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Articles 48751 - 48780 of 48809
Full-Text Articles in Entire DC Network
Non-Gaussian Phenomena In Light Scattering And Applications, Shubham Atul Dawda
Non-Gaussian Phenomena In Light Scattering And Applications, Shubham Atul Dawda
Graduate Studies Theses and Dissertations 2026
Physical reality is rarely deterministic; which, when probed by electromagnetic fields that also fluctuate, leads to observables that are most efficiently modelled as statistical processes. At equilibrium, this is usually achieved by invoking the Gaussian statistics of underlying physical processes, however, in practice, one often encounters out-of-equilibrium conditions where Gaussian descriptions may not suffice. Such situations are plentiful in nature– from biology to astronomy. This dissertation addresses several non-Gaussian phenomena associated with light scattering, and includes specific models’ derivations, experimental techniques developments, and demonstrations of potential applications. The systematic presentation will consider circumstances that infringe upon specific assumptions of the …
Optically-Pumped Semiconductor Optical Amplifiers, Dhruvkumar Desai
Optically-Pumped Semiconductor Optical Amplifiers, Dhruvkumar Desai
Graduate Studies Theses and Dissertations 2026
Semiconductor optical amplifiers (SOAs) offer a low-cost, compact solution for power amplification needs in an optical communication system compared with the dominant erbium-doped fiber amplifiers (EDFAs). They can also provide a wide gain bandwidth. However, conventional electrically-pumped SOAs suffer from larger noise figures, low saturation power, and polarization dependence, in comparison with EDFAs. We propose an optically-pumped SOA (OP-SOA) that will maintain the benefits of conventional SOAs while closing the gaps in other amplifier performance metrics. The underlying reasons for optical pumping are twofold. First, optical pumping allows higher carrier injection and thus "population inversion." Second, optical pumping decouples carrier …
Minimizing Performance Overheads For Crash-Consistency In Disaggregated Persistent Memory, Khan Shaikhul Hadi
Minimizing Performance Overheads For Crash-Consistency In Disaggregated Persistent Memory, Khan Shaikhul Hadi
Graduate Studies Theses and Dissertations 2026
Compute express link (CXL) enables persistent memory disaggregation with memory pooling and hardware managed multi-host memory sharing capability, resulting in better resource utilization, increased scalability. Persistency-aware applications need to manage crash consistency across the system which results in significant performance overhead. This dissertation systematically investigates performance overhead to achieve crash consistency in disaggregated persistent memory and proposes solutions to enable persistency-aware application scaling for distributed system. First, we study persistent parallel programming to scale computation capability beyond single processor and determine the underlying hardware limitation to adopt lock-free data structure. We propose hardware support to design durable atomic instruction (DAI) …
Stolen Childhood: Picture Book Stories Of Indian Residential Schools, Maughn Rollins Gregory
Stolen Childhood: Picture Book Stories Of Indian Residential Schools, Maughn Rollins Gregory
Picture Books
In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …
Shin-Chi’S Canoe (2008) By Nicola Campbell, Maughn Rollins Gregory
Shin-Chi’S Canoe (2008) By Nicola Campbell, Maughn Rollins Gregory
Picture Books
In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …
The Effects Of Systematic Instructional Interventions On Functional Communication, Vocational Independence, And Academic Performance For High School Students With Autism In A Self-Contained Special Education Setting, Sarah O. Shalash
University of Kentucky Master's Theses
This project evaluated the effects of systematic instruction on functional communication, vocational independence, and functional mathematics for three high school students with autism in a self-contained special education classroom using three A–B single-case designs. Interventions included a system of least prompts for AAC requesting and vocational task completion and constant time delay for a functional timer-setting task. Student performance was measured as the percentage of independently completed responses across instructional sessions. Student T demonstrated meaningful improvement in independent AAC requesting and reached 75% independence in the final session. Student B demonstrated emerging improvement in timer-setting performance and reached 60% independence …
H2 Matrix Compression For Fast Magnetic Field Post-Processing, Calvin M. Demps
H2 Matrix Compression For Fast Magnetic Field Post-Processing, Calvin M. Demps
University of Kentucky Master's Theses
Large-scale computational electromagnetic simulations frequently require the assembly of dense system matrices, whose computation time and memory cost grow rapidly with problem size and can render high-resolution simulations impractical. This thesis presents a benchmark of the H2 hierarchical matrix method applied to the construction of a coupling matrix that maps magnetization current in a structure to the magnetic field at observation points external to the structure. The underlying field interaction is derived from Maxwell's equations and discretized using a Nyström approach, producing a dense matrix.
