

Unveiling The Patent Landscape Of Biologic Drugs, Michael D. Frakes, Melissa F. Wasserman

Northwestern University Law Review

It is undeniable that the escalating price of biopharmaceuticals is a critical issue, as high prices limit patients’ access to life-saving medications and strain our healthcare system. Biologics, or large-molecule drugs, which are revolutionizing modern healthcare, are significantly contributing to the escalating cost of prescription drugs. While biologic drugs represent only 2% of all U.S. prescriptions, they comprise close to 50% of net drug spending.

Policymakers have proposed a series of interventions to decrease drug prices that target the patent practices of pharmaceutical firms. Yet due to differences in law, we have a robust source of patenting information for small-molecule …

Embodied Transcendence: Psychedelics And The Evolution Of Moral Abstraction, Emanuel Jas

Journal of Conscious Evolution

This paper explores the role of psychedelics in the context of evolutionary brain development and the conceptual capacity for moral realism. Drawing on theories from evolutionary anthropology, neuroscience, and moral philosophy, the first part provides a brief overview of human evolution and brain expansion. From here, recent empirical data from the neurosciences is assessed on the effect psychedelics have on the brain, along with speculations on the role of psychedelics in our hominoid evolutionary history—specifically, the capacity for phenomenologically rich, conscious, subjective experiences that are incredibly vivid and real. This imaginative capacity for transcendence and disembodiment could enable the realization …

Targeted Therapy In Hepatobiliary Pancreatic Cancer (Hpc): Advantages And Advancements Of Antibody Drug Conjugates, A Type Of Chemo-Biologic Hybrid Drugs, Tushar Deb Nath, Attrayo Mukherjee, Subhash Chauhan, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Currently, there are very few efficient treatment options for hepatobiliary pancreatic cancer (HPC), which comprises pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC), and hepatocellular carcinoma (HCC). The HPC tumors are the most lethal malignant tumors in the world. Traditional chemotherapy offers little survival benefit and is associated with notable systemic toxicity, which has made antibody–drug conjugates (ADCs) a hopeful treatment option. Strong cytotoxic drugs combine with monoclonal antibodies to attack tumor-associated antigens. This review discusses the benefits and current developments of Antibody–Drug Conjugates (ADCs) in treating HPC. It also covers their mechanisms of action, ongoing clinical trials, and the …

Characterisation Of Pouch Secretions From Breeding Tasmanian Devils, Manujaya W. Jayamanna Mohottige, Emma Peel, Angéla Juhász, Mitchell G. Nye-Wood, Katherine Belov, Michelle L. Colgrave, Carolyn J. Hogg

Research outputs 2022 to 2026

Tasmanian devils (Sarcophilus harrisii), like all marsupials, give birth to altricial young. Here we employ proteomic analysis to identify components of devil pouch secretions that may contribute to offspring survival and development. Proteins were extracted from five samples and analysed by liquid chromatography-tandem mass spectrometry. Peptide-level evidence revealed proteins involved in a diverse set of immune pathways, including those mediating iron-ion transport, defence responses to bacteria, innate immune responses, and antigen processing. A core set of 200 proteins was identified across at least three samples, 63 of which were associated with antimicrobial or immunoregulatory functions. These included immunoglobulins, components of …

Engineering 50 Years From Today: A Purdue Engineering Community Perspective, Arvind Raman

Purdue University Press Books

Since opening its doors in 1874, Purdue University’s College of Engineering and its graduates have been at the forefront of technological breakthroughs and are now poised to lead the next generation of engineers in the United States and around the globe. Featuring more than twenty-five essays from former Boilermakers, Engineering 50 Years From Today both celebrates the program’s 150th anniversary and looks ahead, exploring what the field of engineering might look like half a century from now. Leading luminaries from Purdue’s engineering community, including prominent university professors as well as innovators working in the private sector, reveal how technologies related …

Medical Detection Dogs: A Visual Exploration Of Canine Olfactory Anatomy & Volatile Organic Compounds As Applied To Non-Invasive Biomedical Detection, Kirsten Santiago

