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Articles 22981 - 23010 of 23029
Full-Text Articles in Entire DC Network
Music Teacher Wellbeing And Flourishing In Australian Primary Schools, Han Meng, Jason Goopy, Narelle Lemon
Music Teacher Wellbeing And Flourishing In Australian Primary Schools, Han Meng, Jason Goopy, Narelle Lemon
Research outputs 2022 to 2026
Teacher wellbeing is often generalised across roles, while a nuanced understanding of specialist teachers is often overlooked. This study used the positive psychology strengths-based PERMAH model to investigate factors that support wellbeing and flourishing of primary school music teachers in Australia and opportunities for growth. As part of a larger mixed-methods research project, data for this article were generated through interviews with 14 music teachers who deliver primary school class music and were analysed using reflexive thematic analysis. Findings indicated that music teacher wellbeing was promoted by joy derived from students’ learning, passion for teaching music, and recognition and support …
Nurses' Perceptions Of Their Non-Technical Skills In Recognising And Responding To Clinical Deterioration In Hospital Settings: A Systematic Review, Darlene Archer, Amineh Rashidi, Rajbeer Kaur, Allison Roderick, Olivia Gallagher
Nurses' Perceptions Of Their Non-Technical Skills In Recognising And Responding To Clinical Deterioration In Hospital Settings: A Systematic Review, Darlene Archer, Amineh Rashidi, Rajbeer Kaur, Allison Roderick, Olivia Gallagher
Research outputs 2022 to 2026
Aim: To understand nurses' perceptions of non-technical skills in recognising and responding to clinical deterioration in hospital settings.
Design: A mixed methods systematic review was undertaken, guided by the Joanna Briggs Institute Manual for Evidence Synthesis.
Methods: A systematic search of the primary research literature published between 2012 and October 2025 was undertaken. A convergent integrated approach to synthesis, without meta-analysis, was undertaken.
Data Sources: The MEDLINE, CINAHL, Scopus, PsychInfo and Embase electronic databases were searched. Reference lists of full-text articles retrieved were reviewed for additional data sources.
Results: Twenty-four primary studies were included. Narrative synthesis resulted in six main …
Pain In People With Dementia Is A Significant Contributor To Increased Professional Caregiver Burden: Results Of An Observation Study, Kreshnik Hoti, Ipsit Vahia, Paola Chivers, Jeffery Hughes
Pain In People With Dementia Is A Significant Contributor To Increased Professional Caregiver Burden: Results Of An Observation Study, Kreshnik Hoti, Ipsit Vahia, Paola Chivers, Jeffery Hughes
Research outputs 2022 to 2026
Aim: To investigate the association between the presence of neuropsychological symptoms, professional caregiver burden and pain intensity.
Methods: Eleven neuropsychiatric symptoms reportedly associated with caregiver burden which are included within the PainChek® pain assessment tool were identified: aggressiveness, inappropriate behavior, distressed, verbally offensive, confusion, restlessness, pacing and wandering, crying, screaming, altered sleep and resisting care. A caregiver burden score based on binary scoring of the presence of these indicators was calculated (summative score range from 0 to 11). Generalized estimating equations were used to evaluate the relationships between (1) pain score and sum of caregiver indicators present and (2) pain …
Relationships Between Physical Performance Characteristics And Match Characteristics Of English Academy Soccer Players, B. Dickinson, P. Jones, P. Comfort
Relationships Between Physical Performance Characteristics And Match Characteristics Of English Academy Soccer Players, B. Dickinson, P. Jones, P. Comfort
Research outputs 2022 to 2026
The aim of this study was to determine the relationships between physical performance and match characteristics of Elite academy soccer players using pooled data across U15, U16, U18, U23 age groups. Sixty elite academy soccer players including u15 (Subject: N = 15; age: 14.64 ± 0.25; mass: 59.88 ± 9.12 kg; height: 171 ± 6.69 cm), u16 (Subject: N = 15; age: 15.42 ± 0.36; mass: 65.11 ± 8.70 kg; height: 175 ± 7.21 cm), u18 (Subject: N = 15; age: 17.00 ± 1.00; mass: 72.85 ± 7.43 kg; height: 179 ± 6.43 cm), u23 (Subject: N = 15; age: …
Selective Human Resource Practices, Psychological Safety Climate And Employee Wellbeing, Yvonne Brunetto, Matthew J. Xerri, Geremy Farr-Wharton
Selective Human Resource Practices, Psychological Safety Climate And Employee Wellbeing, Yvonne Brunetto, Matthew J. Xerri, Geremy Farr-Wharton
Research outputs 2022 to 2026
Purpose: Engineers and healthcare professionals perceive higher levels of stress compared with the general population, suggesting that past human resource management (HRM) systems have failed to manage them appropriately. This study examines whether psychosocial safety climate (PSC) acts as a psychological conduit in translating HRM practices and mediating their impact on wellbeing using the common good HRM (CGHRM) and Conservation of Resources theoretical frameworks.
