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Global Insight 2026, Masey Smith, Chance Carden, Hayley Pounds

Books

Global Insight 2026 is the annual publication of the International Institute at Mississippi State University, documenting the university’s global engagement across education, research, service, and institutional partnerships. This issue highlights Mississippi State University’s international impact through faculty‑led study abroad programs, international research and development initiatives, global fellowships, and comprehensive international student support services. Featured content includes narrative case studies of student and faculty experiences abroad, data‑driven insights into study abroad participation and international enrollment trends, and in‑depth examinations of international research collaborations spanning Africa, Latin America, Europe, and Asia. The magazine also showcases the work of the English Language Institute …

Investigating The Knowledge, Attitudes And Practices Towards Type 2 Diabetes Mellitus In A Student Population In The United Kingdom: A Quantitative Study, Philip Boadu Anim

Theses

Aim: To explore the knowledge on the risk factors, signs and symptoms, management, and complications of Diabetes, attitudes, and practices towards prevention of Diabetes Mellitus among university students in the United Kingdom.

Methods: The researcher utilised a quantitative study design in carrying out the study. The study was conducted at Cardiff Metropolitan University with Cardiff Met students being the target population. Thirty (30) participants were recruited through convenient sampling. Data was collected through questionnaires using closed ended questions. The Statistical Package for Social Science (SPSS) version 27 as used to analyse the data collected. Statics were performed to form a …

Impact Of Apitegromab On Motor Function In Spinal Muscular Atrophy, Jordyn Linfield, Ashley Jacob, Haylee Whyde, Owen Fox, Kaitlyn Bowden, Connor Dains, Brenna Hissong, Manoranjan D'Souza

Pharmacy and Wellness Review

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder characterized by the progressive loss of alpha motor neurons in the anterior horn of the spinal cord, leading to muscle weakness, atrophy, and impaired motor function.¹ SMA remains an extensive and difficult-to-treat condition, with only three disease-modifying therapies currently available to patients. A new investigational agent with a unique mechanism of action, apitegromab (SRK-015), has shown promising results in recent clinical trials. The safety and efficacy of apitegromab in patients with SMA have been explored in several clinical trials, with the TOPAZ and SAPPHIRE studies being the most notable. This …

Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

The endocrine system coordinates and integrates cellular activity throughout the body by regulating cellular and organ function and maintaining homeostasis. Homeostasis, the dynamic maintenance of internal balance despite changing external or internal conditions, is essential for proper cellular function. The endocrine system achieves this through a complex regulatory network of hormone-mediated signaling among multiple endocrine organs, relying on precisely regulated synthesis and release of hormones and specific hormone-receptor interactions. Endocrine-mediated actions coordinate critical physiological processes, including growth, metabolism, reproduction, stress adaptation, and circadian rhythms throughout the lifespan. Endocrine glands—such as the hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, adrenal glands, and …

Development Of An Educational Intervention To Enhance Nurses’ Knowledge And Intent To Implement Evidence-Based Diabetes Self-Management In Clinical Practice, Anne Marie Sieyou Ngouane

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project was purposed with closing critical gaps in staff knowledge and adherence to diabetes self-management protocols in a busy primary care clinic. Rising readmission rates and uneven use of American Diabetes Association (ADA) standards signaled an urgent need for a structured approach to staff education. To address this, a one-hour interactive training session was created that blended teaching, evidence-based handouts, and a practical diabetes care checklist. Staff learning was measured through pretest and posttest, confidence and adherence used a 5-point Likert-scale survey, and 21day readmission data tracked patient outcomes. The project question asked if …

Evaluation Of Unmet Needs Of Vulnerable Populations And At-Risk Communities Through Disaster Management Planning, Ryan Austin Crowe

Walden Dissertations and Doctoral Studies

This community-based non-profit organization aimed to aid those most in need by providing critical social services. The client organization has been selected numerous times as a recipient of federal disaster case management programs, often not until a year after the disaster, resulting in distrust of the federal government and organizations contracted to perform recovery services. Providing services to areas impacted has been difficult due to contract delays. The practice research question addressed in this study was: How can a client organization address the one-year service gap frequently associated with federal contracts through a disaster management planning system? The purpose of …

