Digital Commons Network^™

Thriving Through Occupation: Enhancing Occupational Participation For Cancer Survivors, Leslie B. Martinez

OT Doctoral Capstones

Cancer survivors often experience decreased participation in meaningful occupations, along with physical, mental, emotional, and financial challenges (Newman et al., 2024). This capstone project developed an educational series to promote engagement in meaningful occupations and provide strategies to combat the negative physical and mental effects of cancer and treatment. Four classes covering various health topics, including cancer-related fatigue, cognitive impairment, mental health, and nutrition, were implemented for cancer survivors at the Rio Grande Cancer Foundation. The classes included an educational portion in which participants were introduced to each topic, followed by interactive learning activities designed to promote the application and …

Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota

Faculty, Staff and Student Publications

Background: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive deficiency of glucose-6-phosphatase (G6Pase), an enzyme necessary in glycogenolysis and gluconeogenesis. To maintain normal blood glucose levels and ensure survival, individuals living with GSDIa must frequently consume complex carbohydrates (eg, uncooked cornstarch). Dietary management can result in chronic complications and significant patient burden. DTX401 (pariglasgene brecaparvovec) is an investigational adeno-associated virus serotype 8 vector (AAV8)-based gene therapy designed to restore endogenous glucose production.

Objectives: Patient experience interviews were conducted as part of an open-label, phase 1/2 dose-escalation trial (NCT03517085) evaluating the safety and efficacy of …

Case Report: Management Of A Challenging Case Presenting With Dysphagia After Thyroidectomy Requiring Administration Of Liquid 131i Via Mic-Key Low-Profile Tube—A Multidisciplinary Approach, Ahmed Ebada Salem, Sandra Ramirez, Brian R Weston, Akram Hussein, Simone Krebs

Faculty, Staff and Student Publications

Radioactive iodine (RAI) therapy with 131-iodine (131I) remains a cornerstone in the postoperative management of differentiated thyroid carcinoma (DTC). The standard route of administration is oral, typically in capsule form and less commonly as a liquid. However, in patients with severe dysphagia and compromised airway, traditional oral 131I delivery may be contraindicated due to the risk of aspiration and radioactivity contamination. These scenarios present unique clinical challenges that necessitate deviation from conventional protocols. While liquid 131I may be administered through the mouth or via nasogastric or percutaneous gastrostomy tubes, there is currently no standardized approach, and potential risks, such as …

Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang

Faculty, Staff and Student Publications

Mutations in isocitrate dehydrogenase (IDH) genes sensitize gliomas to PARP inhibition (PARPi) by inducing epigenetic reprogramming of DNA damage repair circuits. However, tumors treated with PARPi eventually relapse despite initial responsiveness. In this study, it is demonstrated that the anti-angiogenic agent lenvatinib synergizes effectively with PARPi, resulting in substantial tumor regression and significantly extended survival. Genomic analysis of tumors reveals that PARPi induces widespread transcriptomic changes that are predominantly pro-inflammatory, thereby promoting tumor angiogenesis. Prickle4, a planar cell polarity protein, is identified as a critical mediator of PARPi-induced neovascularization. Targeting Prickle4 effectively overcomes PARPi resistance in these tumors. Collectively, these …

Excluded At The Root: Health Insurance Discrimination Against Hair Loss Conditions, Stacey A. Tovino, Tracy Hresko Pearl

Faculty Articles

No abstract provided.

Meat Is Dead, Melissa D. Mortazavi

Faculty Articles

The legal and cultural landscape surrounding meat in the United States is evolving as plant-based alternatives, GMO farm animals, and cell-cultivated meat move from test tube to table. While global demand for meat rises amid environmental, ethical, and resource challenges, cell-cultivated meat emerges as a scientifically viable alternative, offering identical nutritional value without the drawbacks of conventional livestock production. Despite federal regulatory approval from USDA and FDA, multiple states have enacted unusually restrictive laws—including bans— targeting cell-cultivated meat. These are motivated largely by economic protectionism, but also deeper cultural anxieties tied to tradition and identity. This Article argues that food …

