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Quality Of Life In Patients With P16+ Oropharyngeal Cancer Receiving Accelerated Radiation Therapy With Either Cisplatin Or Cetuximab In The Nrg/Rtog 1016 Randomized Controlled Trial, Jolie Ringash, Pedro A Torres-Saavedra, Maura L Gillison, Jimmy J Caudell, David J Adelstein, Paul M Harari, Erich M Sturgis, Ethan Basch, Shlomo A Koyfman, Greg A Krempl, Dukagjin M Blakaj, James Edward Bates, Thomas J Galloway, Christopher U Jones, Beth M Beadle, Jonathan Harris, Quynh-Thu Le, Sue S Yom, Benjamin Movsas

Faculty, Staff and Students Publications

Purpose: NRG/RTOG 1016 was a phase III randomized noninferiority de-escalation trial comparing cetuximab versus cisplatin, concurrent with accelerated radiation 70 Gy/6 weeks, in p16+ oropharyngeal cancer. Quality of life (QOL) was a secondary endpoint.

Methods and materials: Eligible/consenting patients among the first 400 entered completed the EORTC QLQ-C30/H&N35 at baseline, end of treatment, 3, 6, and 12 months posttreatment, to provide 90% power to detect an effect size of 0.5 in the between-arm change in QOL scores from baseline to 6 months. We report completion, responsiveness, and patterns over time across domains between arms, considering a difference of >10 points …

Impact Of Statin Medication Use On Glycemic Control And Complications In Type 1 Diabetes, Ryan Bailey

USF Tampa Graduate Theses and Dissertations

Introduction: Hydroxymethylglutaryl-CoA enzyme inhibitors (statins) are frequently used to prevent cardiovascular events in individuals at high risk for cardiovascular diseases, including individuals with diabetes. Prior research has indicated that statins may increase the risk of developing type 2 diabetes (T2D) and may increase hyperglycemia among those previously diagnosed with T2D. To date, little research has investigated the impact of statins on glycemic control and diabetic complications associated with poor glycemic control in those with type 1 diabetes (T1D). The objective of this dissertation is to investigate the association between statin use and measures of glycemic control including hemoglobin A1c (HbA1c), …

: Knowledge, Attitude And Practice Regarding Obesity And Its Related Complications In Medical Student Of The College Of Medicine Of Al-Qadisiyah University, Rajaa Mohamed, Hassan Raji Jallab

Al-Qadisiyah Medical Journal

Abstract Background: Obesity, being a widespread epidemic, affects individuals of all age categories, spanning from children, teenagers, adults, to the elderly. The swift escalation of obesity cases is giving rise to an increasing array of ailments, thus evolving into a significant health dilemma. Vitamin D insufficiency stands out as a prevalent issue globally, ranking high among common conditions that can be prevented. Hence, it becomes crucial to delve into the depths of public consciousness and perceptions regarding this deficiency, pinpointing areas where daily routines could potentially hinder the maintenance of adequate vitamin D levels within their systems. Aim of the …

Unveiling The Therapeutic Potential Of Crispr-Cas9 Technology In The Correction Of Scd Gene Mutation., Vincent Weiss Weiss

Al-Qadisiyah Medical Journal

Sickle-cell disease (SCD) is a genetic disorder characterized by a mutation in the HBB gene. This mutation leads to abnormal hemoglobin production. CRISPR-Cas9 is a gene- editing tool that holds promise for correcting this mutation. This review explores the fundamental principles of CRISPR-Cas9 but it also considers the associated ethical concerns. The author furthermore explains how CRISPR-Cas9 differs from more traditional gene-editing therapies. Additionally, we provide an overview of the current research landscape. The focus of this review is on therapeutic applications of CRISPR- Cas9 for SCD. With the help of a hypothetical experiment the author illustrates how CRISPR-Cas9 can …

Evaluation Low Density Lipoprotein Cholesterol And Triglyceride Concentrations And Gene Expression Of P53 May Predict The Risk For Breast Cancer, Elaph Ali Al-Esawi, Buthainah Abbas Al-Azzawi

