Digital Commons Network^™

Development Of A Bidirectional Tmv-Based Plant Expression Vector For Dual Gene Co-Expression, Matisse Schutten-Burgess

Scripps Senior Theses

Monoclonal antibodies, or mAbs, have recently joined the growing array of biopharmaceuticals used to treat a variety of chronic, autoimmune, and infectious diseases. Antibody therapy is highly customizable, as mAbs can be genetically engineered to target specific disease markers. Traditional systems of producing monoclonal antibodies use mammalian cells, most prominently Chinese Hamster Ovary Cells. While these systems are widely used, they are time-intensive and costly. Because of this, plant-based antibody production systems have risen in prominence, as they provide a more cost-efficient and faster way to generate antibodies. One drawback that has surfaced is that the co-expression of antibody heavy …

Assessing The Effect Of Wildfire-Specific Air Pollutants On Copd Hospitalizations In Los Angeles County, Kimberly Young

Scripps Senior Theses

As the fourth leading cause of death in the world, chronic obstructive pulmonary disorder (COPD) is one of the most severe respiratory disorders characterized by airway inflammation.  For the past two decades, climate change has exacerbated the prevalence of wildfires in California due to rising temperatures and lower precipitation. With the influx of wildfires, poor atmospheric air quality continues to be a serious health problem in the Los Angeles area, especially after the recent Eaton fire in January of 2025. My study hopes to assess whether the air pollutants particulate matter 2.5 (PM_2.5), particulate matter 10 (PM_{10 …}

The Role Of Satirical And Self-Deprecating Humor In Destigmatizing Mental Health In Black Women, Zoe S. Cooper

Scripps Senior Theses

Black humor has long served as a mode of resilience, critique, and emotional expression for Black communities, yet its potential to reduce mental health stigma among Black women remains underexplored. This study examined whether exposure to culturally grounded satirical or self-deprecating humor reduces internalized mental health stigma among Black women and individuals who have experienced Black womanhood. It further investigated whether humor moderates the relationship between endorsement of the Black Superwoman Schema and internalized stigma, a framework closely tied to emotional suppression and stigma in Black women’s mental health. Participants were Black/African American women ages 18–30, as well as individuals …

Climate Change In An Educational Context: A Model Addressing Psychological Distance, Hope, And Concern, Brooke E. Kasl-Godley

Scripps Senior Theses

As the threat of climate change becomes more urgent, educators should focus on fostering climate concern and action instead of simply providing climate information. These studies present a novel model of climate education where locally-framed and action-oriented curriculum increases students’ environmental concern through the mechanisms of psychological distance and hope. This curriculum was taught over two years to sixth-grade students at a school in the Los Angeles Metropolitan Area. Study 1 examines students’ environmental concern and sense of responsibility before and after delivery of the curriculum. Study 2 is a proposed follow-up study, that will address limitations of Study 1 …

L'Affaire Baby Loup : Nouvelle Laïcité Ou Laïcité Coloniale ?, Grace Gorden

Scripps Senior Theses

La saga juridique de la crèche Baby Loup, où une directrice-adjointe était licenciée pour avoir porté le voile au travail, est souvent proclamée comme l'instauration de la « nouvelle laïcité » en France.  L'arrêt Baby Loup fait partie d'une série de changements sur la laïcité depuis les années 1980 en France, où le principe de laïcité devient de plus en plus associé au domaine privé. Le jugement final de la saga Baby Loup établit que la discrimination religieuse doit être jugée selon des normes de proportionnalité et de justification. Ce renoncement au principe de laïcité dans les tribunaux et ensuite …

Recipes And Resources: Food As A Decolonial Tool For The 1.5 Generation, Reyna Guadalupe Silva Carrillo

Scripps Senior Theses

Food is more than just nourishment for the 1.5-generation, people who come to the United States as children and now navigate between cultures; it is a language of memory, resistance, and survival across borders. This project raises an important question: how do 1.5-generation students navigate identity, belonging, and survival through food, and how can a zine serve as a medium for sharing community knowledge? My project argues that food is an important way 1.5-generation students use language to remember, resist, and survive across borders. Using pláticas, an informal conversation-based approach, this project focuses on the experience of 1.5-generation students at …

Implementing Climate Remedies, Camila Bustos

Elisabeth Haub School of Law Faculty Publications

Climate change litigation has emerged as a powerful tool for addressing the climate crisis, particularly in the face of executive and legislative inaction. Across jurisdictions, courts have issued landmark decisions mandating stronger mitigation targets and recognizing rights-based claims against governments and corporations. While recent scholarship has examined the trends, legal theories, and broader effects of this relatively new phenomenon, it has primarily focused on bringing and winning legal challenges. Less attention has been paid to a crucial phase: the implementation and enforcement of judicial rulings. A deeper understanding of how climate remedies are implemented can provide valuable insights for climate …

Otras Iluminaciones. Narrativa, Cultura Y Psicodélicos. Otras Iluminaciones. (2nd Edition), Alberto Ribas-Casasayas, Ana Luengo

Faculty Book Gallery

No abstract provided.

