Digital Commons Network^™

Global, Regional, And National Burden Of Epilepsy, 1990–2021: A Global Burden Of Disease Study, Jinqing Zhao, Qiannan Chen, Jiahan Dong, Meng Gao, Siqi Ge, Anxin Wang

Research outputs 2022 to 2026

Background: Epilepsy is a common neurological disorder characterised by spontaneous seizures without an identifiable cause, leading to high morbidity and a significant public health burden. Understanding trends in its incidence, prevalence, mortality, and disability-adjusted life years (DALYs) is essential for developing effective prevention and treatment strategies. We aim to describe global trends in epilepsy over the past 32 years and explore the impact of sociodemographic index (SDI) levels on disease burden using the Global Burden of Disease 2021 data. Methods: We analysed the global burden of epilepsy (1990–2019) using age-standardised rates (ASRs) and their 95% uncertainty intervals (UI). We assessed …

Gender Justice In The Triple Planetary Crisis: A Scoping Review, Catelyn Richards, Micah Peters, Julia Charalambous, Lila Singh-Peterson, Lucy Osborn, Aletha Ward, Jessica Leclair, Tracy Levett-Jones

Research outputs 2022 to 2026

Aim: To identify and report how gender justice is conceptualised and discussed in contemporary health literature in relation to the Triple Planetary Crisis of climate change, pollution and biodiversity loss, with a particular focus on the experiences of women and gender-diverse populations, and the representation of nurses and other healthcare professionals dominated by women. Design: Scoping review. Data Sources: Searches were conducted across MEDLINE (Ovid), Scopus, CINHAL, Embase and ProQuest, focusing on studies published from January 1 2000–23 September 2024. Review Methods: The review was conducted in accordance with the JBI methodology for scoping reviews and reported against the Preferred …

Health Determinant Effects Of Audience Experiences At Live First Nations Music Events In Central Australia, Naomi Sunderland, Kristy Apps, Brigitta Scarfe, Ping Zhang, Darren Garvey, Rae Cooper, Brydie Leigh Bartleet, Phil Graham, Glenn Barry

Research outputs 2022 to 2026

Objectives: First Nations musicians often describe live performance as a means of fostering social, cultural, and political change that shapes determinants of health (DoH) for First Nations Peoples. This study examined how audience experiences of First Nations live music events in Central Australia may influence those DoH–including intercultural understanding, social cohesion, and community wellbeing–and explored the durability of such effects over time. Design: Guided by an Indigenist mixed‑methods approach, we conducted a pilot survey at two arts festivals featuring diverse First Nations musicians, followed by optional six‑month “mini yarn” interviews to explore immediate and longer‑term audience experiences. Quantitative analyses included …

How Expert Designers Foster Expertise: A Study Of Professional Visual Communication Practice, Grant Ellmers, Marius Foley, Juliana Peloche

Research outputs 2022 to 2026

While design expertise has been widely studied across domains such as industrial design, engineering and architecture, visual communication design has received limited attention. Earlier research examined novice designers’ development of reflective capability, and its link to expertise progression. This study extends that work by investigating how expertise manifests and is fostered among experienced designers within visual communication design practice. Through in-depth interviews with five experienced designers (20–35 years’ industry experience), this qualitative case study employed thematic analysis grounded in Schön’s reflective-practice theory and Lawson and Dorst’s (2013) design-expertise model. This approach enabled close examination of how reflective processes, mentoring structures …

It Was Part Of The Plan, So I Showed Up: An Exploration Of Patient Experiences With An Embedded Exercise Referral Process During Cancer Treatment, Mary A. Kennedy, Jack Dalla Via, Kim Edmunds, Pam Eldridge, Yvonne Zissiadis, Lauren Fortington