The method is benchmarked across various geometries of increasing complexity and for increasing mesh …
The Nature And Origin Of The Strodes Creek Member Of The Lexington Limestone, Central Kentucky, Claire J. Mendenhall
The Nature And Origin Of The Strodes Creek Member Of The Lexington Limestone, Central Kentucky, Claire J. Mendenhall
University of Kentucky Master's Theses
The Strodes Creek Member of the Lexington Limestone is a small, unusual member that is largely known for its beds of fragmented and overturned stromatoporoids. The Strodes Creek Member occurs as two distinct stratigraphic bodies, wholly encompassed by the Millersburg Member, which represents a shallow, open-marine, mixed-clastic-carbonate platform, characterized by thin-bedded to nodular, fossiliferous calcarenites and calcirudites interbedded with shale. In contrast to the Millersburg, the Strodes Creek exhibits a lithologic background of dark, organic-rich, calcareous shales with a westward-thickening section of very irregularly bedded, stromatoporoid-rich, fossiliferous calcisiltites (packstones and wackestones). The calcisiltites are commonly associated with hummocky crossbedding, pinch-and-swell …
Development Of An Atmospheric Particle Imaging System (Apis), James W. Hebert
Development Of An Atmospheric Particle Imaging System (Apis), James W. Hebert
University of Kentucky Master's Theses
The study of atmospheric particulates plays a crucial role in both climate change studies and the improvement of hypersonic travel. The current issue at hand is a lack of knowledge of stratospheric particulate content and the high cost that is associated with conducting research at these altitudes. This project focuses on the development of an Atmospheric Particle Imaging System (APIS) to be a low-weight, low-cost optical payload. The goal is to make a device that can be mounted onto an uncrewed aerial system that has the capability of imaging particulates moving at steady flow velocities, and thereby characterize the individual …
Minimizing The Incidence Of Falls On An Adult Inpatient Cardiac Step-Down Unit, La’Tricia Danielle Harvey
Minimizing The Incidence Of Falls On An Adult Inpatient Cardiac Step-Down Unit, La’Tricia Danielle Harvey
Doctor of Nursing Practice (DNP)
Background: Inpatient falls are a significant risk to patient safety in acute care settings. Local Problem: A 24-bed adult cardiac step-down unit with elevated fall rate lacked standardized fall risk protocols. Methods: Iterative Plan-Do-Study-Act (PDSA) cycles were used to implement, evaluate, and refine a structured workflow over 12 weeks. Interventions: A protocol-guided fall prevention checklist was deployed, supported staff education, peer coaching and leadership audits. Results: Nursing protocol knowledge increased from 83% to 93.11%, checklist compliance averaged 90%, and these process improvements correlated with a 83.3% reduction in the overall unit fall rate. Conclusions: Standardizing care via a protocol-guided fall …
Quantifying Uncertainty In Landscape Evolution And Provenance Analysis: Insights From Statistical And Numerical Modelling, Vivian Carmello Grom
Quantifying Uncertainty In Landscape Evolution And Provenance Analysis: Insights From Statistical And Numerical Modelling, Vivian Carmello Grom
LSU Doctoral Dissertations
Landscape evolution models (LEMs) and detrital zircon provenance are widely used to investigate Earth surface processes, yet both face challenges related to quantifying model behavior and interpreting sedimentary signals under realistic, heterogeneous conditions. This thesis addresses these challenges through analysis and case studies that develop and apply new approaches for analyzing landscape dynamics and assessing uncertainties in sediment provenance.