Al-Qadisiyah Medical Journal

Breast cancer is a condition in which cancerous cells in the breast tissue proliferate and divide uncontrollably. Through blood arteries or lymph, these cells infiltrate harmless surrounding tissues, where they cause the development of secondary cancer metastases . Abnormality in lipid metabolism (typically by poor diet or obesity) and cholesterol changes can be risky factor for cancer in breast have been subject to the substantial research. Circulating lipids not only associated with etiology but also with prognosis in cancer. Lipids are crucial in the emergence and progression of cancer. LDL-C has been linked to a higher risk of breast carcinoma. …

Echocardiographic Finding In Chronic Kidney Disease Patients On Hemodialysis In Al-Diwaniyah Teaching Hospital, Meld Qasim Kamal, Aqeel Raheem Al-Braqawee

Al-Qadisiyah Medical Journal

 Background: Chronic kidney disease is irreversible deterioration of renal function which results into impairment of excretory, metabolic and endocrine functions leading to development of the clinical syndrome of uremia. Patients with Chronic kidney disease are at significantly increased risk for both morbidity and mortality from cardiovascular disease. Patients on dialysis have a 10- to 30-fold increased risk for cardiovascular mortality compared with the general population. Cardiovascular disease is the single most important cause of death among patients receiving long-term dialysis; accounting for 44% of overall mortality. The magnitude of the problem has become more apparent as patients now survive longer …

Biochemical Indices In Diabetic Patients With Overweight And Obesity At Al-Diwaniya Province, Noora Flayyih, Majid Abdulwahab Maatook, Aqeel Raheem Hassan

Al-Qadisiyah Medical Journal

Background: The World Health Organization (WHO) explains that "the fundamental cause of overweight and obesity is an energy imbalance between calories consumed and calories expended" and defines overweight and obesity as "abnormal or excessive fat accumulation that may impair health." Aim of study: The study aims to determine the connection between diabetes and certain biochemical indicators in order to evaluate the metabolic characteristics of the adult population with diabetes. Methods: A convenient sample of 123 individuals who have diabetes type 2 was examined by an internal consultant and the Specialized Center for Diabetes and Endocrinology (SCDE) at Al-Diwaniya Teaching Hospital …

The Prevalence Of Perceived Stress-Related To Covid-19 Pandemic Among Undergraduate Medical Students In The University Of Al-Qadisiyah/Iraq: Effect Of Covid-19 Pandemic On Medical Students, Noor Yahya, Hassan Raji Jallab

Al-Qadisiyah Medical Journal

Background: The global pandemic has posed significant challenges for medical students, resulting in increased rates of depression, anxiety, and stress. The pandemic has also resulted in substantial disruptions to academic endeavors, clinical training, and prospective career opportunities. Many students have faced increased academic demands as they strive to adapt to virtual learning methods while also dealing with the uncertainty surrounding future clinical placements. Objective: To assess the prevalence of perceived stress associated with the outbreak of Coronavirus disease 2019 (COVID-19) among medical students and to investigate potential correlating factors to higher prevalence. Subjects and methods: The study constitutes a cross-sectional …

Attitude And Practice Regarding Obesity And Its Complications Among Medical Students Of University Of Al-Qadissiyah/ Iraq, Dhifaf Kareem Abed, Hassan Raji Jallab

Al-Qadisiyah Medical Journal

Background: Obesity is a growing health concern worldwide, and Iraqis no exception to this trend .In Iraq, more than half (55%) of all mortality in 2016 was attributable to non-communicable diseases(NCDs) which may be considered as an obesity complications. Medical students represent a vital component of health care system and have a critical role in promoting healthy lifestyle habits and preventing chronic disease, including obesity. Therefore, understanding their attitude and practice regarding obesity is crucial in developing effective interventions to tackle this issue. Aim of the study: Our study aimed to evaluate the current attitude, and practice regarding obesity and …

The Significance Of Serum Cea And Haematological Materials In The Diagnosis And Prognosis Of The Colorectal Carcinoma, Ali Hussein, Haider Abd .Jabbar Alammar, Mazen .J.Ibrahim