Research outputs 2022 to 2026

Introduction: Exercise is a key part of cancer care, yet its integration into routine practice remains limited. This study explored the experiences of people living with and beyond cancer, with an updated, opt-out referral model embedded within a supportive oncology setting, focusing on initial engagement with exercise physiology appointments. Through this model, patients were automatically scheduled for a consultation with an in-house exercise professional during their cancer treatment. Methods: A qualitative descriptive design comprised of two focus groups with 13 participants was employed to explore views across pre-defined elements of the model: referral to exercise, appointments, counselling, and tailoring. Results: …

Opportunities To Improve The Implementation Of Relational Health Interventions For Children And Families: A Secondary Analysis Of A Scoping Review, Natasha Pearce, Natasha Pearce, Donna Cross, Jacinta Francis, Jonathan H. Sae-Koew, Alexander M. Godley, Caitlin Attwell, Tracy Evans-Whipp, Tracy Evans-Whipp, Jacqueline Allen, Ross Homel, Craig A. Olsson, Stephen R. Zubrick, Lu Zhang, Sarah Whittle, Liz Spry, Tim Slade, Lisa Ritland, Naomi Priest, Felicity Painter, Craig Olsson

Research outputs 2022 to 2026

Despite the availability of universally delivered evidence-based relational health interventions, their wide-scale translation into practice is slow and unsustained. Measuring implementation outcomes within intervention trials is critical to understand their effectiveness and inform future scaling. This study aimed to determine the extent to which universally delivered relational health interventions measured and reported on implementation outcomes to inform their effectiveness. A secondary analysis of a scoping review examined the extent to which 123 RCT-evaluated relational health intervention studies referred to (1) implementation related theories or frameworks; (2) implementation data collection methods; (3) implementation measures, and; (4) each of twelve implementation outcomes …

Peptidomic Profiling Of In Vitro Digesta From Diverse Microalgae Species, Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim Lee Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle L. Colgrave

Research outputs 2022 to 2026

Microalgae are a sustainable protein source, yet few species are used for human nutrition. This study evaluated eight species for protein quality, digestibility, and peptide profiles after simulated gastrointestinal digestion using INFOGEST. Amino acid content, and intestinal-phase peptide mixtures were analysed by mass spectrometry. The methanol precipitation method was used to separate digested (supernatant) and undigested (pellet) peptides following in vitro INFOGEST digestion. The pellet was further separated by molecular weight into 3–10 kDa and >10 kDa fractions to isolate the lower molecular weight peptides from the higher ones. This separation method enabled the identification of potential digested peptides within …

Putting Lived Experience At The Centre: A Critical Review Of Multidisciplinary, Person-Centred Mental Health Care, Laura Grattidge, Darren Haywood, Nicolas H. Hart, Bridget Elizabeth Hamilton, Ellie Fossey, Melissa Petrakis, David J. Castle

Research outputs 2022 to 2026

Purpose: Person-centred care is widely endorsed in mental health policy yet remains inconsistently enacted in multidisciplinary practice, particularly where services default to diagnostic dominance, risk management, and service-led priorities. This critical review examines what is required to operationalise person-centred, rights-based care across disciplines and settings, positioning lived and living experience as core expertise rather than a supplementary perspective and considering implications for suicide prevention. Methods: A critical review of peer-reviewed and grey literature was undertaken, focusing on person-centred and multidisciplinary mental health care. Five commonly used approaches were compared: the Optimal Health Program, the Strengths Model, Open Dialogue, traditional case …

Reflecting On Themes From Telehealth Consultations Early In The Pandemic: An Opportunity To Learn From Multiprofessional Colleagues, Maggie Meeks, Laura R. Joyce, John Dean, Lorna Davies, Tika Ormond, Philippa Seaton, Dale Sheehan, Dean Sutherland, Melanie Welfare, Arindam Basu

Research outputs 2022 to 2026

Aims: This study is aimed at documenting the reflections of New Zealand healthcare professionals on the use of synchronous telehealth consultations. Methods: A qualitative narrative inquiry was conducted to explore the practice of telehealth in New Zealand. Purposive sampling was used to identify clinicians from multiple professions who used telehealth during the initial phase of the COVID-19 pandemic. Fifteen semistructured interviews were conducted between October 2020 and May 2021 with clinicians from primary and secondary care, including multiple professional backgrounds. Interview transcripts were analysed thematically. Results: Six themes were identified: (1) equitable access: There were concerns regarding equitable access to …

