Digital Commons Network^™

The Positronic Law On Biological Substrate: Mapping Stoicheion Governance Axioms To Bacterial Quorum Sensing And Slime Mold Computation Using Published Peer-Reviewed Data, David Lee Wise

Defensive Publications Series

This paper extends Wise's Positronic Law (TD Commons #9442) from silicon substrates to biological substrates. Using published, peer-reviewed research on bacterial quorum sensing and slime mold (Physarum polycephalum) computation, we demonstrate that the governance architecture documented in the STOICHEION framework maps structurally to biological systems that have been performing substrate-independent governance for 3.5 billion years. No new experiments were conducted. All evidence is drawn from existing peer-reviewed publications. The contribution is the mapping: demonstrating structural correspondence between STOICHEION governance axioms and documented biological governance mechanisms. If the mapping holds, the Positronic Law is confirmed as natural law: governance is inherent …

Tennessee 2025 State Wildlife Action Plan: Appendix H - Comprehensive Hierarchy Of State Conservation Actions, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

Tennessee State Wildlife Action Plan 2025, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

Mitochondrial Transfer And Induced Ros As A Therapeutic Strategy In Idh2-Mutant Chondrosarcoma, Vegas R. Bedder, Caleb Wyckoff, Chris Osgood, Gavin A. Vasquez, Michael Stacey

Knowledge and Creativity Expo

Chondrosarcoma (CS) are common bone cancers that produce cartilaginous tumors and are extremely refractive to chemo-and-radiation therapies, leaving very limited treatment options. They contain mutations in the isocitrate dehydrogenase genes, IDH1 or IDH2. Either IDH1 or IDH2 mutations are present in individual tumors, but not both. They both convert alphaketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG). D2HG can be transported from the tumors to cells of the tumor microenvironment (TME) where it can alter metabolic and epigenetic profiles in recipient cells. The process of α-KG to D2HG conversion occurs in the cytoplasm of IDH1 mutant cells, and in the …

Human Subject Studies For The Alignment Of Llm-As-A-Judge Evaluation Metric For Science News, Gabriel Vega Osborne

Knowledge and Creativity Expo

Science news has become an important vehicle to disseminate scientific breakthroughs, discoveries, and technological innovations. With the advancement of large language models and related AI models, it is possible to automatically generate science news from scientific papers, extending the reader population from domain scientists to a broader scope. However, how to evaluate the quality of the generated news warrants research. Traditional token based metrics have been shown to fail to evaluate the semantics and nuances of science news. Inspired by the fact that a major goal of science news is to educate readers with new knowledge, we thus propose knowledge …

The Effect Of Tropical Temperature Conditions On Salmonella Typhimurium Growth, Elyza Dionne A. Constantino, Anastasia Charlotte D.C. Pabriga, John Vergel A. Pamintuan, Mark Daniel A. Velasco, John Albert D. Gurtiza

DLSU Senior High School Research Congress Conference Proceedings

Salmonella contamination remains a significant health concern, particularly in environments where temperature fluctuations influence bacterial survival. While previous studies have identified temperature as a key factor in microbial growth, the specific effects of varying heat levels on Salmonella enterica serovar Typhimurium concentration require further investigation, particularly in the context of the Philippines. This study examined bacterial concentration across different temperatures by assessing S. typhimurium under controlled laboratory conditions at 37 °C, 42 °C, and 47 °C. Microbiological analysis quantified bacterial colonies (CFU/mL), revealing a decreasing trend in S. typhimurium concentration as temperature increased. The highest concentration was observed at 37 …

Spatiotemporal Risk Analysis Of Fall Armyworms (Spodoptera Frugiperda) Using Growth Indicators In Tarlac, Philippines, Frans Josef Gotis De Justo, Reese Gianna Hernandez Gollod, Katherine Samantha Salvador Manaig, Mary Dominique Vargas Padilla, Angela Nicole S. Masongsong

DLSU Senior High School Research Congress Conference Proceedings

In recent years, Fall Armyworm (FAW) reports have steadily increased in warmer regions of various continents, causing significant losses in the agricultural sector, especially in staple crops such as rice, corn, and sorghum. The pest species travels across warmer areas by riding wind currents and targeting crops. To combat FAW, farmers have developed and improved pesticide formulas and other control strategies, as the pest has shown resistance to many commercial pesticides used. However, FAW monitoring remains a challenge for the agricultural sector. With the agricultural nature of the Philippines,  it is crucial to monitor the pest's spread behavior in order …