Al-Qadisiyah Medical Journal

Background: The second-leading source of neoplasm-related death and a primary factor in gastrointestinal Cancer, colorectal Cancer (CCR) affects both genders globally. Poor eating behaviours, tobacco, an intestinal inflammatory disorder, swellings, inherited characteristics, and the elderly all increase the threat of acquiring this malignancy. The illness is more hostile in patients detected at earlier ages, although 90% of patients with colorectal tumours are older than 50, with a median oldness of 64 years. American Cancer Association estimates that it caused more than 49,700 fatalities in 2015.

The Significance Of Serum Ca15-3 And Haematological Materials In The Diagnosis And Prognosis Of Invasive Ductal Carcinoma Of The Breast, Nooralhuda Jalil

Al-Qadisiyah Medical Journal

Background: The other most prevalent malignancy amongst females is breast tumour. A mammary tumour is a multi-step process involving different cell categories, challenging to avoid internationally. Solitary of the finest methods to prevent mammary tumours is by initial identification. Due to initial recognition, the 5-year comparative persistence ratio for individuals with breast tumours is 80% in numerous developed countries. Together the appreciation of mammary tumours and the construction of avoidance measures have progressed considerably in the previous ten years.

Correlation Of Hepcidin With Hemoglobin And Iron Parameters In Iraqi Patients With Beta -Thalassemia Major, Sameh Nahi, Ferdous Jabir

Al-Qadisiyah Medical Journal

Background: Thalassemia is characterized by genetic abnormalities in the synthesis of hemoglobin, leading to a decrease or missing production of one or more in the globin chains. Consequently, this disrupts the synthesis of hemoglobin molecules, resulting in anemia, which is a prominent manifestation of thalassemia. Iron is an essential element for cellular health and is involved in various functions, including oxygen transportation, biomolecule synthesis, respiration, and homeostasis. Hepcidin, a low molecular weight peptide produced in the liver, plays a crucial role in regulating iron homeostasis. Objectives: Study the correlation of Hepcidin with Hemoglobin, Ferritin, and Iron Parameters in  Patients with …

The Effect Of Serum Vitamin D Level On Asthma Severity In Children Admitted To Al Diwaniyah Maternity And Children Teaching Hospital, Mohammed M Al-Shamsi, Suzan Sabbar Mutlag, Munther M Al-Shami

Al-Qadisiyah Medical Journal

Backdrop: recent reseaches reported that vitamin D inadequacy and paucity are widespread throughout the world and related to large number of illnesses encompassing asthma.Objective of study: to assess vitamin D inadequacy and paucity in children with asthma in Al Diwaniyah maternity and children teaching Hospital and their relations to the disease severity .Methods: This case-control study was carried out on 173 child, 87 had asthma and 86 normal children as control group, aged 2 to 5 years in Al Diwaniyah maternity and children teaching Hospital, Iraq, during the period from the17th of September to3rd of November 2014. Patients with asthma …

Common Causes Of Death In Childbearing Age Women In Al Diwanyia Governorate/Iraq, Ahmed Kadhim Challab, Hussein Abdulzahra Al Janabi, Sanaa Hussein Kandooh, Jawad K. Krafe

Al-Qadisiyah Medical Journal

Background Women in the reproductive age group comprise a dangerous part of ur population because they face a double burden of communicable and non communicable diseases in addition to high risk of pregnancy complication. Thus an expected death of women in reproductive age  had big trauma to family in psychological and social level of other member in family. Objective 1-To find out the unrecorded maternal death in health institution   2- To throw alight on most common causes of death in reproductive age groups woman Methods  A cross sectional description type study was carried out from 1st june to 28thjune 2013 …

Level Of Knowledge And Attitude Of Mothers Through Health Awareness Programs Towards Nursing Bottle Caries: A Cross Sectional Study At Al-Karkh Primary Health Care Sector., Ammar Jaleel Sebahi, Dunia Mundher Jumhaa