Scope And Adherence To The Consider Statement In Aboriginal And Torres Strait Islander Injury Prevention Research In Australia, Bep Uink, Michelle Barrett, Courtney Ryder, Aleina Humphreys, Graham Peter Barker

Research outputs 2022 to 2026

Introduction: Effective injury prevention for Aboriginal and Torres Strait Islander people hinges on the availability of culturally safe policies, resources and programmes, alongside best-practice research. Contemporary injury prevention research has increasingly centred Aboriginal and Torres Strait Islander knowledges, yet there is still room for improvement. Identification of relevant resources, policies and programmes, as well as the extent to which injury prevention research meets international criteria for ethical research with Aboriginal and Torres Strait Islander peoples will provide practitioners with critical insights into best-practice injury prevention initiatives. Method: We examined the breadth and scope of Aboriginal and Torres Strait Islander injury-related …

Strengthening Social Structures To Improve Informal Care For Older People With Chronic Life-Limiting Illnesses In Rural Ghana, Barbara Adonteng-Kissi, Obed Adonteng-Kissi

Research outputs 2022 to 2026

Traditional family-based care for older people in Ghana is declining as globalization and social change weaken historical support systems. This analysis is informed by a review of scholarly literature concerning the implications of globalization for the provision of caregiving for older people managing chronic life-limiting illnesses. We aimed to explore ways of strengthening social structures to enhancing the quality of lives of older people with chronic life-limiting illnesses in rural Ghana amongst 15 older people; 15 family caregivers; 10 healthcare professionals. Critical Social Theory (CST) functions as the primary theoretical framework for conducting an interrogation of the systemic structures that …

The First Systematic Review Of Treatment Characteristics And Recidivism Outcomes For Indigenous People Who Have Sexually Offended, James L. Finney, Natalie Gately, Suzanne Rock, Braden Hill

Research outputs 2022 to 2026

It is of great importance that research investigates the impact of sexual offender treatment programmes given the damage caused by sexual offences to victims and society more broadly. However, psycho-criminological literature has focused on reporting post-treatment recidivism outcomes for people who have sexually offended homogeneously and has not investigated the unique experiences of Indigenous people. Therefore, we systematically collated and critically appraised studies reporting recidivism outcomes for Indigenous people who have received treatment for sexual offences. Fourteen studies were identified utilising a sample of 5,635 individuals (30.7% Indigenous or First Nations). Recidivism was lower for Indigenous and First Nations people …

The Prevalence Of Varus Thrust: A Systematic Review And Meta-Analysis, Haonan Shen, Nicole D'Souza, Claire E. Hiller, Marnee J. Mckay, Kun Hu, Zhiyong Wang, Milena Simic

Research outputs 2022 to 2026

Objective: To determine the prevalence of varus thrust in adults with and without knee osteoarthritis (OA), including across clinically relevant subgroups. A secondary objective was to explore whether varus thrust prevalence varied according to age, body mass index (BMI), and knee pain severity, where sufficient data were available. Design: A systematic review was conducted in accordance with PRISMA guidelines. Five electronic databases and Google Scholar were searched from inception to January 21, 2025. Studies reporting varus thrust during gait in adults, assessed using clinical observation methods, were included. Two independent reviewers screened studies, extracted data, and assessed methodological quality. Results: …

Towards Transgressive Inclusion In Physical Education? The Experiences And Perspectives Of People With Disabilities In Western Australia, Steven Connelly, Dawn Penney, David Aldous

