Digital Commons Network^™

The Contribution Of Nursing And Midwifery To Achieving The Sustainable Development Goals: A Bibliometric Analysis, David C. Benton, Andrew D. Benton, Kate Buchanan, Gemma Doleman, Karen Strickland, Lisa Whitehead

Research outputs 2022 to 2026

Background: Nurses and midwives are central to achieving the Sustainable Development Goals (SDGs) as the largest regulated sector of the global health workforce and as professions explicitly encouraged by the International Council of Nurses and the World Health Organization to advance the 2030 Agenda. This paper updates a 2016 bibliometric analysis to examine changes in nursing and midwifery scholarly engagement with the SDGs.

Methods: A bibliometric analysis of Scopus, CINAHL Ultimate, and PubMed was undertaken for publications from 2000 to 2025 containing Millennium Development Goal (MDG) or Sustainable Development Goal (SDG) terminology in nursing and midwifery literature. VOSviewer was used …

The Ecology Of Hope: Building Rainbows In Education Systems, Jennifer Achari

Research outputs 2022 to 2026

Hope is frequently invoked in education, yet rarely theorised. Where it has been theorised, it has been understood in two largely separate ways: as an individual psychological capacity, in the positive-psychology tradition and as a critical-emancipatory stance, in the pedagogy of hope. This article proposes a third: a theory, the ecology of hope, that locates hope not in the individual alone but in the relationship between a person and the systems that surround them. Bringing the cognitive psychology of hope into dialogue with ecological systems theory, the social-ecological account of resilience, and utopian methodology, in which a better society is …

The Evolution Of Match-Play In Major League Soccer From 2018 To 2023, Callum J. Mccaskie, Christopher Wing

Research outputs 2022 to 2026

Major League Soccer (MLS) has experienced significant growth since its establishment 30 years ago. However, no research has investigated the on-field performance trends. Thus, the purpose of this study was to examine the evolution of MLS match-play via technical and tactical key performance indicators, and investigate the differences between teams according to league finishing position. MLS on-field performance indicators were obtained across six seasons from open-source website FBref. Mean game values were collected from 21 match performance indicators for every MLS team over six seasons. Teams were also classified according to their league finishing position at the conclusion of each …

Towards The Acoustic Characterisation Of Ngilgi Cave's Amphitheatre Chamber In Western Australia, Mary Rapp, Manuj Yadav, John Bassett

Research outputs 2022 to 2026

Ngilgi Cave, Western Australia’s first show cave and a site of Wardandi custodianship for tens of thousands of years, has long been celebrated for its “remarkable acoustics”. This reputation is anchored in the early twentieth-century anecdote of Dame Nellie Melba singing in its Amphitheatre chamber. This paper presents a quantitative acoustic characterisation of that chamber using in situ measurements within a nominal 2500 m3 interconnected limestone volume with dense speleothem surfaces. Room acoustic parameters were measured as per ISO 3382–1 across four receiver positions spanning 1–15 m from the source. Spatially-averaged mid-frequency Reverberation Time was 1.2 s, Early Decay Time …

Trends And Indications For Cesarean Section In The Origins Birth Cohort, Kristjana Einarsdottir, Lisa Gibson, Sarah Whalan, Jacqueline Davis, Laurence Amy Payette, Ravisha Srinivasjois, Desiree T. Silva

Research outputs 2022 to 2026

Objective: Cesarean section (CS) rates have increased substantially in Australia, with particularly high use observed in private maternity care and for pre-labor CS. The aim of the present study was to describe the CS rates and the clinical indications for pre-labor CS in the ORIGINS birth cohort.

Methods: This study analyzed data from the ORIGINS birth cohort, a large birth cohort in Western Australia, including 9473 births occurring at Joondalup Health Campus between 2016 and 2024. Rates of CS and pre-labor CS were compared across study periods (2016–2020 and 2021–2024) and by facility type (public vs. private). Indications for pre-labor …

Understanding Barriers And Motivators For Fruit And Vegetable Intake In Female Stroke Survivors: A Qualitative Study, Caroline R. Hill, Jack Dalla Via, Lauren C. Blekkenhorst, Montana Dupuy, Rosanne Freak-Poli, Liezhou Zhong, Jonathan M. Hodgson, Moira Sim, Mandy Stanley, Amanda Devine, Simone Radavelli-Bagatini

Research outputs 2022 to 2026

Purpose: Adequate fruit and vegetable (FV) intake is the foundation of a healthy diet; however, intake is especially low among stroke survivors. This study explores barriers and motivators to FV intake in female stroke survivors and informs strategies to improve well-being.

