Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (2193)
- Life Sciences (1275)
- Social and Behavioral Sciences (750)
- Public Health (511)
- Education (495)
-
- Medical Specialties (489)
- Medical Sciences (406)
- Physical Sciences and Mathematics (264)
- Nursing (246)
- Arts and Humanities (244)
- Nutrition (213)
- Agriculture (205)
- Dietetics and Clinical Nutrition (196)
- Diseases (196)
- Animal Sciences (193)
- Food Science (190)
- Law (190)
- Plant Sciences (183)
- Psychology (160)
- Business (135)
- Higher Education (132)
- Rehabilitation and Therapy (132)
- Biology (127)
- Sociology (118)
- Public Health Education and Promotion (117)
- Public Affairs, Public Policy and Public Administration (115)
- Medical Education (114)
- Sports Sciences (109)
- Engineering (106)
- Pediatrics (96)
- Institution
-
- The Texas Medical Center Library (250)
- Edith Cowan University (211)
- Universitas Padjadjaran (208)
- University of Texas at Arlington (194)
- Advocate Health - Midwest (188)
-
- University of Kentucky (166)
- Arkansas State University (155)
- Walden University (151)
- Changsha University of Science and Technology (150)
- Universitas Indonesia (106)
- Utah State University (105)
- TÜBİTAK (104)
- Liberty University (97)
- Western Kentucky University (96)
- University of Arkansas, Fayetteville (93)
- University of Al-Qadisiyah (89)
- Thomas Jefferson University (84)
- University of New Hampshire (80)
- Old Dominion University (71)
- University of Plymouth (70)
- University of Mississippi (65)
- Chulalongkorn University (63)
- University of Montana (63)
- Children's Mercy Kansas City (60)
- University of South Carolina (59)
- Sigma Theta Tau International Honor Society of Nursing (58)
- Technological University Dublin (58)
- Aga Khan University (55)
- Nova Southeastern University (55)
- University of Texas Rio Grande Valley (55)
- Keyword
-
- Humans (244)
- Female (180)
- Male (153)
- Obesity (102)
- Nutrition (94)
-
- Hospital newsletter (88)
- Newsletter (85)
- Adult (84)
- Middle Aged (82)
- ASMC (80)
- Employee newsletter (80)
- ASLMC (67)
- Child (61)
- Aged (60)
- Pregnancy (56)
- Adolescent (52)
- Diet (52)
- Mental health (49)
- Exercise (48)
- Nursing (48)
- Health (46)
- Food insecurity (44)
- United States (44)
- Hypertension (43)
- Animals (39)
- Children (38)
- Infant (38)
- Physical activity (38)
- Nurse (37)
- St. Luke's Medical Center (37)
- Publication
-
- Research outputs 2022 to 2026 (207)
- Jurnal Ilmu Ternak Universitas Padjadjaran (185)
- Historical Documents - Combined (169)
- The Shorthorn Newspaper Collection: 1980s (155)
- Food and Machinery (150)
-
- Walden Dissertations and Doctoral Studies (139)
- All Approved Curriculum (128)
- Faculty, Staff and Students Publications (97)
- Theses and Dissertations (96)
- International Journal of Exercise Science: Conference Proceedings (95)
- Al-Qadisiyah Medical Journal (89)
- Faculty, Staff and Student Publications (86)
- Honors Theses (58)
- Doctoral Dissertations and Projects (52)
- Faculty Publications (52)
- IGC Proceedings (1977-2023) (47)
- Children’s Nutrition Research Center Staff Publications (44)
- Manuscripts, Articles, Book Chapters and Other Papers (44)
- Electronic Theses and Dissertations (42)
- 2020-Current year OA Pubs (39)
- Saudi Medical Journal (38)
- Graduate Theses and Dissertations (35)
- International Nursing Research Congress (INRC) (35)
- All Graduate Theses and Dissertations, Fall 2023 to Present (33)
- DRS Biennial Conference Series (32)
- University of Montana Course Syllabi, 2026-2030 (32)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (31)
- Theses (31)
- Baghdad Science Journal (30)
- Turkish Journal of Agriculture and Forestry (30)
- Publication Type
Articles 2101 - 2130 of 6873
Full-Text Articles in Entire DC Network
Soft Power, Arab Media And Sports Mega Events: Coverage Of Fifa 2022 And Lessons For Future Arab Hosting, Lynne Kennedy, Maaira Shahbaz, Ala Al Rajabi
Soft Power, Arab Media And Sports Mega Events: Coverage Of Fifa 2022 And Lessons For Future Arab Hosting, Lynne Kennedy, Maaira Shahbaz, Ala Al Rajabi
All Works