Theses

Medical detection dogs provide a non-invasive early method of disease and medical alert detection that is underrepresented in the medical visualization sector. The domesticated dog, or Canis familiaris, is known for its loving nature and has become an important member of many households, but they are also incredibly intelligent with a capacity for specialized training. Dogs have a specialized olfactory system, allowing them to detect scents with high acuity (Guest & Otto, 20). Volatile organic compounds or VOCs are molecular substances associated with metabolic processes that are often a result or byproduct of certain diseases and can be influenced by …

Perceived Social Exclusion Among Mothers Of Autistic Children, Rahim Hamli Maraj, Zainab Hussein Dawood Salman

Alustath Journal for Human and Social Sciences

Interaction with the environment is one of the basic pillars of the process of building civilization, as it represents the vital relationship between man and the surrounding nature. Investing in natural resources and harnessing them to serve society is what ensures the continuity and growth of civilizations. Hence, it becomes clear that any civilization cannot be built in isolation from the environment, as it is the incubator that provides man with raw materials, and it is also the field in which he tests his abilities to innovate and develop.The ancient Egyptian civilization is a prominent example of how to interact …

Radiation Doses To Cardiac Substructures Predict Elevation In High-Sensitivity Cardiac Troponin T Levels In Radiation Therapy For Lung Cancer, Xinru Chen, Xiaodong Zhang, Ting Xu, Radhe Mohan, Ruitao Lin, Mei Chen, Rachel C Maguire, Yao Zhao, Efstratios Koutroumpakis, Nicolas L Palaskas, Anita Deswal, Ali Ajdari, Joshua S Niedzielski, Sanjay S Shete, Laurence E Court, Jinzhong Yang, Zhongxing Liao

Faculty, Staff and Student Publications

Purpose: Cardiotoxicity is a major concern for patients undergoing thoracic radiation therapy. This study compared the predictive power of radiation dose-volume histogram (DVH) parameters and radiomic/dosiomic features of the whole heart (WH) and cardiac substructures for elevated circulating high-sensitivity cardiac troponin T (hs-cTnT), a biomarker for early detection of cardiac adverse events.

Methods and materials: A retrospective cohort of 160 patients with non-small cell lung cancer (NSCLC) from a completed prospective trial and a prospective cohort of 57 patients with NSCLC enrolled in an ongoing trial were analyzed. The endpoint was hs-cTnT elevation, indicated by an increase of ≥5 ng/L …

High Dietary Fiber Is Associated With Improved Outcomes In Patients With Melanoma And Sarcoma Treated With Immunotherapy Regardless Of Gut Microbiome Dysbiosis And Social Vulnerability, Brittany C Fields, Raymond S Traweek, Kai Jiang, Russell G Witt, Ashish Damania, Yi-Ju Chiang, Nadim Ajami, Elise Nassif-Haddad, Emily Z Keung, Manoj Chelvanambi, Xiaotao Zhang, Christine B Peterson, Jennifer A Wargo, Carrie R Daniel, Christina L Roland, Ashley M Holder

Faculty, Staff and Student Publications

Background: Social vulnerability, dietary fiber, and the gut microbiome have been individually implicated in clinical outcomes for melanoma and sarcoma patients. This study hypothesized that increasing social vulnerability is associated with insufficient dietary fiber intake and negatively associated with microbiome composition and clinical outcomes.

Methods: Clinicopathologic data, baseline fiber intake, and gut microbiome profiles were assessed in 153 patients with melanoma or sarcoma treated with immune checkpoint blockade (ICB) and prospectively followed. Patients' social vulnerability index (SVI) and fiber intake were evaluated for associations with microbiome composition, treatment response, and overall survival (OS).

Results: SVI percentile was 0.4 (interquartile ratio …

Weaving Healthcare Needs Of Maine Law Enforcement Officers With Exercise Is Medicine, Patricia Hubel

Doctorate in Kinesiology

A law enforcement officer’s health is impacted by an occupation of high stress, shift work, sleep disruption, mental stresses, and primarily sedentary work which is interrupted by brief periods of highly intense physical demands (Adams et al., 2010; Boyce et al., 2008, 2009). This descriptive study explored the use of exercise is medicine by primary care practitioners on patients who are law enforcement officers in the state of Maine. It also examined physical activity and health of the law enforcement officers. An online survey collected demographic data, responses from two validated surveys, and information from their last physical examination. The …

