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Determining A Likely Mechanism Of Missingness In Repeated Measures Sleep Data From Wearable Fitness Trackers: Longitudinal Analysis, Kate Mobley, Kevin B. Gittner, Karen Nielsen, Lauren Matheny, Gita Taasoobshirazi, Charles Natuhamya, Monica H. Swahn

Faculty Articles

Background: Wearable fitness trackers have become a valuable tool in public health research due to their ability to collect large-scale, individual-level data at a low cost. Because of this, wearables have the potential to mitigate the urgent need for health research in low-resource settings. However, their use has been largely limited to high-income settings, and a major challenge remains: high rates of missing data. This problem may be exacerbated in low-resource environments where logistical and operational barriers further complicate data collection. Wearable sleep data collected in an urban informal settlement in Uganda during The Onward Project on Well-being and Adversity …

Relationship Between Immune Profile And Respiratory Parameters In Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis, Shehab M. Abd El-Kader, Tamer M. El-Saeed, Marwa M. I. Ismaeel, Mohamed F. El-Banna, Ahmed M. Aboeleneen, Amany G. Atiaa, Fatma A Hegazy, Mona M. Abdelkhalek

Journal of Medical Rehabilitation Science

Background: Children with Down Syndrome (DS) exhibit immune dysregulation and increased susceptibility to severe pneumonia. While associations between immune status and infection risk are known, the relationship between specific baseline immune markers and respiratory parameters at the initial presentation of acute pneumonia in this population is unclear. Objective: To investigate the correlation between baseline serum immunoglobulin levels, white blood cell count (WBCs), and baseline respiratory parameters (respiratory rate and arterial oxygen saturation) in children with DS presenting with acute pneumonia. Material and methods: This descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior …

Predictive Role Of Mindset And Neuroplasticity Knowledge On Epistemological Beliefs Among Academic Doctors, Fahad A Somaa

Journal of Medical Rehabilitation Science

Background: Neuroplasticity the brain's capacity for structural and functional reorganization, plays a central role in learning, adaptation, and professional development. Educators' understanding of neuroplasticity, together with their mindset, may influence their epistemological beliefs and teaching practices. Objectives: The purpose of this study was to examine the extent to which mindset and neuroplasticity knowledge predict epistemological beliefs among academic doctors working in medical and rehabilitation education. Materials and Methods: A cross-sectional survey was undertaken among the 309 academic doctors working in medical colleges and teaching hospitals. Demographics, neuroplasticity knowledge, mindset and epistemological beliefs were the primary outcome measures and collected data. …

Prevalence And Association Between Major Depressive Disorder And Cognitive Impairment In Hemodialysis Patients At King Abdulaziz University Hospital, Jeddah, Saudi Arabia, Faten N. Alzaben

Journal of Medical Rehabilitation Science

Objectives: Patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis experience a substantial psychological and cognitive burden. This study aimed to determine the prevalence of major depressive disorder (MDD) and examine its association with cognitive impairment among patients receiving hemodialysis. Materials and Methods: A cross-sectional study was conducted among 30 consecutive patients aged 18–65 years undergoing maintenance hemodialysis at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Major depressive disorder was diagnosed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), with cognitive impairment defined as a MoCA score …

Modulation Of Pulpal Mmp-8 And Vegf-Alpha By Bioactive Calcium Silicate And Blood Cockle Shell Extract Combination In Rats, Angelia Conny Nidiaty, Noor Hikmah, Kezia Rachellea Mustakim, Wahyuni Suci Dwiandhany, Hafsah Katu, Juni Jekti Nugroho

International Arab Journal of Dentistry

Objectives: This study evaluated MMP-8 and VEGF-Alpha expression in rat dental pulp inflammation after application of bioactive calcium silicate combined with blood cockle shell extract.

Methods: Forty mandibular incisors were randomly assigned to four groups: 100% bioactive calcium silicate (control) and three treatment groups containing 25%, 50%, or 75% shell extract with the remainder calcium silicate. Direct pulp capping was performed, and samples were collected on days 1, 3, 7, and 14.

Results: Immunohistochemistry and one-way ANOVA revealed significant differences in MMP-8 expression on days 1 and 3, and VEGF-Alpha expression across all time points (p < 0.05). The 75% shell extract group showed the lowest MMP-8 and highest VEGF-Alpha expression.