Al-Qadisiyah Medical Journal

Introduction:Tooth decay in infants and toddlers is often referred to as Nursing  Bottle Caries(NBC),and as a comprehensive address, referred to Early Childhood Caries(ECC), Children need strong, healthy teeth to chew their food, speak and have a good-looking smile, also it is important for their general health,The role of mothers in avoiding children with nursing  Bottle caries is a large and fundamental ,mothersorientations and knowledge , is essential to reduce the percentage of children with tooth decay, developed countries are concerned with awareness and health education programs as a first step in achieving a healthy and disease-free society.Objective:the purpose of this …

Thyroid Dysfunction In Patients With Unstable Angina, Mazin Zamel Muhammad Al-Shibani, Mohammed Fadil Hadi

Al-Qadisiyah Medical Journal

Background  Unstable angina has considerable effect on homeostasis of thyroid gland with consequences effect in form of mortality and morbidity. Thyroid hormone has an important effect in the cardiovascular system. Small changes of the thyroid hormone within the normal physiological response have been an adverse effect on cardiovascular results. Aim of study The study was designed to assess the profile of thyroid hormonein patients with unstable angina who wereadmitted to the Coronary care unit and toevaluate short term affection. Patients and methods An observational study was enrolled 40 patients were admitted to the CCU of AL-Diwanyia Teaching Hospital during period …

Prevalence Of Under Nutrition And Associated Maternal Risk Factors In Children Under Five Years Of Age In Babylon 2013, Ahmed Abdul Abbas, Sura Kuhtan Mohammed

Al-Qadisiyah Medical Journal

Background:Malnutrition is one of most serious world health problems and is the major cause of illness and death throughout the world. It is associated with about half of all child death. It affects physical growth, morbidity, mortality, cognitive development, reproduction, and physical work capacity, and it consequently impact on human performance, health and survival. Thus, when attempting to reduce child mortality, monitoring and reducing the prevalence of malnutrition in vulnerable population is essential. Malnutrition is an outcome of various factors resulting from unfavorable socioeconomic circumstances. Objective: To determine the prevalence of undernutrition (wasting, stunting and underweight) and associated maternal risk …

Evaluation Of The Effect Of Using Nsaids On Ovulation In Women During Reproductive Age: A Case Control Study, Saba Shamran

Al-Qadisiyah Medical Journal

Background: Unovulation is an important cause of female infertility whether primary or secondary. Prostaglandins play an important role in normal physiology of ovulation. Non-steroidal anti-inflammatory drugs (NSAIDs) are often prescribed for treatment of a variety of medical conditions in the field of obstetrics and gynecology. Sufficient controversy about the role of NSAIDs on ovulation exists.    Aim of the study: to evaluate rate of ovulation in two groups one was healthy fertile women receiving NSAIDs and the other group include healthy fertile women receiving placebo treatment. Patients and methods: The present case control study included two groups of healthy fertile women. …

Causes Of Neonatal Mortality In Neonatal Care Units Al-Diwaniya Province –Iraq 2013, Nazhat Jassab Hamza

Al-Qadisiyah Medical Journal

Background: Neonatal mortality refers to death of a new born within the first 28 days of life. A child’s risk of death in the first four weeks of life is nearly 15 times greater than any other time before his or her first birthday. Methods: A cross sectional study was conducted to review records of neonatal deaths that took place in all neonatal care units in AL- Daiwynia province during the year 2013. Data collection form was designed to collect the demographic data, data concerning pregnancy and delivery and any complication during pregnancy, delivery and perperium, mode of delivery, place …

Causes Of Antibacterial Resistance In Some Of Enteropathogens Isolated From Colon Cancer Patients In Al-Dewaniyah Governorate., Abdul-Jabbar K.Hassoon Al-Zeydi, Akeel M.Hamza Al-Hamdawee