Design/methodology/approach: Data were collected using surveys collected at two points – one-month apart, and then analysed using structural equation modelling (Analysis of Moment Structures) to manipulate survey data from 300 matched employees.
Findings – The variance …
The Ecology Of Hope: Building Rainbows In Education Systems, Jennifer Achari
The Ecology Of Hope: Building Rainbows In Education Systems, Jennifer Achari
Research outputs 2022 to 2026
Hope is frequently invoked in education, yet rarely theorised. Where it has been theorised, it has been understood in two largely separate ways: as an individual psychological capacity, in the positive-psychology tradition and as a critical-emancipatory stance, in the pedagogy of hope. This article proposes a third: a theory, the ecology of hope, that locates hope not in the individual alone but in the relationship between a person and the systems that surround them. Bringing the cognitive psychology of hope into dialogue with ecological systems theory, the social-ecological account of resilience, and utopian methodology, in which a better society is …
The Influence Of Self-Compassion On The Mental Health And Well-Being Of Women Experiencing Infertility: A Systematic Review, Shwikar Othman, Mitra Javanmard, Lauren Roberts, Lisa Conlon, Mary Steen
The Influence Of Self-Compassion On The Mental Health And Well-Being Of Women Experiencing Infertility: A Systematic Review, Shwikar Othman, Mitra Javanmard, Lauren Roberts, Lisa Conlon, Mary Steen
Research outputs 2022 to 2026
Infertility can cause significant distress to women, increasing the risk of anxiety and depression. This systematic review examined the influence of self-compassion interventions on mental health and well-being among women experiencing infertility. The review was conducted in accordance with Joanna Briggs Institute (JBI) methodology and reported following PRISMA guideline. Databases searched included Medline, Embase, Ovid nursing database, Emcare, PsycINFO and Cochrane Library from inception to November 2024. Quality assessment was conducted using JBI critical appraisal tools. Title and abstract screening was conducted by three reviewers, and data extraction was performed independently by two reviewers. Sixteen studies met the inclusion criteria, …
When The Panic Sets In: Ai-Proofing As Pedagogical Violence In Social Work Education, Norah Hosken, Susan Bailey
When The Panic Sets In: Ai-Proofing As Pedagogical Violence In Social Work Education, Norah Hosken, Susan Bailey
Research outputs 2022 to 2026
Universities’ rushed responses to generative Artificial Intelligence (AI) constitute pedagogical violence against students and educators in social work programs. Drawing on Matusov and Sullivan’s pedagogical violence framework and Bourdieu’s symbolic violence, we examine how institutional mandates to ‘AI-proof’ assessments contradict core social work values while inflicting systematic harm. AI-proofing policies impose time-limited assessments disadvantaging disabled students and those with caring responsibilities, deploy surveillance technologies that discriminate against non-native English speakers, demand unsustainable workload increases from burned-out educators, and dismantle scaffolded pedagogy aligned with how social workers learn to practise. Using collaborative autoethnography, we document our experiences across Australian universities and …
Women Are Discriminated Against On The Basis Of Sex: Anti-Trans Epistemologies In Australian Universities, Emily M. Gray, Jacqueline Ullman, Mindy Blaise
Women Are Discriminated Against On The Basis Of Sex: Anti-Trans Epistemologies In Australian Universities, Emily M. Gray, Jacqueline Ullman, Mindy Blaise
Research outputs 2022 to 2026