Enhancing Phonemic Awareness Through Explicit Instruction In A Kindergarten Classroom: An Action Research Study, Emily M. Caylor

Graduate Research Papers

This action research study examined the implementation of early phonemic awareness exposure and the impact of an Elkonin Box multisensory Tier II support focused on segmentation, blending, isolation, and manipulation. The study involved a small group of kindergarten students with varied backgrounds over a fifteen-week period. Data collection included a pre-assessment, four bi-weekly progress checks, and a post-assessment. Results indicated a connection between the implementation of the Tier II support and student growth over time. The researcher recommends this Tier II support as a complement to core instruction to strengthen phonemic awareness development. For classroom teachers, the study highlights the …

Dietary Responses Of Taste Receptor Genes To Plant-Based Diets In Farmed Fish: A Literature Review, Leonildo Dos Anjo Viagem, Jean Nepomuscene Hakizimana, Cyrus Rumisha, Brunno Da Silva Cerozi, Gerald Misinzo

All Rsif Scholars' Publications

Taste receptor genes, particularly those in the bitter (tas2r) and umami/sweet (tas1r) families, are critical in regulating chemosensory perception and feeding behavior, influencing fish’s acceptance of plant-based diets. This review synthesizes the current research on how these genes respond to plant-based diets in farmed fish. A comprehensive search of scientific databases, including Web of Science, Scopus, PubMed, and Google Scholar, was conducted to identify relevant studies. Plant-based diets modulate gene expression, receptor activity, and signaling pathways, enabling fish to adapt to alternative feeds. The findings of the studies analyzed in this review show that plant ingredients affect fish taste receptor …

Forecasting Future Adoption Rates Of Agroecological Innovations Using Machine Learning: Perspectives From Burkina Faso’S 45 Provinces From 2010 To 2020, Theodore Nikiema, Pamela Giselle Katic, Issaka Abdou Razakou Kiribou, Sylvain Kpenavoun Chogou, Eugene C. Ezin

All Rsif Scholars' Publications

Implementation of agroecological innovations tends to be long-term processes, withthe practices of one year often linked to those of previous years. However, previousstudies have focused on understanding drivers of adoption at farm level, with adoptionmeasured at a point in time. In this study, we use a decade of panel data from thePermanent Agricultural Survey in Burkina Faso from 2010 to 2020 and machine learningapproaches, to model adoption rates of agroecological innovations at the provinciallevel as an autoregressive process. This modeling approach allows us to exploit the timeseries nature of our dataset to forecast future adoption rates. Our results showcase thepotential …

Occurrence And Levels Of Multiple Veterinary Antibiotics In Broiler Chicken Processed And Sold In Southern Mozambique, Noemia Andre Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia

All Rsif Scholars' Publications

Antibiotic residues in chicken meat pose a health risk to the general public, particularly to sensitive consumers. The aim of this study was to determine the level of antibiotic residues in on-the-market dressed chicken in the Southern Region of Mozambique. A total of 160 samples were randomly collected from eight markets located in five districts in the provinces of Maputo, Gaza, and Inhambane. The residues of β-lactams, quinolones, tetracyclines, and sulfonamides in chicken breast muscle were separated, identified, and quantified using high-performance liquid chromatography (HPLC), coupled with ultraviolet light (UV–VIS). Results revealed that 26.9% of the analyzed samples displayed detectable …

Osteogenic Differentiation Properties Of Blgfs/Odex Hydrogel Doped With Collagen Derived From Chambo Tilapia Fish Skin, Bhahat Lawlley Zimba, Xiaohan Yang, Mwemezi Rwiza, Elingarami Sauli, Shenqi Wang

All Rsif Scholars' Publications

Background

Bone defects caused by trauma, congenital disorders and degenerative diseases such as osteoporosis remain a major clinical challenge, especially in developing regions. Although bone grafting is the current gold standard for treating bone defects, it faces limitations, including donor site morbidity, limited availability and immune rejection. This study developed and evaluated a novel hybrid biomaterial composed of bovine β-lactoglobulin fibrils (BLGFs), oxidized dextran (ODEX) and collagen (COL) extracted from Chambo tilapia fish skin for bone tissue engineering applications.

