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2026

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Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone Jan 2026

Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone

2020-Current year OA Pubs

UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …


Healthy Places Healthy People Toolkit: A Resource For The Navajo Nation, Sally Davis, Elijah Maas, Marla Pardilla, Sheldon Benally, Latasha James, Carmella Kahn, Cindy Blair, Julia Hess, Tyrell Pablo Jan 2026

Healthy Places Healthy People Toolkit: A Resource For The Navajo Nation, Sally Davis, Elijah Maas, Marla Pardilla, Sheldon Benally, Latasha James, Carmella Kahn, Cindy Blair, Julia Hess, Tyrell Pablo

Healthy Places, Healthy People Toolkit

The University of New Mexico’s Prevention Research Center (UNM PRC) developed an evidence-based model to increase physical activity in rural communities in NM. Starting in the small, rural town of Cuba, NM, the model was expanded to other rural communities. Given the success of the model, the PRC was invited to partner with 10 Navajo Chapters (communities) in the Eastern Agency of the Navajo Nation, with funding from the Centers for Disease Control and Prevention (CDC). Together, they engaged in a project called Healthy Places— Healthy People.