Digital Commons Network^™

A Unified Automated And Explainable Ai Framework For Drug Discovery, Clinical Diagnostics, And Public Health Data Prediction, Lord Coffie

College of Graduate Studies: Theses & Dissertations

This thesis investigates the development of automated, explainable artificial intelligence systems to improve automated scientific discovery, clinical diagnostic support, and public health decision-making. Three independent yet thematically aligned studies were conducted across cheminformatics, radiology, and population health. Study A introduces an automated and explainable machine learning pipeline for Quantitative Structure–Activity Relationship (QSAR) modeling using RDKit-derived molecular descriptors. The pipeline performs systematic preprocessing, consensus-based feature selection (mutual information, random forest importance, RFECV), and benchmarks six supervised models—Random Forest, XGBoost, Support Vector Machine, Balanced Random Forest, EasyEnsembleClassifier, and a blended meta-ensemble, achieving AUC = 0.90 and accuracy = 0.83, while ensuring interpretability …

Varying Dna Methylation Patterns In The Florida Sand Skink (Plestiodon Reynoldsi) In Relation To Fire Histories, Victoire Hj Litre

College of Graduate Studies: Theses & Dissertations

Epigenetics is the study of changes in phenotype not caused by changes in DNA sequence. DNA methylation is the most well-studied epigenetic mechanism in an ecological context. Reptiles use DNA methylation to respond to environmental stressors and differences among habitats. The Florida Sand Skink (Plastidome reynoldsi) is federally listed as a threatened species. They are endemic to the threatened, fire-dependent Florida scrub habitat. As they persist in burned habitats, the Florida Sand Skink must be able to rapidly respond to wildfires. To better understand how the Florida Sand Skink adjusts to fire-driven habitat changes, it is important to …

Ai-Driven Real-Time Detection Of Zero-Day Browser Exploits Using Webassembly-Based Instrumentation, Temitope Damilola Elijah

College of Graduate Studies: Theses & Dissertations

The rapid evolution of web browsers into fully fledged application execution environments has significantly expanded their attack surface, making them prime targets for sophisticated zero-day exploits that evade traditional signature-based security mechanisms. To address this challenge, this research proposes an AI-driven framework for real-time detection and analysis of zero-day exploits in web browsers by integrating browser-level telemetry monitoring, unsupervised anomaly detection, and large language model–based threat interpretation. The framework introduces a lightweight WebAssembly telemetry agent embedded within the browser runtime to capture low-level execution behaviors, including WASM module instantiation, memory growth patterns, network interactions, and runtime API activity. These telemetry …

Assessing The Diversity And Composition Of Crayfish Assemblages In The Ogeechee River Basin, Reginald Turner

College of Graduate Studies: Theses & Dissertations

Crayfish assemblage composition in the southeastern United States is understudied relative to other aquatic taxa, such as aquatic insects and fishes, and the Coastal Plain watersheds of that region are particularly underrepresented in the contemporary literature on this topic. For example, although 38% of the crayfish species in Georgia are considered “species of greatest conservation need,” most of the distributional data used to make these designations are outdated, with some dating back over 50 years. This thesis sought to update our understanding of the contemporary distributions of crayfish species within the Ogeechee River Basin (ORB), a watershed in southeastern Georgia …

Swimming In Uncertainty: Filling Data Gaps And Providing An Educational Platform For Beach Water Quality At Tybee Island, Georgia, Lukas Roberson

College of Graduate Studies: Theses & Dissertations

@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0in; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman";}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; mso-font-kerning:0pt; mso-ligatures:none;}div.WordSection1 {page:WordSection1;}

Swimming in beaches water contaminated with high levels of bacteria can make you sick. Current monitoring at the public beaches on Tybee Island consists of weekly monitoring and enumeration of fecal indicator bacteria that takes 24 hours for results. If the number of bacteria exceed regulatory limits, a public health advisory is issued, and affected waters are retested until …

Professional Learning Community Implementation And Perceptions Of Influence On School Culture, Herbert L. Chambers Jr.

College of Graduate Studies: Theses & Dissertations

As school leaders strive to achieve educational success at all levels in schools, this research provided educational professionals with feedback on how the implementation of professional learning communities (PLCs) is perceived as influencing school culture. The purpose of this non-experimental quantitative survey design was to examine how educators perceived that school culture is influenced by the practice of PLCs. Descriptive statistics were calculated for 57 survey items. This research design provided the perceptions of school leaders, teachers, and support staff at the elementary, middle, and high school levels based on five identified dimensions of the Professional Learning Community Assessment – …

Exploring The Relationship Between Principal Instructional Leadership Practices And Student Achievement In Rural Schools, Moneak Mccrary

College of Graduate Studies: Theses & Dissertations

The purpose of this quantitative study was to examine the distribution of College and Career Ready Performance Index (CCRPI) content mastery scores and investigate the relationship between principal instructional leadership practices and student achievement in rural Georgia middle schools. To this end, we analyzed differences in CCRPI content mastery scores based on school rurality and geographic region and compared principal instructional leadership practices in higher- and lower-performing schools. Hallinger’s (1983) Principal Instructional Management Rating Scale (PIMRS) was used to assess three dimensions of instructional leadership: Defining the School Mission, Managing the Instructional Program, and Developing the School Learning Climate. The …