Methods

BLGFs were synthesized from whey protein, while ODEX was produced by oxidizing dextran. Three biomaterials–COL, BLGFs/ODEX and BLGFs/ODEX/COL–were synthesized and …

Dog Waste Creates A Preference-Performance Mismatch For Urban Dung Beetles, Erin L. Mccullough, Beatrice M. Altopp, Daniel F. Kellogg, Madelyn S. Mcinnis, Luna J. Pagan

Biology

Urban environments expose animals to novel conditions that may favor behavioral flexibility but can create preference-performance mismatches when attractive resources are associated with reduced reproductive success. Dung beetles are often considered dietary generalists, yet little is known about how they respond to altered food availability in human-dominated habitats. We combined field surveys and laboratory experiments using two domestic dung types to examine diet preference, maternal provisioning, and offspring performance in the urban dung beetle Onthophagus orpheus. Beetles strongly preferred dog dung over cow dung, and offspring reared on dog dung developed faster and emerged as larger adults. Despite these apparent …

Clinical Challenges Associated With Enhancing Hypertension Among The Underserved African American Population, Ashley Richardson

Doctor of Nursing Practice (DNP) Scholarly Projects

Background 

African Americans face a significantly higher prevalence of hypertension, tend to develop complications at younger ages, and have disproportionately higher mortality rates. Key social determinants of health (SDoH)—including food deserts, unequal access to healthcare, and geographic disparities in healthcare resources—contribute to these ongoing inequities. Addressing both systemic and individual barriers is crucial for effective hypertension management.

Objective

This study aims to assess the effectiveness of a culturally relevant, community-based intervention designed to reduce both systolic and diastolic blood pressure among Black adults with uncontrolled hypertension.

Methods 

Quality improvement (QI) initiatives typically employ multicomponent, equity-focused models. The primary components of …

I, Cock-A-Doodle-Do: Reclaiming Masculinity Through Queer Joy And Humorous Self-Exploration, Nelson J. Garcia

Graduate Studies Theses and Dissertations 2026

I examine the contemporary norms of masculinity. My research wrestles with ultimately unresolvable stereotypes and imagery influencing current masculine behavior. I unearth queer potential through the physicality and behavior of the stereotypical “man’s man”. I infuse my own queer identity into my studio practice with an emphasis on humor and joy to subvert traditional models of male performance. This process drives self-exploration that allows me to personally respond, react, be directed, and redirected by the interactions between queerness and masculinity. Masculine and queer representations across various media, such as film, music, and television, historically and continuously inform restrictive cultural norms. …

Reliability Of Staged Maximal Aerobic Capacity Protocol Using A Combined Upper- And Lower-Body Air-Braked Ergometer, Jack J. Livingston

Graduate Studies Theses and Dissertations 2026

Maximal oxygen uptake (VO₂max) is widely recognized as the preeminent measure of aerobic capacity and is typically assessed using graded exercise testing (GXT). This study examined the test–retest reliability of VO₂peak and associated physiological responses during a staged GXT performed on a combined upper- and lower-body air-braked ergometer. Fifteen recreationally active adults (9 males, 6 females; age: 26.9 ± 7.2 years; body mass: 75.1 ± 11.0 kg) completed one familiarization session and two trials separated by ≥72 hours. Participants performed a staged GXT (40 RPM start, +3 RPM every 3 min to exhaustion) on a combined upper- and lower-body air-braked …

Place Matters: Investigating The Social And Environmental Drivers Of Hypertension In Nashville, Marquinta Harvey, Michael D. Oliver, Tatum Brown, Deya Rassul, Thomas Strickler, Jarod Parrish, Catherine Bass

Funded Scholarship

Hypertension disparities persist across communities, driven by interactions between social determinants of health (SDOH) and behavioral factors. This study examines geographic and demographic patterns of hypertension in Nashville, Tennessee, to assess how socioeconomic, environmental, and behavioral factors contribute to inequities in prevalence, treatment, and control. Granular ZIP code-level analyses highlight community-specific drivers and the need for policy reforms to advance health equity.