This article offers an analysis of qualitative data from a multi-phased project entitled Understanding and Addressing Everyday Sexisms in Australian Universities. The project’s key aim was to improve the ways in which gender-based discrimination is understood and addressed in Australian universities. It achieved this aim through adopting a situated, intersectional, and creative approach to data generation and analysis. The authors examine data from phase three of the project, a large-scale survey that was distributed across 12 of Australia’s 39 public universities, yielding 1257 responses. The survey was designed to encourage academic staff of all genders to participate and aimed to …
Investigating Policy Enactment In Community Sport Coaching: Directions For Future Research, Ben Ives, Dawn Penney, Jimmy O’Gorman, Adam J. Nichol, Paul Potrac, Lee Nelson
Investigating Policy Enactment In Community Sport Coaching: Directions For Future Research, Ben Ives, Dawn Penney, Jimmy O’Gorman, Adam J. Nichol, Paul Potrac, Lee Nelson
Research outputs 2022 to 2026
This article calls for a sophisticated investigation of policy enactment in sport-related environments, with community sport coaching used as an example case. Emphasis is placed on the need for in-depth empirical research into and theorisation of: 1) political skills involved in the enactment of policy; 2) emotion management when enacting policy; 3) performative and fabricated aspects of policy enactment; and 4) impacts of policy enactment for the health and wellbeing of workers. In doing so, this article challenges scholars to move beyond the study of policy actor types and to develop more nuanced understandings of the political, economic, organisational, interpersonal, …
Stakeholder Perceptions Of The Feasibility Of E-Portfolio-Based Assessment Of Physical Literacy In Primary Health And Physical Education, Jaxon Hogan, Dawn Penney, Eibhlish O’Hara, Joseph Scott
Stakeholder Perceptions Of The Feasibility Of E-Portfolio-Based Assessment Of Physical Literacy In Primary Health And Physical Education, Jaxon Hogan, Dawn Penney, Eibhlish O’Hara, Joseph Scott
Research outputs 2022 to 2026
Background: Physical literacy (PL) is widely acknowledged as an integral component of high-quality physical education programmes. However, what constitutes appropriate assessment of PL remains a contested issue. This study drew on Whitehead’s conceptualisation of PL as a lifelong journey and investigated how primary school teachers can support students’ PL learning through innovative and engaging assessment methods. The study specifically examined the feasibility of using e-portfolios to facilitate quality PL learning and quality assessment in Physical Education (PE), from different stakeholder perspectives. Methods: This interpretive study employed a qualitative design and methods to investigate aspects of feasibility with three purposive participant …
It Makes You Nervous When You Start Talking About Racism: Shining Light On Teacher Educators’ Experiences Of Anti-Racist Pedagogy In Australian Teacher Education, Sasha Janes
Research outputs 2022 to 2026
Teacher educators have a significant responsibility in promoting anti-racist pedagogy and guiding preservice teachers to engage in critical self-examination regarding dominant narratives. However, many teacher education programmes fall short of adequately equipping aspiring teachers for diverse classrooms as they often perpetuate a predominantly white system and curricula. Informed by Critical Pedagogy and underpinned by a lens of Culturally Sustaining Pedagogies, this paper discusses the experiences of teacher educators facilitating anti-racist pedagogy within teacher education programmes at Australian universities. Semi-structured interviews were held with 23 experienced teacher educators employed at universities across Australia. Data reveal teacher educators’ efforts to promote anti-racist …
Winding Roads: A Qualitative Phenomenological Study Of Female Educational Leadership, Nicole Casper
Winding Roads: A Qualitative Phenomenological Study Of Female Educational Leadership, Nicole Casper
Graduate Student Theses, Dissertations, & Professional Papers