Conclusions: These findings suggest …

Organic Management Of Pillbugs And Sowbugs In Strawberries And Other Fruits, Briger Carey, Marion Murray, Emilie Demard, Jennifer R. Reeve

All Current Publications

Pillbugs and sowbugs are collectively known as isopods that typically feed on soil organic matter, but under certain conditions, they can be a pest of many young plants and berries. This fact sheet reviews identification, life cycle, damage, and organic management strategies for pillbugs and sowbugs.

Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine-Induced Kidney Injury Via Oxct1-Mediated Ketolysis In Mice, Shoji Omachi, Sho Sugahara, Junya Horiguchi, Mako Yasuda-Yamahara, Shogo Kuwagata, Kosuke Yamahara, Yuki Tanaka-Sasaki, Shogo Ida, Tetsuro Kusaba, Benjamin D Humphreys, Kenji Kufukihara, Jin Nakahara, Masami Chin-Kanasaki, Shinji Kume

2020-Current year OA Pubs

Ketone bodies have traditionally been recognized as glucose-sparing energy sources, with hepatic ketogenesis and peripheral ketolysis serving pivotal functions in maintaining energy homeostasis during fasting. Although they are commonly seen as harmful due to their link with ketoacidosis, recent studies emphasize their roles in organ protection. This has sparked interest in their possible use as a treatment for chronic kidney disease (CKD). In this study, we examined both exogenous and endogenous ketone body supplementation in adenine-induced kidney injury in mice. Supplementation with the ketone body precursor 1,3-butanediol significantly improved adenine-induced renal fibrosis, inflammation, and apoptotic cell death. However, genetically deleting …

Post-Hemorrhagic Hydrocephalus Of Prematurity Is Associated With Disruption Of Tight Junctions And Increased Macrophage Activity In The Choroid Plexus, Maria Garcia-Bonilla, Rajiv Swarup, Owen W Limbrick, Habeebah Z Vohra, Ayodamola Otun, Konrad Mckalip, William Bernhardt, Kirill Shumilov, Marie Michenkova, Jayne Crouthamel, Mackenzie Newman, Krikor Dikranian, James P Mcallister Ii, David D Limbrick

2020-Current year OA Pubs

BACKGROUND: Previous studies on intraventricular hemorrhage (IVH), a common and severe complication of preterm birth, and subsequent post-hemorrhagic hydrocephalus (PHH), have predominantly concentrated on the secretory function of the choroid plexus (ChP), with considerably less emphasis on its barrier function. We hypothesized that PHH is associated with immune-related alterations in the junction biology of ChP. METHODS: We examined differences in tight junctions and macrophages using a neonatal mouse model of PHH (n = 40) and in vitro ChP explants (n = 22), as well as human post-mortem samples (n = 6). To test our hypothesis, we employed histology, immunofluorescence, magnetic …

Evaluation Of Optimized Mechanical Properties Of Gum-Arabic/Powdered Pentaclethra Macrophylla Pod Brake Pad Composite., I. C. C. Iloabachie, A. M. Nwankwo

Engineering and Technology Journal

The mechanical properties of brake pad composites produced from powdered Pentaclethra macrophylla pod reinforced with gum Arabic resin were investigated. The pods were cleaned, air-dried, oven-dried at 110 °C to constant weight, pulverized, and sieved, after which a portion was carbonized at 950 °C. Composite formulation was carried out using a pre-impregnation technique, with the reinforcement content varied from 10 to 50 wt% at 10 wt% intervals, while other constituents were maintained constant. The composites were molded in a hot platen press using a 50 mm × 50 mm × 8 mm mold at 180 °C, a pressure of 15 …

Effects Of Types And Amount Of Organic Matter On The Engineering Properties Of Soil, Afaq H. Malleh, Mohammed Y. Fattah, Hussein H. Karim

Engineering and Technology Journal

Organic soils exhibit highly variable geotechnical behavior due to differences in the type, content, and decomposition state of organic matter, which are often inadequately distinguished in engineering practice. This study investigates the influence of organic matter origin on soil behavior through a comparative analysis of sapric organic soils and sewage sludge soil tested under identical one-dimensional consolidation conditions. Laboratory tests included physical characterization, standard consolidation tests under vertical stresses of 200 kPa and 800 kPa, post-consolidation organic matter measurements, and microstructural analyses using SEM–EDS and XRD. The results show that increasing sapric organic matter content from 23% to 35% led …

Preferences For Mathematics And Science Education Majors Among Senior High School Students In Bataan, Zydrick L. Avelino

Jurnal Pendidikan Sains

This study examines the factors influencing Senior High School students’ preferences for Bachelor of Secondary Education (BSEd) majors in Bagac and Morong, Bataan, with particular focus on the low interest in Mathematics and Science specializations despite increasing demand for STEM educators. Using a descriptive quantitative design, data were collected from 369 students through a structured survey and analyzed using frequency and percentage distributions. The results reveal a strong preference for non-STEM majors, with Social Studies (42.12%) and English (35.04%) dominating, while Science (15.43%) and Mathematics (7.395%) received significantly lower interest. Personal interest emerged as the primary determinant (58.8%), followed by …

Hubungan Hukum Adat Dengan Hukum Islam, Prof. Dr. Soerjono Soekanto, S.H., M.A.