Chapter 1 introduces a quantitative framework for evaluating LEM outputs using Shannon Entropy, Moran’s I, and Geary’s C. Applied to simulations with steady uplift, periodic uplift, spatially variable uplift, and a timeseries of DEMs, these metrics capture spatial organization and information …
The Classical Limit In Geometric Quantization By Group Extension, Paul Bracken
The Classical Limit In Geometric Quantization By Group Extension, Paul Bracken
School of Mathematical & Statistical Sciences Faculty Publications
Physical systems as a rule are associated with a symmetry group. The group approach to geometric quantization makes use of this to introduce a quantization by means of group extension. This procedure is discussed and applied to a physical system whose group law has its origin with the Galilean group. The main intention is to investigate the classical limit and its relationship under this approach to geometric quantization. The classical quantization conditions are obtained based on a deeper foundation.
Toward An Analytical Radicalism: Revisiting Radical Institutionalism’S Basic Concepts, Beliza Borba De Almeida, Jacob Powell
Toward An Analytical Radicalism: Revisiting Radical Institutionalism’S Basic Concepts, Beliza Borba De Almeida, Jacob Powell
Working Papers
No abstract provided.
Beyond Green Scarcity: Ecological Economics, Demand-Led Growth, And The External Constraint, Matias Vernengo
Beyond Green Scarcity: Ecological Economics, Demand-Led Growth, And The External Constraint, Matias Vernengo
Working Papers
No abstract provided.
Gpu And Pso Accelerated Low-Latency Fully-Coherent All-Sky Search For Compact Binary Coalescences, Soumya D. Mohanty
Gpu And Pso Accelerated Low-Latency Fully-Coherent All-Sky Search For Compact Binary Coalescences, Soumya D. Mohanty
Physics & Astronomy Faculty Publications
The fully-coherent all-sky (FCAS) search, which combines data from a gravitational wave detector network into a single likelihood function, is the preferred method prescribed by statistical theory for Gaussian noise. However, so far, its exorbitant computational cost has blocked its use for compact binary coalescence searches. We introduce a solution combining Particle Swarm Optimization with Graphics Processing Unit (GPU) acceleration that is ≈ 50-fold faster than real-time analysis. This transforms the prospect of a low-latency FCAS search on all GW data into a practical reality for the first time. With large-scale simulations enabled by this speedup, we examine the issue …
Efficient Search For Detection Candidates Using A Peak Finder Strategy For All-Sky-All-Frequency Gravitational Wave Radiometer, Arindam Sharma, Deepali Agarwal, Sanjit Mitra
Efficient Search For Detection Candidates Using A Peak Finder Strategy For All-Sky-All-Frequency Gravitational Wave Radiometer, Arindam Sharma, Deepali Agarwal, Sanjit Mitra
Physics & Astronomy Faculty Publications
The first all-sky-all-frequency (ASAF) radiometer search was conducted using data from the first three observing runs of the Advanced LIGO and Advanced Virgo detectors. The significance of this search lies in its fast and unmodeled approach, leveraging a cross-correlation technique to identify common signals across the detector network. As a result, this method serves as an excellent alternative to search for unknown or poorly modeled continuous wave sources and narrow band components of the gravitational wave (GW) background. For continuous wave sources whose waveform can be modeled, this method can serve as the first stage of a hierarchical scheme by …
Computational Insights Into Orthotropic Fracture: Crack-Tip Fields In Strain-Limiting Materials Under Non-Uniform Loads, Saugata Ghosh, Dambaru Bhatta, S. M. Mallikarjunaiah