Simulated Oral Environment Affects Zirconia Aging And Mechanical Strength, Danyal A. Siddiqui, Smriti G. Natarajan, Bhuvana L. Chandrashekar, Danieli C. Rodrigues

School of Podiatric Medicine Publications

Background: Zirconia is an emerging alternative to titanium for dental implant systems. However, zirconia surfaces can deteriorate under aqueous conditions, thereby compromising mechanical performance. The goal of this study was to assess the impact of biological exposure or aging simulating the oral cavity on the surface integrity and mechanical strength of surface-treated zirconia.

Methods: Partially yttria- or magnesia-stabilized zirconia specimens were polished, acid-etched, or sandblasted. Zirconia disks were exposed to mammalian cells or bacteria. Surface degradation via tetragonal-to-monoclinic phase transformation was assessed by Raman microscopy. Zirconia bars were subjected to accelerated aging by exposure to autoclave steam. Surface morphology was …

Case Report: Primed Dendritic Cell Immunotherapy For Multiple Solid Tumors, Jeffrey Jones, Aly Alrabaa, William Decker, Luis Ferbeyre, Gregorio Viramontes, Rafael Gonzalez, Elideth Angulo, Antonio Zamudio, Raul Hernandez, Stephen Noga, Susana Hernandez-Reyes, Paul Zhang, Darryl Smith, Ara Karamanian, Luis Tamara, Dalton Greenwood, Matthew Halpert

Faculty, Staff and Students Publications

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard treatments, such as immune checkpoint inhibition, radiation, surgery, or endocrine therapy. Five patients, including prostate adenocarcinoma (n=1), malignant …

Evaluating Mesothelin As An Immunotherapeutic Target For Endogenous T Cells, Kiriakos Koukoulias, Ryu Yanagisawa, Alejandro G Torres Chavez, Penelope G Papayanni, Yovana Velazquez, Hyun-Sung Lee, Spyridoula Vasileiou, Ann M Leen

Faculty, Staff and Students Publications

Background: Mesothelin (MSLN) is a GPI-anchored cell surface glycoprotein that is overexpressed in various solid tumors, including mesothelioma, triple-negative breast cancer, colon, ovarian and pancreatic cancer, with restricted normal tissue expression.

Methods: To explore the immunogenicity and immunotherapeutic potential of MSLN to T cells with native receptor specificity, 29 individuals of diverse HLA backgrounds were interrogated for T cell activity against MSLN.

Results: Twenty one (72%) subjects (21/29) mounted a specific T cell response when repetitively challenged with MSLN antigen. Reactive cells were Th1-polarized, polyfunctional, predominantly detected in the CD8+ T cell compartment and cytotoxic toward autologous and MSLN+/HLA-matched tumor …

Pd-L1-Centric Whole Blood-Based Immune Signature Profiles Of Tuberculosis Patients During Therapy, Johanna Eggeling, Martina Sester, Christoph Lange, Jan Heyckendorf, Barbara Kalsdorf, Anna M Mandalakas, Andrew R Dinardo, David Lewinsohn, Dagmar Schaub, Tina Schmidt, Eva Tolosa, Maja Reimann, Patricia M Sánchez Carballo

Faculty, Staff and Students Publications

This prospective study investigated whole blood-based immune cell biomarkers for pulmonary tuberculosis (TB) immunoprofiling. Blood samples from 34 healthy controls and 51 tuberculosis patients were analyzed at three timepoints: Prior to therapy (T0), after 14 days of therapy (T1), and at the end of treatment (Te). Using multiparameter flow cytometry, 386 immune cell populations were analyzed. Predictive models were developed using two machine learning algorithms. A TB5LF change score, which was based on five cell populations, effectively distinguished tuberculosis patients from controls (AUC = 0.89) and tuberculosis patients before and at the end of treatment (AUC = 0.92). Similarly, the …

