Digital Commons Network^™

Courts Of Indian Offenses, Courts Of Indian Resistance, Alexandra Fay

Articles, Chapters in Books and Other Contributions to Scholarly Works

No abstract provided.

Psychometric Properties Of A Novel Affective Bias Task And Its Application In Clinical And Nonclinical Populations, Prathik Kalva, Kourtney Kanja, Brian A Metzger, Xiaoxu Fan, Brian Cui, Bailey Pascuzzi, John Magnotti, Madaline Mocchi, Raissa Mathura, Kelly R Bijanki

Faculty, Staff and Students Publications

To mitigate limitations in self-reported mood assessments, we introduce a novel affective bias task (ABT). The task quantifies instantaneous emotional state by leveraging the phenomenon of affective bias, in which people interpret external emotional stimuli in a manner consistent with their current emotional state. This study establishes task stability in measuring and tracking depressive symptoms in clinical and non-clinical populations. Initial assessment in a large non-clinical sample established normative ratings. Depressive symptoms were tracked relative to task performance in a non-clinical sample, as well as in a clinical cohort undergoing surgical evaluation for severe epilepsy. In both cohorts, a stronger …

Lessons Learned From An Epic Transformation Of A Radiation Oncology Department In Guatemala: Keys To Success, Edgar Ruiz, Hiram A Gay, Milton Ixquiac, Angel Velarde, Baozhou Sun, Jose García-Ramirez, Eric Laugeman, Benjamin Li, Jeff Michalski, Vicky De Falla, Geoff Hugo, Jacaranda Van Rheenen

Faculty, Staff and Students Publications

Purpose: We describe the radical modernization of a radiation oncology department in a developing country, Guatemala, from 2015 to the beginning of 2024. The Instituto de Cancerología y Hospital Dr. Bernardo del Valle S (INCAN) is the only public radiotherapy clinic serving patient referrals from the Ministry of Public Health and Social Assistance program.

Methods and materials: We describe the state of the radiation oncology department in 2015 versus 2024 while chronicling its gradual transformation. This multifaceted collaboration involved academic centers, government agencies, International Atomic Energy Agency (IAEA), industry, and nonprofits and continues to this day. We analyze the infrastructure, …

Tau In Alzheimer’S Disease: Shaping The Future Patient Journey, Catherine J Mummery, Christopher Chen Li-Hsian, Cristian A Lasagna-Reeves, Rik Ossenkoppele, Christopher C Rowe, Douglas W Scharre, Huali Wang, Simon Kyaga, Jeffrey L Cummings

Faculty, Staff and Students Publications

Alzheimer's disease is a complex and multifactorial disease characterized by two key pathological hallmarks: amyloid-beta plaques and tau neurofibrillary tangles. Recent progress has led to the development and approval of disease-targeted therapies for Alzheimer's disease in the form of anti-amyloid-beta monoclonal antibodies. However, findings suggest that amelioration of multiple pathological drivers may be required to maximize clinical effect. An increasing body of evidence suggests that tau is a critical player in Alzheimer's disease pathophysiology, contributing significantly to neurodegeneration and cognitive decline. There are now several tau-targeting drugs in clinical development. In this review, we build on research and advancements in …

Unraveling Posttranslational Modification Complexity: Advances In Quantitative Histone Proteoform Mass Spectrometry, Karl F Poncha, Alyssa T Paparella, Nicolas L Young

Faculty, Staff and Students Publications

Histone proteins and their posttranslational modifications are central to chromatin structure and function. These modifications often occur in combinations, generating a diverse array of histone proteoforms that contribute to the dynamic regulation of chromatin architecture. Advancements in mass spectrometry-based proteomics, particularly top-down and middle-down approaches, have significantly enhanced our ability to characterize these proteoforms and elucidate PTM crosstalk. This review provides an analysis of the epigenetic machinery involved in the addition, recognition, and removal of histone PTMs, emphasizing the complexity introduced by histone variants and combinatorial PTM patterns. We examine the challenges and limitations of traditional antibody-based methods for PTM …

Clinical Factors And Diagnoses Associated With Inappropriate Urine Culture Ordering In Primary Care, Marissa Valentine-King, Barbara W Trautner, Michael A Hansen, Roger Zoorob, Lisa C K Danek, Kenneth Muldrew, Forrest Hudson, Robert L Atmar, Larissa Grigoryan

Faculty, Staff and Students Publications

Objective: Evaluate the prevalence and risk factors for inappropriately ordered urine cultures in primary care.

Design: Cross-sectional study using chart reviews.