High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using …

Effects Of Acute And Multi-Day Beetroot Juice Supplementation On Power And Velocity Of Ncaa Division I Baseball Players, Justin M. Foster, Raymond T. Gerardo, Sydney N. Brennan, Trevor J. Molnar, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation can enhance power via modulating type II muscle fiber contractility; however, no study has examined the ergogenic potential of nitrate in elite level power-based athletes that heavily rely on type II muscle fiber activation such as baseball players. Moreover, there are no nitrate dosing guidelines available for elite level athletes. PURPOSE: To investigate if acute and multi-day nitrate supplementation influences power and velocity during barbell back squat and barbell bench press in elite level baseball players. METHODS: Eighteen male collegiate baseball athletes (NCAA Division I) reported to the laboratory for 6 visits over ~8 weeks, and were …

Effect Of Sodium Bicarbonate On Gastrointestinal Injury During Repeated Sprints In The Heat, Ozan Kumbasar, Jonathan W. Specht, Marissa Ramirez, Jennifer Raef, Mackenzie Schwartz, Alyssa R. Bailly, Oscar Chavez Jr., Jade X. Dawson, Jessica Apodaca, Raul Freire, Withley C. Atkins, Flávio De Castro Magalhães, Jason Siegler, Fabiano T. Amorim

International Journal of Exercise Science: Conference Proceedings

Sodium bicarbonate (SB) is a widely used supplement that can enhance repeat sprint performance; however, a common side effect is gastrointestinal (GI) distress. Exercise in the heat can cause intestinal injury and endotoxemia, but no study has examined whether SB heightens this injury. PURPOSE: To determine whether SB ingestion exacerbates intestinal discomfort, injury, and endotoxemia during repeated sprints in the heat. METHODS: Ten endurance-trained athletes (6 male) completed randomized, counterbalanced, double-blind trials in which they ingested capsules containing SB (0.2 g·kg⁻¹ body mass) or placebo following a high-carbohydrate meal. The trials consisted of a 22-min warm-up followed by …

Dietary Nitrate Supplementation Worsens Resistance Exercise Performance In Resistance-Trained Females, Sydney N. Brennan, Raymond T. Gerardo, Trevor J. Molnar, Justin M. Foster, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation appears to preferentially target type II muscle fibers for beneficial effects; however, research examining the efficacy of nitrate in females and resistance exercise is scarce. PURPOSE: To investigate if dietary nitrate, provided as concentrated nitrate-rich beetroot juice (BR), improved resistance exercise performance in back squat and bench press compared to nitrate-depleted beetroot juice (PL) in resistance-trained females. METHODS: Eighteen resistance-trained females aged reported to the lab for a total of four visits over a 2-week period. Participants performed a one repetition maximum protocol (1RM) and familiarization to the experimental protocol, and were assigned in a randomized, double-blind …

Acute And Chronic Dietary Nitrate Supplementation On Resistance Exercise Performance In Healthy Resistance-Trained Adults., Trevor J. Molnar, Sydney N. Brennan, Justin M. Foster, Ryan Tran, Raymond T. Gerardo, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

The efficacy of dietary nitrate supplementation for enhancing resistance exercise remains unclear, and nitrate dosing guidelines are relatively unexplored. PURPOSE: To determine whether acute and chronic dietary nitrate supplementation, provided in the form of nitrate-rich beetroot juice (BR), can improve resistance exercise performance in resistance-trained males. METHODS: Thirty-six resistance-trained males and females will be recruited. Participants will complete a standardized one-repetition maximum (1RM) test in barbell back squat and barbell bench press and a familiarization prior to experimental visits. In a randomized, double-blind, controlled, fashion, participants will complete two conditions of 14-day supplementation periods to consume: (1) nitrate-depleted beetroot juice …

Stair Stepping And Peripheral Heating With Negative Pressure Improve Postprandial Glucose In Sleep Restricted Young Adults, Sabrina S. Stringfellow, Rachel Demonteverde, Jeff Moore, Jochen Kressler

