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2026

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Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon Jan 2026

Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon

Research outputs 2022 to 2026

Epigenetic changes, in particular DNA methylation, accumulate with age across different tissues, but whether these changes follow consistent patterns across different organs remains poorly understood. Here we show, through a meta-analysis of more than 15,000 human methylation profiles spanning 17 tissues, that aging produces both conserved and tissue-specific epigenetic signatures. We identify systemic shifts in methylation levels, increases in methylation variability, and growing molecular disorder across tissues. Network analysis revealed tightly connected gene clusters that are not modified by beneficial interventions, alongside a more modifiable cluster linked to NAD+ metabolism, supporting NAD+ as a potential therapeutic target in …

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Optimizing Subgroup Selection In Petrochemical Industries: A Robust Data Envelopment Analysis Approach For Uncertainty Management, Sadegh Niroomand, Hilda Saleh, Morteza Shafiee, Dragan Pamucar, Ali Mahmoodirad Jan 2026

Optimizing Subgroup Selection In Petrochemical Industries: A Robust Data Envelopment Analysis Approach For Uncertainty Management, Sadegh Niroomand, Hilda Saleh, Morteza Shafiee, Dragan Pamucar, Ali Mahmoodirad

Research outputs 2022 to 2026

This study addresses the critical challenge faced by organizations in selecting an optimal subgroup of decision-making units (DMUs). Such a selection procedure can significantly influence efficiency, profitability, and strategic development. Recognizing the limitations of existing methods in handling inexact data and incorporating managerial preferences, this study proposes a novel framework that integrates data envelopment analysis (DEA) with binary linear programming models. The model applies belief-degree–based representations of uncertainty to capture imprecise inputs and outputs. For this model, two solution approaches—namely, chance-constrained programming and expected value approaches—were developed. These approaches are suitable for real-world applications using standard optimization software. The effectiveness …

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Patients’ And Health Professionals’ Perspectives On Transforming The Burden Of Haemodialysis (Hd) Treatment To An Opportunity: An In-Depth Qualitative Investigation, Haseeba Shouket, Eyal Gringart, Deirdre Drake, Ulrich Steinwandel Jan 2026

Patients’ And Health Professionals’ Perspectives On Transforming The Burden Of Haemodialysis (Hd) Treatment To An Opportunity: An In-Depth Qualitative Investigation, Haseeba Shouket, Eyal Gringart, Deirdre Drake, Ulrich Steinwandel

Research outputs 2022 to 2026

Most patients with End Stage Kidney Failure (ESKF) in Pakistan must undergo maintenance haemodialysis (HD) to survive. Session duration and the often lifelong nature of this treatment, along with other factors associated with HD, make it difficult to tolerate. This study took a positive psychological perspective and considered that HD sessions’ duration, which has been a major challenge for HD patients, can be turned to an opportunity for patients’ meaningful engagement. Such meaningful engagement can positively transform Pakistani patients’ experience of HD and extend into their lives outside HD. Twenty-four HD patients and six healthcare professionals were interviewed to explore …

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Precarity On The Move: The Relative Economic Precarity Of Mobile Youth Moving To Australia, Lara Mckenzie, Anita Harris, Loretta Baldassar Jan 2026

Precarity On The Move: The Relative Economic Precarity Of Mobile Youth Moving To Australia, Lara Mckenzie, Anita Harris, Loretta Baldassar

Research outputs 2022 to 2026

Analyses of precarity often focus on how insecure employment, careers, finances, and geographies influence people’s lives for the worse, with young people understood as especially precarious in their economic stability and transitions to adulthood. This article analyses accounts of precarity amongst middling transnationally mobile youth, drawing from 24 semi-structured interviews incoming to Australia, and longitudinal survey data. We show that experiences of economic precarity are impacted by their access to work, government support, ability to access or sustain visas, and access to support from family and partners. By drawing on migration scholars’ observations that transnational mobility can be privileged and …

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Supporting Displaced Students With Disabilities In Post-Secondary Education: An International Scoping Review, Tetiana Bogachenko, Jia Xu, Larysa Klymanska, Nadia Chubko Jan 2026

Supporting Displaced Students With Disabilities In Post-Secondary Education: An International Scoping Review, Tetiana Bogachenko, Jia Xu, Larysa Klymanska, Nadia Chubko