The Impact Of Remittances On Food Security In Times Of Crisis—Evidence From Covid-19 In Latin America And The Caribbean, Colin Cannonier

Funded Scholarship

This study examines the association between workers’ remittances and food insecurity in Latin America and the Caribbean using data from a Coronavirus survey covering over 100,000 individuals during the COVID-19 pandemic. Results indicate that receipt of remittances is associated with an 8.8% decrease (2.5% points) in overall food insecurity. Heterogeneous effects are observed among females, individuals in Latin America, and households with children. Remittances from the USA exhibit a stronger influence on reducing food insecurity. The findings underscore the potential importance of remittances in improving food security at both extensive and intensive margins. Policy issues are also discussed.

Coalition Building And Citizen Science For Radon Risk Reduction, Stacy Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, David Gross, Caitlyn Curtis, Amanda Thaxton-Wiggins, Mary Kay Rayens, Ellen J. Hahn

Nursing Faculty Publications

We evaluated the implementation of local coalitions led in partnership with citizen scientists, community-based organizations, and public libraries in four rural communities to lower exposure to radon in the home. The objectives were to (1) describe the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) of four radon coalitions, and (2) compare RE-AIM factors among citizen scientists who participated in the coalitions and those who did not. A larger community-engaged research project embedded coalition building using a citizen science approach. Three of the four coalitions focused on health and wellness more broadly (18–34 members); one focused solely on radon (10 members). Coalition membership and activities varied …

Taxonomy, Distribution And Ecology, Biology, Nutritional Composition, And Conservation Status Of Critically Endangered Lake Chala Tilapia Oreochromis Hunteri (Günther, 1889): Implications For Aquaculture Development, Jonathan Munguti, Mavindu Muthoka, Domitila Kyule, Esther Magondu, Jacob O. Iteba, Kevin Obiero, Paul Orina, Menaga Meenakshisundaram, Tanga M. Chrysantus

All Peer-Reviewed Publications

Oreochromis hunteri Günther, 1889, commonly known as Lake Chala tilapia, is an endemic cichlid restricted to the small crater lake, Lake Chala, on the border of Kenya and Tanzania. This review synthesizes existing knowledge on the taxonomy, and phylogenetic placement, distribution and ecology, and biology including nutritional composition, and conservation status of O. hunteri and identifies knowledge gaps to assess its potential for aquaculture development. The knowledge gaps include its reproductive biology, population structure, and adaptive capacity to environmental and climatic variability. As the type species of the genus Oreochromis, O. hunteri is a unique, genetically isolated lineage within a …

Insect Farming Innovations: A Pathway To Self-Reliance In Agrifood Systems In Africa, Zewdu Abro, Menale Kassie, Dennis Beesigamukama, Shaphan Yong Chia, Ermias Engida Legesse, Subramanian Sevgan, Julius Ecuru, Chrysantus M. Tanga

All Peer-Reviewed Publications

Insect farming as an innovative approach to transforming agrifood systems

Insect farming has emerged as a transformative and sustainable approach to addressing the interconnected challenges of food insecurity, environmental degradation, and economic vulnerability in Africa’s agrifood systems. By converting organic waste into high-value products (protein-rich feed, frass fertilizers, and bioactive compounds), insect farming offers an efficient circular economy solution that bridges nutrition, livelihoods, and ecological resilience (Lalander et al. 2025; Mei et al. 2024; Barragán-Fonseca et al. 2022; Xia et al. 2021; Van Huis 2020; Barragán-Fonseca et al. 2017; Van Huis and Oonincx 2017; Yi et al. 2014). Almost all …