International Journal of Exercise Science: Conference Proceedings

Sleep restriction (SR) impairs glycemic control, elevating the postprandial blood glucose (BG) response, an independent predictor of morbidity and mortality. Stair stepping and peripheral heating with negative pressure have been shown to acutely improve glycemic indices but have not been tested after SR. PURPOSE: To examine if stair stepping or peripheral heating with negative pressure improve postprandial BG after SR. We hypothesized 1-minute of brief, low-effort stair stepping and 60 min peripheral heating with negative pressure would improve postprandial glucose in sleep restricted (≤4 hours) young adults. METHODS: Participants (N=24; 22 (2) y; 13 female; 23.8 (5) kg/m2) performed a …

Susceptibility To Eccentric Contractions-Induced Locomotor Muscle Injury In Cigarette Smoke-Exposed Mice, David Tran, Leonardo Nogueira

International Journal of Exercise Science: Conference Proceedings

Chronic exposure to tobacco cigarette smoke (CS) leads to pulmonary damage, inflammation, exercise intolerance, and skeletal muscle contractile and repair dysfunction, as our group has shown that CS exposure also delays muscle repair after eccentric contractions. This study investigated whether chronic CS exposure increases the susceptibility of locomotor muscles to injury from a session of eccentric contractions, as previous studies have shown that smokers have a greater risk of muscle injuries. Methods: Young adult (8 weeks old) wild-type mice (C57BL/6J, IACUC 25-071, n=24) were exposed to daily periods of CS or air (as controls) for eight consecutive weeks. After the …

Empowering Black Girls Through Joy, Strength, And Sisterhood: The Smart Fit Girls, Black Girl Joy Program, Alexis O. Pope, Kellie Amanda Walters

International Journal of Exercise Science: Conference Proceedings

BACKGROUND: Compared to adolescent boys, girls are more likely to be obese, sedentary, and experience psychosocial distress such as depression, anxiety, and low self-esteem. Physical activity (PA) is strongly linked to psychosocial well-being, particularly in girls, yet girls of color face fewer opportunities to engage in structured PA programs. PURPOSE: Smart Fit Girls, Black Girl Joy (SFG BGJ) is a culturally immersive 7-week program combining PA, nutrition, and psychosocial lessons to strengthen psychosocial well-being in Black middle school girls. METHODS: A mixed-methods design was used with 6th–8th graders in the Long Beach Unified School District. Quantitative data was collected …

Concurrent Heart Rate Validity And Reliability Of Polar Verity Sense Devices During Light And Moderate Intensity Resistance Training In Recreationally Active Adults, Kynlee Sperry, Catalina Kerwin, Juni Timmins, Jamaal Bovell, Jose Vasquez, Satereh (Star) Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence

International Journal of Exercise Science: Conference Proceedings

Our laboratory previously determined that while wrist-worn wearable technology devices (e.g. Garmin watches) are not valid or reliable for heart rate, bicep-worn wearable technology devices (e.g., Polar Verity Sense) were valid and reliable for heart rate during light intensity resistance training (RT). However, these devices have never been tested for validity or reliability with varied intensities during resistance training. PURPOSE: To determine the concurrent validity and reliability of identical Polar Verity Sense bicep-worn devices to assess valid measures of average and maximum heart rate (HR) during light and moderately heavy RT. METHODS: Twenty adults (n=16 male, n=4 female, age: 25.65±8.59 …

The Impact Of Deadlift Exercise Intensity On Rating Of Perceived Exertion, Perceived Fatigue And Anxiety During An Acute Session In Recreationally Active Adults, Juni Timmins, Kynlee Sperry, Catalina Kerwin, Jae Bovell, Jose Vasquez, Setareh Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence

International Journal of Exercise Science: Conference Proceedings

Most literature examining the influence of exercise intensity on anxiety symptoms has been aerobic training and has found high-intensity efforts to be more beneficial than low-intensity on reducing symptoms. Yet, no study has directly assessed resistance training exercise intensity on anxiety symptoms and other perceptual outcomes acutely. PURPOSE: To determine the impact of deadlift exercise intensity on rating of perceived exertion (RPE), perceived fatigue and anxiety during an acute session. METHODS: 20 recreationally active adults (n=4 females, n=16 males, age: 25.7±8.6 yrs; mass: 92.8±29.7 kg; height: 179.4±9.8 cm) completed 4 sets of 6 repetitions of the deadlift exercise at a …