Research outputs 2022 to 2026

This paper foregrounds the voices of people with disabilities (PwD) and their experiences of Physical Education (PE) in Western Australia (WA) in exploring interests in transgressive inclusion that are grounded in social justice and equity for PwD (DeLuca, 2013). Towards an interdisciplinary framework for educational inclusivity. Canadian Journal of Education, 36(1), 305–348. https://journals.sfu.ca/cje/index.php/cje-rce/article/view/1157/1475). The study employed a questionnaire method to pursue the perspectives of PwD in relation to (i) their experiences of lower secondary PE (years 7-10), (ii) teacher support in PE classes, (iii) experiences beyond PE in sport and physical activity, and (iv) their views regarding ways to improve …

Understanding The Journey To Higher Education: Decision-Making Insights From Aboriginal And Torres Strait Islander Students, Melissa Fong-Emmerson, Claire Lambert, Braden Hill, Maria M. Ryan

Research outputs 2022 to 2026

This study investigates the decision-making process of Indigenous Australian students in pursuing higher education, addressing a gap in understanding their educational choices. It identifies the key factors influencing university enrolment decisions and how these shape students’ educational pathways. Using a narrative-inquiry approach, the study explored the lived experiences of Indigenous students from two Western Australian universities. Through written autobiographies, yarning sessions and one-on-one interviews, participants shared rich, nuanced insights into their journeys to higher education. Findings reveal the pivotal role of ‘sparks’ in normalising higher education as a viable option. Students relied minimally on formal information search, depending heavily on …

A Knowledge-Driven, Ai-Assisted Cyber Defence Framework For Iomt Remote Patient Monitoring, Kulsoom S. Bughio, David M. Cook, Abdul M. Unar

Research outputs 2022 to 2026

The rapid adoption of Internet Medical Things (IoMT) technologies in remote patient monitoring has reshaped healthcare delivery by enabling continuous, real-time clinical observation outside traditional care settings. However, this shift has also expanded the cyber-attack surface across heterogeneous, resource-constrained medical devices, wireless networks, cloud services, and third-party platforms. In cyber warfare, healthcare has become an incorporated target of geopolitics, with hospitals, remote monitoring systems, and emergency health systems being used to broaden the attack surface for adversaries to exploit. Existing security approaches for IoMT environments remain largely manual, fragmented, and reactive, limiting their effectiveness in dynamically assessing vulnerabilities and supporting …

A Survey-Based Assessment Of Treatment Preferences For Distal Radius Fractures In Participants Aged 65 Years And Older, Zayd Al Rawi, Elizabeth Graesser, Lindley B Wall

2020-Current year OA Pubs

PURPOSE: The management of distal radius fractures (DRF) in patients aged ≥65 years is debated because there is evidence that operative and nonsurgical treatment yield similar outcomes 1 year after injury. When more than one reasonable treatment option exists, shared decision-making between the patient and physician should be used. This study elicited preferences for the treatment of DRF using a survey of participants aged ≥65 years.

METHODS: A survey for participants ≥65 years was administered using Amazon Mechanical Turk. Participants were presented with a theoretical scenario in which they sustained a DRF, followed by two treatment options (surgery or casting) …

Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.

2020-Current year OA Pubs

BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (HCC) generally experience poor outcomes despite current therapies, necessitating the development of alternative treatments. ADP-A2AFP is an investigational autologous T-cell therapy with an affinity-enhanced T-cell receptor (TCR) targeting alpha-fetoprotein (AFP).

METHODS: We describe a phase I, open-label, first-in-human clinical trial of ADP-A2AFP (NCT03132792) in human leukocyte antigen-eligible participants with AFP-expressing HCC (or other tumor) not amenable to transplant/resection who progressed on, were intolerant to, or refused prior systemic therapy. Participants received lymphodepletion chemotherapy (cyclophosphamide 500 mg/m

RESULTS: Twenty-one participants, 20 with advanced HCC and one with gastric hepatoid carcinoma received ≥1 ADP-A2AFP …

Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th

2020-Current year OA Pubs

Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …

Coordinated Regulation Of Capping Protein By Carmil And V-1/Myotrophin, John A Hammer, John A Cooper