Methods: Female stroke survivors completed questionnaires and attended either a focus group or an interview, with the resulting transcripts analysed using reflexive thematic analysis.

Results: Ten female stroke survivors aged (mean [SD]) 66.3 [17.1] years completed the study. Across the focus groups (n = 3) and interviews (n = 2), three themes emerged: (1) “Navigating alone,” reported that survivors …

Fostering Relational Leadership Skills In Mining: The Signal Online Program, Arian Kunzelmann, Armaghan Shafaei, Esme Franken, Kate Blackwood, Tim Bentley, R. Xia, L. Deacon

Research outputs 2022 to 2026

Summary: Leaders play a critical role in shaping workplace well-being, respect, and mental health in mining. This study examined the relational leadership capabilities underpinning the SIGNal program and explored the contextual factors that influence leadership development and the application of learning in mining workplaces. The quantitative findings showed that supportive, inclusive, growth-oriented, and adaptive leadership behaviours tend to co-exist and are strongly associated with positive worker outcomes. Workers who perceived their leaders as highly relational reported substantially higher levels of job satisfaction, work engagement, well-being, and respect at work. The findings also highlighted the importance of organisational factors, with psychosocial …

A Delicate Balance: Experiences And Wellbeing Of Pre-Service Teachers Navigating Demands And Benefits Of Studying While Working As A Teacher, Caroline F. Mansfield, Jane Kirkham, Narelle Lemon, Lisa Papatraianou

Research outputs 2022 to 2026

In the face of a global teacher shortage various strategies are being used to bolster the teaching workforce. In Australia, one such strategy has been to employ pre-service teachers under alternative permission to teach contracts. Given the recency of this phenomenon, there is little empirical evidence about the impact of this strategy on pre-service teachers, specifically how this experience may influence their wellbeing and retention in the profession. Utilising the Job Demands-Resources (JD-R) framework, this study explores the benefits and demands of alternative permission to teach arrangements on pre-service teachers, and in particular the impact on their wellbeing and career …

A Qualitative Analysis To Identify Implementation Strategies For A Deprescribing Clinical Practice Guideline Using The Cfir-Eric Matching Tool: Perspectives From Consumers And Professional Stakeholders, Hui Wen Quek, Xisco Reus, Kenneth Lee, Veronika Seda, Leon Adams, Osvaldo P. Almeida, Gillian E. Caughey, Jennifer Gowan, Kerryn Hart, Andrew Heredia, Anne Marie Hill, Lisa Kalisch Ellett, Dina Logiudice, Arduino A. Mangoni, Anthony Marinucci, Treasure Mcguire, Nilufeur Mckay, Vasi Naganathan, Christopher Ng, Maz Osborne, Kevan R. Polkinghorne, Constance D. Pond, Sepehr Shakib, Angela Shiu, Andrew Stafford, Tim Whitmore, Christopher Etherton-Beer, Amy Page

Research outputs 2022 to 2026

Introduction: Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting its uptake into routine practice is a critical next step.

Aim: This study aimed to identify implementation strategies, informed by stakeholder-perceived barriers, to support the implementation of deprescribing guidelines.

Method: A qualitative analysis was undertaken of open-text responses collected during the guideline public consultation (24 April–31 May 2025). Inductive thematic analysis identified implementation barriers, which were then deductively mapped to the Consolidated …

A Survey Of Australian Healthcare Practitioners’ Perspectives On Goal Setting In Occupational Rehabilitation, Grace Redden, Christopher J. Stevens, Jodie Cochrane Wilkie, Syeda Farah Zahir, Christian Swann

Research outputs 2022 to 2026

Introduction: Nearly half a million Australians experience workplace injury or illness each year, and return-to-work rates have declined, particularly for psychological conditions. Practitioners use goal setting to structure return-to-work planning and are directed by national guidance to set SMART (Specific, Measurable, Achievable, Realistic, Time-bound) goals. How practitioners apply these criteria across different injuries and illnesses is not well understood. This study examined practitioners’ perspectives on goal setting in workers’ compensation rehabilitation in Australia, with a focus on SMART goals.