Computational Insights Into Orthotropic Fracture: Crack-Tip Fields In Strain-Limiting Materials Under Non-Uniform Loads, Saugata Ghosh, Dambaru Bhatta, S. M. Mallikarjunaiah
School of Mathematical & Statistical Sciences Faculty Publications
A finite element framework is presented for analyzing crack-tip phenomena in transversely isotropic, strain-limiting elastic materials. Mechanical response is characterized by an algebraically nonlinear constitutive model, relating stress to linearized strain. Non-physical strain singularities at the crack apex are mitigated, ensuring bounded strain magnitudes. This methodology significantly advances boundary value problem (BVP) formulation, especially for first-order approximate theories. For a transversely isotropic elastic solid with a crack, the governing equilibrium equation, derived from linear momentum balance and the nonlinear constitutive model, is reduced to a second-order, vector-valued, quasi-linear elliptic BVP. This BVP is solved using a robust numerical scheme combining …
Prevalence And Correlates Of Anxiety And Depression Symptoms Among Medical Students: The Role Of Student Debt Burden, Foroozan Afsharchi, Joshua F. Edwards, Kailash S. Ram, Jingru Huang, Valicia Hale, Ismail El Moudden
Prevalence And Correlates Of Anxiety And Depression Symptoms Among Medical Students: The Role Of Student Debt Burden, Foroozan Afsharchi, Joshua F. Edwards, Kailash S. Ram, Jingru Huang, Valicia Hale, Ismail El Moudden
Department of Family and Community Medicine Faculty Publications
Background
This cross-sectional study examined whether anxiety and depression symptoms decrease as medical students progress through training (suggesting adjustment disorder) or persist (suggesting chronic conditions), while identifying associated risk factors, including student debt burden and treatment effectiveness.
Methods
We surveyed medical students (years 1-4) at VHS-ODU using a sociodemographic questionnaire and validated screening instruments (GAD-7 for anxiety and PHQ-9 for depression) via RedCap from September to November 2024.
Results
Among 126 students, Scores were higher in Years 2-3 than in Years 1 and 4, but differences by year were not significant (GAD-7 p=0.055; PHQ-9 p=0.352). Students with a prior mental-health …
Healthcare Provider Perspectives On A Clinical Decision Tool To Support Individualized Exercise Prescriptions And Discussions For Breast Cancer Survivors, Jinani Jayasekera, Oliver W. A. Wilson, Kaitlyn M. Wojcik, Eleanor M. Kerr, Rachelle Brick, David Berrigan, Jennifer Yeong-Shin Sheng, Takeo Fujii, Kathleen Thomas, Henri K. Parson, Padma Sheila Rajagopal, Richard L. Street Jr.
Healthcare Provider Perspectives On A Clinical Decision Tool To Support Individualized Exercise Prescriptions And Discussions For Breast Cancer Survivors, Jinani Jayasekera, Oliver W. A. Wilson, Kaitlyn M. Wojcik, Eleanor M. Kerr, Rachelle Brick, David Berrigan, Jennifer Yeong-Shin Sheng, Takeo Fujii, Kathleen Thomas, Henri K. Parson, Padma Sheila Rajagopal, Richard L. Street Jr.
Department of Medicine Faculty Publications
Purpose: We evaluated healthcare providers' current knowledge, practices, and perspectives on a novel clinical decision tool (beta-version) to facilitate individualized exercise prescriptions and discussions in clinical settings.
Methods: We recruited healthcare providers who had treated or provided care to breast cancer survivors aged >= 35-years in the past 12 months. The participants were presented with a tool to provide individualized exercise recommendations considering women's individual, clinical, and contextual characteristics. Validated and reliable pre-existing instruments were used to survey providers' current knowledge, practices regarding exercise discussions, and perspectives on the beta-version (paper-draft) of the novel tool.