Sport mega-events (SMEs) increasingly transcend athletic competition, functioning as strategic instruments for national identity formation, statecraft, and soft power projection. This dynamic is particularly pronounced in the Gulf, where Qatar’s successful hosting reignited regional rivalries and attracted unprecedented global scrutiny. While existing scholars have extensively examined Western media portrayals of SMEs, a notable gap remains for academic engagement with Gulf media. Dismissed as state-controlled and analytically lacking, we contend that such media offer a rich site for exploring how small states use media as soft power, to construct and contest legitimacy, identity, and global influence. This analysis suggests how state-aligned …
Holistic Management Of Epilepsy In Adults With Intellectual Development Disorders, Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef
Holistic Management Of Epilepsy In Adults With Intellectual Development Disorders, Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef
Peninsula Medical School
This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic, therapeutic, and psychosocial challenges. Accurate diagnosis is hampered by limitations in communication, necessitating reliance on caregivers' observations. In adults with IDD and epilepsy, utilization of diagnostic tools, e.g., video electroencephalograph (EEG) monitoring, is helpful but can be challenging. Management requires careful consideration of cognitive and behavioral comorbidities and the effects of antiseizure medications (ASMs) on …
Household Hegemon: Domestic And Affective Traces Of Us Influence In Mexico In The 1950s And 1990s, Edgar Solórzano
Household Hegemon: Domestic And Affective Traces Of Us Influence In Mexico In The 1950s And 1990s, Edgar Solórzano
Masters Theses
“Household Hegemon: Domestic and Affective Traces of US Influence in Mexico in the 1950s and 1990s” is a collection of personal essays, historical research, and fictional texts that examine the impact of US-American soft power on Mexican society. This project expands and deepens the research and work developed during my two-year MFA in Sculpture at RISD, evolving material investigations into a comprehensive written and visual record of the 1950s post-WWII boom and the 1990s post-NAFTA transition. These two decades not only represent the most significant in terms of American influence but also the years in which my parents and I …
Another Palace For The People, Kate Holbrook
Another Palace For The People, Kate Holbrook
Masters Theses
Coined the “Palace for the People,” the American public library was established as a free, democratic haven for the public’s literary and educational needs. Adapting to the changing needs of its patrons, the public library’s services have extended beyond book access to provided services ranging from tool rentals to warming centers, postal services, and more. As both an essential landmark of the physical city through its exterior and provider of social infrastructure on its interior, public libraries seek sustainable avenues to continue their tradition of gathering, idea exchange, and provision. Expanding upon the identity of the public library as a …
Resistant Silence Engraved Trauma, Silence In Domestic Spaces, & Acts Of Resistance, Priyanka Kumar
Resistant Silence Engraved Trauma, Silence In Domestic Spaces, & Acts Of Resistance, Priyanka Kumar
Masters Theses
This thesis argues that silence surrounding trauma within domestic spaces is not merely an absence of speech or a condition of voicelessness, but it functions as an act of resistance. Focusing on domestic abuse within patriarchal structures, this research examines the ways trauma is embodied, negotiated, and concealed in everyday life. Central in this inquiry is the figure of the “sole witness” to abuse, those who live in close proximity to violence, endure its aftermath and negotiate survival through subtle and often unseen acts of resistance.
I am not attempting to define trauma, but the thesis explores the traces trauma …
Staff Education To Emergency Department Professional Nurses, Florence Chukwuneke Chukwuneke
Staff Education To Emergency Department Professional Nurses, Florence Chukwuneke Chukwuneke
Walden Dissertations and Doctoral Studies
No abstract provided.