2020-Current year OA Pubs

Capping Protein (CP) plays a central role in controlling actin filament dynamics in almost all eukaryotic cell types by virtue of its ability to block monomer addition and loss at the barbed end of the actin filament. Like other proteins that control actin assembly, CP is subject to regulation. Here we focus on two direct regulators of CP-CARMIL and V-1/Myotrophin. Specifically, we review recent biochemical, structural, imaging, and cell biological data that argue these two proteins cooperate to create a regulatory cycle for CP that controls its availability, activity, and site of action in the cell. Finally, we discuss unresolved …

Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True

2020-Current year OA Pubs

Limb-girdle muscular dystrophy D1 (LGMDD1) is a rare, dominantly inherited neuromuscular protein-misfolding chaperonopathy caused by mutations in the Hsp40 co-chaperone DNAJB6, primarily in the glycine-phenylalanine (GF) or J-domains. Currently, no treatments are available, and a challenge in understanding the disease is identifying a specific client protein for DNAJB6 in skeletal muscle. DNAJB6 has homology to the yeast DNAJ family member, Sis1. Our previous research indicated that LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity. Herein, we employed functional assays along with advanced molecular simulation studies to understand the regulatory interdomain interactions in disease-causing mutants of …

Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways, Steven J Wilhelm, Grace E Curry, Neel Matiwala, Jianguo Lin, Tran Quach, Mark E Lowe, Miklós Sahin-Tóth, Xunjun K Xiao

2020-Current year OA Pubs

BACKGROUND & AIMS: Increasing evidence suggests that protein misfolding and proteotoxicity is an important mechanism of chronic pancreatitis (CP) in patients with genetic variants. Two mouse models carrying misfolding digestive enzyme variants, CPA1 N256K and PNLIP T221M, recapitulate the human CP phenotype. We hypothesized that both models develop CP through similar disease mechanisms.

METHODS: We conducted a comprehensive analysis of mice aged 1 to 6 months using histology, immunohistochemistry, protein immunoblotting, quantitative polymerase chain reaction (qPCR), transmission electron microscopy (TEM), and RNA sequencing (RNA-seq) analysis to characterize pancreatic pathological changes.

RESULTS: Both homozygous models exhibited CP hallmarks, including progressive acinar …

A Deep Learning Model To Guide Personalized Mechanical Circulatory Support Use In Cardiogenic Shock Patients Undergoing Pci, Amit P Amin, Richard G Bach, Darren C Tsang, Weili S Zheng, Raed A Qarajeh, Emmanouil S Brilakis, Hemant Kulkarni

2020-Current year OA Pubs

BACKGROUND: Cardiogenic shock (CS) in patients undergoing percutaneous coronary intervention (PCI) involves rapidly changing clinical, hemodynamic, and metabolic factors that current models cannot effectively integrate.

OBJECTIVES: The purpose of this study was to develop and validate a deep learning (DL) model to guide personalized use of mechanical circulatory support (MCS) devices in CS patients undergoing PCI.

METHODS: The authors analyzed data from 1,408 CS patients treated with intra-aortic balloon pump (IABP) or microaxial flow-pump (mAFP) at multiple hospitals (2004-2019). Clinical, hemodynamic, and metabolic variables from admission to MCS placement were compiled into longitudinal vectors. Using Python 3.7 and TabNet in …

Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.

2020-Current year OA Pubs

As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, …

Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle

2020-Current year OA Pubs

INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.

DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …

Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings

2020-Current year OA Pubs

BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.

METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …

A Single-Cell Atlas Characterizes Dysregulation Of The Bone Marrow Immune Microenvironment Associated With Outcomes In Multiple Myeloma, William C Pilcher, Lijun Yao, Yizhe Song, Kazuhito Sato, Julia T Wang, Reyka G Jayasinghe, Jennifer A Foltz, Mark A Fiala, Chiang I-Ling, Julie Fortier, Michael Slade, Stephen T Oh, Michael P Rettig, John F Dipersio, Shaji Kumar, Ravi Vij, Li Ding, Et Al.