Mind–Body Medicine Training For Incarcerated Men And Women, Julie K. Staples, Jesse Rice, Kathleen S. Farah, Sabrina N'Diaye, James S. Gordon

Student Publications

Background/Objective: Mind–body programs teaching mindfulness-based techniques have benefits for incarcerated people, as do programs in which individuals teach yoga to their incarcerated peers. However, there are no studies of comprehensive programs that combine a variety of self-care techniques with group support and enable people in prison to enhance their own well-being and then share what they have learned with their peers. This study evaluated the effects of such a training program in the United States. Methods: Thirty-eight incarcerated men and women began the 8-day mind–body medicine training and 31 completed the training. Mind–body techniques taught included soft belly breathing, meditation, …

Speleoco: An Open, Low-Cost Arduino Co₂ Datalogger For Cave Microclimate Monitoring, Christos Pennos, Dimitrios Christaras

International Journal of Speleology

Carbon dioxide (CO₂) dynamics in caves are critical for karst processes, speleothem growth and dissolution, microclimate regulation, and caver safety. In cave atmospheres, CO₂ commonly derives from soil respiration, epikarst degassing, microbial activity, and, in tectonically active regions, deep-seated fault-related emissions. Fault-related CO₂ degassing may also track tectonic activity. However, continuous monitoring remains limited due to the cost and inflexibility of commercial instruments. Here we present an open-source, low-cost Arduino-based CO₂ datalogger designed for cave applications. The logger integrates a COZIR NDIR CO₂ sensor, a DS1337 real-time clock, microSD storage, and power-gating for extended deployment in humid environments. Firmware and …

Simulated Hearing Loss In Healthy Young And Older Adults Results In Poor Reaction Time In Older Adults., Victoria Kowalewski, Nicoleta Bugnariu, Rita M. Patterson, Jessica Hartos

Pacific Journal of Health

Emerging evidence links hearing loss to increased fall risk in older adults, yet mechanisms remain unclear. This study examined the impact of simulated hearing loss on reactive balance control in healthy young and older adults. Participants performed dual-task scenario involving auditory sentence repetition and unexpected surface translations. Hearing loss was simulated using Adobe Audition, applying frequency-specific attenuation based on moderate sensorineural hearing loss levels from the literature.

Speech-in-noise performance significantly declined under simulated hearing loss for both age groups (p < .001), confirming effective simulation, but not significant differences were found between age groups. Maximum COP-COM displacement (the scalar distance between Center of Pressure and Center of Mass) increased with perturbation intensity (Level 1 vs. Level 2: p < .001), but no significant differences were found between hearing conditions or age groups (p > .05), suggesting compensatory step execution was preserved.

Reaction time analysis revealed a significant interaction between hearing condition and perturbation level …

A Distributed Model For Undergraduate Education In Environmental Remote Sensing: Increased Student Interest In Science And Sense Of Science Identity And Belonging, Gregory R. Goldsmith, Monae Verbeke, Jeremy Forsythe, Joshua B. Fisher

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

"We present results from a new open-access course in satellite remote sensing of the environment that uses evidence-based, active learning pedagogy to train the next generation of interdisciplinary scientists The course, called Observing Earth from Above, teaches students how to access, visualize, and communicate satellite remote sensing data from NASA’s ECOSTRESS instrument to address a variety of environmental challenges. The resources focus on follow-along tutorials for students and also include recorded lectures and interviews with remote sensing scientists."

Flight Of The Gods: Charting The Terra Incognita Of Belief Through Dragon Literature, Alanna Hess

Undergraduate Honors Theses

“Flight of the Gods” is a fantasy short story that portrays a religious relationship between humans and dragons to explore themes of religious questioning. In doing so, “Flight of the Gods” unites with modern dragon literature by adapting the dragon motif to address real-world issues. Drawing from research on falcons and falconry, the dragons in this short story exhibit a complex relationship with their human counterparts that emphasizes themes of religious doubt and the complexity of belief. The thesis begins with a critical introduction discussing these topics and then presents the short story.