Muscle Changes In Critically Ill Children Following An Early Progressive Exercise In The Paediatric Intensive Care Unit: A Pre- And Post-Intervention Study, Shaodan Qi, Yuxia Yang, Jing Hu, Weijie Shen, Hao Zhou, Jos M. Latour, Weiming Chen, Ying Gu
Muscle Changes In Critically Ill Children Following An Early Progressive Exercise In The Paediatric Intensive Care Unit: A Pre- And Post-Intervention Study, Shaodan Qi, Yuxia Yang, Jing Hu, Weijie Shen, Hao Zhou, Jos M. Latour, Weiming Chen, Ying Gu
School of Nursing and Midwifery
Background: Most critically ill children in the paediatric intensive care unit (PICU) are immobilised. Prolonged immobilisation in the PICU negatively affects children's physical health outcomes. Aim: The aim of the study was to evaluate the effectiveness of an early progressive exercise (EPE) intervention to improve the PICU-acquired muscle weakness and to assess the safety of the EPE intervention. Study Design: A single-centre pre- and post-intervention design was adopted. The intervention was the EPE starting within 48–72 h after PICU admission. Primary outcome was the 7-day difference of right rectus femoris muscle cross-sectional area (RRMCSA). Secondary outcomes were the 7-day difference …
Member Spotlight- Dr. Julian Metts Quietly Making A Difference, Frank P. Iuorno Jr., Dds
Member Spotlight- Dr. Julian Metts Quietly Making A Difference, Frank P. Iuorno Jr., Dds
Virginia Dental Journal
No abstract provided.
The Inter Health Professionals Alliance- A Student-Led Initiative, Lyubov D. Slashcheva Dds
The Inter Health Professionals Alliance- A Student-Led Initiative, Lyubov D. Slashcheva Dds
Virginia Dental Journal
No abstract provided.
Feeding Tube Weaning Outcomes Across Pediatric Age Groups In A Multidisciplinary Feeding Clinic, Julianne Brogren, Lori A. Erickson, Amy Ricketts, Kristina Nash, Ryan Thompson, Dana Bakula, Sarah Bullard, Lindsay R. Groh, Sarah Edwards, Rachel Graham
Feeding Tube Weaning Outcomes Across Pediatric Age Groups In A Multidisciplinary Feeding Clinic, Julianne Brogren, Lori A. Erickson, Amy Ricketts, Kristina Nash, Ryan Thompson, Dana Bakula, Sarah Bullard, Lindsay R. Groh, Sarah Edwards, Rachel Graham
Research Showcase
Background: Pediatric Feeding Disorder affects 1 in 37 young children, with some using feeding tubes for survival. Due to the financial, social, and medical burden of feeding tubes, the goal is to transition to all oral feedings when medically ready; however, children are referred to the multidisciplinary feeding clinic with wide variability in age, nutritional needs, and tube feeding duration. Understanding how these differences influence weaning outcomes is essential for optimizing outpatient interventions and tube weaning success.
Objectives/Goal: To evaluate whether age at enrollment (< 20 months, 20–44 months, >44 months) is associated with baseline nutritional dependency, time to full oral intake, and tube …
Adapting And Promoting Tourism For Children In Venice And The Lagoon Islands: A Comparative Analysis Of Food-Related Discourse Strategies In English And In Italian, Daniela Cesiri Prof.
Adapting And Promoting Tourism For Children In Venice And The Lagoon Islands: A Comparative Analysis Of Food-Related Discourse Strategies In English And In Italian, Daniela Cesiri Prof.
International Journal of Islands Research
According to the latest available version of the Annual Tourism Survey drafted by the City of Venice, in 2023, 12,628,079 tourists visited Venice and the Lagoon Islands (Bettiol & Marini, 2025). This survey does not provide data on the age groups of these visitors, but they are available in the previous version of the same Survey (Bianchetto & Marini, 2022), which reports that 29% of tourists were in the 46-71 age group. Therefore, we can presume that, excluding the older age groups, quite a large proportion of visitors is likely composed of young tourists and families with children. This study …
Adolescent Literacy: Bridging Literacy Gaps In Georgia's Social Studies Classrooms A Call For Disciplinary Literacy In Secondary Education, Kimberly N. Miles
Adolescent Literacy: Bridging Literacy Gaps In Georgia's Social Studies Classrooms A Call For Disciplinary Literacy In Secondary Education, Kimberly N. Miles
Teaching Social Studies in the Peach State
This article advocates integrating disciplinary literacy into secondary Social Studies instruction, arguing that the content area is critical to strengthening adolescent reading skills, particularly in alignment with the Georgia Standards of Excellence (GSE). Drawing from the "Bridging Literacy Gaps" presentation, the paper asserts that literacy is not merely a prerequisite for studying history but the very methodology by which students learn to read, write, and think like historians.