Research outputs 2022 to 2026

Students with disabilities who are forced to leave their homes due to armed conflict, persecution, environmental crises, or other forms of involuntary displacement, within their country or internationally, face compounded barriers to accessing and succeeding in post-secondary education. Yet, their experiences, educational trajectories, and the supports available to them remain underexplored. This scoping review examines existing empirical research on the experiences of students with disabilities in post-secondary education who come from forced migration backgrounds. By addressing the intersection of disability, displacement, and post-secondary education, this review highlights the unique challenges faced by this population as well as supports identified as …

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Text Messaging Programs To Support Family Literacy Practices: A Scoping Review, Lennie Barblett, Leanne Lavina, Nicola Johnson, Caroline Barratt-Pugh Jan 2026

Text Messaging Programs To Support Family Literacy Practices: A Scoping Review, Lennie Barblett, Leanne Lavina, Nicola Johnson, Caroline Barratt-Pugh

Research outputs 2022 to 2026

Using bulk digital text messaging has been shown to be effective in many different fields such as health program interventions and supporting parents/carers. Evaluations of these interventions indicate positive changes in practice; however, it appears the potential of digital messaging through short message services (SMS) have not been fully taken advantage of in early childhood education. This scoping review using Arksey and O’Malley’s (2005) approach investigates the current practices of text messaging programs to support families in the development of preschool aged children’s language and literacy learning. Searches of five databases identified 16 articles that fitted our criteria. Results indicate: …

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The Challenges Of International Travel Insurance For Leisure Travellers With Pre-Existing Mental Health Conditions, Alison Mcintosh, Gregory Willson, Dhananjana Madushani Morayes Gajaweera Marthinna Moraslage Jan 2026

The Challenges Of International Travel Insurance For Leisure Travellers With Pre-Existing Mental Health Conditions, Alison Mcintosh, Gregory Willson, Dhananjana Madushani Morayes Gajaweera Marthinna Moraslage

Research outputs 2022 to 2026

International leisure travel is deemed therapeutic for reducing stress and improving mental health and wellbeing, although unfamiliar environments can exacerbate pre-existing mental health conditions. Travel insurance plays a crucial role in mitigating risks for travellers. There is a lack of critical evaluation regarding how insurers assess risk, determine coverage eligibility and communicate exclusions. International travel insurance policies may contain restrictive clauses, ambiguous wording and outright exclusions that may disproportionately disadvantage travellers with pre-existing conditions, including mental health conditions. This paper evaluates whether New Zealand’s international travel insurance policies adequately accommodate travellers with pre-existing mental health conditions. Analysis of 23 international …

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The Basis For Recommending The Selection Of Samplers In Determining Occupational Exposures To Aerosols, Martin Harper, Pieter Bertier, Marcus Cattani, Karen Galea, Darrah Sleeth, Steven Verpaele Jan 2026

The Basis For Recommending The Selection Of Samplers In Determining Occupational Exposures To Aerosols, Martin Harper, Pieter Bertier, Marcus Cattani, Karen Galea, Darrah Sleeth, Steven Verpaele

Research outputs 2022 to 2026

Measurements are considered to be the basis of exposure assessments used to determine risks to workers. Inhalation exposure poses the greatest risk for most airborne chemicals, and measurements are based on collecting (sampling) and analyzing air samples. Samplers have been developed for more than 120 years. Each new design has been intended to address flaws perceived in earlier designs. Users are faced with a varied array of samplers from which to choose. Comparisons are difficult to make because tests of sampler performance were not standardized until recently and have not been applied consistently. The existing large body of work does …

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The Complex And Multifaceted Nature Of Social Media: Perspectives From Young Adolescents, Parents And Experts, Cindy Branch-Smith, Diarmuid Hurley, Nasim Salehi Jan 2026

The Complex And Multifaceted Nature Of Social Media: Perspectives From Young Adolescents, Parents And Experts, Cindy Branch-Smith, Diarmuid Hurley, Nasim Salehi