Methods: A cross-sectional online survey of Australian healthcare practitioners who treated physical conditions, psychological conditions, or both, was conducted. Quantitative data …

Activity Profiles And Their Correlates In Patients With Localised Renal And Colorectal Cancer Shortly After Treatment: A Cross-Sectional Analysis, Annemone Siffels, Martijn J.L. Bours, Eline H. Van Roekel, Matty P. Weijenberg, J. P.Michiel Sedelaar, Stéphanie O. Breukink, Eric T.P. Keulen, Maryska Janssen-Heijnen, Koen G. Frenken, Katja K.H. Aben, Jake S.F. Maurits, Lambertus A.L.M. Kiemeney, Laurien M. Buffart, Alina Vrieling

Research outputs 2022 to 2026

Purpose: The purpose of this study is to identify activity profiles and their correlates in patients with localised renal cell carcinoma (RCC) and colorectal cancer (CRC) shortly after treatment completion.

Methods: In the ReLife (n = 326 patients with RCC) and EnCoRe (n = 358 patients with CRC) studies, we measured physical activity and sedentary behaviour at 3 months and 6 weeks after treatment completion using accelerometers. We used latent profile analyses to determine activity profiles. Demographic, lifestyle-related, and clinical correlates were investigated with multinomial regression analyses.

Results: We identified three activity profiles for both populations: a most sedentary (RCC:28%, …

Advancing Programmatic Assessment In Dietetics Through A Multi-Institutional Community Of Practice, Gemma Jenkins, Claire Palermo, Therese A. O'Sullivan, Alexander M. Clark, Leesa Costello

Research outputs 2022 to 2026

Programmatic assessment has gained momentum in health professions education for its potential to address challenges in competency-based education. Yet, little is known about how to create the cultural and systemic changes needed for sector-wide enactment. This study used realist evaluation to develop and refine theory about how, why, and in what contexts a community of practice for Australian and New Zealand dietetic educators contributed to advancing programmatic assessment in dietetics higher education. Programme theory highlights the influence of committed, cross-institutional members, supported by an experienced and inclusive facilitator, on both the functioning and outcomes of the community of practice. Within …

Cash Flow, Working Capital Management And Firm Performance - A Cross-Sectoral Study In An Emerging Market Context, Thuy Thanh Nguyen

DLSU Business & Economics Review

This study investigates the impact of operating cash flow and working capital management on firm performance, with a particular focus on how these relationships are moderated by industry characteristics in an emerging market context. Using a dataset of 1,480 firm-year observations from 185 Vietnamese enterprises between 2016 and 2023, the analysis employs panel data regression with feasible generalized least squares estimation. The results reveal that operating cash flow and accounts payable turnover positively influence return on assets, whereas accounts receivable turnover has a negative effect. Inventory turnover is not statistically significant. Notably, the magnitude and direction of these effects vary …

Diffusion Of The Internet And Digital Divide In Post-Soviet Countries, Behrooz Asgari, Cosmos Amoah, Sudipa Majumdar

DLSU Business & Economics Review

This study explores the diffusion process of the internet in countries that were previously known as the U.S.S.R. and are currently divided into 15 countries. Utilizing the S-shaped logistic curves, this paper forecasts future trends in internet diffusion in these economies. Data varied in range, with each country having different time frames for similar variables. The logistic curves for each country determined the length of time of internet diffusion, maximum carrying capacity, and different stages of the diffusion process, namely, emerging, growth, maturity, and saturation. The results show that all countries have exceeded the emerging and growth phases, with 13 …

Boodja First, Country First: Kaarl Ngaariny, Right Fire, Sandra Wooltorton, Len Collard, Oral Mcguire

Research outputs 2022 to 2026

How might belonging to Country guide us toward reciprocity, care and renewal in a time of breached planetary boundaries? Drawing on Noongar knowledge and the environmental humanities, this research paper explores how homes, gardens, farms, energy systems and investments are already entangled within Country, inviting a shift from separation to nurture. We propose that ideas around ownership, social mobility, comfort and growth shape suburban identities (including our own) and inhibit regenerative change. Within high-carbon economies such as Australia, ecological limits are often experienced as external constraints on human flourishing. When people recognise themselves as part of Country, however, limits can …

Common Census Methods Can Lead To Fundamentally Different Ecological Interpretations Of Coral Reef Fish Communities, Helen F. Yan, Samantha K. Crisp, David R. Bellwood, Alexandre C. Siqueira, Sterling B. Tebbett