Pathway Mapping Of Bioactive Compounds In Guyabano (Annona Muricata) Leaves On Anti-Diabetic Proteins Found In Homo Sapiens, Miryea Andrea Cayetano, Gabrielle Micha Co, Akhicko Beatrize Simone Tablazon Facilan Ms, Jane Abigail M. Santiago-Santos

DLSU Senior High School Research Congress Conference Proceedings

Diabetes is a global health concern, leading to increased efforts to explore alternative treatments. Annona muricata, commonly known as Guyabano, is frequently used in traditional medicine, particularly its leaves and fruits, to alleviate symptoms associated with diabetes. However, despite its widespread use, limited research has explored the molecular mechanisms of bioactive compounds in A. muricata leaves in relation to anti-diabetic effects. This study aimed to bridge this gap by using in silico methods to examine the interactions between bioactive compounds from A. muricata leaves and human proteins implicated in anti-diabetic activity. Bioinformatics tools, including molecular docking and pathway mapping, were …

Impact Of Sugar Content And Ph Levels On The Microbial Load Of Street Food Dipping Sauces, Maffae Ashley L. Padernal, Yeinniel Miguel D. Cao, Jamie M. Velasquez, John Albert D. Gurtiza

DLSU Senior High School Research Congress Conference Proceedings

Foodborne illnesses cause millions of deaths annually, posing a significant public health concern, particularly in regions with thriving street food cultures like the Philippines. This study investigated how sugar content and pH levels in street food dipping sauces affect microbial growth. Six sauce samples were prepared with varying sugar (25g, 50g, 75g) and pH levels (4.0, 3.6, 3.1). Microbial load was measured using the Standard Plate Count (SPC) method. While a moderate sugar concentration (50g) showed the lowest microbial load, this difference was not statistically significant (p=0.77). However, pH significantly impacted microbial growth (p=0.0034), with pH 3.6 showing the lowest …

From Forest To Table: A Meta-Analysis On The Native Fruit Food Resources Of The Philippines, Jocelyn Louise S. Gan, Jonathan B. Gutierrez Jr., Gwyneth Anne G. Taban, Patricia Elizabeth Y. Yu, Ma. Patricia D. Cortez

DLSU Senior High School Research Congress Conference Proceedings

The Philippines boasts a rich plant biodiversity as it is located in the tropical region of the Earth. This opens up many opportunities for ethnobotanical research, which studies the many practical and cultural aspects of the plants present within a region. Native fruits are fruits grown in a specific region that have been neglected by the country’s market, as it prioritizes industrialization over cultural and native traditions and practices. As a result, research on native fruits is becoming few and far between. The researchers see this as a missed opportunity to widen and enrich both the country’s biodiversity and culture. …

Comparative Analysis Of Maceration Extraction Methods For Annona Muricata Leaf Extract Against Bacillus Subtilis Biofilm, Mikylla Eunice G. Santos, Drew Antoinette T. Roxas, Ayumi B. Santos, John Albert D. Gurtiza

DLSU Senior High School Research Congress Conference Proceedings

Biofilms, which are widespread microbial communities protected by a self-produced matrix, pose a significant threat to human health, industrial processes, and food safety. While synthetic antimicrobials are widely used, concerns about resistance and environmental impact drive the search for natural alternatives. Guyabano (Annona muricata), a tropical fruit known for its antimicrobial properties, shows potential as a natural antibiofilm agent. This study aimed to compare the impact of three different maceration extraction methods (aqueous, ethanolic, and methanolic) on the antibiofilm efficacy of A. muricata leaf extract against Bacillus subtilis biofilm. Each extract was subjected to a 96-well microplate biofilm inhibition assay, …

Assessing The Antimicrobial Activity Of Avocado (Persea Americana) Peel Extract: Microbial Load Inhibition On Chicken Meat, Geneva Gloelle S. Tejada, Prescious Ñina S. Quinan, Chloie Marjorie D. Ganggangan, Angelica M. Nadonga

DLSU Senior High School Research Congress Conference Proceedings

Bacterial contamination of chicken meat poses significant health and economic risks globally. This study explored the potential of Avocado Peel Extract (APE) as a natural antimicrobial agent to inhibit microbial load. Raw chicken meat samples were treated with varying APE concentrations (10%, 1%, 0.1%) and a negative control. Microbial Load Count (MLC), measured in colony-forming units per gram (CFU/g) via Aerobic Plate Count (APC) after 24-hour incubation at 37°C, ranged from 1.73E+09 CFU/g (Control, 10% APE (1.83E+09 CFU/g), 1% APE (3.03E+09 CFU/g), 0.1% APE (2.17E+09 CFU/g). One-way Analysis of Variance (ANOVA) revealed no statistically significant difference (p=0.149). The lack of …