Ecological Intensification Of Maize-Kale Systems In Kenya By Biofertilization And Push-Pull Management Shifts Nematode Communities, Agnes Kiriga, Johnnie Van Den Berg, Frank Chidawanyika, Solveig Haukeland, Bianca Greyvenstein, Dennis Beesigamukama, Chrysantus M. Tanga, Sevgan Subramanian, Daniel M. Mutyambai

All Peer-Reviewed Publications

Plant-parasitic nematodes (PPNs) pose a persistent threat to vegetable production in Kenya, contributing to reduced yields and soil degradation. The management of PPNs in vegetables in Kenya has largely remained unaddressed. The integration of ecological intensification strategies such as the vegetable integrated push-pull (VIPP) system and the use of black soldier fly frass fertilizer (BSFF) is gaining traction in sustainable agriculture. The aim of this study was to determine the effects of integrating VIPP and BSFF on nematode abundance and diversity in maize-kale cropping systems. Field trials were conducted in two different agroecological zones in Kenya. Field treatments involved plots …

No Groundwater, No Fish: The Critical Role Of Groundwater In Supporting Non-Glacial, Salmon-Bearing Rivers In South-Central Alaska, Tyelyn Brigino, Kai Rains, Edgar Guerron-Orejuela, Jacob Argueta, Syverine Bentz, Coowe Walker, Mark Rains

School of Geosciences Faculty and Staff Publications

Groundwater discharge plays an important role in the hydrologic and ecologic functioning of rivers including sustaining streamflow and related habitat year-round. Simultaneously, groundwater supports the increasing demands of people as the global population continues to grow. Balancing the needs of users becomes increasingly important as climate change introduces greater uncertainty in water resources and fisheries, especially for economically important anadromous species that depend on freshwater resources. We investigated the seasonal and regional variability of groundwater contributions to six non-glacial mainstem salmon-bearing rivers in south-central Alaska. We hypothesized that groundwater contributes more than half of the annual streamflow, and nearly all …

Poly(A) Probe Hcr Rna-Fish Specifically Marks Pyriform Nurse Cells In The Brown Anole Lizard Ovary, Zoe B Griffin, Bonnie K Kircher, Richard R Behringer

Faculty, Staff and Student Publications

Hybridization chain reaction RNA-fluorescent in situ hybridization (HCR RNA-FISH) is a powerful and increasingly used method for visualizing gene expression in cells and tissues. A probe set against polyadenylated RNA (poly(A)) is often used as a positive control for RNA integrity and staining quality. While optimizing this technique in the ovary of the brown anole lizard (Anolis sagrei), we found that the poly(A) probe produced a strikingly specific and intense signal in pyriform cells, a specialized lizard-specific nurse cell type. This staining pattern was found in both whole-mount samples and paraffin sections, suggesting that poly(A) signal intensity can serve as …

Host Modulation Therapy In Periodontitis: From Established Therapies To Emerging Technologies, Aonjittra Phanrungsuwan, Jiaqi Huang, Neeraja Dharmaraj, Alejandra Cobos Perez, Omid Veiseh, Simon Young, Chun-Teh Lee

Faculty, Staff and Student Publications

Periodontitis is a biofilm-induced chronic inflammatory disease, characterized by gingival inflammation and alveolar bone loss. According to a national survey, approximately half of the U.S. adults are affected by periodontal disease. To effectively prevent and treat periodontitis, it is essential to address its underlying causes. The primary etiological factors include polymicrobial synergy and dysbiosis of the oral microbiota, and a dysregulated immune response. The standard therapeutic approach, mechanical removal of biofilm through debridement, sometimes demonstrates limited efficacy, particularly in cases of severe periodontitis, which may require adjunctive or additional therapy. Emerging evidence indicates that periodontal tissue destruction is initiated by …

Nemolizumab As An Alternative Therapeutic Option For Indolent Systemic Mastocytosis, Sezim Minbaeva, Stephen K Tyring