Research outputs 2022 to 2026

Purpose: This study explores the complex and multifaceted nature of social media use among young adolescents, drawing on the perspectives of young adolescents, parents and experts. It examines both the benefits and risks of social media and associated implications for adolescent mental health, self-development and social relationships. Methodology: A qualitative, interpretive design was utilised, using interviews across three stakeholder groups, with data analysed using reflexive thematic analysis. Findings: The analysis identified a range of perceived opportunities, benefits and challenges associated with adolescent social media engagement. Participants highlighted its role in fostering connection, education and self-expression, alongside significant risks, including cyberbullying, …

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The Impact Of A Vancomycin Intervention On Vancomycin-Associated Nephrotoxicity In Children: A Quality Improvement Initiative, Megan R. Nettleton, Hwi Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell Jan 2026

The Impact Of A Vancomycin Intervention On Vancomycin-Associated Nephrotoxicity In Children: A Quality Improvement Initiative, Megan R. Nettleton, Hwi Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell

Research outputs 2022 to 2026

Background: Vancomycin is first-line treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections. However, despite guideline recommendations, there is no evidence that targeting vancomycin trough concentrations of ≥15 mg/L in children confers clinical benefit and is associated with vancomycin-associated nephrotoxicity (VAN). Aim: This study aimed to evaluate the impact of a vancomycin safety bundle on VAN and vancomycin utilisation in hospitalised paediatric inpatients. Method: A pre–post-intervention study was conducted in a tertiary paediatric hospital comparing January–December 2018 (pre-intervention) to May 2019–April 2020 (post-intervention). Hospitalised children, aged 30 days to <18 years, that received intravenous vancomycin with at least one trough concentration were included. The intervention bundle comprised: (1) lowered empiric vancomycin trough targets (5–15 mg/L), (2) enhanced creatinine monitoring (concomitant serum creatinine with vancomycin trough), (3) guideline modification (reduced pre-authorised indications for empiric vancomycin use), and (4) prescriber education initiatives. Ethical approval was granted by the WA Child and Adolescent Health Service Research Ethics Committee, Governance Evidence Knowledge Outcomes Program (Reference no: 41830) and the study conforms with the National Health and Medical Research Council's Ethical considerations in quality assistance and evaluation activities. Results: A total of 314 vancomycin prescriptions were analysed (n = 204 pre-intervention; n = 110 post-intervention). Post-intervention, VAN incidence decreased almost twofold from 0.46 to 0.25 episodes per 1000 patient bed days (p ≤ 0.01), and vancomycin prescription days decreased by 19%. Total hospital drug costs for vancomycin decreased by AUD $16 033. Overall, and for paediatric invasive MRSA, no significant difference in clinical outcomes or 30-day mortality was observed between study periods. Conclusion: This study demonstrated the implementation of a vancomycin safety bundle significantly reduced paediatric VAN and vancomycin utilisation without compromising clinical outcomes. These data support antimicrobial stewardship interventions to improve medication safety for children.

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Tourism Low-Carbon Decision-Making Through The Avoid–Shift–Improve Framework, Pezhman Hatamifar, Arghavan Hadinejad, Jalayer Khalilzadeh, Kourosh Esfandiar, S. Mostafa Rasoolimanesh Jan 2026

Tourism Low-Carbon Decision-Making Through The Avoid–Shift–Improve Framework, Pezhman Hatamifar, Arghavan Hadinejad, Jalayer Khalilzadeh, Kourosh Esfandiar, S. Mostafa Rasoolimanesh

Research outputs 2022 to 2026

Using the Avoid–Shift–Improve framework, this study examines how demographic factors and psychological, behavioral, and attitudinal drivers are associated with tourists’ low-carbon decision-making across mobility, consumption, and accommodation. Survey data were collected from 416 young Finnish travelers, and analyzed using correlation tests, repeated-measures ANOVA, and cluster segmentation to examine cross-domain and cross-strategy variation. Findings show that demographic factors have limited influence, whereas psychological, behavioral, and attitudinal drivers motivate sustainable choices. Shift dominant mobility decision-making, Avoid emergence in consumption, and Improve are most common in accommodation. Three adopter groups are identified as strong, moderate, and weak, reflecting different levels of engagement. Theoretically, …

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What Are Information Literacy Skills? Western Australian Primary Teachers’ Interpretations Of The Ict Curriculum, Louise Moroney, Vaille Dawson Jan 2026