Al-Qadisiyah Medical Journal

Background:  Bacterial infections associated with multidrug resistance have been implicated in high mortality and morbidity reported among cancer patients. Objective:To detect the  causes of  ?-lactamase  resistance  inEscherichia coli and Klebsiella spp. isolated from colon Methods: Twenty -eight  stool samples from colon cancer patientssamples ,in addition to that, 25 samples were collected from control group (healthpersons). Samples  were labeled and transported to the laboratory in portable containerthenstreaked on MacConkey agar and incubated at 37?C for 24 hours under aerobic condition. The antimicrobial susceptibility testing was done by the agar discs diffusion method. Results:  out of 28 samples from colon cancer patients, …

Zinc Status Among Children With Bronchial Asthma In Central Child's Teaching Hospital/Baghdad, Mahdi Mohammed Murad, Mohannad Salim Ismail, Khamees M Al-Dulaimy

Al-Qadisiyah Medical Journal

Background:Pediatric asthma is a syndrome of lung dysfunction with an imbalance between the forces that maintain airway patency and those forces that operate to narrow or close the pediatric airway. Zinc has been supposed to have anti-oxidant, anti- apoptotic, anti-inflammatory and anti-allergic effects in the organism . Zinc deficiency is suspected to play a role in the pathogenesis, control, and severity of allergic, skin and airway diseases. Objectives: To evaluate the relationship between zinc serum level and bronchial asthma( its duration and severity). Patients and methods:  A prospective case –control study was conducted at the central Child teaching hospital in …

Study Of Neural Tube Defects At Al-Diwaniyah Province / Iraq, Abdulaziz Wannas Abd, Meethak Ali Ahmed, Mahmood Jasim Mohammed

Al-Qadisiyah Medical Journal

Background: The Neural tube defects NTDs refers to defect ocurr at birth resulting from defect in  closure of the neural tube during early intra uterine life after conception; these anomalies  are usually divided into cephalic and spinal forms. They include three main type , anencephaly, spina bifida and encephalocele ,  These NTDs are considered important causes of morbidity and mortality in infancy, childhood, and even young adulthood . Objective: The aim of study is to study the type and incidence of the neural tube defect and it is it is risk factors and other associated variable. Methods :  This  descriptive …

The Study Of The Effect Of Serum Zinc Level In The Mothers And Neonates On Neonatal Jaundice In Al-Diwanyia, Nasma Naji Al-Hajjiah

Al-Qadisiyah Medical Journal

Background : Zinc has a role in normal growth and development during pregnancy, childhood, and is needed for the proper sense of taste and smell. Studies on animals, adolescents and low birth weight neonates showed that oral zinc salt intake decreased serum bilirubin level, probably through inhibition of the bilirubin enterohepatic circulation. Objective : To study the effect of serum zinc level of the newborn and their mothers on neonatal jaundice. Patient and methods A case control study included a total 130, 65 with jaundice and 65 healthy neonates with their mothers. The study was carried out from May to …

Estimation Of Hepcidin Level And Its Correlation With Iron State In Pregnant Women, Ghufran Mohammed Hussein, Nibras Yahya Hussein

Al-Qadisiyah Medical Journal

This study aimed for determination of serum hepcidin level and its association with ?iron ?state in pregnant women with and without anemia. ?This study comprises ?86 pregnant women divided into two groups, the first ?group comprises 49 pregnant women without iron deficiency ?anemia?, the second group comprises 37 pregnant women with iron ?deficiency anemia. ?Blood was drawn from all pregnant women for determination of serum ferritin and hepcidin concentrations. The results establish a significant decrease in serum ferritin ?and hepcidin concentrations in pregnant women with anemia as paralleled with pregnant women without anemia. The outcomes of linear regression analysis demonstrate …

Polymorphism Of Vitamin D Receptor (Re2228570) In Sera Of Coronary Artery Diseases And Its Association With Various Anthropometric And Biochemical Parameters, Siham Abdul Zahra Rahi, Fadhil Jawad Al-Tu’Ma, Anwar Madlool Al-Ganabi, Jawad F. Al-Tu’Ma