Modeling Accreditation Standards And Evaluation Methods To Inform Strategic Planning In Public Health Education, Debra Rich

College of Graduate Studies: Theses & Dissertations

Public health has long benefited from the relationship between postsecondary education, accreditation, and government employment. Assessment and accreditation are important tools in postsecondary education to ensure fiscal responsibility, professional competencies, and quality assurance. The competency standards implemented in post-secondary education are not under the direct control of the federal government; however, policy amendments aimed at specific accreditation criteria could result in changes to public health curriculum and create eligibility barriers for students who rely on federal financial support. The Central Washington University Public Health program has provided educational support in professional public health for decades, and there is an increased …

Cogram: A Computational Pipeline For Genome Assembly And Reconstruction Using Graph Neural Networks, William Coggins

College of Graduate Studies: Theses & Dissertations

Genome assembly — the reconstruction of a complete DNA sequence from short, overlapping reads — remains a fundamental challenge in computational biology. A central difficulty is distinguishing true genomic overlaps from spurious connections arising from repetitive sequences, a task that traditional assemblers address through hand-tuned heuristic rules applied to de Bruijn or overlap graphs. This thesis introduces COGRAM (Coggins–Ramasamy Assembly Method), a genome assembly pipeline that reframes sequence reconstruction as an edge classification task on a k-mer overlap graph, replacing heuristic graph cleaning with a learned model.

COGRAM constructs a directed overlap graph from raw sequencing reads using a k-mer …

The Influence Of Localized Water Quality On Eastern Oysters (Crassostrea Virginica) And Their Internal Microbiome Under Changing Environmental Conditions, Jessie Rivera Lafreniere

College of Graduate Studies: Theses & Dissertations

Oysters are found ubiquitously in estuaries along the Georgia coast, where marsh morphology and large daily tidal fluctuations create dynamic and stressful conditions to which oysters may be locally adapted. Based on water quality data from the Sapelo Island National Estuarine Research Reserve, it is evident that changing climatic conditions are rapidly causing shifts in water quality that may be adversely affecting oyster health, especially as ocean acidification alters the carbonate buffering capacity, increasing the amplitude of daily pH variations. Importantly, the rate of change of conditions are not uniform within estuaries, varying on spatial and temporal scales. The symbiotic …

When The Gorenstein Projective Modules Are Precovering: A Survey On The Existence Of The Gorenstein Projective Precovers, Alexis L. Mcburney

College of Graduate Studies: Theses & Dissertations

This thesis surveys known results on the existence of Gorenstein projective precovers and studies conditions under which the class of Gorenstein projective modules is precovering. In classical homological algebra, projective resolutions are used to study modules, while relative homological algebra replaces projective modules with a different class that must be precovering for resolutions to exist. Gorenstein homological algebra extends these ideas using Gorenstein projective modules. We review key developments by Jorgensen, Murfet and Salarian, Estrada, Iacob, and Yeomans, and Cortés and Saroch. We discuss the strongest known existence result, showing that Gorenstein projective precovers exist under suitable conditions; in particular, …

From Panels To Power: Empowering Middle Schoolers Through Comics, Ali Geigerman

College of Graduate Studies: Theses & Dissertations

This dissertation explores how craftivism, grounded in feminist theory and informed by multiliteracies, can be used to disrupt and reclaim the traditionally male-dominated genre of comics for girls and non-binary students. While the New London Group’s concept of multiliteracies expands definitions of literacy to include visual, spatial, and multimodal forms of meaning-making, it does not fully address questions of power, representation, and voice. Drawing specifically on the work of bell hooks as a theoretical anchor, this study positions comics not only as legitimate multiliterate texts but also as sites of feminist intervention. By blending multiliteracies, feminism, and craftivism, this research …

Formalizing Asymmetric Control-Telemetry Separation In Distributed Industrial Control Systems, Andrew Manison

College of Graduate Studies: Theses & Dissertations

Distributed industrial control systems often place control and telemetry traffic on the same communication substrate even though the two workloads impose different requirements. Control paths need bounded request-response latency and predictable acknowledgement semantics, whereas telemetry paths benefit from scalable publish-subscribe fanout and tolerance for consumer-side delay. This thesis argues that, for the tested class of mixed workloads on shared commodity infrastructure, these communication roles should be separated architecturally rather than forced through a single protocol. To evaluate that claim, the thesis formalizes an asymmetric control- telemetry pattern and instantiates it in the Asymtra framework using gRPC for synchronous control and …

The Effect Of Chamber Geometry On The Performance Of Oscillating Water Column, Timilehin O. Osunade