Setting: Two primary care, safety-net clinics in Houston, Texas.

Patients: Non-pregnant adults without a urinary catheter who had a urine culture and a primary care visit between 11/2018 and 3/2020.

Methods: We classified patients lacking physician documentation of the following symptoms as having an inappropriately ordered urine culture: dysuria, frequency, urgency, hematuria, fever, chills, costovertebral angle tenderness, nephrolithiasis, and pain (suprapubic, pelvic, or flank). We extracted patient demographics, visit-related diagnostic codes, past medical history, and urine culture results. Diagnostic …

In Vivo Volumetric Visualization And Quantification Of Cumulus Expansion In Mice With Intravital Optical Coherence Tomography, Kohei Umezu, Frank J Brooks, Irina Larina

Faculty, Staff and Students Publications

Ovulation is preceded by a critical physiological process known as cumulus expansion, during which the cumulus cell layer surrounding the oocyte undergoes structural remodeling. Despite the recognized importance of this process for reproductive success, live quantitative imaging of cumulus expansion has not been previously achieved due to limitations of current imaging technologies for deeply located ovaries. In this study, we employed intravital optical coherence tomography for three-dimensional visualization of mouse follicles containing cumulus-oocyte complexes (COC) within the physiological context of the ovary, both ex vivo and in vivo. This method enabled time-lapse measurement of cumulus layer thickness and COC …

Evolving Burden Of Metabolic Dysfunction-Associated Steatotic Liver Disease And Its Complications In A Us Nationwide Healthcare System, Basim Ali, Ronald Samuel, Jennifer R Kramer, Liang Li, Xian Yu, Yumei Cao, Roxanne Desiderio, George Cholankeril, Steven M Asch, Hashem B El-Serag, Fasiha Kanwal

Faculty, Staff and Students Publications

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health problem. Measuring the burden of cirrhosis and its complications in people with MASLD is important to inform health care delivery.

Methods: We aimed to quantify the changes in the burden of MASLD-related cirrhosis and hepatocellular carcinoma (HCC) in a nationwide U.S. healthcare system. We used data from the Veterans Health Administration to examine temporal trends between 2010 and 2021 in the annual incidence and prevalence of cirrhosis and HCC in a large cohort of patients with MASLD, and to compare them to those in patients with hepatitis C …

Platelet Extravasation In The Microvasculature: An Under-Appreciated Role For Platelets, Justin A Courson, Vahid Afshar-Kharghan, Alan R Burns, Rolando E Rumbaut

Faculty, Staff and Students Publications

In recent years, evidence has accumulated highlighting the presence and role of platelet extravasation - wherein platelets accumulate in tissue parenchyma - at a variety of sites throughout the body. While platelets are traditionally known for their roles in hemostasis and thrombosis, it is evident that platelets are potent mediators of inflammation across an array of physiological and pathological contexts. While anucleate and small in size, platelets contain a rich diversity of molecules in their granules capable of modulating cell proliferation, tissue repair, and a host of immune responses. There is growing evidence that platelet extravasation out of the vascular …

Survodutide For Treatment Of Obesity: Baseline Characteristics Of Participants In A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (Synchronize™-1), Carel W Le Roux, Sean Wharton, Biykem Bozkurt, Elke Platz, Gabriele Bleckert, Samina Ajaz Hussain, Martina Brueckmann, Elena Startseva, Isabel M Kloer, Lee M Kaplan

Faculty, Staff and Students Publications

Aims: Survodutide, a novel glucagon receptor and glucagon-like peptide-1 (GLP-1) receptor dual agonist, elicited significant weight loss in a phase 2 trial in individuals with obesity without type 2 diabetes (T2D). Two multinational phase 3 trials are investigating survodutide for obesity management in individuals with or without T2D. We report the baseline characteristics of participants in the SYNCHRONIZE-1 trial in adults with obesity without T2D (ClinicalTrials.gov: NCT06066515).