Results: The sample consisted of …
A Comprehensive Review Of Bone Remodeling After Trauma And Operative Treatment In Orthopedic Surgery, Sarah E. Rabin, Ian P. Marshall, Benjamin A. Nelson, Justine N. Li, Madison M. Baldauf, Ashley B. Bozzay, Benjamin W. Hoyt
A Comprehensive Review Of Bone Remodeling After Trauma And Operative Treatment In Orthopedic Surgery, Sarah E. Rabin, Ian P. Marshall, Benjamin A. Nelson, Justine N. Li, Madison M. Baldauf, Ashley B. Bozzay, Benjamin W. Hoyt
Department of Medicine Faculty Publications
Bone remodeling is a dynamic process involving bone resorption and formation that is regulated on a cellular level and impacted by mechanical stress. A variety of Orthopedic surgery treatment strategies can affect bone remodeling, which can in turn may have long-term impacts on skeletal stress tolerance and function. This review provides a comprehensive overview of bone remodeling involved in Orthopedic surgery. Materials related to bone remodeling principles across Orthopedic surgery domains were selected and compiled using databases including PubMed, MEDLINE, AccessMedicine, and CINAHL; case studies were not included. Relevant literature was summarized for a general review of bone remodeling and …
Cefazolin: A Rare Etiology Of Induced Coagulopathy, Ahmed Ismail, Anam Habib, Cayleigh Blumrick
Cefazolin: A Rare Etiology Of Induced Coagulopathy, Ahmed Ismail, Anam Habib, Cayleigh Blumrick
Department of Medicine Faculty Publications
Cefazolin, a first-generation cephalosporin, is commonly used to treat methicillin-susceptible Staphylococcus aureus (MSSA) infections. Although generally well tolerated, coagulation abnormalities have rarely been reported during therapy. We describe the case of an 81-year-old man treated with prolonged cefazolin for MSSA endocarditis who developed severe coagulopathy characterized by marked elevation of both the international normalized ratio (INR) and activated partial thromboplastin time (aPTT). The abnormalities occurred after initiation of cefazolin and worsened despite cessation of other anticoagulants. Following discontinuation of cefazolin and administration of vitamin K, coagulation parameters rapidly improved and subsequently normalized. This case highlights a rare but clinically significant …
Criterion Validity Of The Functional Status And Pain Assessment Scale Versus Pain And Length Of Stay In Hospitalized Adults With Scd, Wally R. Smith, Daniel M. Sop, Yue May Zhang, Margaret S. Guy, Rehan Qayyum
Criterion Validity Of The Functional Status And Pain Assessment Scale Versus Pain And Length Of Stay In Hospitalized Adults With Scd, Wally R. Smith, Daniel M. Sop, Yue May Zhang, Margaret S. Guy, Rehan Qayyum
Department of Medicine Faculty Publications
Objectives
In prior research we demonstrated face, construct, discriminant, and preliminary convergent validity of the newly developed, 10-item Functional Status Pain Assessment (FSPA) scale (0-50) in adult SCD patients hospitalized with VOC. We aimed in this study to further demonstrate criterion validity of the FSPA.
Methods
This was a prospective observational study of 561 daily functional and pain assessments from 91 hospitalized adults with SCD from January 2018 to June of 2019. Principal Component Analysis (PCA) Partial Least Squares (PLS) models determined the relationship between LOS, pain intensity, and FSPA. A Generalized Linear Model (GLM) to quantified the impact of …
Persistent Hypoxemia On Home Sleep Apnea Testing Prompting Further Evaluation For Pulmonary Embolism: A Case Report, Kyle Admire, Andrew Githaiga
Persistent Hypoxemia On Home Sleep Apnea Testing Prompting Further Evaluation For Pulmonary Embolism: A Case Report, Kyle Admire, Andrew Githaiga
Department of Medicine Faculty Publications
Obstructive sleep apnea is a condition characterized by recurrent upper airway collapse during sleep, which may be associated with sleep disruption and repetitive oxygen desaturations. It is diagnosed by nocturnal in-lab polysomnography or home sleep apnea testing. We present a case of an otherwise healthy individual who had home sleep apnea testing that revealed persistent, unexplained hypoxemia which, on further investigation, was found to be due to a saddle pulmonary embolism.