Research outputs 2022 to 2026

In an era of large-scale stressors, scientists are racing to collate equally large datasets to answer macroecological questions. Coral reefs lie at the forefront of system-wide transformations and are thus the focus of many macroecological studies. A lack of standardised, global data across time, however, has resulted in the coalition of data from disparate sources, often comprising different survey methods. However, can we make the same ecological inferences from data collected using different survey protocols? Here, we employed two of the most common reef fish census techniques—point counts and belt transects—of varying survey effort (time and area) to assess whether …

Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance And Plasma P-Tau181 Levels In Cognitively Unimpaired Older Adults, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Henrik Zetterberg, Nicholas J. Ashton, Manohar L. Garg, Kaj Blennow, Ralph N. Martins

Research outputs 2022 to 2026

Emerging evidence suggests altered circulating metabolite levels in individuals with Alzheimer’s disease (AD) and/or mild cognitive impairment (MCI) compared to healthy controls; how these metabolites alter with early cortical amyloidosis—before symptom onset—remains unclear. This cross-sectional study aimed to investigate plasma metabolites obtained through targeted profiling using the Biocrates AbsoluteIDQ® p400 HR kit. The study cohort comprises 100 cognitively unimpaired (CU) older adults, stratified into CU Aβ− (negative positron emission tomography [PET]-amyloid-beta [Aβ]) and CU Aβ+ (positive PET-Aβ) groups. Significantly altered metabolites were further analysed for associations across amyloid plaque deposition, cognitive performance and plasma tau phosphorylated at threonine 181 (P-tau181) …

Effect Of Blood Flow Restricted Walking On Cardiovascular Fitness, Muscular Development, And Functional Performance In Adults: A Systematic Review With Meta-Analysis, Michael Beere, James R. Mckee, Isaac Selva Raj, Kieran J. Marston, Kristen De Marco, Brook Galna, Jeremiah J. Peiffer, Belinda Brown, Keith D. Hill, Peter Edwards, Brendan R. Scott

Research outputs 2022 to 2026

Increasing evidence from randomised controlled trials demonstrates blood flow restriction (BFR) improves walking intervention outcomes compared to walking without BFR. This systematic review and meta-analysis examined the effects of BFR walking interventions on cardiovascular fitness, muscle strength and hypertrophy, and functional performance in adults, and moderators of age, health status, training volume and intensity. Six databases were systematically searched following PRISMA guidelines, up to April 2025. Studies were eligible if participants were ≥ 18 years, included randomised controlled trials with BFR walking interventions ≥ 12 sessions and ≥10 min/session, at least one measure of cardiovascular fitness, muscular strength, muscular hypertrophy, …

Edible Coatings Application For Postharvest Fruits Preservation: Bibliometric Trends, Material Design, Physiological Mechanisms, And Safety Perspectives, Muslim Qadir, Navjot Kaur, Dali Vilma Francis, Abdelmoneim K. Abdalla, Zora Singh, Zienab F.R. Ahmed

Research outputs 2022 to 2026

Fresh fruits play a vital role in ensuring food and nutritional security, while also making significant contributions to global trade. However, due to their highly perishable nature, they are susceptible to postharvest losses during storage, transportation, and marketing. Edible coatings (ECs) and edible films are effective postharvest preservation technologies for retarding senescence and preserving fruit quality. This review provides a comprehensive update on recent developments in ECs and films aimed at reducing postharvest losses in fresh fruits. These coatings are formulated using biopolymers, including polysaccharides, proteins, and lipids, along with food-grade additives. The review discusses how ECs modulate postharvest physiology …

Ethical Positionings Of Risk And Harm For Adolescents Encountering Sexual Content Online, Lelia Green, Giselle Woodley, Carmen Jacques, Elisabeth Staksrud, Liza Tsaliki, Brian O’Neill, Debra Dudek, Despina Chronaki, Thuy Dinh, Kelly Jaunzems

Research outputs 2022 to 2026

This paper interrogates the ethical complexities of talking with 12 to 17-year-olds about sexual content online. Authors were granted ethics approval by the Edith Cowan University Human Research Ethics Committee (2019-00583-GREEN) with three other participant countries translating Australian ethical protocols into their national contexts: Greece, Ireland and Norway. This paper addresses the four national contexts and examines the ethical issues arising for different countries’ ethics procedures when researchers conduct sensitive research with adolescents. Given widespread concern around the risk that children will be ‘sexualised’ by encountering sexual content online the ethical procedures adopted in each national context, and the way …