The experiences of female superintendents were examined in this study to provide insight into the commonalities in their leadership journeys within public school organizations. A phenomenological, qualitative approach, aligned with Moustakas’s (1994) framework, was used to explore participants’ shared experiences. Comprehensive interviews were conducted with 17 female superintendents serving during the 2022–2023, 2023–2024, and/or 2024–2025 academic years in the states of Idaho, Montana, Oregon, and Washington. Through phenomenological reduction, three overarching commonalities emerged: (a) barriers, (b) challenges, and (c) supporting factors. The findings illuminate how organizational, societal, and gendered influences interact to shape female leadership advancement toward assistant superintendent or …
Effectiveness Of Behavioral Cough Suppression Therapy In A Closed Enrollment Group Telehealth Delivery Model And Comparison To A Rolling Enrollment, Kinsey Louise Roberts
Effectiveness Of Behavioral Cough Suppression Therapy In A Closed Enrollment Group Telehealth Delivery Model And Comparison To A Rolling Enrollment, Kinsey Louise Roberts
Graduate Student Theses, Dissertations, & Professional Papers
Background:
Refractory chronic cough (RCC) is a subtype of chronic cough (CC) that persists
despite guideline-based treatment and can negatively affect quality of life. Behavioral cough
suppression therapy (BCST), typically delivered by speech-language pathologists (SLPs), is an
effective treatment for RCC. However, access to BCST remains limited due to geographic
barriers and a shortage of trained providers. Group-based telehealth may help expand access to
treatment. This study evaluated the effectiveness of BCST delivered via telehealth using
a closed enrollment group model and compared outcomes to a rolling enrollment group model.
Methods:
In this prospective sequential cohort study 32 participants attended …
Beyond Words: The Horse-Human Encounter In Equine-Assisted Psychotherapy For Residential Substance Use Treatment, Leah Finch Lungren
Beyond Words: The Horse-Human Encounter In Equine-Assisted Psychotherapy For Residential Substance Use Treatment, Leah Finch Lungren
Graduate Student Theses, Dissertations, & Professional Papers
Equine-assisted psychotherapy (EAP) has emerged as a promising experiential therapeutic intervention, yet the lived experience of adults participating in EAP within residential substance use disorder (SUD) treatment settings remains underexplored. This hermeneutic phenomenological study examined the lived experience of 12 adults who participated in EAP groups during residential SUD treatment across three treatment facilities in the United States. The primary research question was: What is the lived experience of participating in EAP for adults in residential SUD treatment? Data was collected through semi-structured interviews and analyzed through iterative hermeneutic interpretation guided by van Manen’s (1990) existential framework.
Six themes emerged …
What Really Matters In Behavioral Cough Suppression Therapy? A Retrospective Look At Targeted Treatment Components, Mary B. Walsh, Laurie Slovarp, Kassidi Heinle, John Quindry, Jane Salois
What Really Matters In Behavioral Cough Suppression Therapy? A Retrospective Look At Targeted Treatment Components, Mary B. Walsh, Laurie Slovarp, Kassidi Heinle, John Quindry, Jane Salois
Graduate Student Theses, Dissertations, & Professional Papers
Background:
Refractory chronic cough (RCC) is a prevalent condition that substantially impairs quality of life and is associated with significant physical, psychological, and social burden. Behavioral cough suppression therapy (BCST), delivered by speech-language pathologists, is an evidence-based nonpharmacologic intervention shown to improve cough-related quality of life. However, variability exists in how BCST is implemented, and the relative contribution of specific treatment components remains unclear.