Insurance Disparities In Hidradenitis Suppurativa: A Comprehensive Review Of Demographics, Outcomes, And Access To Care, Alim Osman, Alexandra R. Nigro, Michael C. Povelaitis, Marc Z. Handler
Insurance Disparities In Hidradenitis Suppurativa: A Comprehensive Review Of Demographics, Outcomes, And Access To Care, Alim Osman, Alexandra R. Nigro, Michael C. Povelaitis, Marc Z. Handler
Department of Medicine Faculty Publications
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that disproportionately affects women, African Americans, and individuals of biracial descent. It is associated with substantial physical and psychiatric morbidity, reducing quality of life.
Objective: This review analyzed disparities in treatment outcomes, disease progression, and healthcare access among HS patients based on insurance type.
Methods: Using PRISMA guidelines, a comprehensive literature search identified 7 studies meeting inclusion criteria. Owing to data heterogeneity, studies were qualitatively analyzed.
Results: Findings consistently demonstrated that Medicaid patients experienced worse outcomes than those with private insurance or Medicare. Medicaid patients had higher rates of comorbid …
Percutaneous Closure Of Ventricular Septal Rupture After Myocardial Infarction:, Thomas A. Cook, Simone K. Schumaecker, Anjani Patibandla, Nicholas J. Valle, Matthew R. Summers
Percutaneous Closure Of Ventricular Septal Rupture After Myocardial Infarction:, Thomas A. Cook, Simone K. Schumaecker, Anjani Patibandla, Nicholas J. Valle, Matthew R. Summers
Department of Medicine Faculty Publications
BACKGROUND: Ventricular septal rupture (VSR) following acute myocardial infarction is a rare but deadly complication with mortality rates exceeding 90% when left untreated. Coronary ischaemia leads to myocardial necrosis and friability resulting in septal rupture, most commonly 3-5 days post-infarction. The sudden development of a left-to-right shunt causes volume overload in the right ventricle, pulmonary vasculature, and left atrium, precipitating biventricular failure, and cardiogenic shock. Management requires careful consideration of timing and modality of closure along with stabilization with mechanical circulatory support in severe cases.
CASE SUMMARY: A 65-year-old female presented with anterior ST-segment elevation myocardial infarction complicated by VSR …
Enlarging Fingertip Nodule Mimicking A Pyogenic Granuloma In A Man In His 60'S, Avery H. Seward, Jocelyn H. Larocque, Stephen M. Hughes
Enlarging Fingertip Nodule Mimicking A Pyogenic Granuloma In A Man In His 60'S, Avery H. Seward, Jocelyn H. Larocque, Stephen M. Hughes
Department of Medicine Faculty Publications
[Case presentation] A man in his 60's with a history of hypertension, hyperlipidemia, and resected colon cancer in remission presented with a 4-month history of an enlarging nodule on the right fourth fingertip. The patient recalled having a splinter removed from the same site a few weeks prior to the development of the lesion. The lesion was initially diagnosed by an orthopaedist as a pyogenic granuloma (Figure 1a), and the patient was advised to apply table salt to the area several times daily. However, the lesion continued to enlarge over 3 months with occasional bleeding and mild tenderness. Physical examination …
Platypnea-Orthodeoxia Syndrome Caused By A Patent Foramen Ovale And Interatrial Septal Aneurysm: A Case Report, Abes A. Bautista Neughebauer, Raymond L. Benza, Deepak Talreja