Materials and methods: Participants aged ≥18 years with BMI ≥30 or ≥27 kg/m2 with ≥1 obesity complication without T2D were randomized 1:1:1 to double-blind, once-weekly, subcutaneous injections of survodutide (up-titrated to 3.6 …

What Race Means For Health Among Black Americans: How Microaggressions Shape Self-Efficacy And Readiness For Behavior Change, Amanda Lee Almond

Publications and Research

Objectives: Persistent racial disparities in cardiovascular health among Black Americans reflect not only structural inequities in the United States, but also the racialized meanings of cardiovascular disease reproduced through public and private health communication. Drawing on ecological systems theory, this research examines how beliefs linking race and cardiovascular disease are reinforced through routine clinical interactions and how these meanings shape health behavior change. Method: Across two experimental mixed-methods studies, a model integrating ecological, social–cognitive, and behavior-change frameworks was tested. In Study 1 (N = 374), health-message framing was experimentally manipulated to examine effects on self-efficacy and decisional balance while controlling …

A Study Of The Impacts Of Infusing Data Analysis And Research In An Interdisciplinary Environmental Economics Course, Sean P. Macdonald

Publications and Research

This paper explores the impacts of introducing quantitative literacy skills in an interdisciplinary Environmental Economics course typically taught as an issues and policy course without a quantitative component. The study examines the effects of infusing an engaging, student-selected data collection and analysis assignment on students' quantitative reasoning skills, as well as their interest in and attitudes about data analysis and quantitative information. Using data gathered from a set of pre- and post-assessment questions designed to measure changes in quantitative reasoning skills and attitudes, the findings point to significant attitudinal impacts, gains, but smaller, insignificant gains in quantitative reasoning skills.

Improving Efficiency In Noma Schemes Having Inter-User Interference Using Mechanism Design, Zory Marantz

Publications and Research

Modern wireless systems utilize non-orthogonal multiple access to increase their rate capacities; however, the efficiency of the individual utility defined in bits per Joule has yet to be considered. Multiple variations of non-orthogonal multiple access have the interference of the signal-to-interference-plus-noise ratio as a function of the received power from multiple other users due to code implementations that are non-orthogonal or non-ideal cancellation in successive-interference-cancellation methods. Game theoretic concepts are used to improve user bits-per-Joule performance. Previous solutions increment transmit power and are not based on closed form systematic methods. The mechanism design presented here led to a non-cooperative Nash …

A Brief Measure Of Decisional Balance For Health Equity Engagement Among Health Professionals, Amanda Lee Almond

Publications and Research

Racial health and healthcare inequities are sustained in part by health professionals’ beliefs about the benefits and costs of equity-focused action, yet no validated decisional balance measure exists for this domain. This study introduces and evaluates the Health Equity Decisional Balance (HEDB) scale. Eighty-eight health professionals completed the scale of ten proposed items assessing perceived pros and cons of engaging with health and healthcare equity work, along with a measure of Anti-Racist Efficacy (ARE) (Eschmann et al., 2023). Confirmatory factor analysis and structural equation modeling were used to test the latent structure of the scale and its predictive validity. A …

Reclaiming Agency: Ai Hallucinations And Translingual Interrogations In The City Tech Writing Center,, Joseph Franklin, Anna Laura Falvey

Publications and Research

No abstract provided.

Infection Control Across Clinical And Laboratory Dental Settings Protocols, Risks, And The Role Of Emerging Technologies, Khrystyna Vyprynyuk, Laura Andreesku

Publications and Research

This article explores infection prevention strategies and disease transmission pathways in dental settings, emphasizing the critical connection between clinical practice and dental laboratories. It highlights the risks of cross-contamination, disinfection and sterilization challenges, and the growing role of technology in enhancing infection control.

Archives And Children's Knowledge, Elliott Kuecker, Ashley Rockenbach

Publications and Research

This article argues for the importance of collecting works created by children—not just about and not just for—in formal archival collections. Framed through the ideas of legitimate knowledge and epistemic injustice, this piece combines notions important to children’s rights activists and childhood studies scholars with the role archives can play in preserving children’s knowledge through child-created materials. The authors describe how researchers struggle to find work created by children within archives, impacting the ability to create child-centered research that centers children’s views of the world as prominently as adult views of the world. Some collections that do include child-created materials …

Hidden In The Mist: Three New Species Of Salamanders Of The Genus Pseudoeurycea (Amphibia: Plethodontidae) From Oaxaca, Mexico, Eduardo A. Aguilar-Herrera, Salomón Sanabria-Urbán, Dulce L. Flores-Martínez, José David Gómez-Tapia, Misael Seba-Chacha, Leopoldo D. Vázquez-Reyes, Francisco A. Rivera-Ortíz, Patricia Ramírez-Bastida, Bruno Cortés-Ortiz, R. Alejandro Calzada-Arciniega, Etienne U. Avila-Ortega, Dónovan I. Víquez-Vega, Omar Hernández-Ordoñez, Christopher Blair, Víctor H. Jiménez-Arcos