Exploring Factors That Influence Meal Management And Eating Behaviours In People Living With Huntington’S Disease, Joanna Rees, Ran Yan, Melanie Clark, Melanie Jolly, Alex Fisher, Amanda Devine, Simon M. Laws, Kelly Moes, Travis Cruickshank

Research outputs 2022 to 2026

Purpose: People living with Huntington’s disease (pwHD) experience cognitive and motor changes that affect meal planning, preparation and food consumption. This study explored factors that influence meal management and eating behaviours of pwHD and their families.

Methods: This is a qualitative study employing semi-structured interviews and thematic analysis. Participants included gene-positive individuals living in Perth Western Australia, ranging from asymptomatic or experiencing subtle changes, to early to mid-stage HD.

Results: Nine individuals (mean age 47 ± 12.3 years) were interviewed for the study, including five gene-positive being asymptomatic or minimal symptoms. Seven themes were identified reflecting participants’ existing meal management …

How Perceived Empowerment And Place Attachment Drive Residents’ Support For Sustainable Tourism In Central Vietnam: A Serial Mediation Model, Phuong Kim Thi Tran, Nhi Thao Ho-Mai, Tuan Nien Tran, Vinh Trung Tran

Research outputs 2022 to 2026

From the Theory of Planned Behavior (TPB) and the Stimulus-Organism-Response (S–O–R) framework, this study proposes a serial mediation model to examine psychological drivers of residents’ support for sustainable tourism development (STD) in central Vietnam. Specifically, this study investigates how perceived empowerment and place attachment as stimulus influence residents’ attitudes (ATT), subjective norms (SN), and perceived behavioral control (PBC) as organism, which in turn shape their intentions to support STD as response. The study empirically surveyed 686 residents engaging with tourism services in three cities, namely Hue, Da Nang, and Quang Nam, in central Vietnam. This study utilised both online and …

Leveraging Hr Analytics Capability For Sustainable Supply Chains: The Roles Of Green Hrm, Ai-Driven Capabilities And Resource Commitment, Philip Opoku Mensah, Emmanuel Mensah Kparl, Abdul Razak Suleman, Michael Kyei-Frimpong, Adam Abdul Mumin, Elias Appiah-Kubi, Charlotte Adjanor-Doku

Research outputs 2022 to 2026

Among many firms in emerging economies, investments in HR analytics promise strategic insight yet often fail to translate into measurable sustainability gains. This study theorises and tests how HR analytics capability drives supply chain sustainability through the strategic enactment of Green HRM (GHRM). Drawing on dynamic capability theory and socio-technical systems theory, we propose that HR analytics capability indirectly enhances supply chain sustainability by enabling firms to design and implement data-informed GHRM strategies that align workforce practices with environmental objectives. We further argue that this indirect effect is contingent on two distinct enabling conditions: AI-driven capability, which strengthens the translation …

Participatory Work Design Intervention In A Disability Support Organization: Effects On Job Demands, Social Support, And Burnout, Arian Kunzelmann, Connie Deng, Lucinda Iles, Ryan Cheng, Helena Nguyen, Anya Johnson, Sharon K. Parker

Research outputs 2022 to 2026

This study evaluates the effectiveness of a participatory work design intervention to improve job quality and mental well-being in a disability support organization. We investigate whether the intervention is associated with changes in burnout (i.e. disengagement, work-related, client-related), and we assess the changes in work design through which the intervention has its effects. We hypothesized that the effects of the work design intervention on burnout occur via changes in social support (i.e. co-worker instrumental and emotional support) and job demands (i.e. role conflict, time pressure). 72 participants were involved (N = 21 in the intervention group, 66.7% female; N = …

Playworld Translanguaging: A Place-Based Approach For Translanguaging Play Pedagogy In Early Childhood, Christine Robinson, Carly Steele, Toni Dobinson, Grace Oakley, Samina Manado, Katie Grace, Graeme Gower