Platypnea-Orthodeoxia Syndrome Caused By A Patent Foramen Ovale And Interatrial Septal Aneurysm: A Case Report, Abes A. Bautista Neughebauer, Raymond L. Benza, Deepak Talreja
Department of Medicine Faculty Publications
Platypnea-orthodeoxia syndrome (POS) is a rare condition characterized by positional hypoxemia, often due to right-to-left shunting across a patent foramen ovale (PFO) despite normal right-sided pressures. Early recognition is essential as symptoms may be subtle and imaging is often unrevealing. A 78-year-old female patient with a known PFO presented with one week of lower abdominal pain and mild exertional dyspnea without chest pain. She was profoundly hypoxic to 76% on room air, with improvement when supine and worsening when upright. Initial labs were unremarkable, and arterial blood gas revealed primary respiratory alkalosis with severe hypoxemia. Despite unremarkable chest radiography, CT …
When Unilateral Leg Swelling Is Not Deep Vein Thrombosis: A Case Of Disseminated Kaposi Sarcoma Revealing Advanced Human Immunodeficiency Virus, Ahmed Ismail, Zachary Wilson, Thomas Currow, Michael Dileonardo, Carsten Kirby
When Unilateral Leg Swelling Is Not Deep Vein Thrombosis: A Case Of Disseminated Kaposi Sarcoma Revealing Advanced Human Immunodeficiency Virus, Ahmed Ismail, Zachary Wilson, Thomas Currow, Michael Dileonardo, Carsten Kirby
Department of Medicine Faculty Publications
Kaposi sarcoma (KS) is an acquired immunodeficiency syndrome (AIDS)-defining malignancy that can involve the skin, lymph nodes, and visceral organs in patients with advanced human immunodeficiency virus (HIV). We report the case of a 35-year-old man with no known prior medical history who presented to the charity care clinic complaining of recurrent thrush and two weeks of progressive right lower extremity swelling. His physical examination revealed painful, pruritic violaceous papules and plaques over the proximal right thigh that had been present for one week. He was referred to the emergency department (ED) for further workup. Venous duplex ultrasonography was negative …
Drug-Induced Lichen Planus Associated With Ocrelizumab, Avery Seward, John D. Strickley, Jeffrey P. Callen
Drug-Induced Lichen Planus Associated With Ocrelizumab, Avery Seward, John D. Strickley, Jeffrey P. Callen
Department of Medicine Faculty Publications
This case report highlights recurrent cutaneous lichen planus as a rare adverse effect of ocrelizumab, with flares occurring after each infusion and improving with prophylactic prednisone. Recognizing this association may help clinicians diagnose and manage similar cases while allowing patients to continue an otherwise effective therapy.
Nirmatrelvir-Ritonavir Targeting Viral Persistence In Post-Covid-19 Condition (Long Covid) In The Usa (Recover-Vital): A Randomized, Double-Blind, Placebo Controlled, Phase 2 Trial, Lindsey R. Baden, Nirav S. Shah, Sean T. H. Liu, Jonathan Cohen, James May, Andre Kumar, Grace A. Mccomsey, Peter Chen, Michelle Floris-Moore, Nora G. Singer, Inti Fernandez, Alex J. Slandzicki, Zanthia Wiley, Alexandra Kadl, David A. Kaminsky, Harvey Hsu, Tiffany A. Walker, Aluko A. Hope, Luis Ostrosky-Zeichner, Jason D. Goldman, Michael J. Peluso, Thomas F. Patterson, Sairam Parthasarathy, Janet M. Mullington, Paul Bolin Jr., Sarah E. Jolley, Jerry A. Krishnan, Mario Castro, Sally L. Hodder, Priscilla