The article details three high-leverage strategies for Social Studies educators:
-
Disciplinary Literacy and Multimodal Text Integration: Teaching students how experts analyze primary and secondary sources, and integrating diverse media (e.g., political cartoons, …
Malnutrition At The Time Of Surgery Predicts Increased Morbidity After Distal Femur Fracture Fixation: A Propensity-Matched Analysis, Jawad Saad, Amir Ghafarian, Tyler Forbes, Muaaz Wajath, Noor Saad, Khaled Saleh
Malnutrition At The Time Of Surgery Predicts Increased Morbidity After Distal Femur Fracture Fixation: A Propensity-Matched Analysis, Jawad Saad, Amir Ghafarian, Tyler Forbes, Muaaz Wajath, Noor Saad, Khaled Saleh
Medical Student Research Symposium
Abstract
Background: Distal femur fractures (DFF) are serious injuries most often affecting older adults with multiple medical comorbidities. Malnutrition is known to worsen outcomes in elective orthopedic surgery, but its impact in urgent DFF fixation, where optimization time is limited, remains unclear. This study evaluated whether preoperative malnutrition predicts 90-day morbidity after DFF fixation and whether implant choice influences risk among malnourished patients.
Methods: Adults undergoing operative DFF fixation from 2005–2025 were identified using the TriNetX U.S. Collaborative Network. Malnutrition was defined as serum albumin ≤3.5 g/dL or leukocyte count ≤1.5×10³/µL within one year preoperatively. After 1:1 propensity matching for …
Impact Of Dietician Counseling On Outcomes In Newly Diagnosed Celiac Disease, Andreas Mozny B.A., Alyusuf Elnaggar B.A., James Mo M.D., Suraj Suresh M.D.
Impact Of Dietician Counseling On Outcomes In Newly Diagnosed Celiac Disease, Andreas Mozny B.A., Alyusuf Elnaggar B.A., James Mo M.D., Suraj Suresh M.D.
Medical Student Research Symposium
Title: Impact of Dietician Counseling on Outcomes in Newly Diagnosed Celiac Disease
Background: Dietician counseling is routinely recommended for newly diagnosed celiac disease (CD), yet its measurable impact is not well defined. This study examined whether early dietician involvement improves clinical symptoms or serologic outcomes.
Methods: We retrospectively reviewed adults with biopsy-confirmed CD at a single center from 2020–2024. Demographics, symptoms, and laboratory data were collected by chart review with ≥6 months of follow-up. Patients who met with a dietician formed the dietician group; all others were assigned to the non-dietician group. Fisher's Exact tests evaluated abdominal …
Twice As Long, Half The Risk: Piccs Outperform Cvcs In Pediatric Burn Patients, Christian Hudson-Bradford Md, Megan Zacarias Bs, Samantha Carranza Bs, Elika Ridelman Phd, Christina Shanti Md
Twice As Long, Half The Risk: Piccs Outperform Cvcs In Pediatric Burn Patients, Christian Hudson-Bradford Md, Megan Zacarias Bs, Samantha Carranza Bs, Elika Ridelman Phd, Christina Shanti Md
Medical Student Research Symposium
Title: Twice as Long, Half the Risk: PICCs Outperform CVCs in Burn Patient
Christian Hudson-Bradford MD, Megan Zacarias BS, Elika Ridelman PhD, Samantha Carranza BS, Christina Shanti MD
Background: Venous access is critical in burn care for fluid resuscitation, medication delivery, and nutritional support. While central venous catheters (CVCs) are traditionally used, peripherally inserted central catheters (PICCs) offer an alternative option with a potentially favorable safety profile, longer dwell time, and reduced need for re-insertion. This study compares patient characteristics, complication rates, and catheter duration between PICC and CVC lines in pediatric burn patients, advocating for early PICC …
Effect Of Spry Of Potassium Ratio And Cycocel On Physiological Traits Of Maize (Zea Mays L), Asmaa Mohammed Hussein, Eabdallah Yasin Ali
Effect Of Spry Of Potassium Ratio And Cycocel On Physiological Traits Of Maize (Zea Mays L), Asmaa Mohammed Hussein, Eabdallah Yasin Ali
AUIQ Complementary Biological System
The aim of this work was to investigating the effect of foliar application of potassium (K) and the growth regulator Cycocel (CCC) on the physiological traits of maize (Zea mays L). The experiment was designed using a split-plot arrangement within a randomized complete block design (RCBD) with three replicates. The treatments included foliar application of potassium at concentrations of 500, 1000, and 1500 mg.L–1, as well as three concentrations of the growth regulator Cycocel (0, 150, and 200 mg.L–1). The results indicated a significant increase in Protein (P), phosphorus, and carbohydrate contents at the concentration of …
Evaluating The Association Between Chronic Health Conditions And Caregiver Burden For Male Dementia Caregivers, Dareion D. Hill-Smith
Evaluating The Association Between Chronic Health Conditions And Caregiver Burden For Male Dementia Caregivers, Dareion D. Hill-Smith
Walden Dissertations and Doctoral Studies
No abstract provided.