Objective:
To evaluate the effectiveness of a BCST program implemented in a community otolaryngology clinic that emphasizes consistent suppression at the urge-to-cough and neuroplasticity-informed behavioral principles.
Methods:
This observational retrospective case series examined clinical records of …
An Exploratory Analysis Of The Role Of Sex In Load Carriage, Rachel E. Perez, Dustin R. Slivka, Brent C. Ruby
An Exploratory Analysis Of The Role Of Sex In Load Carriage, Rachel E. Perez, Dustin R. Slivka, Brent C. Ruby
Graduate Student Theses, Dissertations, & Professional Papers
Axially loaded weight may impose a metabolic demand equivalent to that of fat mass (FM) during load carriage. Males (M) typically have a lower body fat percentage than females (F), resulting in metabolic demand differences during load carriage that may be mitigated by accounting for FM in pack loads. PURPOSE: To determine whether normalizing pack load to FM equalizes metabolic cost across sexes during load carriage. METHODS: Twenty-eight participants (14M, 23 ± 5 y, 1.81 ± 0.07 m, 78.7 ± 10.0 kg, 12.7 ± 5.4% body fat, VO2peak 4.18 ± 0.54 L·min-1; 14F, 22 ± 4 …
Adults With Dyslexia: Experiences Accessing And Using Reading Strategies And Assistive Technology, Brenda Rosalie King
Adults With Dyslexia: Experiences Accessing And Using Reading Strategies And Assistive Technology, Brenda Rosalie King
Graduate Student Theses, Dissertations, & Professional Papers
Dyslexia is a specific learning disorder of neurobiological origin characterized by persistent difficulties with accurate and/or fluent reading, word recognition, spelling, and decoding. Although dyslexia is widely recognized as a lifelong learning difference, the majority of research has historically focused on children and adolescents, with less attention given to adult experiences. The purpose of this study was to explore how adults with dyslexia access and use reading strategies and assistive technologies to support reading comprehension and independence across contexts. The study also examined barriers and supports influencing access to these tools, as well as the emotional experiences associated with their …
Advancing Understanding Of Lived Experience Of Unhoused People To Reduce Social Stigma And Promote Community Health: A Theoretically-Guided Photovoice Study, B-Rad Stephen Applegate
Advancing Understanding Of Lived Experience Of Unhoused People To Reduce Social Stigma And Promote Community Health: A Theoretically-Guided Photovoice Study, B-Rad Stephen Applegate
Graduate Student Theses, Dissertations, & Professional Papers
Homelessness is a persistent public health challenge shaped by structural inequities, stigma, and exclusion from social and health systems. Community-Based Participatory Research (CBPR) has increasingly been used to center the knowledge of people who are unhoused, yet limited attention has been given to the theoretical frameworks guiding this work across disciplines. The purpose of this dissertation was to examine theories and methods used in CBPR with unhoused populations and to explore the extension of Margaret Newman’s Theory of Health as Expanding Consciousness from a nursing-focused theory to a public health framework for understanding lived experience.
Using a scoping review methodology …
Ghostly Grieving In Theatre’S Now Also The Dramaturgy Of Perception And The Body In Contemporary American Ghost Plays, Jacob Mann Christiansen
Ghostly Grieving In Theatre’S Now Also The Dramaturgy Of Perception And The Body In Contemporary American Ghost Plays, Jacob Mann Christiansen
Graduate Student Theses, Dissertations, & Professional Papers
“Ghostly Grieving in Theatre’s Now Also” explores how contemporary American plays and playwrights stage the dead as a way of understanding theatre’s unique language for dealing with the shared, complex human experience of grief. Focusing on theatrical ghosts and other “impossible” presences, I articulate how these figures function as dramaturgical devices. I also argue that theatre’s ghosts “set the stage” (as it were) for communicable meaning-making by inviting audiences into the tasks of creation and mourning.