Publications and Research

We describe three new species of lungless salamanders (Plethodontidae) in the genus Pseudoeurycea from Cerro Rabon, located on the eastern slopes of the Sierra Mazateca, Oaxaca, Mexico. This mid-elevation mountain, largely surrounded by warmer lowlands, remains relatively understudied. We present molecular and morphological evidence distinguishing the three new species from their congeners. According to our phylogenetic analysis, one of the new species belongs to the P. leprosa group, while the other two are members of the P. juarezi group. Notably, one of the new species represents the fourth worm salamander known from west of the Isthmus of Tehuantepec, and another …

Ancient Wisdom & Its Cultural Relevance: Reimagining Deeper Learning In Science Classrooms Through The Lens Of Yoga And Vedānta, Raaghav Pandya

Publications and Research

Contemporary calls to reconceptualize how science is taught and understood have brought deeper learning to the forefront of education at-large for its emphasis on critical perspectives, creativity, and student-centered inquiry. Yet this paper argues that its prevailing framework remains constrained by Cartesian dualism, a materialist foundation that disassociates the individual from self, other, and nature, and falls short of addressing the mental health, environmental, and cultural challenges facing youth today. To address this limitation, this paper proposes a complementary convergence between deeper learning and the contemplative traditions of Yoga and Vedānta, whose ancient paradigms of self-inquiry, interconnectedness, and well-being offer …

What Race Means For Health Among Black Americans: How Microaggressions Shape Self-Efficacy And Readiness For Behavior Change, Amanda Lee Almond

Publications and Research

Objectives: Persistent racial disparities in cardiovascular health among Black Americans reflect not only structural inequities in the United States, but also the racialized meanings of cardiovascular disease reproduced through public and private health communication. Drawing on ecological systems theory, this research examines how beliefs linking race and cardiovascular disease are reinforced through routine clinical interactions and how these meanings shape health behavior change. Method: Across two experimental mixed-methods studies, a model integrating ecological, social–cognitive, and behavior change frameworks was tested. In Study 1 (N = 374), health-message framing was experimentally manipulated to examine effects on self-efficacy and decisional balance while …

Evaluating Mesothelin As An Immunotherapeutic Target For Endogenous T Cells, Kiriakos Koukoulias, Ryu Yanagisawa, Alejandro G Torres Chavez, Penelope G Papayanni, Yovana Velazquez, Hyun-Sung Lee, Spyridoula Vasileiou, Ann M Leen

Faculty, Staff and Students Publications

Background: Mesothelin (MSLN) is a GPI-anchored cell surface glycoprotein that is overexpressed in various solid tumors, including mesothelioma, triple-negative breast cancer, colon, ovarian and pancreatic cancer, with restricted normal tissue expression.

Methods: To explore the immunogenicity and immunotherapeutic potential of MSLN to T cells with native receptor specificity, 29 individuals of diverse HLA backgrounds were interrogated for T cell activity against MSLN.

Results: Twenty one (72%) subjects (21/29) mounted a specific T cell response when repetitively challenged with MSLN antigen. Reactive cells were Th1-polarized, polyfunctional, predominantly detected in the CD8+ T cell compartment and cytotoxic toward autologous and MSLN+/HLA-matched tumor …

Perceived Barriers And Recommendations To Improve Well-Child Visits Among Medicaid Enrollees: An Explanatory Sequential, Mixed-Methods Study, Shawnda Schroeder, Keona Manuelito

Indigenous Health Faculty Publications

Despite the critical role of well-child visits (WCVs) in preventive care, many Medicaid-enrolled children miss these appointments, leading to gaps in early intervention and immunization. Existing research has largely focused on either quantitative analyses of visit rates and predictors or qualitative insights into patient and provider experiences. This study employs a mixed-methods, community-based approach to examine barriers to WCV attendance among Medicaid-enrolled families in North Dakota who missed all WCVs in 2021. Through administrative data analysis (n=64,364), surveys (n=1,294), and focus groups (n=40), findings reveal structural, economic, and cultural obstacles, including cost concerns, lack of Medicaid transparency, and logistical challenges. …

Brewed Differently: Comparing Subheading Use In Embase And Medline, Cynthia M. Schmidt, Danielle Westmark

Posters and Presentations: Leon S. McGoogan Health Sciences Library

This project compared MEDLINE and Embase indexers' use of therapy subheadings and discusses the implications for literature searching. Objectives Our long experience with MEDLINE searching and attendance at NNLM-sponsored PubMed training sessions taught us to depend on specific patterns of subheading use by MEDLINE’s indexers. For instance, we learned to expect that drug trials would be indexed with a drug heading combined with a therapeutic use subheading. Our library licensed EMBASE in 2012. We soon began to suspect that subheading application was not as predictable in EMBASE as it was in MEDLINE. We wanted the recommendations we provide novice EMBASE …

Supporting Clinical Readiness And Well-Being In New Graduate Nurses: A Scoping Review, Angela Cyr Msn, Rn, Rnc-Nic, Npd, Bc

MaineHealth Maine Medical Center

Objectives: To map and synthesize current evidence on orientation strategies that integrate clinical and psychosocial support for newly licensed nurses, with a focus on first-year retention outcomes.