Utilizing A Culture System For Horizontal Cells To Study Neural Circuit Assembly In The Developing Mouse Retina, Ross M Perez, Yong H Park, Ajeet Singh, Collin Todora, Marlon F Mattos, Daniela Becerril, Rajashree Venkatraman, Arlene A Hirano, Nicholas C Brecha, Rinki Ratnapriya, Benjamin J Frankfort, Elizabeth Zuniga-Sanchez

Faculty, Staff and Students Publications

The precise wiring of the nervous system relies on neurons extending their processes at the right time and place to find their appropriate synaptic partner. The mechanisms that determine when and where neurons extend their neurites during synaptogenesis remains a central question in the field. In the present study, we used a cell culture system coupled with live imaging to investigate the wiring mechanisms in the developing mouse retina. We focused on horizontal cells which are a class of interneurons in the outer mouse retina known to synapse selectively to the distinct types of photoreceptors. Previous research has shown horizontal …

Updates In Mycobacterial Keratitis Diagnosis And Treatment, Uma L Balakrishnan, Ryan T Wallace, Patricia Chévez-Barrios, Alejandro Arboleda, Masih U Ahmed

Faculty, Staff and Students Publications

Mycobacterial keratitis is an uncommon but challenging form of infectious keratitis, often associated with postsurgical eyes. Clinical presentation is variable and may be difficult to recognize, resulting in delays in diagnosis and challenges in management. Traditional diagnostic techniques from corneal scrapings are limited by slow organism growth and may yield negative results. Treatment is challenging due to antimicrobial resistance and typically requires prolonged multidrug therapy. Advances in diagnostic modalities, antimicrobial therapies, surgical approaches, and adjunctive treatments such as corneal crosslinking have improved clinicians' ability to mitigate or avoid severe visual consequences. Despite these developments, optimal management strategies remain incompletely defined, …

Roots To Recovery: How Therapeutic Horticulture Can Heal Sexual Trauma, Fiona E. Larsen-Teskey

Scripps Senior Theses

Sexual assault is one of the most prevalent sources of trauma among females. While still requiring more research, therapeutic horticulture (TH), also known as gardening therapy, has so far shown promising results regarding trauma recovery. In this study, I seek to discover how TH can aid in female sexual assault recovery. To determine its impact, I will conduct a three-month experiment with two groups: those who receive cognitive behavioral therapy (CBT) and those who receive CBT plus TH. I will specifically measure three common side effects survivors face: dissociation, shame, and PTSD. These categories will be measured through surveys and …

Doikayt And The Ethics Of Belonging: Lessons In Place-Making From The Jewish Labor Bund, Zoë L. Jacobs

Scripps Senior Theses

This thesis traces the evolution of doikayt—the Bundist principle of hereness—from its origins in the Jewish Labor Bund to contemporary applications in North America. Rooted in a refusal of both assimilation and nationalist escape, doikayt emphasizes cultivating safety, solidarity, and belonging through collective responsibility rather than territorial claims.

Building on this foundation, the exploration situates hereness within a settler-colonial context, where ethical dwelling is complicated by Indigenous dispossession. Drawing on Alexis Shotwell alongside Indigenous thinkers Vanessa Watts and Kyle Whyte, I examine how inhabiting place requires confronting historical injustices and ongoing relational responsibilities. Chapter 3 analyzes Linke Fligl (2016–2022) as …

Art Therapy’S Effect On The Social And Emotional Skills Of Children With Autism: A Naturalized Parent Mediated Design, Abigail Adell

Scripps Senior Theses

This study examines the effect of art therapy on the social and emotional skills of children with autism. Using sensitive design and language, participants will take the CARS2 and ADOS-2 and then undergo an eight-week art therapy program. Families will attend weekly training sessions at the autism center their child already attends for eight consecutive weeks, with each session lasting approximately 90 minutes. Parents will implement the assigned art activity at home five times per week between training sessions, with each home session lasting fifteen to twenty minutes. The program uses a naturalized parent-mediated design so topics and projects can …

Boredom And Creativity: The Effects Of Unstructured Play Versus Screen Time On Creative Performance, Vivienne J. Swenson

Scripps Senior Theses

Children today spend increasing amounts of time engaged with digital media, raising questions about how screens may displace developmental experiences that support creativity. Although research suggests that unstructured play and even mild boredom can facilitate divergent thinking, few studies have directly compared unstructured, self-directed play with passive screen use in early childhood. The present study proposes an experimental design to examine whether 20 minutes of unstructured play leads to higher creativity scores on the Thinking Creatively in Action and Movement (TCAM) than an equivalent period of passive screen engagement among children ages 3–5. Using matched-group assignment based on demographic, cognitive, …