Exploring The Impact Of Mental Health On Childhood Obesity In Southern African American Youth Ages 12-18, Shari Scott Robinson
Exploring The Impact Of Mental Health On Childhood Obesity In Southern African American Youth Ages 12-18, Shari Scott Robinson
Walden Dissertations and Doctoral Studies
No abstract provided.
Organizational Redevelopment: A Systematic Approach To Behavioral Health Mergers, Acquisitions, Or Consolidations, Inesha Shairon Trahan
Organizational Redevelopment: A Systematic Approach To Behavioral Health Mergers, Acquisitions, Or Consolidations, Inesha Shairon Trahan
Walden Dissertations and Doctoral Studies
No abstract provided.
Improving Early Detection Of Dementia In Primary Care, Terry E. Smith
Improving Early Detection Of Dementia In Primary Care, Terry E. Smith
Group: Northern Arizona University School of Nursing, DNP Doctoral Papers
Dementia remains under-detected in primary care despite recommendations to assess cognitive health during Medicare’s Annual Wellness Visit (AWV). Persistent gaps in clinician knowledge and workflow standardization contribute to delayed diagnosis and missed opportunities for early intervention. Strengthening early detection practices is essential to improving outcomes for individuals with dementia. This project aimed to improve early detection of dementia by implementing a brief clinician education program and evaluating its impact on dementia knowledge, mild cognitive impairment (MCI) diagnostic coding, and utilization of the Cognitive Assessment and Care Planning Visit (CACPV). The DNP (Doctor of Nursing Practice) project was conducted in two …
Titanium Dioxide: An Inquiry Into The Mechanisms And Implications Of Exposure In Gut Dysbiosis And Metabolic Disorders, Meghan Gardiner
Titanium Dioxide: An Inquiry Into The Mechanisms And Implications Of Exposure In Gut Dysbiosis And Metabolic Disorders, Meghan Gardiner
Senior Honors Theses
Titanium dioxide (TiO2) is one of the most prevalent food additives utilized in commercial products in the United States. While TiO2 was originally hailed as a nontoxic and cost-effective additive, studies are beginning to reveal that TiO2 is not as safe as it once seemed. TiO2 may contribute to the development of insulin resistance and metabolic disorders through direct and indirect mechanisms. The compound induces gut dysbiosis, leading to alterations in bacterial metabolites and pro-inflammatory cytokines, which results in the selective resistance of glucocorticoid receptors. Additionally, TiO2 itself can translocate from the gut to …
Vol 6. May '26 Cover, Publishing, And Table Of Contents, Donna L. Williams
Vol 6. May '26 Cover, Publishing, And Table Of Contents, Donna L. Williams
Journal of the Louisiana Public Health Association
No abstract provided.
Adherence To Clinical Practice Guidelines For Chronic Venous Leg Ulcers In Federally Qualified Health Centers, Paul Chizoba Ezenwa
Adherence To Clinical Practice Guidelines For Chronic Venous Leg Ulcers In Federally Qualified Health Centers, Paul Chizoba Ezenwa
Walden Dissertations and Doctoral Studies
No abstract provided.
Experiences Of Recent High School Graduates In Missouri Regarding Stress Management And Coping Skills Within Their Health Education Curriculum, Courtney Faye Thomas
Experiences Of Recent High School Graduates In Missouri Regarding Stress Management And Coping Skills Within Their Health Education Curriculum, Courtney Faye Thomas
Walden Dissertations and Doctoral Studies
No abstract provided.
Standardized Pediatric Obesity Screening Guideline For Children Ages 5–17 Years, Jennifer Nacius
Standardized Pediatric Obesity Screening Guideline For Children Ages 5–17 Years, Jennifer Nacius
Walden Dissertations and Doctoral Studies
No abstract provided.
