Digital Commons Network^™

31p Solution Nmr Investigation Of Abasic Dna, Clarissa R. Krimmel

Graduate Theses/Dissertations

Base excision repair (BER) mechanisms fix single base lesions in DNA, such as T:G mismatches. During the base excision repair mechanism, an abasic site (AP site) is formed as an intermediate. AP sites are unstable and highly mutagenic; they can stop DNA replication. This research investigates how the conformational properties of abasic sites in DNA affect the binding recognition of enzymes involved in DNA repair mechanisms, including BER. Three different abasic sequences are being analyzed for this research project. A second project looks at the effects of a naturally occurring purine derivative, hypoxanthine, on the DNA backbone. These hypoxanthine lesions …

Strict Scrutiny And The Viewpoint Continuum, A.G. Harmon

Scholarly Articles

Consider the following instances: A cell phone photograph picturing a man's left kneecap. A statement that the speaker thinks, "The name Josiah is really cool." A woman who runs her bicycle over a business owner in order to gain celebrity and increase attention for her new podcast. An intentional lie told to acquire a job. A student who insists on answering his math exam questions in runic symbols.

At one point or another, American courts have considered the merits found in favor of instances similar to these and other like circumstances as amounting to "viewpoints." As such, they …

The Constitutional Significance Of The First American Pope: The Promise Of Listening In An Era Of Mutual Suspicion, Derek A. Webb

Scholarly Articles

Pope Leo XIV has focused a good deal of writing and speaking in the first year of his pontificate on the theme of listening, dialogue, and bridgebuilding. For Leo, listening, dialogue, and creating harmony across diverse perspectives where possible are at the heart of the Christian life. But his reflections on these themes, while rooted in theology, are aimed at a wider audience, going well beyond the church community, and addressing philosophical issues of universal human concern. Indeed, the first American pope happens to be highlighting certain ideals regarding dialogue that, while perhaps forgotten today, are central to the American …

Guide To: Conferences. Brigham-Kanner Property Rights Conference, Wolf Law Library Archives

Collection Guides & Finding Aids

No abstract provided.

Attenuation Of Cardiac Dysfunction In The Collagen-Induced Arthritis Mouse Model Mediated By A Reactive Aldehyde Species Inhibitor, Wenxian Zhou, Hannah J. Johnson, Michael J. Duryee, Ali Namvaran, Aradhana Thapa, Cole Blasing, Amy J. Nelson, Engle E. Sharp, Carlos D. Hunter, Bryan T. Hackfort, Bryant England, Tate M. Johnson, Daniel R. Anderson, Adam Lazorchak, Robert G. Bennett, Jill A. Poole, Keshoer R. Bidasee, Geoffrey M. Thiele, Ted R. Mikuls

Journal Articles: Cellular & Integrative Physiology

Individuals with rheumatoid arthritis (RA) experience increased risk of heart failure. Malondialdehyde-acetaldehyde (MAA) adducts are overexpressed and co-localize with citrullinated (CIT) proteins in RA myocardium. This study investigated whether reactive aldehyde species (RASP) inhibitors prevent MAA formation in vitro and attenuate cardiac dysfunction in a collagen-induced arthritis (CIA) mouse model. Among eight RASP inhibitors screened, ADX-246 demonstrated the greatest inhibition of MAA formation in vitro. Mice with early CIA (week 5) exhibited elevated levels of myocardial MAA adducts, myocardial inflammation, and reduced ejection fraction, but normal cardiac collagen deposition and diastolic function vs. control. By weeks 10-12, mice with chronic …

A Scalable Magnetic Field Mapping Approach For Pouch-Type Lithium-Ion Batteries, Luiz G.C. Melo, Chun H. Law

Études primaires

Ensuring safety in energy storage systems increasingly relies on advanced diagnostic tools, among which magnetic field mapping plays a critical role. This work aims to develop and validate a high-sensitivity magnetic field sensor array for accurate field mapping and preliminary battery diagnostics. We present a 4 × 4 array of magnetic sensors integrated with a calibration procedure to ensure accurate output. The system was experimentally tested by characterizing the magnetic field generated by two planar copper conductors. Finite element simulations were performed for comparison and validation. Experimental measurements exhibited strong agreement with the simulation results, confirming the reliability of the …

Lumbosacral Orthosis Can Improve Postural Control In Older Adults With Chronic Low Back Pain, Régis M.-L. D'Assomption, Christian Lariviere, Hakim Mecheri, Suzy Ngomo, Rubens A. Da Silva

Études primaires

Background

Older adults with chronic low back pain may report poor postural control and increased fall risks. Possible key mechanisms are altered lumbar spine proprioception, stiffness and mobility, which could be enhanced through lumbar stabilization approaches. The purpose of this study was thus to evaluate the immediate effects of two lumbar stabilization approaches on postural control measures, namely a lumbosacral orthosis and the abdominal drawing-in maneuver.