Jurnal Hukum & Pembangunan

Abstract

The Dangers Of Social Media In Political Theory, Eden M. Shimanek

Global Tides

Increasing political polarization is a prominent feature of the twenty-first-century political landscape, with social media playing a significant role. This essay evaluates social media as a political platform through Hannah Arendt’s notion of the Vita Activa, which describes the political realm and the ideas of totalitarianism. Using this framework, I argue that the surging political use of social media creates digital “echo chambers” that result from the loss of human plurality, which ultimately marks the diverse nature of the political realm. I would continue to argue that these chambers evolve into the notion that Arendt notes as world alienation or …

Comparative Sharia Law In Iran And Nigeria: Effects On Athletes And Recommendations For Sports Governing Bodies To Increase Access For Muslim Women And Girls, Rachel Crass

Denver Sports & Entertainment Law Journal

No abstract provided.

Vol. 30, No. 1: Full Issue, University Of Denver Sports & Entertainment Law Journal

Denver Sports & Entertainment Law Journal

No abstract provided.

From Studio To Stage: The Real Dancer Who Inspired Degas And The Lasting Impact Of The Little Dancer Aged Fourteen, Khendal Wimberly

Epochs Art History Journal

No abstract provided.

Gci #274: The Neuro-Clearance Research Architecture, Michael Victor Caldwell Mr.

Defensive Publications Series

This disclosure describes the GCI-274 Neuro-Clearance Engine (v3.1), a non-medical, open-hardware research architecture designed for the study of complex fluid dynamics in cranial-mimetic phantom models. The system integrates 21 independent Gemini Caldwell Inventions (GCI) into a unified Vortex-Acoustic Transport Stack to explore the mobilization and redistribution of protein-analog aggregates in non-Newtonian fluids (PVA-Cryogel).

The architecture utilizes a multi-layer physical approach:

1. Kinetic Lift Layer: Employs the GCI #102 Vortex Spine featuring GCI #18 J-Groove Rifling to induce passive vortex shedding and helical upward flow without mechanical impellers.

2. Acoustophoretic Layer: Utilizes a 12-element GCI #75 Phased Array mapped to a GCI …

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Optically Isolated, Current-Controlled Closed-Loop System For Magnetically-Mediated Temporal Interference Neuromodulation (M-Ttis), Olexandr Lozovyi

Defensive Publications Series

We disclose a neuromodulation system implementing closed-loop, magnetically-mediated temporal interference stimulation (m-tTIS). While inspired by traditional electric tTIS, the disclosed architecture utilizes coherent magnetic field synthesis for non-invasive tissue penetration. To suppress electromagnetic interference (EMI) below functional detection thresholds and limit hardware-induced demodulation artifacts, an "Absolute Optical Air-Gap" architecture is detailed. The device is partitioned into galvanically isolated domains, interconnected exclusively via plastic optical fiber (POF). The power stage employs a Class D amplifier with a second-order LC filter and hardware current sensing for amplitude stabilization. Control is based on adaptive optimization of physiological spectral metrics. Firmware execution provides deterministic, …

The Role Of Emerin In Myogenic Differentiation, Nicholas Marano

Theses and Dissertations

The nucleus harbors genetic material encapsulated by the nuclear envelope which is composed of an inner and outer nuclear membrane. The establishment and organization of chromatin at the INM is essential for cell fate during the differentiation program. Integral INM proteins are responsible for chromatin organization at the nuclear envelope. Emerin is a highly conserved type II integral INM protein with roles in chromatin organization, cell signaling, and nuclear structure. Mutations in the emerin gene cause Emery Dreifuss Muscular Dystrophy 1 (EDMD1). Emerin is ubiquitously expressed, but loss of emerin function affects specifically skeletal muscle and cardiac tissue. The precise …

Ole Miss Students Strengthen Ties With Community Through Big Event, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – With spring in the air, University of Mississippi students gave back to the place they call home during the Big Event, held Saturday (March 28) throughout Oxford and Lafayette County.