Faculty, Staff and Student Publications

Indolent systemic mastocytosis (ISM) is a clonal mast cell disorder characterized by recurrent symptoms that can persist despite treatment with antihistamines, leukotriene antagonists, and mast cell stabilizers. Treatment options are limited when symptoms remain refractory, and avapritinib is contraindicated or declined. We describe the case of a 62-year-old female with an 11-year history of ISM who developed worsening pruritus and urticaria despite extensive conservative and biologic therapies, including topical corticosteroids, hydroxyzine, montelukast, omalizumab, and dupilumab. Given her history of stroke, she declined avapritinib. Nemolizumab was initiated with a 60 mg loading dose followed by 30 mg every four weeks. After …

Skeletal Markers: Interpreting Trauma, Healing, And Survival Through Osteological Remains From Medieval Pomerania, Michael Mulliner-Szyndler

Cal Poly Humboldt theses and projects

Traditionally, studies in bioarcheology have cited the presence of individuals with evidence of healed traumatic injuries and certain pathologies as an indication of social care either at the time of the trauma or throughout the individual’s lifetime. Here, I present three case studies of individuals who present with signs of having survived traumatic injuries and related pathologies. These individuals are from a late medieval cemetery in Żelewo, in the historical region of Pomerania in present-day northwestern Poland. The site is associated with the nearby town of Kołbacz, which is home to the oldest Cistercian monastery in Pomerania. This study aims …

The Phenomenon Of Existential Ecumenism In Contemporary Ukraine, Iryna Kondratieva, Andrii Marchenko, Oleksii Marchenko

Occasional Papers on Religion in Eastern Europe

An analysis of existential ecumenism as a dimension of inter-church unity, which is being formed in modern Ukraine due to a common existential threat from the Russian aggressor, when Ukrainian churches unite in an ecumenical response to war crimes, focusing on practical cooperation in real life, on the tasks of social service, and not on existing doctrinal or institutional differences. Existential ecumenism combines the main ideas of existential philosophy, with its emphasis on the value of the human person, the significance of the themes of human freedom and human choice in the face of meaninglessness and death, and ecumenism as …

Tools Used To Measure Fear Avoidance Behaviour In The Management Of Mild Traumatic Brain Injury (Concussion), Liam Sherwood

Theses: Doctorates and Masters

Concussion can present challenges with respect to diagnosis and management. Fear avoidance behaviour and beliefs may be perpetuating factors in the clinical course of concussion. Understanding which patients may adopt such behaviours and beliefs can offer important information to allow tailoring of clinical management and implementing strategies to minimise the risk of progression to persisting post-concussion symptoms.

In this thesis, I:

-       systematically reviewed the current measurement tools used to assess fear avoidance behaviours and beliefs associated with concussion;

-       explored the experience of clinicians, researchers and people with lived experience of concussion in relation to fear avoidance behaviours;

- …

Detecting Habitat Use Of Three Endemic Freshwater Fish Of Far Southwestern Australia, Paige Rhiannon Wilson

Theses: Doctorates and Masters

The wetland ecosystems of far southwestern Australia face multiple threats including land clearing, historical cattle grazing, changed hydrology, extensive groundwater extraction, and changed fire regimes. Each is exacerbated by a drying climate, and together they provide a significant challenge to the on-going survival of the freshwater fish in this region particularly fish that are endemic, range restricted, and therefore, more likely to be more vulnerable. This study focuses on three such species: Galaxiella munda, Galaxiella nigrostriata and Lepidogalaxias salamandroides, the latter two of which are known to aestivate.

In order to make conservation decisions regarding management of wetlands for …

The Experience Of Homelessness Among Older Adults In Bhutan - A Narrative Inquiry Study, Phuntsho Om

Theses: Doctorates and Masters

A shift in the demographics of homelessness started to occur in the 1900s, with a significant increase in the number of middle-aged or elderly men and women being recognised as a part of the homeless population. The rising urgent global concern of homelessness of older adults necessitates a deeper understanding of the lived experience and holistic well-being of these marginalised adults. This thesis aimed to explore the phenomenon of homelessness of older adults in Bhutan, which is an often neglected topic in both national and international gerontological research.

Employing narrative inquiry within the constructivist approach as articulated by Pino Gravidia …