Methods

57 older adults (> 65 yrs): 22 with chronic low back pain and 35 healthy controls performed two trials (30 s) of a semi-tandem balance task on a force platform, while three experimental …

Rendering Knowledge Graphs From Aerospace Dentistry Processes For Clinical Decision Support Systems, Muhammad Tuan Amith, Jessica Vu, Serena Hou, Vinu Sista, Yang Gong, Ronak Shah, Ana C Neumann

Faculty, Staff and Student Publications

NASA and commercial space flight companies expect to make long-term missions into deep space with the Artemis project and Mars mission. Health care in deep space is a priority as the missions require limited crew and equipment to accommodate astronauts' needs. Analyzing the probable clinical procedures and workflows for this setting is needed to ensure quality care and safety. This paper introduces Business Process Modeling and Notation (BPMN) and OWL2-based modeling to represent aerospace dental workflows for low-earth orbit and potential deep space missions. We developed BPMN process models and created ontology-based knowledge graph representations for individual dental procedures using …

A User-Friendly Graphical User Interface For Paw Touch Classification In Rodent Cylinder Testing, Tyler R Johnson, Katherine D Zerefos, Dawn M Taylor

Faculty, Staff and Student Publications

In unilateral rodent models of disease or injury, deficits are induced in only one side of the body, allowing the difference in right versus left limb usage to serve as a metric of disease/injury severity and recovery with various treatments. Unilateral rat models are commonly used for conditions such as Parkinson’s disease (via the neurotoxin 6-hydroxydopamine, 6-OHDA), stroke, and traumatic brain injury, as well as cervical spinal cord injury and peripheral nerve damage. The ‘cylinder test’ has been used for over two decades as a reliable metric of asymmetry in forelimb usage. In this test, videos are taken of the …

Centered A Story Of Family And Compassion In The Face Of Parkinson's Disease, Savannah Hill

Graduate Studies Theses and Dissertations 2026

Centered is a three-dimensional (3D) animated short film that explores the topic of parental illness and how families must respond with compassion and adaptability when loved ones face mental or physical challenges. The story is inspired by the director’s own experience with her father’s diagnosis of Parkinson’s Disease when she was in high school. The main characters, a father and daughter, must navigate the father’s changing needs after his diagnosis by prioritizing their connection and adapting to his new physical challenges. In the film, they do this through the creation of pottery. The imperfect, handmade design style of the film …

Physical Activity And Health Outcomes In Children With Dyslexia During Summer Versus School Months, Tina J. Glatz

Graduate Studies Theses and Dissertations 2026

Children in the United States continue to experience rising rates of overweight and obesity. Children with learning disabilities are twice as likely to have obesity than typically developing peers, partly due to difficulties with motor skills and behavior regulation. The purpose of this study was to examine and compare differences in health outcomes and physical activity (PA) during summer versus school months in children with dyslexia, using a within- subject study design.

At three timepoints (May, August, December 2025), children’s height, weight, and fitness were measured via a portable stadiometer, dual-frequency foot-to-foot bioelectric impedance device, and Progressive Aerobic Cardiovascular Endurance …

Emotional Support Friends: Creating Social Impact Through Art And Polite Humor, Kenyari Gil Rosario

Graduate Studies Theses and Dissertations 2026

This thesis aims to provide new imagery to the conversation of mental health and neurodivergence. It does this through forms of soft sculpture, digital paintings, marker drawings, and community murals. Inspired by the practices of Keith Haring, iconographic characters are used to portray common struggles and coping habits of mental conditions in an endearing light. With the goal of social impact, this project is affiliated with the non-profit organization Providing Autism Links and Support (P.A.L.S). This partnership has given the community an opportunity to share their compassion through art and donations and uses art as a means of social impact …

I, Cock-A-Doodle-Do: Reclaiming Masculinity Through Queer Joy And Humorous Self-Exploration, Nelson J. Garcia