Auditory Stimulation Rescues Cognitive Deficit In, Mohamed Ouardouz, Amanda E Hernan, J Matthew Mahoney, Rodney C Scott

Faculty Research 2026

Background/Objectives: Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by a triplet repeat expansion in the Fmr1 gene leading to the loss of Fragile X Messenger Ribonucleoprotein (Fmr1 protein). The loss of Fmr1 protein modulates many cell biological processes and leads to the emergence of intellectual disability and autism. FXS is modeled in Fmr1-KO mice that display features consistent with human FXS, including hypersensitivity, cognitive and learning deficits, hyperactivity and audiogenic seizures. Here, we investigated the effect of auditory stimulation during a range of developmental stages on recognition memory and sociability deficits in Fmr1-KO mice. Methods: Fmr1-KO …

Family-Level Mediators In The Intergenerational Transmission Of Maternal Childhood Trauma: Systematic Review And Meta-Analysis Of Pooled Effect Measures, Emma J. Mew, Rhayna Poulin, Veronika Shabanova, Hannah Gorman, Marie-Claire Meadows, Jessica L. Bonumwezi, Victoria Chung, Rachel Hennein, Audrey Y. Huang, Kevin Quach, Vanessa Blas, Ashlin Ondrusek, Karly Sara Weinreb, Kate Nyhan, Si’Itia Soliai-Lemusu, Jueta Mccutchan-Tofaeono, Nicola L. Hawley, Sarah R. Lowe

Department of Psychology Faculty Scholarship and Creative Works

Children of mothers with childhood trauma are at an increased risk for mental health problems, yet the most influential family-related mediators of this intergenerational transmission remain unclear. This systematic review and meta-analysis synthesized effect sizes from 29 studies (n = 352,279 dyads) examining psychosocial family-level mediators between maternal childhood trauma and child mental health. We identified 380 simple and 40 serial mediation paths across four domains: child characteristics, maternal characteristics, parent–child relationship factors, and household characteristics. Maternal characteristics showed the largest pooled effects (proportion median [PM]: 31.2%; ratio median [RM]: 0.21), particularly maternal mental health (PM: 36.0%), maternal attachment style …

Coping Strategies, Barriers, And Supports Of Female Nurses And Veterans With A Work-Related Traumatic Exacerbation Of An Existing Respiratory Disorder, Joanna Lynn Phillips

Walden Dissertations and Doctoral Studies

The United States Department of Defense and Bureau of Labor Statistics estimated that female veterans and nurses experience work-related trauma at rates of 51% or higher. While many studies have examined their mental health outcomes, posttraumatic worsening of physical health has been less studied in this population. This generic qualitative inquiry was conducted to gain a deeper understanding of the subjective lived experiences of female nurses and veterans' work-related traumatic exacerbation of an existing respiratory disorder. The coping strategies developed, the potential barriers they overcame, and the support systems used were examined. The theoretical framework that grounded this study was …

Plantas Medicinales En El Territorio: Una Vista Desde Los Saberes Ancestrales, Eugenio Alexander Garnica Serrano, Gloria Naidu Cuevas Rodríguez, Diana Carolina Molina León

Ciencias de la Salud

Plantas medicinales en el territorio: una mirada desde los saberes ancestrales, recoge la memoria viva de Cundinamarca y la sabiduría de nuestros mayores, quienes han sabido transmitir el uso de las plantas para aliviar dolencias cotidianas (insomnio, problemas digestivos o los dolores articulares). Esta obra enlaza tradición y ciencia, ofreciendo un testimonio que fortalece la identidad cultural y se convierte en legado para las generaciones presentes y futuras. Más que un compendio de plantas y remedios, este libro es un homenaje a los adultos mayores que cuidan y preservan estas plantas en sus hogares. Su publicación contribuye a la …

Exercise Effects On Decreased Levels Of Depression In Female Breast Cancer Patients, Dorothy Y. Spencer

Walden Dissertations and Doctoral Studies

Breast cancer patients with major depressive disorder (MDD) are at a high risk of experiencing pain and fatigue, anxiety and substance use, poor quality of life, marital spouses with elevated depression, impaired sexual functioning, sleep disorders, poor immune system functioning, rapid progression of cancer, and higher mortality rates. Grounded in Fritz Heider’s attribution theory, the purpose of this quantitative quasi-experimental study was to examine the relationship between physical exercise and a decrease in MDD. The participants comprised of 15 female breast cancer patients, 18 years of age and older, who may have experienced depression. The participants completed the Beck Depression …