The Impact Of Resistance Exercise Intensity And Position Of Wrist-Worn Wearable Technology Devices Measuring Heart Rate Validity During An Acute Session In Recreationally Active Adults, Catalina M. Kerwin, Jae Bovell, Kynlee Sperry, Juni Timmins, Jose Vasquez, Setareh Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence

International Journal of Exercise Science: Conference Proceedings

Wearable technology is widely used in recreational exercise. We recently found that wrist-worn devices (e.g., Garmin Instinct) were not valid or reliable for measuring average or maximal heart rate (HR) during resistance training (RT). We postulated that lack of accuracy could be due to the intensity of RT or even positioning of the device on the wrist. PURPOSE: To determine the impact of RT intensity or wrist position on average or maximal HR validity and reliability of identical wrist-worn Garmin Instincts. METHODS: 21 recreationally active adults (n=4 females, n=17 males, age: 25.7±8.6 yrs; mass: 92.8±29.7 kg; height: 179.4±9.8 cm) completed …

Healthy Eating And Army Combat Fitness Performance: The Mediating Roles Of Vo2 Max And Lean Body Mass, Lillian M. Tang, Anthony Acevedo, Zachary Zeigler

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Optimal physical performance in military personnel is influenced by both lifestyle behaviors and physiological attributes. PURPOSE: To examine whether lean body mass and VO2 max mediate the relationship between healthy eating and Army Combat Fitness Test (ACFT) performance. METHODS: Eighty-nine ROTC cadets (age range: 18-24 years) completed assessments of healthy eating (Healthy Eating Index), VO2 max, lean body mass (kg), and ACFT scores. Covariates included age, gender, and ROTC activity level. Mediation analysis was conducted using PROCESS v5.0 in SPSS with 5,000 bootstrap samples. RESULTS: Healthy eating significantly predicted ACFT scores (direct effect = 1.42, p …

Neuromuscular Performance In Strength Or Endurance Trained Individuals: Construct Validity Of Mcpet Variables, Jeff Moore, Paolina Chavez Ibarra, Daniel T. Cannon, Harry B. Rossiter Facsm, Carrie Ferguson

International Journal of Exercise Science: Conference Proceedings

The musculo-cardiopulmonary exercise test (mCPET) assesses neuromuscular performance during a standard ramp-incremental cycle ergometer exercise test using the addition of brief (5s), maximal effort isokinetic cycling power (Piso) measurements at baseline and intolerance. mCPET quantifies 4 additional variables: maximum voluntary isokinetic power (Baseline Piso); the fraction of Baseline Piso achieved at V̇O₂peak (Aerobic Power Index, API); neuromuscular fatigability between baseline and intolerance Piso (Fatigue Index, FI); and the difference between peak ramp power and Piso at intolerance (Power Reserve, PR), reflecting the degree neuromuscular performance limits the exercise. PURPOSE: To determine construct validity of the mCPET using …

Time-Of-Day And Sex-Dependent Effects Of Exercise On Cardiometabolic Health In Mice With Social Jetlag, Graham R. Mcginnis

International Journal of Exercise Science: Conference Proceedings

Physiology has adapted to function on a 24 hour time scale, referred to as the circadian rhythm. Operating outside of this time scale leads to circadian rhythm disruption, which invariably leads to pathological outcomes. Social jetlag (SJL), a common form of circadian rhythm disruption, occurs when an individual’s sleep/wake schedule differs throughout the week (i.e. – staying up late on the weekends), and has been associated with obesity and cardiovascular disease. Exercise is a potential intervention to prevent SJL-induced impairments, but the time of day at which exercise is most effective is unknown.