College of Graduate Studies: Theses & Dissertations

This thesis investigates the effect of internal chamber geometry on the performance of a piezoelectric oscillating water column (OWC) wave energy harvester. Four acrylic chamber configurations with internal top-surface angles of 0°, 30°, 45°, and 60° were tested under 32 controlled conditions combining synchronous (SYN) and asynchronous (ASC) forcing at input voltages of 4, 6, 8, and 10 V. A 35 mm piezoelectric disc mounted at the chamber roof served as the power take-off element and, subject to the RC-limit caveat disclosed in Section 3.2.1, as a first-order dynamic analogue of the chamber pressure for phase-based compressibility analysis. All test …

I Am Because We Are: A Narrative Inquiry Of Waiver Teachers’ Sense Of Belonging In Title I High Schools, Bernard Young

College of Graduate Studies: Theses & Dissertations

This qualitative narrative inquiry examined how former waiver teachers in low-performing Title I high schools in Georgia experienced a sense of belonging within their school communities and how that sense of belonging influenced their engagement in professional learning and their perceived effectiveness in supporting student achievement. Grounded in the Belongingness Hypothesis and guided by narrative inquiry methodology, the study framed participants’ experiences through the Bildungsroman structure to explore their journeys of professional becoming. Data were collected using a life-story interview protocol that combined open-ended narrative invitations with responsive follow-up questioning and were analyzed through a multi-phase narrative inquiry process informed …

Evaluating Source Material And Seed Propagation Techniques For Spartina Alterniflora To Enhance Salt Marsh Restoration In Coastal Georgia, Maygan Palacios

College of Graduate Studies: Theses & Dissertations

Salt marshes provide critical ecosystem services, including carbon sequestration, flood attenuation, and habitat for diverse aquatic and terrestrial species. Despite their ecological importance, these habitats are increasingly threatened by anthropogenic activities and rising sea levels. To protect and restore salt marshes and their ecosystem services, restoration efforts using living shorelines (LS) have become more common. Along the Eastern and Gulf coasts of the United States, the native grass Spartina alterniflora is commonly used in LS installations for its key role in salt marsh food webs, resilience to abiotic stress, and ability to stabilize and build sediment. Previous studies have documented …

The Monster Consuming American Education: An Ethnodramatic Exploration Of Standardized Testing And Student Stress, Jennifer Bagley

College of Graduate Studies: Theses & Dissertations

This study looks at how elementary students experience Standardized Testing, focusing on the emotional and physical effects of the Georgia Milestones Assessment System (GMAS). Most research on high-stakes testing focuses on scores, accountability, and policy, but fewer studies look at how students actually describe these experiences. Grounded in Cultural Studies and informed by Critical Pedagogy, this study examines how students interpret and make meaning of their testing experiences within the broader culture of accountability and standardized assessment. This study focuses on student voices to better understand what testing feels like for them and how they make sense of it in …

Evaluating Benthic Macroinvertebrate Communities In Streamside Management Zones In Private, Working Forests, Haley Vaglienti

College of Graduate Studies: Theses & Dissertations

Forestry operations can alter riparian vegetation and increase sediment and nutrient inputs to streams, affecting water quality and aquatic biota. Forestry best management practices (BMPs) including streamside management zones (SMZs) are designed to mitigate those effects by reducing sediment delivery and moderating temperature, flow, and nutrient regimes. We assessed ecological integrity at 24 intermittent stream sites with SMZs in private, working forests across the Piedmont and Southeastern plains of Georgia. At each site, we conducted physical habitat evaluations and characterized benthic macroinvertebrate assemblages. Sites represented a gradient of habitat conditions, SMZ widths, and pine stand ages, allowing for comparisons of …

Factorial Design: A New Look Through Overlap Measures, Sarah W. Liebenow

College of Graduate Studies: Theses & Dissertations

Traditional factorial analysis often relies on ANOVA, which assumes normality and equal variances. This thesis presents a nonparametric approach for assessing main and interaction effects in a 2 × 2 factorial design using the overlap coefficient, estimated through kernel density methods. A bootstrap procedure is used to approximate its sampling distribution for hypothesis testing. Simulation studies compare the overlap-based test with the ANOVA F-test, permutation F-test, and the Kruskal–Wallis test under heteroskedasticity and non-normal conditions. Results show that the overlap measure is highly sensitive to differences in spread and shape, detecting effects that traditional methods frequently miss.

Vibrio In Oysters: Exploring The Impact Of Harvesting Practices, Samin Yasar

College of Graduate Studies: Theses & Dissertations

The rapid growth of oyster aquaculture in the Southeastern United States necessitates the validation of post-harvest processing strategies to mitigate the risk of Vibrio spp. infection. This study investigated the efficiency of three cooling methods - Direct Ice Burial, Indirect Ice Cooling, and Ambient Control, on the prevalence and abundance of V. cholerae, V. parahaemolyticus, and V. vulnificus in cultured oysters (Crassostrea virginica) harvested in Georgia. Additionally, the study examined the safety of two different re-submersion periods for oyster safety.

Internal temperature profiles confirmed that while Direct Ice Burial achieved the most rapid cooling (< 10° C in 7.3 ± 1.2 min), the Indirect Ice Cooling protocol successfully reached the safety threshold in 73.7 ± 17.2 min, well within the 2-hour regulatory window. Microbiological analysis (N = 270) revealed that V. …