Digital Commons Network^™

Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone

2020-Current year OA Pubs

UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …

Cgrp Expression And Signaling Sensitization In A Mouse Model Of Chronic Oxaliplatin-Induced Peripheral Neuropathy, Junwei Du, Leland C Sudlow, Margaret H Johnson, Kanishk Satish, Abraham Villagomez, Hongzhen Hu, Mikhail Y Berezin

2020-Current year OA Pubs

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and dose-limiting side effect of oxaliplatin treatment, yet its molecular mechanisms remain incompletely understood. Calcitonin gene-related peptide alpha (CGRPα, encoded by

Come And See: Exploring Complex Dynamics And Abjection Through A Southern Gothic Family Portrait, Lenee N. Peterson

Graduate Studies Theses and Dissertations 2026

“COME AND SEE: Exploring Abject Theory Through a Southern Gothic Family Portrait” examines the artist’s complex familial upbringing through the visual and narrative traditions of Southern Gothic art. Drawing upon abject theory and the cultural references of folk horror and Southern Gothicism, this thesis positions the family portrait where intimacy, trauma, and cultural inheritance collide. The project argues that direct confrontation with abjection can foster recognition, shared experience, and the possibility of collective healing. Grounded in practice-based research, this work functions as a critical and creative response to familial strain shaped by scarcity, social oppression, and emotional precarity. Through a …

Fgf19 As A Colorectal Cancer Serum Biomarker And Fgfr4 As A Mediator Of Anti-Her2 Resistance In Breast Cancer, Jordan Beardsley

Graduate Studies Theses and Dissertations 2026

The fibroblast growth factor 19 (FGF19)-fibroblast growth factor receptor 4 (FGFR4) signaling pathway regulates hepatic metabolism, bile acid (BA) synthesis, and hepatocyte proliferation. This signaling axis also is implicated in promoting tumor progression, therapeutic resistance, and metastasis in certain cancers.

In colorectal cancer (CRC) there is a critical need for non-invasive biomarkers for disease detection and monitoring. We identified FGF19 as a candidate CRC serum marker through meta-transcriptomics and found FGF19 to be expressed and secreted by CRC cell lines. Tumor-derived FGF19 was detectable in mouse serum at levels correlating with tumor volume in a subcutaneous xenograft model. RNA sequencing …

Investigating The Anti-Apoptotic Properties Of The N-Terminus Of The Chlamydia Trachomatis Effector Tarp, Kasey S. Jordan

Graduate Studies Theses and Dissertations 2026

As the most prevalent bacterial STI in the United States and leading cause of infection-related blindness worldwide, the obligate intracellular bacteria, Chlamydia trachomatis (Ct), poses a significant threat to public health. As an obligate intracellular bacteria, invasion of the host cell is a crucial step in Chlamydia’s developmental cycle. To drive invasion, Ct injects prepackaged effectors into the host cell using a T3SS. An early Chlamydial effector, translocated actin recruiting phosphoprotein, or Tarp, interacts with host cell actin to promote invasion, mediated via Tarp’s C-terminal region. Although the function of Tarp’s C-terminus is well defined, the Tarp’s N-terminus …

Towards An Understanding Of Learning In Immersive Virtual Reality: Investigating Learning Affordances To Bridge Theory And Practice, Gregory Mcgowin

Graduate Studies Theses and Dissertations 2026

This dissertation examines how modality-specific scaffolding shapes performance, presence, and transfer in immersive virtual reality (I-VR). Framed through theories of extended cognition, real-time guidance is conceptualized as cognitive scaffolding that structures perception and action by embedding task-relevant information within the environment. Situated within the learning sciences and informed by 4E cognition (embodied, embedded, enactive, extended), this work develops a framework for understanding how I-VR affordances relate to learning and performance.