What Are Information Literacy Skills? Western Australian Primary Teachers’ Interpretations Of The Ict Curriculum, Louise Moroney, Vaille Dawson

Research outputs 2022 to 2026

Teachers must equip students to navigate an increasingly complex world of unique challenges and opportunities, necessitating the development of a diverse range of transferable skills. These skills are embedded in the General Capabilities (GC) of the Australian school curriculum. Upper primary school teachers’ interpretations of one of the GC, Information and Communication Technology (ICT) learning progressions, was examined, as these skills have become increasingly important with the rise in generative and assistive artificial intelligence. Using an interpretivist paradigm, an exploratory study was used to determine the areas where 36 teachers differed in their interpretations of the learning progression. Data collected …

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Yoga Storytelling As An Active Learning Approach: Insights From Early Childhood Classroom Practice, Serap Sevimli-Celik Jan 2026

Yoga Storytelling As An Active Learning Approach: Insights From Early Childhood Classroom Practice, Serap Sevimli-Celik

Research outputs 2022 to 2026

Movement plays a central role in early childhood learning, supporting children’s physical development, emotional regulation and cognitive engagement. In recent years, educators have been paying more attention to movement-based approaches to enhance classroom learning experiences. Yoga, when adapted for young children, offers opportunities for playful movement, body awareness and relaxation. This paper reflects on my experiences as a movement educator and explores how yoga can support active learning in early childhood classrooms. Drawing on a series of 30-minute yoga storytelling sessions delivered to five- and six-year-old children in a preschool setting, the paper illustrates how yoga storytelling can be integrated …

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‘Salami Slicing’ And Issue Estoppel: Foreign Decisions On The Governing Law, Adeline Chong Jan 2026

‘Salami Slicing’ And Issue Estoppel: Foreign Decisions On The Governing Law, Adeline Chong

Research Collection Yong Pung How School Of Law

Whether an issue estoppel arises over foreign decisions on the governing law of the claim has not been directly considered by an English court, but decisions in other jurisdictions show that this question is increasingly being raised in litigation. Is there identity of issue if the two courts apply different choice of law rules? The answer turns on whether a broad or narrow framing of the issue is adopted. It is suggested that, absent an issue which is subject to forum international public policy, forum overriding mandatory rules or which is one that the forum court retains the prerogative to …

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The Shareholder’S Standing To Challenge The Exercise Of Directorial Power: Tianrui (International) Holding Company V China Shanshui Cement Group Ltd, Pearlie M. C. Koh Jan 2026

The Shareholder’S Standing To Challenge The Exercise Of Directorial Power: Tianrui (International) Holding Company V China Shanshui Cement Group Ltd, Pearlie M. C. Koh

Research Collection Yong Pung How School Of Law

An enduring problem with the proper purposes duty is the apparent right of the shareholder to enforce the same despite the duty being owed to the company. The cases on the proper purpose duty have thus far simply assumed the right of the shareholder to do so without dealing with the question of standing. In Tianrui (International) Holding Company Ltd v China Shanshui Cement Group Ltd, the Privy Council dealt with this issue directly and affirmed the shareholder's right to bring the action on the basis of the statutory contract constituted by the memorandum and articles of association of the …

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Relevance Between Strict Liability Theory And Banking Crimes In The Transfer Of Customer Funds: Negligence And Intent, Astrid Athina Indradewi, Evi Kongres, Ananda Chrisna D. Panjaitan, Evelyn Hutami Gunawarman Jan 2026

Relevance Between Strict Liability Theory And Banking Crimes In The Transfer Of Customer Funds: Negligence And Intent, Astrid Athina Indradewi, Evi Kongres, Ananda Chrisna D. Panjaitan, Evelyn Hutami Gunawarman

Research Collection Yong Pung How School Of Law

This article discusses the relevance of the Strict Liability theory to banking crimes in the transfer of customer funds involving elements of negligence as well as intent committed by bank managers. Strict liability places responsibility on the perpetrator without the need to prove fault, but rather by establishing a causal relationship between the act and the harm. In the context of civil law, Articles 1365 and 1367 of the Indonesian Civil Code recognize a form of liability resembling this concept through the mechanism of vicarious liability, whereby the bank as employer may be held liable for the unlawful acts of …

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