Advancements In Extracellular Vesicle Research, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The AAEV (American Association of Extracellular Vesicles) Annual Meeting at the John P. McGovern Commons in Houston, TX convened over 300 leading re- searchers, clinicians, and industry experts from around the world to advance the rapidly evolving field of extracellular vesicle (EV) science. EVs, nanoscale lipid- bound particles released by all prokaryotic and eukaryotic cells, have emerged as crucial mediators of intercellular communication, trans- porting proteins, nucleic acids, and lipids that influence a wide spectrum of physiological and pathological processes. Their involvement in immune modulation, tissue regeneration, cancer progression, metabolic regulation, and other complex biological functions positions EVs as promising …

Age Of Menopause Among Women In Mosul City, Iraq, Omaima A. Zubair

Hilla University College Journal For Medical Science

Background: Low women's awareness of their health during the menopausal period is creating a global hidden problem that affects women's quality of life and their related families and communities. Objectives: The aim of this study was to find changes in the menopausal age after wartime conflict and assess women's knowledge of their health during this critical period. A mixed-method design was adopted. A mixed approach of a multistage cross-sectional study with a sample of 382 women aged ≥ 60 years attending primary health care centers in Mosul, Iraq, was included, supported by private in-depth qualitative interviews with 14 women. Proper …

Characterization Of Biosynthesis Of Silver Nanoparticles And Their Antibiofilm Activity Against Enterococcus Faecalis, Sarah Mahmood Ibrahim, Jaleel N. Samanje, Esam Jummah Naser

Hilla University College Journal For Medical Science

Background: Due to the increasing presence of antibiotic resistance genes, treatment options for clinical infections are becoming increasingly limited. Objectives: This study aimed to synthesize, optimize, characterize, and evaluate the bioactivity of biogenic silver nanoparticles (Ag bioNPs) against a clinical isolate of E.faecalis. Materials and Methods: The formation of silver nanoparticles was confirmed under optimized conditions, with a UV-Vis absorption peak at 419 nm, and their crystal structures were verified by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FTIR) analysis demonstrated the interaction of protein molecules with the nanoparticles, and transmission electron microscopy (TEM) revealed monodisperse spherical silver nanoparticles …

Hba1c, C-Peptide, And Other Biochemical Indicators In The Management Of Type 1 Diabetes Mellitus: A Review, Israa M.Ali Alameen, Sumayah Mahmood Rafid, Baqer K. Hothefa, Farah Ali Hameed

Hilla University College Journal For Medical Science

The number of children and adolescents who are suffering from Type 1 Diabetes Mellitus (T1DM) in Iraq is continuously increasing. Nutritional management and biochemical markers play a major role in controlling the disease. Several criteria are essential for assessing glycemic control and the course of the disease. Methods: This review examined published Iraqi research addressing two topics that have a direct effect on type 1 Diabetes Mellitus (T1DM): nutritional aspects (carbohydrate counting and dietary education) and biochemical markers (HbA1c and C-peptide). The findings were compared with those of other international studies. Results: Iraqi studies consistently recorded higher HbA1c levels and …

Versatile Pericytes As A Solid Candidate In Regenerative Medicine And Dental Implant: A Review, Hassan Jawad Farhan, Akram Yousif Yasear, Mohamed Abdul-Hameed

Hilla University College Journal For Medical Science

Regenerative medicine is a very active topic in medicine. Regenerative medicine is entails the utilization of cells available in our body called stem cells in reaching to the root causes of the diseases rather than treatment of the symptoms of the disease. The advantage of using one's own body cells is to prevent not to consider the stem cells as a heterograft, which are rejected by the immune system of the body. The pericytes possess all the features to be nominated as the main cells in our body to be utilized as stem cells. The pericytes have been considered pleuripotential …

Decision-Making At The Edges Of Capacity: Brain Science And Caregiving, Dr. Julie Yonker

University Faculty Publications and Creative Works

Keynote address at the Disabilities Resources Symposium at City Hope Church in Grand Rapids on 3/14/2026. Attached is her powerpoint.

• Describe why our brains don’t like decisions
• Understand the impact of different types of decisions
• Value suggestions for more sustained decision making
• Consider a faith perspective

Beyond The Brain: How Does Alzheimer’S Disease Affect The Body?, Ye-Jin Park, Hongjie Li

Center on Aging Staff Publications

No abstract provided.