Graduate Studies Theses and Dissertations 2026

I examine the contemporary norms of masculinity. My research wrestles with ultimately unresolvable stereotypes and imagery influencing current masculine behavior. I unearth queer potential through the physicality and behavior of the stereotypical “man’s man”. I infuse my own queer identity into my studio practice with an emphasis on humor and joy to subvert traditional models of male performance. This process drives self-exploration that allows me to personally respond, react, be directed, and redirected by the interactions between queerness and masculinity. Masculine and queer representations across various media, such as film, music, and television, historically and continuously inform restrictive cultural norms. …

If Your Muses Don't Hate You..., Hannah Howe

Graduate Studies Theses and Dissertations 2026

If Your Muses Don’t Hate You… interrogates a speaker who feels she lacks the tools needed to properly assess trauma and grief. This collection follows the speaker as she delves into obsessive analysis of self, often using metaphysical lenses as methods of comprehension. Each section explores a facet of the subject’s identity, and examines whether her heartache is self-inflicted, preordained, or both. Six of the seven sections provide the reader with imaginative interpretations of the speaker’s natal chart, allowing the reader the opportunity to analyze alongside the speaker. The first half of these sections present the speaker struggling to separate …

The Holy Dialectic, Ian Gonsher

Short Stories

Discourse is sacred. Every conversation can be taken to be an aspect of the Divine. Every discussion is a part of a holy dialectic, in every time and every place.

Redox-Mediator Enhanced Electrochemiluminescence Under Non-Aqueous Conditions, Steven J. Blom, Fazeleh Mesgari, El M.S. Martin, Egan H. Doeven, David J. Hayne, Timothy U. Connell, Peter J. Barnard, Narges Saeedizadeh, Seyed Mohammad Jafar Jalali, Paul S. Francis

Research outputs 2022 to 2026

The introduction of small-molecule redox mediators into aqueous co-reactant electrochemiluminescence (ECL) systems has emerged as an effective strategy to increase signal intensity. Herein, we investigate the influence of a series of neutral iridium(iii) complexes (Ir(pmi)3, Ir(ppy)3, Ir(ppz)3 and Ir(ppy)2(acac)) as redox mediators for co-reactant ECL in acetonitrile. Using [Ru(bpy)3]²⁺ as a benchmark luminophore and tri-n-propylamine (TPrA) as a co-reactant, the redox mediators elicit similar effects in this solvent to those of their sulfonated [Ir(sppy)3]³⁻ and [Ir(sppz)3]³⁻ analogues under aqueous conditions. The Ir(ppz)3 complex was most effective; at a concentration of 100 µM it produced an 11-fold increase …

Relating To Difficult Weather Through Creative Practice: Responses To Marrugeku’S Cut The Sky, Helena Grehan, Jo Pollitt, O. J.E. Slater, Sam Fox

Research outputs 2022 to 2026

In this paper we argue that performance and the arts invite a deliberate sensorial connection with the body and can support a bodily turn or return, in order to help artists, scholars and communities more broadly, better attune to increasing climate instability, through collaborative, supportive and reflexive storytelling. Drawing on the three “weather” symposia, the paper focusses on the second symposium which featured a keynote presentation by Rachael Swain, co-artistic director of Marrugeku, Australia’s leading Indigenous Intercultural Dance and Performance Company. Responses to Marrugeku’s work Cut the Sky are collectively presented to illuminate what Swain argues are, “Dramaturgies of consequence” …

Re-Viewing Children’S Relations With Waste Through Commoning, Worlding And Inheriting, Mindy Blaise, Annette Nykiel, Jane Merewether, Stefania Giamminuti

Research outputs 2022 to 2026

Feminist environmental educators have been calling for new ways of dismantling traditional separations such as nature–culture for reconfiguring human–environment relations. The Common Worlds Research Collective is an interdisciplinary research network made up of educators and researchers that conduct feminist and anticolonial pedagogical and methodological work concerned with more-than-human worlds. This visual essay takes inspiration from the inventive ways the Common Worlds Research Collective are thinking and practising with concepts. This visual essay introduces commoning, worlding and inheriting as concepts for rethinking practice. It shows how re-viewing photographic documentation taken of a waste project with young children and educators opens up …

Cytocompatibility, Osteogenic Potential, Antibacterial And Antibiofilm Efficacy Of A Calcium-Silicate-Based Intracanal Medication, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