My work draws on performance theory (especially phenomenological accounts of theatrical storytelling), on dramaturgical analysis, and on grief studies. In this dissertation project, I …
Á’Po’Taki Iiyika’Kimaa Work/Try Hard For Such A Time As This, Misamsai’Piaakíí Longtime Charging Woman Kimberly Lynn Paul
Á’Po’Taki Iiyika’Kimaa Work/Try Hard For Such A Time As This, Misamsai’Piaakíí Longtime Charging Woman Kimberly Lynn Paul
Graduate Student Theses, Dissertations, & Professional Papers
This body of work adds to a recent shift in the academic landscape, valuing interdisciplinary research and Indigenous worldview. Predominant is the reversal of extractive research norms within Indigenous populations and the biosystems they steward, instead claiming Piikani (Blackfeet) led community-needs-based research valuing Indigenous data sovereignty, research methodologies, ethics, equity, and Indigenous empowerment. This research proffers requisite historical information providing the ‘why’ context, followed by three of the author’s studies: in toxic dumping, food sovereignty, and Piikani well-being. Under an environmental justice framework, the first study presents a cursory investigation of decades-long illicit toxic waste disposal reports linked to observed …
Developing Identity After Goodbye: Social Identity Theory And How Adolescent Survivors Navigate Suicide Loss, Elizabeth Susan Lawton
Developing Identity After Goodbye: Social Identity Theory And How Adolescent Survivors Navigate Suicide Loss, Elizabeth Susan Lawton
Graduate Student Theses, Dissertations, & Professional Papers
Adolescents who lose a loved one to suicide, known as suicide-loss survivors, face a disruption to identity development, a life stage defined by identity formation (Adler et al., 2018) and group belonging (Pittman & Richmond, 2008). Suicide bereavement is complicated not only by grief but also by stigma, which can fracture social ties and undermine self-concept. Social identity theory (SIT) provides a framework for examining how young adults, now ages 18 to 30, reconstruct their social identities after experiencing suicide loss in adolescence. Research in other stigmatized contexts shows that adopting positive in-group identities can buffer against stigma and protect …
Hidden Wounds: Exploring Moral Injury In Childhood Exposure To Domestic Violence, Megan Elizabeth Denny
Hidden Wounds: Exploring Moral Injury In Childhood Exposure To Domestic Violence, Megan Elizabeth Denny
Graduate Student Theses, Dissertations, & Professional Papers
The profound impacts of Childhood Exposure to Domestic Violence (CEDV) have been documented extensively, revealing long-term psychological effects such as the potential development of post-traumatic stress disorder (PTSD) and increased likelihood of future victimization or perpetration of violence. Yet, the concept of moral injury (MI) traditionally explored in military and healthcare contexts, remains significantly underexplored in populations exposed to CEDV. This study examines the relevance of MI among individuals who experienced domestic violence (DV) during their youth. The research focused on two primary aims: (1) to describe the level and variability of moral injury-related distress among adults with histories of …
Unmuted: An Augmentative And Alternative Communication User’S Experience In Accessing And Engaging In Mental Health Care, Kanbi Faith Knippling
Unmuted: An Augmentative And Alternative Communication User’S Experience In Accessing And Engaging In Mental Health Care, Kanbi Faith Knippling
Graduate Student Theses, Dissertations, & Professional Papers
Communication accessibility is a critical yet underexamined factor influencing access to and engagement in mental health care for individuals who use augmentative and alternative communication (AAC). Existing literature suggests that AAC users experience significant barriers to obtaining communication-accessible mental health services, including limited provider preparation, communication-related assumptions, and broader structural inequities. Despite growing recognition of these concerns, little research has explored how AAC users experience and navigate mental health counseling or how communication accessibility shapes participation in care.