Pemu, Helen Y. Chu, Michael G. Risbano, Maya R. Jerath, Eleftherios Mylonakis, Ryan T. Hurt, Radica Alicic, Nabila S. Azad, Marc A. Sala, Michelle S. Harkins, Jeffrey Parsonnet, Neil Stafford, Philip Robinson, Sabiha Hussain, Xian Qiao, Sophie Two Hawk, Michael Lillestol, Nathan Erdmann, Kelly A. Gebo, Praveen Sudhindra, Joseph Sassine, Gailen D. Marshall, Tulika Chatterjee, Caryn G. Morse, Eyal Kedar, William W. Stringer, Jennifer A. Frontera, Michael Jordon, Caitlin Blaskewicz, Jorge L. Santana, Rachel A. Foot, Cherry Wongtrakool, Matthew William Mccarthy, Alem Mehari, Arch Amon, Alison K. Cohen, Nita Jain, Christine Maughan, Doug Lindsay, Rachel Olson, Samuel Broderick, Pearl Rowe, Sean M. O'Brien, David R. Walt, Bruce D. Levy, Leonard A. Jason, Phillip A. Low, Cyndya A. Shibao, Barry Make, Lucinda Bateman, Susan Redline, David Knopman, Adrian F. Hernandez, Tracy L. Nolen, Craig Reist, Lisa Berdan, Richard Whitley, Kanecia O. Zimmerman, For The Recover-Vital Clinical Trial Group
Nirmatrelvir-Ritonavir Targeting Viral Persistence In Post-Covid-19 Condition (Long Covid) In The Usa (Recover-Vital): A Randomized, Double-Blind, Placebo Controlled, Phase 2 Trial, Lindsey R. Baden, Nirav S. Shah, Sean T. H. Liu, Jonathan Cohen, James May, Andre Kumar, Grace A. Mccomsey, Peter Chen, Michelle Floris-Moore, Nora G. Singer, Inti Fernandez, Alex J. Slandzicki, Zanthia Wiley, Alexandra Kadl, David A. Kaminsky, Harvey Hsu, Tiffany A. Walker, Aluko A. Hope, Luis Ostrosky-Zeichner, Jason D. Goldman, Michael J. Peluso, Thomas F. Patterson, Sairam Parthasarathy, Janet M. Mullington, Paul Bolin Jr., Sarah E. Jolley, Jerry A. Krishnan, Mario Castro, Sally L. Hodder, Priscilla Pemu, Helen Y. Chu, Michael G. Risbano, Maya R. Jerath, Eleftherios Mylonakis, Ryan T. Hurt, Radica Alicic, Nabila S. Azad, Marc A. Sala, Michelle S. Harkins, Jeffrey Parsonnet, Neil Stafford, Philip Robinson, Sabiha Hussain, Xian Qiao, Sophie Two Hawk, Michael Lillestol, Nathan Erdmann, Kelly A. Gebo, Praveen Sudhindra, Joseph Sassine, Gailen D. Marshall, Tulika Chatterjee, Caryn G. Morse, Eyal Kedar, William W. Stringer, Jennifer A. Frontera, Michael Jordon, Caitlin Blaskewicz, Jorge L. Santana, Rachel A. Foot, Cherry Wongtrakool, Matthew William Mccarthy, Alem Mehari, Arch Amon, Alison K. Cohen, Nita Jain, Christine Maughan, Doug Lindsay, Rachel Olson, Samuel Broderick, Pearl Rowe, Sean M. O'Brien, David R. Walt, Bruce D. Levy, Leonard A. Jason, Phillip A. Low, Cyndya A. Shibao, Barry Make, Lucinda Bateman, Susan Redline, David Knopman, Adrian F. Hernandez, Tracy L. Nolen, Craig Reist, Lisa Berdan, Richard Whitley, Kanecia O. Zimmerman, For The Recover-Vital Clinical Trial Group
Department of Medicine Faculty Publications
Background
Post-acute sequelae of SARS-CoV-2 infection, more commonly known as long COVID, has emerged as a major health problem. The pathogenesis of long COVID is unknown, but among the leading hypotheses is viral persistence. We aimed to investigate whether the use of the SARS-CoV-2 antiviral nirmatrelvir-ritonavir improved long COVID symptoms.
Methods
We conducted a double-blind, placebo-controlled, randomised trial involving adults who had developed persistent symptoms (≥12 weeks) associated with three major symptom phenotypes (cognitive, autonomic, or exercise) after acute SARS-CoV-2 infection at 69 US sites. Participants were eligible if they were 18 years or older and had a previous suspected, …