PURPOSE: Determine if early or late phase …

Acute Sleep Reduction Impairs Heart Rate Variability And Heart Rate Recovery Following Aerobic Exercise In Healthy Adults, Jocelyn Kaveney, Gracie Dupuis, Eric Lessard, Braden Wilson, Grahm Mcginnis, Ryan Perkins

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: According to the CDC, ~35% of American adults are receiving an inadequate amount of sleep (/night). PURPOSE: This study aimed to investigate the effects of acute sleep reduction on heart rate variability (HRV) and heart rate recovery (HRR) following aerobic exercise. METHODS: Healthy, active adults (n=11; 26.4±5.4 yr; 45% female) were screened to ensure eligibility (i.e., meeting the CDC’s sleep recommendations of 7-9hr/night, apparently healthy, recreationally active, and non-smoking), characterize body composition via DXA and measure maximal cardiovascular capacity (VO2max). Utilizing a within subjects, repeated measures design, participants completed an initial 7d period of habitual sleep (CON) followed …

Validation Of Polar Sense Monitor Over Tattooed Skin, Rodolfo I. Mejia

International Journal of Exercise Science: Conference Proceedings

The prevalence of tattoos has increased over the years, and, correspondingly, wearable technology, especially heart rate wearables. The signal from the heart rate wearables may be affected by the permanent ink on the skin because of previous validation studies excluding people with tattoos. PURPOSE: Examine the validity of heart rate monitors on people with arm tattoos. METHODS: 20 participants were recruited for this study. There were three conditions in the study that included heart rate measurements at rest, self-paced walking, and self-paced jogging. The Polar H10 and the Polar Verity Sense armband were used as the heart rate monitors. The …

Effects Of Acute Sleep Reduction And Aerobic Exercise On Metabolic Function In Healthy Adults, Eric Lessard, Gracie Dupuis, Jocelyn Kaveney, Braden Wilson, Grahm Mcginnis, Ryan Perkins

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: The number of adults who receive insufficient sleep is progressively increasing, impacting the established relationship between sleep and metabolic function. PURPOSE: The purpose of this study was to explore the effects of acute sleep reduction on metabolic variables at rest and during aerobic exercise. METHODS: Healthy, active adults (n=11; 26.4±5.4 yr; 45% female) were screened to ensure eligibility (i.e., meeting the CDC’s sleep recommendations of 7-9hr/night, apparently healthy, recreationally active, and non-smoking), characterize body composition via DXA and measure maximal cardiovascular capacity (VO2max). Utilizing a within subjects, repeated measures design, participants completed an initial 7d period of …

Interleukin-6 As A Mediator Of Circadian And Sex Differences In Exercise-Induced Stat3 And Autophagy Signaling, Srushti Wagh, Ariana Khzarjyan, Joshua Corpuz, Elias M. Malek, Charli Aguilar, Michael Dial, Paula Martinez, Graham Mcginnis

International Journal of Exercise Science: Conference Proceedings

Circadian rhythms are highly conserved across tissues and play an important role in regulating how the heart responds to physiological and pathological stress. Exercise is known to be cardioprotective, yet the impact of exercise timing on molecular signaling is still being explored. Interleukin-6 (IL-6) is an exercise-induced cytokine which has been shown to be important to cardioprotection and metabolism. It is currently unknown how exercise timing modulates the IL-6 signaling pathway in the heart.

PURPOSE: To investigate how time-of-day and IL-6 influence exercise-induced activation of STAT3 and its downstream signaling pathways in male and female mouse hearts.

METHODS: Wild-type and …

Unlocking The Potential Of Citrulline Malate: A Pilot Study, Fabiola E. Bejarano, Elisa L. Milkie, Parker Andersen, Jenevieve L. Roper Facsm

International Journal of Exercise Science: Conference Proceedings

Citrulline malate (CM) is an ergogenic aid hypothesized to improve exercise performance by promoting nitric oxide (NO) production resulting in increased vasodilation, blood flow, and oxygen and nutrient delivery to working muscles. It is also thought to increase the synthesis of ATP and aerobic efficiency via malate and the TCA cycle. Prior research demonstrates improvements in upper and lower body submaximal resistance training exercise performance in females; however, limited research exists on the effects of CM supplementation on submaximal aerobic exercise performance in females. PURPOSE: Determine the effects of acute CM supplementation on submaximal time-trial (TT) performance in females. …

Use Of A Smartphone App Influences Diet Quality Among College Students., Alexis Arle, Mandy Korpusik, Delaram Yazdansepas, Gabrielle Besio, Samantha Chuakay Lim, Cameron Sumaquial, Hawley C. Almstedt