Aerocom: Winter 2026, John D. Odegard School Of Aerospace Sciences

Aerocom: John D. Odegard School of Aerospace Sciences Alumni Magazine

No abstract provided.

Restoring The Wild East: Predicting Public Support For Cougar And Red Wolf Reintroduction In The Eastern United States, Benjamin Ghasemi, Jeremy T. Bruskotter, John A. Vucetich, L. Mark Elbroch, Robyn S. Wilson, Neil H. Carter, Axel Moehrenschlager, Shelby Perry, Joseph W. Hinton

Michigan Tech Publications

Restoring large carnivores to human-dominated landscapes remains ecologically and socially contentious, though reintroduction may offer important benefits where coexistence is possible. Yet, efforts to reintroduce cougars (Puma concolor) and red wolves (Canis rufus) in the Eastern U.S. face major challenges, largely due to human-caused mortality and opposition. We employed the hazard acceptance model and structural equation modeling to investigate the socio-psychological drivers of public support for reintroduction. Survey data were collected from residents of the Eastern U.S. for cougars (n = 2665) and red wolves (n = 3825). For both species, support was positively associated with perceived personal and societal …

Yspiwrites Anthology: Selected Fiction, Art, And Poetry, Angelica Esquivel, Ypsiwrites

YpsiWrites Featured Writing

No abstract provided.

Case Report: Primed Dendritic Cell Immunotherapy For Multiple Solid Tumors, Jeffrey Jones, Aly Alrabaa, William Decker, Luis Ferbeyre, Gregorio Viramontes, Rafael Gonzalez, Elideth Angulo, Antonio Zamudio, Raul Hernandez, Stephen Noga, Susana Hernandez-Reyes, Paul Zhang, Darryl Smith, Ara Karamanian, Luis Tamara, Dalton Greenwood, Matthew Halpert

Faculty, Staff and Students Publications

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard treatments, such as immune checkpoint inhibition, radiation, surgery, or endocrine therapy. Five patients, including prostate adenocarcinoma (n=1), malignant …

Metabolites Produced By Agat+ Cells Support Regeneration In The Planarian Schmidtea Mediterranea, Aubrey M Kent, Carlos Guerrero-Hernández, Carolyn Brewster, Sean Mckinney, Jason A Morrison, Mary C Mckinney, Eric J Ross, Frederick G Mann, Blair W Benham-Pyle, Alejandro Sánchez Alvarado

Faculty, Staff and Students Publications

Planarians exhibit extraordinary regenerative abilities driven by pluripotent neoblasts, yet the roles of post-mitotic progenitor and differentiated cells in this process remain incompletely understood. Here, we investigate the function of agat+ cells, epidermal progenitors expressing members of the arginine:glycine amidinotransferase (agat) gene family, in the regeneration of Schmidtea mediterranea. Comprehensive analysis of all five planarian agat paralogs revealed that agat-1, -2, -3, and -4 are co-expressed in subepidermal populations enriched at wound sites, while agat-5 is minimally expressed. RNAi-mediated knockdown of agat-1 and agat-2 resulted in severe defects: agat-1 primarily disrupted tissue homeostasis, …

Esr1 Fusions In Breast Cancer: Functions, Mechanisms And Therapeutic Opportunities, Xuxu Gou, Zoya Farooqui, Charles E Foulds

Faculty, Staff and Students Publications

Approximately 70% of all breast cancers are driven by estrogen receptor-alpha (ERα) that binds the predominant circulating female estrogen, 17ꞵ-estradiol (E2). Because of this, drugs collectively termed “endocrine therapy (ET)” that either suppress E2 level or inhibit the activity of ERα have been used as first-line therapy. While initially effective, resistance to ET drugs occurs with subsequent lethal metastasis. The most common genetic alterations are point mutations in the ESR1 gene within the last exon encoding the ligand-binding domain (LBD), resulting in constitutively active ERα proteins. Recently, new oral selective estrogen receptor degraders (SERDs) that effectively target these point mutants …