Cytotoxicity Of Glucosinolates Extracted From Green Cabbage (Brassica Oleracea Var. Capitata), Albert Ii G. Gonzales, John Henrick M. Monotilla, Andrea Vera D. Hellera, Julia Alexa T. Reyes, Empress Kharen M. Villena, Suzzeth U. Dizon

DLSU Senior High School Research Congress Conference Proceedings

Cancer is a large group of diseases characterized by the uncontrolled growth of abnormal cells, which can invade any organ or tissue. According to WHO (2025), cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or approximately one in six deaths. Despite significant advancements in cancer treatments over the years, such as radiation and chemotherapy, commonly used post-surgical complementary therapies can cause adverse side effects, including nerve damage, fatigue, and chronic pain. Glucosinolate (GSLs) is a naturally occurring compound found in cruciferous vegetables, such as green cabbage. These compounds generate metabolites that exhibit …

Cytotoxicity Of Ageratina Riparia (Mistflower) Biosynthesized Silver Nanoparticles In Allium Cepa Assay, Jharred Martinez, Kathryn Beyonce B. Fajardo, Kathryz Beyonce B. Fajardo, Althea Marie A. Navalta, Abegail B. Palcongan

DLSU Senior High School Research Congress Conference Proceedings

The use of green-synthesized nanoparticles offers a promising route toward eco-friendly and biocompatible alternatives in biomedical research. This study aimed to assess the cytotoxicity of silver nanoparticles (AgNPs) biosynthesized from Ageratina riparia extract. Given the growing interest in plant-mediated nanoparticle synthesis for safe therapeutic applications, evaluating their biological effects is crucial. The extract was obtained through maceration of 60 g of powdered leaves, and green synthesis was conducted using silver nitrate solutions (1 mM, 3 mM, 5 mM). The mixtures were boiled to isolate nanoparticle pellets, which were then redispersed in distilled water for use as treatment liquids in the …

Filipino Parentification On The Eldest Child Enrolled As A Senior High School At De La Salle University - Dasmariñas High School: An Exploration Of Its Effects On Interpersonal Relationships With Friends, Naraeshcka Nailah Molina Lumba, Ron Antoine Ramirez Corpuz, Maria Jhemille Lopez Dela Cruz, Nica Angela Guarin Dulce, Ruzzlyn Myles Briones Manay, Dhey Zamyuel Gonzales Masilang, Miguel Guillen Buhay Orozco, Fionah Zoe Lopez Pros, Isaac Christian Basa Rafio

DLSU Senior High School Research Congress Conference Proceedings

This study examined Filipino parentification among eldest children enrolled as senior high school students at De La Salle University – Dasmariñas, focusing on its impact on friendships. Grounded in Role Theory, it explored how premature parental responsibilities shape social interactions using a qualitative phenomenological approach with semi-structured interviews. Findings indicate that eldest children often assume caregiving, emotional support, and decision-making roles, fostering maturity and resilience, but also leading to trust issues, emotional distancing, and difficulties in maintaining friendships. Certain individuals tend to adopt parental roles within friend groups, while some seek nurturing relationships akin to a ‘youngest’ sibling dynamic. Cultural …

Randomized Controlled Trial Outcomes For Homestyles-2, An Online Obesity Prevention Program For Families With Children In Middle Childhood, Carol Byrd-Bredbenner, Angelica A. Pozzoli, Kaitlyn M. Eck, John Worobey, Karla Pagan Shelnutt, Melissa D. Olfert, Virginia Quick

College of Health Professions Faculty Papers

Background: Parents are children’s primary role models, are food and physical activity gatekeepers, and create the home structure/lifestyle environment. Thus, parents strongly influence children’s weight-related behaviors and have the opportunity to cultivate a “culture of health” within the home. Methods: The aim of the HomeStyles-2 (also called HomeStyles-Child) RCT was to determine whether this online, novel, age-appropriate, family intervention enabled and motivated the 131 systematically randomly assigned by computer parents of children in middle childhood (ages 6 to 11) in the experimental condition to shape home environments and healthy weight-related lifestyle practices to be more supportive of optimal health and …

Recombinant Hagfish Intermediate Filament Proteins Enable Neural Culture Substrates That Promote Neurite Extension And Reduce Oxidative Stress, Justin Jones, Kristin Durrant

Browse all Datasets

This dataset supports the production, characterization, and biological validation of a novel recombinant hagfish intermediate filament (rHIF) protein functionalized with spider silk motifs (rHIF-alpha-GRGGL). The data demonstrates a scalable bioprocess resulting in a 7.76 g/L yield, high structural alpha-helicity (77.2%), and significant support for N2a cells.