Lights, Camera, Aggression!: Exploring The Relationship Between The Horror Genre And Criminality, Taylor M. Wanke

Scripps Senior Theses

This proposed correlational study will examine the effect of exposure and involvement with the horror genre in media and the crime genre in media on one’s antisocial personality traits, criminal thinking, criminal behavior/aggression, and morality in the general population and those who are currently incarcerated. Data will be collected through a Qualtrics survey accessed online for the general sample and printed out for the incarcerated sample. Each participant will complete exposure checklists, involvement scales for each genre, and multiple measures to record their level of each dependent variable. Data will be analyzed using a correlational analysis, 1-sample t-tests, and a …

The Silent Language Of Trauma: Defendant Behavior, Juror Bias, And Expert Testimony, Jensen Goldman

Scripps Senior Theses

Trauma can profoundly influence behavioral presentation, yet jurors often rely on demeanor as a diagnostic cue for guilt, credibility, and remorse. Such reliance poses risks within a legal system that seldom equips jurors to interpret trauma related behaviors accurately. The proposed study will examine how two trauma-linked affective presentations– overemotionality and flat affect– shape juror perceptions of credibility and guilt, and whether expert psychological testimony about trauma-related affect can mitigate these biases. Online survey participants will read one of five trial vignettes with varying defendant conditions (flat affect vs. overemotional) and varying expert testimony conditions (present or not present) and …

Information Law Pluralism, Hannah Bloch-Wehba

Faculty Scholarship

Information-intensive activities are reshaping political, social, and economic institutions. As they respond to these shifts, legislators and regulators are embracing information as a regulatory device for tech. Far from limiting themselves to public disclosure, consumer notice, and other traditional mechanisms of fostering transparency and information flows, however, legislators are using other, more nuanced tools to incentivize regulated entities to obtain, generate, and share information.

This Article maps the landscape of the emerging information-based regimes for regulating tech and assesses their conceptual and practical implications. It canvasses an extensive set of recently enacted laws regulating the information economy and shows that, …

Equal Justice & Generative Ai, Milan R. Markovic

Faculty Scholarship

The United States has long suffered from unequal access to justice, with countless low-and middle-income Americans forced to navigate the legal system alone. Recently, prominent judges, lawyers, and scholars have seized on generative AI as a potential corrective. These techno-optimists maintain that ChatGPT and other large language models can demystify the law and address unmet legal needs. Chief Justice John Roberts has proclaimed that AI-based tools "have the welcome potential to smooth out any mismatch between available resources and urgent needs in our court system."

Although AI will be an increasingly important source of legal assistance for underserved populations, the …

Prevalence Of Substance Use In Northwest Syria: A Cross-Sectional Study, Isabel Draper, Dania Albaba, Heba Mesbah, Huda Taktak, Nidhal Saadoun, Mohammad Alhusein, Elharit Alissa, Anas Barbour, Zaher Sahloul, Nidal Moukaddam

Faculty, Staff and Students Publications

Objectives: Syria has undergone significant socio-political turmoil since 2011 as internal conflict displaced portions of the population, destroyed infrastructure, and destabilized the economy. In the context of multilevel healthcare system disruptions, there have been increasing reports of substance use. This study seeks to evaluate patterns of substance use in Northwestern Syria.

Methods: Trained staff administered questionnaires to community members in Azaz, Syria. Questions focused on the substance use prevalence, societal and public health impacts, and perspectives on treatment availability.

Results: 480 individuals were surveyed (80·88% male, 19·12 % female; 43·39% were 18-25 yrs, 11·5% reported personal substance use). H-booz (amphetamines), …

Challenges In The Diagnosis Of Concurrent T-Lymphoblastic Leukemia/Lymphoma And Thymic Neuroendocrine Carcinoma: A Case Report, Kristen Oliveira, Mary Doan, Ying Pei, Marwan Yared, Songlin Zhang

Faculty, Staff and Students Publications

The co-occurrence of T-lymphoblastic leukemia/lymphoma and thymic neoplasia is a rare event that can present a diagnostic challenge. In this case report, we describe a 31-year-old man who was found to have thymic neuroendocrine carcinoma and T-lymphoblastic leukemia/lymphoma 2 years after initial treatment for T-lymphoblastic leukemia/lymphoma. The thymic neuroendocrine carcinoma was initially detected in a malignant pleural effusion, and a retrospective review of a preceding lung biopsy suggested the involvement of both tumors within one tissue sample. Immunohistochemical analysis was imperative in highlighting these two elements because despite their unique cytomorphological characteristics, a limited amount of each component was seen …

Integrating A Project-Based Learning Methodology Into A Department-Wide Quality Improvement Curriculum: A Nine-Year Experience In Pediatric Subspecialty Training, Venessa Lynn Pinto, Danny Castro, Constance M Wiemann, Liza Bonin, Cagri Yildirim-Toruner, Nicholas A Ettinger, Sharada Hiranya Gowda, Joyee Vachani, Mehmet Fatih Okcu

Faculty, Staff and Students Publications

Background: Quality improvement (QI) training of subspecialty fellows is an essential component of graduate medical education, yet often delivered in silos within departments through a variety of instructional methodologies.