This single-case study explored communication accessibility within the context of an adult AAC users' experiences accessing and engaging in mental health counseling. …
Injuries In Children Undergoing Subspecialty Abuse Evaluations Because Of Intimate Partner Violence, M Katherine Henry, Gunjan Tiyyagura, Joanne N Wood, Jan Leonard, Kristine A Campbell, Daniel M Lindberg, Angela N Bachim, Farah W Brink, Lori D Frasier, Nancy S Harper, Claire Hickey, Natalie Laub, John D Melville, Hannah Sahud, Philip V Scribano
Injuries In Children Undergoing Subspecialty Abuse Evaluations Because Of Intimate Partner Violence, M Katherine Henry, Gunjan Tiyyagura, Joanne N Wood, Jan Leonard, Kristine A Campbell, Daniel M Lindberg, Angela N Bachim, Farah W Brink, Lori D Frasier, Nancy S Harper, Claire Hickey, Natalie Laub, John D Melville, Hannah Sahud, Philip V Scribano
Faculty, Staff and Students Publications
Background and objectives: Intimate partner violence (IPV) and child physical abuse often co-occur, but the frequency and risk factors for abusive injuries in IPV-exposed children remain unknown. Our objectives were to (1) determine frequency of skeletal surveys (SSs) and neuroimaging use because of IPV and their diagnostic value in children aged less than 24 months evaluated by a child abuse pediatrics specialist (CAP) and (2) identify factors associated with performance of and findings on SS and neuroimaging.
Methods: We conducted a retrospective study of children aged less than 24 months undergoing CAP consultations because of IPV exposure from February 2021 …
Reframing Trauma-Informed Care For Refugee And (Im)Migrant Health Systems: From Interpersonal Practice To Structurally Embedded Care, Hyojin Im, Sophia Banu, Aisha Koroma, Sarmaya Mustafayeva
Reframing Trauma-Informed Care For Refugee And (Im)Migrant Health Systems: From Interpersonal Practice To Structurally Embedded Care, Hyojin Im, Sophia Banu, Aisha Koroma, Sarmaya Mustafayeva
Faculty, Staff and Students Publications
No abstract provided.
Phase I Study Of Niraparib With Radiotherapy For Treatment Of Metastatic And Locally Advanced Invasive Carcinoma Of The Cervix (Nivix), Piyush Pathak, Eunji Jo, Susan Hilsenbeck, Matthew L Anderson, Alfredo Echeverria, Shelly Sharma, Jan Sunde, Tracilyn Hall, Anthony Costales, Claire Hoppenot, Michelle Ludwig
Phase I Study Of Niraparib With Radiotherapy For Treatment Of Metastatic And Locally Advanced Invasive Carcinoma Of The Cervix (Nivix), Piyush Pathak, Eunji Jo, Susan Hilsenbeck, Matthew L Anderson, Alfredo Echeverria, Shelly Sharma, Jan Sunde, Tracilyn Hall, Anthony Costales, Claire Hoppenot, Michelle Ludwig
Faculty, Staff and Students Publications
Introduction: This Phase I study evaluated the safety and tolerability of concurrent niraparib, an oral poly(ADP-ribose) polymerase (PARP) 1/2 inhibitor, with definitive radiotherapy in women with locally advanced or platinum-sensitive metastatic cervical cancer. Dose escalation followed a Bayesian Optimal Interval (BOIN) design with a target dose-limiting toxicity (DLT) rate of 30%.