2020-Current year OA Pubs

Multiple myeloma (MM) remains incurable despite advances in treatment options. Although tumor subtypes and specific DNA abnormalities are linked to worse prognosis, the impact of immune dysfunction on disease emergence and/or treatment sensitivity remains unclear. We developed an Immune Atlas of MM by generating profiles of 1,397,272 single cells from the bone marrow (BM) of 337 newly diagnosed participants and characterized immune and hematopoietic cell populations. Cytogenetic risk-based analysis revealed heterogeneous associations with T cells of BM, with 17p13 deletion showing distinct enrichment of a type 1 interferon signature. The disease progression-based analysis revealed the presence of a proinflammatory immune …

A Catecholamine-Independent Pathway Controlling Adaptive Adipocyte Lipolysis, Xiao Zhang, Sreejith S Panicker, Jordan M Bollinger, Anurag Majumdar, Rami Kheireddine, Lila F Dabill, Clara Kim, Brian Kleiboeker, Fengrui Zhang, Kristann L Magee, Adam Kepecs, Gretchen A Meyer, Irfan J Lodhi, Erica L Scheller, Et Al.

2020-Current year OA Pubs

Several adipose depots, including constitutive bone marrow adipose tissue, resist conventional lipolytic cues. However, under starvation, wasting or cachexia, the body eventually catabolizes stable adipocytes through unknown mechanisms. Here we developed a mouse model of brain-evoked depletion of all fat, including stable constitutive bone marrow adipose tissue, independent of food intake, to study this phenomenon. Genetic, surgical and chemical approaches demonstrated that catabolism of stable adipocytes required adipose triglyceride lipase-dependent lipolysis but was independent of local nerves, the sympathetic nervous system and catecholamines. Instead, concurrent hypoglycaemia and hypoinsulinaemia activated a potent catabolic state by suppressing lipid storage and increasing catecholamine-independent …

Perceived Hiv Risk, Barriers, And Preferences For Hiv Testing In Structurally Vulnerable Communities In St. Louis: A Best-Worst Scaling Survey, Emmanuel K Tetteh, Noelle Le Tourneau, Gregory Gross, Mckenzie Swan, Tyrell Manning, Justin Cole, Katie Wolf, Lawrence Hudson-Lewis, Julia D López, Todd Combs, Virginia R Mckay

2020-Current year OA Pubs

BackgroundPersistent gaps in efforts to end the HIV epidemic in the United States highlight the need for community-specific, evidence-based HIV testing strategies. This study investigated barriers and preferences around HIV testing among underserved populations, including Black, queer, and young adults in the St. Louis, Missouri area.MethodsWe conducted a Best-Worst Scaling (BWS) survey with adults (16+ years) recruited at community events, collecting responses electronically and providing a $25 incentive. The survey assessed the relative importance of 13 potential barriers to HIV testing such as stigma, structural barriers, and perceived HIV risk, chosen based on literature review and community input. Mean preference …

Comparison Of Breast And Gastric Her2 Immunohistochemistry (Ihc) Scoring Criteria In The Assessment Of Endometrial Carcinoma, Rachel L Furuya, Whitney Grither, Matthew A Powell, Premal H Thaker, Et Al.

2020-Current year OA Pubs

BACKGROUND: Immunohistochemistry (IHC) testing is the primary method to determine HER2 status at many institutions, often with reflex to in situ hybridization (ISH). DNA- and RNA- based platforms are emerging for HER-2 assessment. While approved IHC algorithms exist for HER2 scoring in breast and gastric carcinomas, neither has been validated in endometrial cancer. This study seeks to compare them and evaluate patterns of DNA and RNA expression.

METHODS: 263 endometrioid endometrial adenocarcinoma (EEA), 275 serous endometrial carcinoma (SEC), and 214 uterine carcinosarcoma (UCS) specimens were randomly selected. Previously stained HER2 IHC slides underwent blinded review by two board-certified pathologists and …