Meeting Their Needs: Experiences Of Uc Berkeley International Graduate Students Navigating Financial Strain, Ryann M. Hirt
Meeting Their Needs: Experiences Of Uc Berkeley International Graduate Students Navigating Financial Strain, Ryann M. Hirt
Master's Theses
Of prior research on student experiences with financial strain, little has specifically focused on international student experiences in higher education while studying in the U.S., in tandem with financial strain. This qualitative study, through utilization of narrative methodology, explores the ways in which international students–in particular, graduate students–experience and navigate financial strain during their studies at a large, R1: Doctoral university: the University of California, Berkeley. The research was guided by three questions: (a) What are UC Berkeley international students’ stories of navigating financial strain? (b) What are the experiences of UC Berkeley international students with external and internal (campus) …
Indocyanine Green Focused Near-Infrared Fluorescence Lymphography Localization In Treatment Of Chyle Leak After Mastectomy With Targeted Left Axillary Sentinel Node Biopsy For Breast Cancer., Bradley C Kruithoff, Dawn Cox, Mark Cripe
Indocyanine Green Focused Near-Infrared Fluorescence Lymphography Localization In Treatment Of Chyle Leak After Mastectomy With Targeted Left Axillary Sentinel Node Biopsy For Breast Cancer., Bradley C Kruithoff, Dawn Cox, Mark Cripe
Women’s Health Articles
We present a woman in her 60s who underwent bilateral mastectomy with left axillary targeted lymph node biopsy in the setting of high grade invasive ductal carcinoma of the left breast with metastasis to a left axillary lymph node. Her postoperative course was complicated by high output milky drainage from her left axillary surgical drain, consistent with a chyle leak, after confirmatory testing demonstrated drain fluid with high triglyceride content. The patient failed non-operative management consisting of low-fat diet and compressive measures. Ultimately, the patient returned to the operating room where indocyanine green near-infrared fluorescence lymphography was used to localized …
Vol 6. May '26 Full Issue, Donna L. Williams
Vol 6. May '26 Full Issue, Donna L. Williams
Journal of the Louisiana Public Health Association
No abstract provided.
Geauxhealth.Org: A Technological Approach To Community Resources In New Orleans, Madelin Mlynczak
Geauxhealth.Org: A Technological Approach To Community Resources In New Orleans, Madelin Mlynczak
Journal of the Louisiana Public Health Association
Background: Connecting patients to appropriate community resources remains a significant challenge for healthcare providers in New Orleans. Existing resource guides have limitations in clinical workflows, highlighting the need for a tool tailored to healthcare professionals. The primary objective of this study was to evaluate the effectiveness of the GeauxHealth.org website in improving medical residents’ and fellows’ knowledge of community resources and decreasing perceived struggle in referring patients to community resources. Methods: We conducted a pre- and post-intervention survey among residents and fellows at two academic institutions in New Orleans. Participants were introduced to GeauxHealth.org, a locally developed and searchable online …
Circulating Metabolites Associated With Protection Against Mycobacterium Tuberculosis Infection And Inhibition Of Mycobacterial Growth, Todia P Setiabudiawan, Lika Apriani, Julian Avila-Pacheco, Edwin Ardiansyah, Vinod Kumar, Bachti Alisjahbana, Ayesha J Verrall, Andrew R Dinardo, Agnes R Indrati, Vera P Mourits, L Charlotte J De Bree, Simone J C F M Moorlag, Clary B Clish, Leo A B Joosten, Arjan Van Laarhoven, Krista E Van Meijgaarden, Mihai G Netea, Simone A Joosten, Valerie A C M Koeken, Philip C Hill, Reinout Van Crevel
Circulating Metabolites Associated With Protection Against Mycobacterium Tuberculosis Infection And Inhibition Of Mycobacterial Growth, Todia P Setiabudiawan, Lika Apriani, Julian Avila-Pacheco, Edwin Ardiansyah, Vinod Kumar, Bachti Alisjahbana, Ayesha J Verrall, Andrew R Dinardo, Agnes R Indrati, Vera P Mourits, L Charlotte J De Bree, Simone J C F M Moorlag, Clary B Clish, Leo A B Joosten, Arjan Van Laarhoven, Krista E Van Meijgaarden, Mihai G Netea, Simone A Joosten, Valerie A C M Koeken, Philip C Hill, Reinout Van Crevel
Faculty, Staff and Students Publications
A significant proportion of individuals who are heavily exposed to infectious tuberculosis patients do not acquire Mycobacterium tuberculosis (Mtb) infection, as detected by an interferon gamma release assay (IGRA). We examined circulating metabolite profiles and metabolic genotypes in 199 heavily exposed IGRA-negative tuberculosis household contacts in Indonesia. Based on differentially abundant metabolites, activity of several pathways including arachidonic acid, arginine and proline, glutathione, and tryptophan metabolism, correlated with a negative IGRA at three months. SNPs near PRODH (involved in arginine and proline metabolism) were associated with circulating proline concentrations and persistently negative IGRA results, while SNPstudys near AFMID (involved in …