This study assessed the biological and antimicrobial properties of a calcium silicate-based material and calcium hydroxide (CH) when used as intracanal medications. MTT assay, osteogenic differentiation of human periodontal stem cells (hPDLSCs), cell mineralization-assay, and determination of ALP activity were assessed to investigate the biological properties. While the agar well diffusion, crystal violet (CRV) assay and LIVE/DEAD staining of dentin slices infected with a mature E. faecalis biofilm were used to assess the antimicrobial properties. Normally distributed data were analyzed using one and two-way ANOVA and post hoc Tukey test, while for non-normally distributed data Kruskal Wallis and Dunn's tests …

Automatic Teeth Segmentation In Panoramic Radiographs Using Attention U-Net, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: The aim of this study is to investigate the effectiveness of the Attention U-Net architecture for teeth segmentation in panoramic dental images. By exploring the potential of Attention U-Net, the study aims to contribute to the development of more precise and automated dental imaging analysis, which could enhance diagnosis, treatment planning, and computer-aided dental systems. Subjects and methods: The TUFTS University dataset consisting of 1000 de-identified panoramic radiographs was used for training and testing an Attention U-Net architecture with 10-fold cross-validation. These scores surpass those of all other networks implemented on the same dataset. using a newly available benchmark …

Effect Of Caries Removal Techniques On Micro-Tensile Bond Strength Of Cad/Cam Composite Blocks To Dentine (In-Vitro Study), Hend Sayed Ahmed, Mohamed Fouad Haridy, Hoda Fouda, Basma Khalifa, Youssef M. Haridy

Dentistry

No abstract provided.

Stress Distribution In Different Toothimplant Supported Mandibular Prostheses Rehabilitating Unilateral Free-End Saddle: A Biomechanical Comparative Finite Element Study, Maha Nagy Kamal, Haytham Amr Mohammed, Abdallah Shokkry

Dentistry

Abstract Aim of the study Utilizing Finite Element Analysis, this research biomechanically assessed three prosthetic designs for mandibular unilateral free-end saddle, specifically interrogating the magnitude and distribution of stresses transmitted to the terminal anterior abutment and the supporting posterior implant. Materials and methods A mandibular unilateral free-end saddle educational cast, with the first premolar as the last standing abutment tooth, was used. The abutment teeth of the free end saddle side were prepared to accommodate two splinted crowns. Then the cast was scanned, and an implant analogue was digitally inserted at the second molar area using Blender4dental software. Three different …

Fracture Resistance Of Resin Composite Restorations With Different Underlying Core Build Up Materials As A Dentin Substitute In Mod Cavities In Premolars (In-Vitro Study), Hend Sayed Ahmed, Mohamed Haridy, Hoda Fouda, Nourhan Kamel, Ahmed Refaat

Dentistry

No abstract provided.

Effect Of Different Packing Protocols On Fracture Resistance Of Maxillary Premolars Restored With Bioactive Composite, Hend Sayed Ahmed, Mohamed Haridy, Hoda Fouda, Alaa Elgembri

Dentistry

Abstract

Objectives: The aim of the present study was to verify effect of different packing protocols on fracture resistance of

maxillary premolar teeth with standardized mesioocclusodistal (MOD) preparations restored with bioactive composite.

Materials and Methods: Seventy sound maxillary premolar teeth with standardized MOD cavities were randomly

allocated to seven groups (n=10): G1 (control): sound teeth; G2: unrestored MOD preparation; G3: was filled by an

incremental technique with nanohybrid resin composite (Beautifil II LS, Shofu); G4: was filled in bulk with flowable

composite (Beautifil Bulk Flowable, Shofu); G5: bulk filled with nanohybrid composite (Beautifil Bulk, Shofu); G6: was

restored by increment …

Reproductive Hormones And Semen Quality Among Fertile Adults With And Without Periodontitis: A Crosssectional Study, Dalia Ghalwash, Rim Ghanem, Mazen Ghanem, Manal Safan, Ahmed Ghanem

Dentistry

No abstract provided.