Auditory Stimulation Rescues Cognitive Deficit In Fmr1-Ko Mice, Mohamed Ouardouz, Amanda E. Hernan, J. Matthew Mahoney, Rodney C. Scott

Department of Medicine Faculty Papers

Background/Objectives: Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by a triplet repeat expansion in the Fmr1 gene leading to the loss of Fragile X Messenger Ribonucleoprotein (Fmr1 protein). The loss of Fmr1 protein modulates many cell biological processes and leads to the emergence of intellectual disability and autism. FXS is modeled in Fmr1-KO mice that display features consistent with human FXS, including hypersensitivity, cognitive and learning deficits, hyperactivity and audiogenic seizures. Here, we investigated the effect of auditory stimulation during a range of developmental stages on recognition memory and sociability deficits in Fmr1-KO mice. Methods: Fmr1-KO mice were …

Deep Brain Stimulation For Psychiatric Disorders: A Systematic Review Of Molecular Imaging With Pet, Shiv Patil, Alexander Gerlach, Fnu Jeevika, Raj Patel, Emily Christner, Jaskeerat Gujral, Om H. Gandhi, Milo Writer, Nicholas M. Wang, Anastasia Kopylova, Satoria A. Zagorski, Cyrus Ayubcha, Thomas Werner, Abass Alavi, Mona-Elisabeth Revheim

Student Papers, Posters & Projects

BACKGROUND: Deep brain stimulation (DBS) is an evolving technique for the treatment of various psychiatric disorders refractory to conventional pharmacotherapy. Neuroimaging with positron emission tomography (PET) has an important role in the planning, delivery, and post-surgical monitoring of DBS. This study aims to determine the clinical relevance of PET as a biomarker of disease status and response to DBS for patients with psychiatric disorders.

METHODS: We performed a systematic review of the PubMed, Web of Science, and Scopus databases to identify original research studies that applied PET to study the effects of DBS for patients with psychiatric conditions (major depressive …

Ribosomal Stress In The Pathogenesis And Treatment Of T-Cell Acute Lymphoblastic Leukemia, Kimberly Bridget Johansson

Arts & Sciences Graduate Student Theses and Dissertations

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which activating mutations in the Notch pathway are thought to contribute to transformation, in part, through activation of c-Myc. Increased expression of c-Myc induces oncogenic stress that can lead to apoptosis through the Mdm2-p53 tumor suppressor pathway. Since the great majority of T-ALL cases maintain wildtype MDM2 and TP53, we hypothesized that T-ALL cells are selectively sensitive to MDM2 inhibition. Treatment with idasanutlin, an MDM2 inhibitor, although only inducing modest apoptosis in T-ALL cells, resulted in a significant upregulation of pro-apoptotic BH3 domain genes BAX and BBC3. This prompted …

Unraveling Hydrologic And Hydrochemical Processes Based On Long-Term Concentration–Discharge Analysis In The Green Lake 4 Catchment, Colorado Front Range, Usa, Fengjing Liu

Michigan Tech Publications

Concentration–discharge (C-Q) relationships were analyzed over decadal, annual, and seasonal timescales from water years 1982 to 2020 to understand hydrologic and hydrochemical processes in the Green Lake 4 catchment, Green Lakes Valley, Colorado Front Range. Geogenic solutes, along with the magnitude of stable isotopes, were dominated by a strong (p < .05) C-Q power law (C = aQ^b, where a and b are constants from the curve fitting, with b usually termed the b-coefficient) and consistent patterns over various timescales. The b-coefficients of geogenic solutes were negative, suggesting that those solutes primarily originated from groundwater with higher concentrations and diluted by shallow source waters with lower …

Inside 'N Out: Etv2 Specification Of Hemangiogenic Lineages From Flk1+ Mesoderm, Dereck Antonio Shakeel Alleyne

Arts & Sciences Graduate Student Theses and Dissertations

The cardiovascular system is generated by mesodermal progenitors that give rise to endothelial, hematopoietic and muscle (smooth muscle and cardiomyocyte) lineages. Although vascular endothelial growth factor (VEGF), its receptor, FLK1/KDR and the transcription factor ETV2 are critically required for hemangiogenic specification, Flk1 and Etv2 expression has been observed in other mesodermal derivatives. During gastrulation, mesodermal progenitors are specified to contribute to the cardiovascular system; however, the early divergence of hemangiogenic and muscle progenitors, and their shared marker expression, complicates identification of common mesoderm progenitor populations contributing to both lineages. In this dissertation, I demonstrate how Flk1+ and Etv2+ lineage relationships …