Point-Of-Care Electrochemical Diagnostic Developments For Multidrug-Resistant Bacteria: Role Of Aptamers And Nanomaterials, Kamna Ravi, Baljit Singh

Research Outputs: 2025-Present

The unchecked and uncontrolled global spread of multidrug-resistant (MDR) bacteria is a serious challenge to healthcare and modern medicine, and demands diagnostic approaches that are rapid, sensitive, multiplexed, and reliable in point-of-care (POC) settings. At the interface of nanomaterials and aptamer-based biosensing, significant advances have been reported. The convergence of portable electrochemical sensing technologies, smartphone-based readout systems, and artificial intelligence (AI)- and machine learning (ML)-based data analysis is also playing a significant role in advancing this area. This perspective reflects on the most recent breakthroughs and translational developments in electrochemical nano-aptasensors for MDR bacterial detection, covering diagnostic targets and translation …

Artificial Intelligence In Mycology: A Systematic Review Of Species Identification, Biotechnological Assessment, And Explainable Deep Learning Methods, Fati̇h Eki̇nci̇, Mehmet Serdar Güzel, Ilgaz Akata

Turkish Journal of Botany

This review offers a comprehensive analysis of the expanding role of artificial intelligence (AI) in mycological research. It highlights how AI supports the identification of fungal taxa at both microscopic and macroscopic levels, facilitates the detection of toxic species, contributes to ecological mapping, aids in discovering new fungal bioproducts, and enhances precision agriculture practices. Advanced techniques such as convolutional neural networks, you only look once, U-shaped network (UNet), and residual network have demonstrated strong performance in classification, segmentation, and object detection tasks. Additionally, explainable AI (XAI) methods like gradient-weighted class activation mapping (Grad-CAM), local interpretable model-agnostic explanations (LIME), and SHapley …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Global Transcriptomic Insights Into Nla-Dependent Boron Toxicity Responses In Arabidopsis Thaliana, Doğa Seli̇n Kayihan

Turkish Journal of Botany

Boron (B) toxicity disrupts multiple metabolic and signaling processes in plants, yet its interaction with post-translational regulators remains poorly understood. The E3 ubiquitin ligase NITROGEN LIMITATION ADAPTATION (NLA) is known to control nutrient transporter turnover, but its role in B toxicity responses has not been previously characterized. Here, we present the first genome-wide transcriptomic analysis of nla mutant Arabidopsis thaliana exposed to mild (1 mM) and moderate (2 mM) B toxicity. Loss of NLA caused a profound reprogramming of gene expression, marked by constitutive activation of ribosome- and translation-related pathways and strong repression of MAPK signaling, α-linolenic acid metabolism, and …

Ethnobotanical Study Of Medicinal Plants Used By The Local Population In And Around Kozak Plateau (Bergama, İzmir, Türkiye), Şükrü Arasan, Hasan Yildirim

Turkish Journal of Botany

This research was conducted between 2020 and 2022 in 21 villages located on the Kozak Plateau and its surroundings, in the Bergama district of İzmir province, Türkiye. The main aim of the study is to document the medicinal uses of plants by the local population and to contribute to the preservation and transmission of ethnobotanical knowledge—passed down through generations— to future generations before it disappears. Interviews were conducted with 159 informants, and the traditional medicinal uses of 126 plant taxa belonging to 54 families were identified. Among these, the therapeutic uses of 37 taxa were recorded for the first time. …

“The Color Question In The Supreme Court”: Black, White, And Red In United States V. Perryman, Gretchen D. Yelmini

Tulsa Law Review

No abstract provided.

Addressing Anti-Black Racism In Nursing, Registered Nurse's Association Of Ontario

General Submissions: Organizations - Position Statements, White and Resource Papers

RNAO’s BPGs are systematically developed, evidence-based documents that include recommendations on specific clinical, healthy work environment and health system topics. They are intended for nurses, other members of the interprofessional team in direct care positions, educators, administrators and executives, policymakers and researchers in health and social service organizations and academic institutions. BPGs promote consistency, cultural humility and excellence in clinical care, administrative policies, procedures and education, with the aim of achieving optimal health outcomes for people, communities, and the health system. RNAO aims to meet international reporting standards for clinical practice guidelines, including the standards outlined in the Appraisal of …