Evaluation Of Periodontal Parameters Among Infertile Men Undergoing Periodontitis Treatment: A Retrospective Study, Dalia Ghalwash, Rim Ghanem, Mazen Ghanem, Manal Safan, Ahmed Ghanem

Dentistry

Background and Objectives: Periodontitis has been linked to idiopathic male infertility and impairment of semen values. However, data on the role of periodontal treatment in sperm parameter outcomes as well as the identification of the value of clinical periodontal infection predictors (BOP, PD, and CAL) as composite measures following active periodontitis therapy are limited. This study aimed to evaluate the role of periodontitis treatment in infertile men and its impact on semen quality. Methods: 58 infertile patients with semen abnormalities underwent treatment of periodontitis. Clinical periodontal and andrological examinations were conducted for all participants. Clinical periodontal parameters (PD, BOP, and …

Brief For Jonathan H. Adler As Amicus Curiae Supporting Respondents And Affirmance, Jonathan Adler

Briefs

Global climate change presents many complex and intractable legal and policy questions. Assuming this Court has jurisdiction, the legal questions in this case are comparatively simple and straightforward. Nothing in federal law, let alone the Constitution, preempts state-law claims seeking relief from injuries allegedly caused or exacerbated by petitioners’ conduct.

At issue in this case is whether allegedly aggrieved parties, including subnational governments, may seek redress under state law from defendants otherwise subject to state court jurisdiction for harms allegedly caused or contributed to by petitioners’ conduct. In order to succeed, respondents will ultimately need to show that the damages …

Differential Impact Of Admission Type And Clinical Complexity On Diabetes Hospitalization Costs Among African American And Hispanic Patients In Southeastern Virginia, Ismail El Moudden, Asra Amidi, Reem Sharaf-Alddin, Michael C. Bittner, Qi Zhang

Department of Obstetrics & Gynecology Faculty Publications

Background

Diabetes mellitus (DM) imposes substantial healthcare costs with documented disparities among African Americans and Hispanic patients. To inform care delivery and resource allocation, this study identified hospitalization cost predictors among African American and Hispanic patients with diabetes in Southeastern Virginia.

Methods

We analyzed 6,011 hospital discharges from the Virginia Health Information database (2016-2020) for adults aged 18-85 with diabetes. Discharges were classified by Medicare Severity Diagnosis-Related Groups: DM with complications/comorbidities (DCC, n = 3,328), DM with major complications/comorbidities (DMCC, n = 1,518), and DM without major complications/comorbidities (DWO, n = 1,165). Because cost distributions were right-skewed (skewness 3.5-8.24), we …

Racial Differences In Adverse Pregnancy Outcomes And Incident Hypertension: A Mediation Analysis, Lucia C. Petito, Xiaoning Huang, C. Noel Bairey, Natalie Bello, Janet Catov, Ernesto Licon, Abbi Lane, David M. Haas, Lisa D. Levine, Rebecca B. Mcneil, Eliza Miller, Uma M. Reddy, Bethany Barone Gibbs, George Saade, Lauren Theilen, Laura E. Wiener, Brian M. Mercer, Hyagriv N. Simhan, Lynn M. Yee, Philip Greenland, William A. Grobman, Sadiya S. Khan

Department of Obstetrics & Gynecology Faculty Publications

Background

Adverse pregnancy outcomes (APOs) are associated with increased hypertension risk. Black women experience higher rates of APOs and hypertension compared with White women, but whether APOs contribute to Black-White hypertension disparities remains unknown.

Methods

The nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be-Heart Health Study) prospectively recruited nulliparous pregnant people at 8 US centers (2010-2013) with follow-up 2 to 7 years postpartum (2014-2017). Race, which represents a social construct, was self-identified. The primary outcome was incident hypertension at follow-up. APOs included hypertensive disorders of pregnancy, preterm birth, and small-for-gestational age birth. Potential confounders (psychological health, social factors, and health behaviors) …

Orthodox Traditionalism In The Late 16th – Early 17th Century: The Religious-Anthropological Dimension, Olena Hudzenko, Olga Dobrodum

Occasional Papers on Religion in Eastern Europe

This article explores the religious-anthropological concepts in the works of Ukrainian thinkers of the late 16th and early 17th centuries. Formed in the context of Catholic expansion and intense confessional conflict, their ideas sought to preserve the Byzantine and Old Rus’ Orthodox tradition. Thinkers of this period emphasized the importance of safeguarding ancestral faith through a return to the principles of Holy Scripture, the foundational structures of early Christian doctrine, and the spiritual legacy of Kyivan Rus. These themes were especially prominent in the theological discourse of the so-called “Ostroh traditionalists,” centered around the Ostroh and Derman religious and cultural …