International Journal of Exercise Science: Conference Proceedings

Diet quality can protect or increase risk for noncommunicable diseases (NCDs). Diets rich in carotenoids are linked to reduced risk of NCDs. Dietary carotenoids can be measured in the skin and can serve as a biomarker of fruit and vegetable intake. PURPOSE: The purpose of this study was to investigate whether use of the In2Eat app improved diet quality among college students. METHODS: We administered a baseline survey including the Diet Quality Questionnaire (DQQ). Participants were also tested for skin carotenoid levels using a spectrophotometer (Konica Minolta 600D) as an indicator of diet quality. Participants were asked to use the …

Validity And Reliability Of Wrist-Worn Wearable Body Composition Estimation, Setareh Zarei, Rodolfo Mejia, James Navalta

International Journal of Exercise Science: Conference Proceedings

Usage of wearable technology is increasing in popularity every day. Samsung is a popular brand that manufactures wearable fitness trackers capable of measuring body composition (Galaxy Watch7). Because body composition is a common way to determine body fat percentage (FM %) and fat mass (FM), the validity and reliability of wearables to provide accurate measures (body fat percentage and fat mass) during body composition is important. PURPOSE: This study aimed to analyze and assess the validity and reliability of body fat percentage and fat mass from the Samsung Galaxy watch7 vs. DXA scan and Bioelectrical Impedance Analysis (BIA). METHODS …

Non-Invasive Monitoring Of Camel Hair From A Free-Grazing Herd As A Biomarker In Linking Environmental Exposure And Nutritional Status In Desert Ecosystems, Ibrahim Albokhadaim

The Thai Journal of Veterinary Medicine

Camels are vital livestock in arid regions, yet their elemental exposure remains underexplored, particularly through non-invasive biomarkers. This study is novel in applying camel hair as a non-invasive, long-term biomarker to assess nutritional adequacy and environmental exposure in a free-grazing desert herd, with age-stratified evaluation of essential and toxic element accumulation. For this purpose, a cross-sectional study was conducted on a herd of 18 apparently healthy camels (≤6 months: 28%; >6 months: 72%). Initially, hair samples were collected, washed, digested, and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The samples were then analyzed to determine the concentrations of 12 …

Enhancing Wound Healing With Synergistic Dual-Drug Electrospun Roflumilast And L-Arginine Loaded Pla/Pva Nanofibers Through Fabrication, Optimization, And In Vivo Assessment, Samar A. Salim

Nanotechnology Research Centre

Current trends in improved wound management emphasize the development of dual-drug-loaded electrospun nanofibrous scaffolds. Herein, electrospun dual-drug loaded PLA/PVA nanofibrous scaffolds, incorporating roflumilast, a selective phosphodiesterase-4 inhibitor with anti-inflammatory activity, and L-arginine, a precursor to nitric oxide with stimulating activity towards wound healing and tissue regeneration, were developed. A dual-spinneret electrospinning process enabled the coloading of drugs in PLA and PVA phases. Scaffolds were characterized by SEM, FTIR, and XRD, showing consistent fiber morphology, and amorphous drug formation. FTIR analysis was performed to confirm drug–polymer compatibility and successful incorporation of roflumilast and L-arginine within the PLA/ PVA nanofibrous matrix. Swelling …

Circulating Tumor Dna: Reducing Burden In Hpv+ Oropharyngeal Cancer Surveillance, Liza M. Joseph Pa-C

Lynchburg Journal of Medical Science

This review examines the rising prevalence of human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) and evaluates the role of circulating tumor HPV DNA (ctHPVDNA) in diagnosis and post-treatment surveillance. A comprehensive literature search of electronic databases, including PubMed, Medline, Cochrane Library, and Google Scholar, identified studies that validated ctHPVDNA as a biomarker with high sensitivity and specificity, assessed its cost-effectiveness, and explored patient and provider perceptions. Clinical evidence supports that plasma-based ctHPVDNA is the most accurate method for detecting disease recurrence and quantifying tumor burden. Patient perception studies reported high confidence in ctHPVDNA testing, while providers viewed it as …