Methods: Women ≥18 years with FIGO stage IIIC2 (bulky nodes >1 cm) or stage IV cervical cancer demonstrating response to platinum-based induction chemotherapy were eligible. Niraparib 100 mg was administered daily concurrent with pelvic radiotherapy (45-57.5 Gy via IMRT with nodal boosts) and brachytherapy, continuing 28 days post-radiation. Per …
The All Of Us Evenings With Genetics Research Program, Stacy M Lloyd, Jasmine Baker, Carolina Jorgez, Julie Coleman, Laterrica Williams, April Adams, Ashley Butler, Elizabeth Atkinson, Shamika Ketkar, Steven Scherer, Kim Worley, Susan Fernbach, Keasia Daniels, Latanya Hammonds-Odie, Laura Rosales, Brendan Lee, Debra Murray
The All Of Us Evenings With Genetics Research Program, Stacy M Lloyd, Jasmine Baker, Carolina Jorgez, Julie Coleman, Laterrica Williams, April Adams, Ashley Butler, Elizabeth Atkinson, Shamika Ketkar, Steven Scherer, Kim Worley, Susan Fernbach, Keasia Daniels, Latanya Hammonds-Odie, Laura Rosales, Brendan Lee, Debra Murray
Faculty, Staff and Students Publications
The All of Us Evenings with Genetics (All of Us EwG) Research Program, funded in part by the National Institute of Health’s All of Us Research Program, engages researchers to utilize the All of Us Researcher Workbench to advance precision medicine. The All of Us EwG program has two core aims: (1) address barriers to research productivity for minorities, disadvantaged, and persons with disabilities aspiring to enter STEM fields; and (2) promote the use of the All of Us Researcher Workbench to develop research focused on health equity. To achieve these goals, the program implements three key activities: (1) …
Personalizing Therapies Over The Course Of Hormone Receptor-Positive/Her2-Negative Metastatic Breast Cancer, Akshara Singareeka Raghavendra, Senthil Damodaran, Carlos H Barcenas, Suzanne A Fuqua, Rachel M Layman, Debu Tripathy
Personalizing Therapies Over The Course Of Hormone Receptor-Positive/Her2-Negative Metastatic Breast Cancer, Akshara Singareeka Raghavendra, Senthil Damodaran, Carlos H Barcenas, Suzanne A Fuqua, Rachel M Layman, Debu Tripathy
Faculty, Staff and Students Publications
The hormone receptor (HR)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer subtype accounts for most early and metastatic breast cancer (MBC) cases. HR‐positive/HER2‐negative MBC is characterized by a relatively prolonged, although variable, disease course and substantial intertumoral and intratumoral heterogeneity. Although endocrine‐based therapies remain the cornerstone of treatment, nearly all patients eventually develop resistance, which is increasingly addressed with biologically targeted agents and newer‐generation cytotoxic drugs. This review summarizes the current understanding of HR‐positive/HER2‐negative MBC biology, highlighting mechanisms of intrinsic and acquired resistance, including driver genomic alterations that, along with clinical factors, help guide therapeutic choices and sequencing. The …
The Words Community Dwelling, Spanish-Preferring Mexican/Mexican American Adults Use To Talk About Alzheimer’S Disease And Genetic Testing: Implications For Education And Outreach, Jamie C Fong, Fatima I Chavez, Karla Silos, Mirna L Arroyo-Miranda, Gabriela Castro Castro, Mark E Kunik, Joshua M Shulman, Luis D Medina
The Words Community Dwelling, Spanish-Preferring Mexican/Mexican American Adults Use To Talk About Alzheimer’S Disease And Genetic Testing: Implications For Education And Outreach, Jamie C Fong, Fatima I Chavez, Karla Silos, Mirna L Arroyo-Miranda, Gabriela Castro Castro, Mark E Kunik, Joshua M Shulman, Luis D Medina
Faculty, Staff and Students Publications
Introduction: Hispanic/Latino (H/L) adults are more likely than non-Hispanic White individuals to have Alzheimer's disease (AD), yet fewer than one in five H/L adults has apolipoprotein E (APOE) Ɛ4, underscoring gaps in understanding genetic risk across H/L heritage groups. H/L adults remain underrepresented in AD research that uses genetic data for participant stratification. To inform culturally appropriate educational materials for 16 million U.S. Spanish speakers, we identified culturally salient words Spanish-preferring H/L adults use to describe AD and genetic testing beyond APOE.
Methods: Community-residing, Spanish-preferring Mexican/Mexican American adults (n = 14) completed freelisting interviews, a method eliciting …