The empirical study investigates how scaffolding modality (audio vs. visual) influences presence and performance in a VR racing simulation. Using a 3 × 2 × 2 mixed factorial design, 111 …

Juegos De Rol Para Colaboraciones De Investigación Interdisciplinar, Sarah Lynne Bowman, Josefin Westborg, Cristo Leon, Antonio Luis Casado Da Rocha, Esteban Etxeberria

STEM for Success Resources

Juegos de rol para colaboraciones de investigación interdisciplinar presenta los juegos de rol como una herramienta formativa para fortalecer la colaboración en equipos de investigación interdisciplinaria. La obra explica cómo el role-playing puede ayudar a desarrollar competencias comunicativas, reflexivas y organizativas necesarias para trabajar entre disciplinas, especialmente en contextos académicos donde los problemas complejos requieren coordinación, negociación de saberes y construcción compartida de conocimiento. Esta traducción al español amplía el acceso a un enfoque innovador para universidades, centros de investigación, facilitadores, docentes y equipos interesados en mejorar sus prácticas colaborativas mediante metodologías participativas, experienciales y orientadas a la investigación. Libro …

Navigating Technology In The Secondary Ela Classroom: Written By Teachers For Teachers, David M. Grant, Alexandra Parham, Ashley Webb, Kimberly Cavalier, Erin Neebel, Amber Schouten

Faculty Book Gallery

This collection is a digital project of dedicated teacher-scholars who met in the summer of 2025 as part of the University of Northern Iowa’s graduate program in Teaching English in the Secondary Schools (TESS). Using the theoretical lens of multiliteracies, developed by the New London Group in the 1990s, students examined the impacts of several electronic and digital technologies on their students and their teaching, especially Artificial Intelligence, or A.I. Through fiction, nonfiction, and discussion, students considered the changes, the challenges, and the opportunities these technologies held. Most importantly, they investigated what these developments meant for their teaching, their districts, …

Part 6: Housing In Hampton Roads, Dragas Center For Economic Analysis And Policy, Old Dominion University

State of the Region Reports: Hampton Roads

In this chapter, we discuss the state of housing in Hampton Roads. We focus on the supply side of the market for reasons that will become apparent throughout the chapter. We start with single-family housing and then discuss multi-family housing. We then explore factors that influence the supply of housing across the region. We conclude with actions that Hampton Roads can take to address the supply and, by extension, the affordability of housing in the region.

Ambulatory Monitoring Of Biomarkers For Enhanced Recovery, Lucas Abrahamian, Gurman Dhami

Bioengineering Senior Theses

Oxidative stress, an imbalance of reactive oxygen species and antioxidants, serves as both a marker and progressor of several chronic and degenerative diseases. These conditions create a major global health burden, accounting for significant cost and deaths. The prevalence of oxidative stress–driven diseases highlights the need for improved strategies to detect the imbalance before irreversible damage occurs. However, despite its major role in disease progression, oxidative stress is typically assessed using static, invasive, or laboratory methods. These approaches are poorly suited for continuous monitoring and fail to serve high-risk groups, such as patients with a family history of disease or …

Development Of In Vitro Hydrogel Blood Clots, Xiomara Garcia, Jasmine Urbina, Sapna Wolf

Bioengineering Senior Theses

Deep Vein Thrombosis (DVT) affects up to almost one million individuals in the United States annually and can lead to life-threatening complications, such as a pulmonary embolism. DVT occurs when a thrombus composed of platelets and fibrin forms within deep veins, obstructing blood flow. Current treatments include anticoagulants, thrombolytics, inferior vena cava filters, and balloon catheter procedures. However, the development and testing of these medical devices heavily rely on animal blood models due to physiological similarities in coagulation, raising ethical concerns and limitations related to cost, scalability, and sustainability. This project proposes a synthetic, in vitro alternative using agarose and …

The Role Of Adolescent Attachment In The Relationship Between Trauma And Identity, Ellie Mitova