Insights Into The Role Of Sox6 In The Developing Heart, Hannah Tarolli

MUSC Theses and Dissertations

Approximately 40,000 babies born each year in the U.S. have a congenital heart defect (CHD). However, only a small percentage of CHDs has a known genetic cause, highlighting the need for research surrounding heart development and the pathogenesis of CHDs. Heart development research aims to elucidate the precise coordination of gene expression and cell signaling with the goal of advancing prevention and treatment methods. During heart development, cells from several origins play a crucial role. This includes cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field. Previous studies have revealed that the transcription factor, SOX9, is …

Determination Of High-Temperature Stress Tolerance In Strawberry Varieties Based On Physiological And Biochemical Mechanisms, Izhar Ullah, Hüsnü Demi̇rsoy, Musa Kavas, Kubi̇lay Yildirim, Leyla Demi̇rsoy

Turkish Journal of Botany

Rising global temperatures due to climate change threaten optimal strawberry growth and sustainable yields. Limited data exist on the physiological and biochemical responses of strawberry cultivars to high-temperature stress and their tolerance mechanisms. T his study evaluated the responses of 21 day-neutral and short-day strawberry cultivars to high-temperature stress and classified their tolerance levels using a novel weighted rating method. Plants were grown in 15-cm plastic pots (3:1:1 garden soil, peat, perlite) under open-field conditions until the 3–4 leaf stage and then transferred to climate chambers. After acclimatization at 25/15 °C (day/night) for 2 weeks, the plants were subjected to …

Functional Trait Structure In A Plant Community In Central Anatolian Steppe, Cansu Ülgen, Zeynep Ladi̇n Coşgun, Bariş Özüdoğru, Çağatay Tavşanoğlu

Turkish Journal of Botany

Exploring the trait structure of grassland plant communities enhances our understanding of how these communities will respond to climate change and disturbances such as herbivory. The trait structure of a plant community was investigated in the Central Anatolian steppe, an ecoregion with high biodiversity that has been largely unexplored in terms of plant functional ecology. Fifty plant species in the community were measured across 9 plant traits, including several leaf traits (leaf area, leaf dry matter content, specific leaf area, leaf thickness, and leaf nitrogen content), two seed traits (seed mass and seed shape), as well as the plant height …

“I’M So Hungry”: Assessing Stem Sensemaking Through Data-Informed Writing, Bailey Nafziger, Alesia Mickle Moldavan, Katie Brkich

Elementary & Special Education: Faculty Publications

To engage elementary learners in the complex task of STEM sensemaking, teachers must entice and inspire learners to ask questions, explore, and communicate their findings. This article shares a 5E/3D lesson designed and taught in our elementary science methods courses to model how preservice teachers can integrate literacy and mathematics into a science investigation for STEM sensemaking. We modified a traditional lesson on bird beak adaptations to have a differentiated, interdisciplinary writing component justified by data. We discuss why data-supported literacy is a non-negotiable in science education reforms and how teachers can differentiate tasks to make scientific writing more approachable …

Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan Mcreynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C Ikezu, Yuka A Martens, Minghui Wang, Bin Zhang, Gregory W Carter, Michael Sasner, David M Holtzman, Junmin Peng, Long-Jun Wu, Takahisa Kanekiyo, Chia-Chen Liu, Guojun Bu

The Brown Foundation: Institute of Molecular Medicine

Background

Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences could impact how we interpret APOE genotype-related outcomes, as well as related underlying molecular mechanisms.

Methods

We conducted a comprehensive molecular comparison of humanized APOE mouse models from three sources: Taconic Biosciences (TAC), the Cure Alzheimer’s Fund (CAF), and The Jackson Laboratory (JAX). We assessed apoE …

Thalamic Organization Differentially Contributes To Clinical Conditions In Epilepsy, Qirui Zhang, Sam S. Javidi, Ankeeta Ankeeta, Michael R. Sperling, Zhiqiang Zhang, Joseph I. Tracy

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: The thalamus plays an important role in key clinical conditions of focal temporal lobe epilepsy (TLE), but no investigation has examined whether the same thalamic local and connectome properties shape a patient's status across these different conditions.

METHODS: This retrospective longitudinal MRI study used resting-state fMRI and structural imaging to identify whole-brain focal/regional and connectome-level features associated with six binary clinical conditions of TLE (pre/post-surgery, seizure and neurocognitive outcomes, pathology, seizure subtype, and SOZ lateralization) in 91 patients across two centers (age range: 15-65 years) and 85 matched healthy participants (age range: 18-60 years).

RESULTS: Across conditions, relative to …