Objective: We applied project-based learning (PjBL) as a guiding methodology for a QI curriculum for pediatric subspecialty fellows and describe our curriculum development, instructional design, and its implementation.

Methods: We integrated the Institute for Healthcare Improvement (IHI) Model for Improvement with the 6 key features of PjBL: a driving question, defined learning goals, active participation in educational tasks, collaboration among learners, scaffolding with learning technology, and production of tangible artifacts. The …

Character Kinetics: An Interactive, Immersive Installation On The Mindfulness Of Asemic Writing, Danielle S. Desmarteau

Scripps Senior Theses

Character kinetics is an installation art piece that explores how writing asemically (without language) can ease the body and mind into the present moment, allowing one to focus on the material and movement of mark-making. Throughout the semester, I held workshops where participants were invited to scribble it out, to express their thoughts and surroundings without needing to make sense in the context of language. The resulting pieces were transformed into sculptural paper forms suspended in air, creating an interactive three-dimensional space inviting viewers to analyze the infinite possibility of interpretation within asemic symbolism.

Modern Psychological Distress: An Expressionist Lens, Abigail Adell

Scripps Senior Theses

“Static Overwhelm” showcases collective stress born from perpetual engagement with the internet and social media. The piece began as a personal reflection of my felt anxiety from online overuse. However, it quickly became a greater social commentary on the modern condition of internet dependence, stress, and unease.

With any basic search engine, any amount or type of information that I could ever need, is at my fingertips. We constantly experience the stress effects of the internet’s misinformation, political pressure, and addictive design.

Inspired by the expressionist movement, I have created a piece that focuses on the expression of raw emotion, …

Seeing Through The Fuzz: Understanding Conformational Diversity In The Fuzzy Coat Of Amyloids Across Fibril Polymorphs Using Solid-State Nmr, Carah K. Allen

Scripps Senior Theses

The aggregation of α-synuclein (α-syn) into amyloid fibrils is a central pathological hallmark of Parkinson’s disease and other related synucleinopathies. Although monomeric α-syn is intrinsically disordered, the protein assembles into multiple fibril polymorphs that differ in their β-sheet core structures. Surrounding each polymorph is the “fuzzy coat,” which is a highly dynamic, intrinsically disordered region (IDR) that is not resolved by high-resolution structural techniques, such as Cryo-EM, but is thought to influence fibril interactions, propagation, and toxicity. Understanding whether different polymorphs maintain distinct fuzzy-coat conformational ensembles is therefore essential for connecting amyloid structure to biological function. To address this question, …

Madison, Wisconsin As A Climate Haven: Infrastructure, Environmental Justice, And Community Voice, Sophia N. Heffner

Scripps Senior Theses

As climate change accelerates internal migration within the United States, the concept of “climate havens” has emerged as a way to identify communities that may become receiving zones for displaced populations. Madison, Wisconsin has increasingly been positioned within academic, policy, and media discourse as a potential climate haven due to its geographic advantages, strong public infrastructure, and proactive climate policy environment. This paper evaluates Madison’s readiness for this role through an equity-centered, participatory planning lens. Drawing on planning documents, climate data, municipal policies, and interdisciplinary scholarship, it argues that Madison’s long-term success as a sustainable and inclusive climate haven depends …

Cycling For All: Designing With The "Invisible Cyclist" As A Pathway Towards Urban Sustainability And Citizenship, Eloise Heimert

Scripps Senior Theses

This thesis explores the role of “invisible cyclists” in cycling networks and practices. Through an application of the “right to the city,” spatial production, and mobility justice frameworks, this paper investigates the experiences of women and disabled cyclists in London, England. By examining a city with an emerging cycling network, this thesis offers insight into measures for increasing the inclusivity and resilience of them. The argument establishes that these lines of analysis reveal important lessons in urban design and planning for a more sustainable future. Firstly, this thesis examines social barriers to cycling participation, and thus urban citizenship. In the …