Al-Qadisiyah Medical Journal

 Objective : Coronary artery disease is increasing and accounts for a high proportion among others diseases. In Iraq various studies have been reported that the polymorphism of vitamin D receptor VDR-Fok I gene like rs 2228570 are associated with CAD patients. Aim: This study was aimed to investi­gate the association between the SNP of VDR Fok I (rs2228570) gene with various anthropometric and biochemical parameters as a risk for CAD in Iraqi population. Methods and Materials :  The  current case - control study consisted of  300 samples , 150 of them were obtained from CAD patients who underwent the angiography …

Antibiotics Resistance And Integron Class 1 Among Commonsal Escherichia Coli, Manal M. Khadhim, Meraim A. Kazaal

Al-Qadisiyah Medical Journal

Normal intestinal microbiota are a reservoir for antibiotic resistance (genes) especially Escherichia coli (E. coli). The goal of this study was to investigate the prevalence of integrons class 1 and antibiotic resistance among commensal E. coli isolates and detect the association of integron class 1 with antibiotic resistance (single or multiple drug resistance) that may be transport horizontally to other bacteria. Three hundred one E. coli isolates from stools were obtained from healthy individuals (age from 1to 80 years). All isolates were tested for their susceptibility against 16 antimicrobial agents using standard disc diffusion method and for the presence of …

Risk Factors Of Congenital Anomalies In Karbala, Khalid K. Alaarji

Al-Qadisiyah Medical Journal

BACKGROUND; Congenital anomalies can be defined as structural or functional abnormalities present at birth. They are an important cause of morbidity and mortality in infants. Various risk factors have been identified as contributing factors to these defects. The objectives of the present study are to determine the frequency of different structural congenital anomalies and possible risk factors responsible for these anomalies. METHODS; This case - control study was carried out in the neonatal intensive care unit of Kerbala teaching hospital for children in Karbala / Iraq. The study was conducted over 18 month’s period from January 1, 2014 to May …

Breast Feeding And Asthma In Children In Diwanyiah, Nasma Naji Al-Hajjiah

Al-Qadisiyah Medical Journal

Background:     the protective effect of  and the association between breastfeeding and  asthma has raised substantial interest and is a subject of debate. Objectives:  to study the relationship between asthma and  feeding pattern in children up to the age of 12 years in Diwaniah, Iraq with a focus on breast feeding. Patients and methods: this is a prospective study accomplished  in the maternity and children teaching hospital in Diwaniah ,Iraq during the period from January 2015 to March 2016. The study involves 1242 patients with the diagnosis of asthma and control group of 1350 healthy infants and children were chosen for …

Use Of Isotretnion To Decrease Recurrence Of Chalazion, Zainab Adil Hashim Al-Hassnawi

Al-Qadisiyah Medical Journal

Chalazion; is a nodular swelling occur as a result of accumulation of sebaceous secretions from abnormally functioned sebaceous glands situated in the eye lid causing ocular surface problems like dryness , irritation and refractive error due to pressure effect on the cornea in addition to cosmetic blemish ,topical treatment usually ineffective so we do surgical drainage . isotretnion is one derivatives of retinol a chemical name of the essential micronutrients vitamin A which have important role in human reproduction and development in addition this drug is well known by dermatologist and it is commonly used for treatment of seborrhea and …

Distribution Of Granulicatella Adiacens And Porphyromonas Gingivalis Among Ortho And Non-Orthodontic Patients With Gingivitis In Kufa City /Iraq., Manar Hussain Abbas, Ahlam Kadhum Al- Yasseen, Wisam Wahab Alhamadi

Al-Qadisiyah Medical Journal

This study aimed to investigate the distribution of Granulicatella adiacens and Porphyromonas gingivalis and the role of orthodontic wire on antibiotic resistance pattern of bacterial isolates. A total of 78 gingival swab samples have been collected from patient with orthodontic wires suffering from gingivitis and 71 samples were collected from healthy without orthodontic wire during four months from private dental clinics.The results of isolation and identification of bacterial isolates by using culture and conventional biochemical tests as well as molecular technique using 16S rRNA for detection of G. adiacens and insertion seqence element IS1126 for detection of P. gingivalis showed …