Development Of A Problem-Based Learning Model Assisted By The Interactive Canva Application To Improve Critical Thinking And Collaboration Skills Of Fourth Grade Elementary School Students, Fitri Dwi Utami, Heris Hendriana, Galih Dani Septyan Rahayu

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Penelitian ini dimotivasi oleh rendahnya kemampuan berpikir kritis dan kolaborasi siswa kelas empat sekolah dasar yang disebabkan oleh pembelajaran konvensional dan kurangnya penggunaan media pembelajaran interaktif. Studi ini bertujuan untuk mengembangkan model Pembelajaran Berbasis Masalah (PBL) yang dibantu oleh aplikasi interaktif Canva yang layak dan efektif untuk meningkatkan kemampuan berpikir kritis dan kolaborasi siswa. Metode penelitian yang digunakan adalah model Penelitian dan Pengembangan (R&D) Borg & Gall yang meliputi tahapan analisis kebutuhan, perencanaan, pengembangan produk, validasi ahli, revisi produk, dan uji lapangan. Subjek penelitian terdiri dari 21 siswa pada uji terbatas, 30 siswa pada uji luas, dan 60 siswa pada …

2. Impact Of Gum Chewing On Postoperative Ileus Following Open Heart Surgery, Jacinta Smith

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Professional Quality Of Life Among Medical Surgical And Telemetry Registered Nurses, William Lim, Emy-Lee Marie Anglo Ricafrente, Jenny Carrillo

Providence Nursing Research Conference 2023 – Present

No abstract provided.

From The Classroom To The Computer, Tina S. Herzberg, Laura M. Hooks

Teacher Education Journal of South Carolina

This article investigates the increased use of technology to provide distance education within the School of Education at the University of South Carolina (USC) Upstate. Interestingly, graduate education programs have been receptive to distance learning and now offer various courses each semester via distance education. This has allowed the university to provide flexibility and attracted graduate students throughout the Upstate region. Currently, there is a need for faculty in undergraduate programs at USC Upstate to explore if and how methodology courses could be developed as distance education courses while maintaining academic integrity.

Analysis Of Traditional Wisdom For Ecological Sustainability In Tanzania: A Case Study Of Metaphorical Source Domains In Pangwa Ritual Texts, Winne Stephen Mtega, Angelus Mnenuka

Journal of Humanities and Social Sciences

Campaigns for ecological sustainability have gained a great currency in the contemporary academic discourse. Nonetheless, from time immemorial, Africans have pushed the ecological sustainability agenda through cultural taboos and regulated resource harvesting. Many African societies have embedded ecological consciousness in daily life expressions, and have intricately expressed it through literary and ritual texts. This study focuses on ecological awareness in the ritual texts of the Pangwa community. It analyses how environmental domains—such as land, seeds, and fruits—serve as the basis for metaphors in the Pangwa community to prove the use of wisdom to promote and sustain ecological practices (ecocriticism). The …

Ecosystem-Based Flood Disaster Risk Reduction In The Little Ruaha River Basin, In The Southern Highlands Of Tanzania, Mawazo Ghambi, Tiemo Romward Haule

Journal of Humanities and Social Sciences

Ecosystem-based approach that integrates floods and environmental risk management is believed to reduce flood disaster risk while providing socio-economic and environmental benefits to floodplain occupants. This study examined the socio-economic and environmental benefits of the ecosystem-based approach in managing flood disaster risk in the Little Ruaha River Basin in the southern highlands of Tanzania. The study involved 157 participants and employed the mixed research design to collect quantitative and qualitative data. Semi-structured interviews, in-depth interviews, direct field observation and Focus Group Discussions were used to collect primary data, whereas documentary review was used to collect secondary data. Findings revealed that …

Enhancing Staff Knowledge And Confidence In Depression Screening Using The Patient Health Questionnaire-9, Melkamzer Chari

Walden Dissertations and Doctoral Studies

Depression is a serious public health concern affecting over 280 million people globally and leading to significant morbidity and mortality if left undetected and untreated. At the local organization, leadership identified inconsistent depression screening as a practice problem among nursing staff. Thus, the purpose of this doctor in nursing practice (DNP) project was to determine if an educational intervention focused on depression, the importance of depression screening, and the use of the Patient Health Questionnaire-9 (PHQ-9) increased knowledge and confidence among nursing staff working in a local organization. Fifteen participants volunteered to participate in the project. The average age was …