Graduate Studies Theses and Dissertations 2026

Traumatic experiences have been shown to influence identity development during emerging adulthood, a complex developmental period. However, research examining how trauma interacts with adolescent attachment qualities to shape identity processes remains limited. Previous studies have primarily focused on infant attachment styles and their long-term developmental outcomes, leaving a gap in understanding how attachment qualities developed through relationships with parents and peers during adolescence may influence identity development in emerging adults. Additionally, while traumatic experiences have been associated with maladaptive identity processes such as rumination and identity distress, some research suggests that trauma may also contribute to deeper identity exploration and …

Character Judgements Of Rap Music Fans, Kaila C. Putter, Dan J. Miller, Amy M. Belfi, James Rees, Amanda E. Krause

Psychological Science Faculty Research & Creative Works

Extending Fischoff, we used vignettes to examine people's perceptions of a hypothetical rap fan accused of murder. Study 1 (N = 300) used a 2 (murder accusation) x 2 (inclusion of rap lyrics) x 2 (fan gender) experiment, asking participants to judge how capable of murder and sexually aggressive they found the fan. The presentation of lyrics and murder accusation were associated with the fan being more capable of murder, while rap lyrics and participants' rap attitudes were associated with the fan being more sexually aggressive. Thematic analysis revealed that, in conditions containing both the lyrics and the murder accusation, …

When The Internet Attacks, Craig Cowie

Cardozo Law Review

Courts have struggled with applying personal jurisdiction in cases involving intentional torts where the defendants act outside the forum, and the problem is particularly apparent and acute when the defendants use the internet to commit the tort. For example, is there jurisdiction when a defendant doxxes someone and calls for violence? What if they leave a bad Yelp review? Or tweet a defamatory statement? Courts have used many tests for determining whether personal jurisdiction is appropriate in these situations, but there has been relatively little recent scholarship on whether these tests are appropriate for analyzing personal jurisdiction in these contexts. …

Rivers Of Sovereignty: The Epa’S New Water Quality Standards Rule As A Potential Channel For Revitalizing Tribal Reserved Water Rights, Mostyn Josty

Cardozo Law Review

This Note explores the federal government’s evolving approach to its obligation to protect tribal reserved water rights through a case study of the Environmental Protection Agency’s (EPA) 2024 Water Quality Standards Regulatory Revisions to Protect Tribal Reserved Rights rule (the “WQS Rule”). It argues that while the WQS Rule represents a step forward in safeguarding tribal water rights, the legal challenge it faces underscores broader issues of federalism, administrative authority, and the country’s fluctuating commitment to tribal sovereignty. The Note examines the WQS Rule’s legal foundation, its potential challenges, and the implications for tribal self-determination, emphasizing the need for a …

Does The Internet Equalize Youth’S Civic Engagement? Examining Online And Offline Civic Engagement Among Adolescents And Young Adults, Yue Ni

Psychology Faculty Publications and Presentations

In this study, I examined disparities in online and offline civic engagement among 400 youth aged 15-25 years (Mage = 20.9; SD = 3.1) by subjective socioeconomic status (SES), race/ethnicity, and immigrant status. Results indicated that patterns of disparities in online civic engagement largely mirrored those observed offline. SES was the most consistent predictor: Youth who perceived their families as more well-off reported higher participation across both online and offline civic activities. In contrast, no significant differences were found between white youth and youth of color. Foreign-born youth reported higher levels of civic engagement in online and several …

The Ocean Is Not A Machine: A Feminist Media Analysis Of Oceanographic Models, Simulations, And Futures, Clarissa Chevalier

Study of Women, Gender, & Sexuality: Faculty Publications

This article examines how scientific and artistic representations and technologies shape ocean futures. Dominant Western oceanography frequently engages mechanistic metaphors that conceptualize the ocean as a machine, pump, or carbon sponge. This way of visualizing the ocean, guided by the logics of control and quantification, shapes contemporary remote sensing, modeling, and prediction technologies. Alternative approaches to oceanographic representation, including Indigenous, anticolonial, Black feminist, and artistic approaches, offer critical counterweights to destabilize the authority granted to mechanistic oceanographic representations. Ocean simulations and scale models are infrastructures through which ocean futures are rendered and presented in multidimensional space. Through a comparative media …