Research outputs 2022 to 2026

Conceptualised from a vision to honour children’s languages, agency and cultural ways of knowing, this research presents findings from a place-based translanguaging play pedagogy for early childhood called Playworld Translanguaging. In the remote Kimberley of Western Australia, researchers collaborated with educators in a Kindergarten/Primary/Yr 1 class of mostly Aboriginal children who have Bardi Jawi as their ancestral language, co-designing ways to revitalise this language through play pedagogy in ways intimately connected to place. Our Playworld Translanguaging approach reimagined Conceptual PlayWorlds (Fleer, 2018) with the intention of integrating pedagogical translanguaging. Following Indigenist research principles, critical participatory action research (CPAR) was the …

Serum Igg N-Glycosylation Profiles Distinguish Primary Sjögren’S Disease, Rheumatoid Arthritis, And Systemic Lupus Erythematosus And Are Associated With Disease Activity In Sjögren’S Disease, Zhixian Chen, Xiaojia Xu, Manshu Song, Fengcai Shen, Haifeng Hou, Wei Wang, Ling Lin

Research outputs 2022 to 2026

Background: IgG N-glycosylation regulates immune effector functions and inflammation, but disease-specific patterns in primary Sjögren’s disease (SjD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are insufficiently defined, particularly in SjD.

Objectives: To identify serum IgG N-glycan biomarkers that differentiate SjD, RA, and SLE and reflect disease activity in SjD.

Design: A clinical case-control study.

Methods: Serum IgG N-glycans from 88 SjD patients, 102 RA patients, 86 SLE patients and 91 healthy controls were profiled using ultra-performance liquid chromatography. Discriminative glycans were selected through machine learning-based feature selection and evaluated for their diagnostic performance using cross-validated logistic regression and receiver …

The Alteplase Dose Assessment For Pleural Infection Therapy (Adapt) Study-3: Efficacy And Safety Of 1 Mg Alteplase As A Starting Intrapleural Dose, Estee P.M. Lau, Michaela Donaghy, Sam Faber, Sophie Krivinskas, Francesco Piccolo, Calvin Sidhu, Tommaso D'Orsogna, Sona Vekaria, Edward Fysh, Y. C. Gary Lee

Research outputs 2022 to 2026

Introduction: Intrapleural tissue plasminogen activator/deoxyribonuclease (tPA/DNase) therapy has revolutionised management of pleural infection. However, the optimal tPA dose is still unknown. The Alteplase Dose Assessment for Pleural infection Therapy (ADAPT) study-3 aims to evaluate the efficacy and safety of a lower starting intrapleural dose of 1 mg tPA (with 5 mg DNase) for pleural infection.

Methods: Consecutive patients with pleural infection who required intrapleural fibrinolytic therapy were treated with 1 mg tPA/5 mg DNase. Escalation of tPA doses were permitted at any time at the discretion of treating physicians.

Results: A total of 100 patients (22% female, mean age = …

Targeting Of The Oncogenic Fusion Ewsr1-Fli1 In Ewing Sarcoma By Crispr/Dcas9 Silencers, Shahama Taifour, Chee Wai Wong, Christopher Wallis, Edina Wang, Ash W.J. Tie, Eleanor Woodward, Charlene Waryah, Mahnaz Hosseinpour, Dilys Lam, Ryan Lister, Larissa Dymond, Andrew Woo, Peter J. Houghton, K. Swaminathan Iyer, Marck Norret, Cameron W. Evans, Louise Winteringham, Silvana Gaudieri, Pilar Blancafort

Research outputs 2022 to 2026

Despite the revolutionary impact of genome engineering tools in medicine, the safe and effective intracellular delivery of CRISPR remains a major obstacle to clinical applications. Here, we utilize precision molecular targeting and delivery strategies based on CRISPR-nuclease-dead Cas9 (dCas9) systems adapted for epigenetic repression (dCas9-Krüppel-associated box [KRAB]) to silence oncogenic drivers with high selectivity. As proof of principle, we target the EWSR1-FLI1 translocation, which encodes a chimeric and hard-to-drug oncogenic transcription factor driving approximately 85% of the cases of Ewing sarcoma (EWS)—an aggressive childhood malignancy. We describe the development of a programmable, non-viral polymeric system for the delivery of dCas9-KRAB …

The Gender Gap In Writing: Gender Profiles For Paper- And Computer-Based Writing In Early Education, Anabela Malpique, Deborah Pino-Pasternak, Mustafa Asil

Research outputs 2022 to 2026

Research Findings: The gender gap in writing has received strong interest from literacy education and research, based on recurrent reports of gender differences in writing typically favoring female students. In this study, we investigated gender differences on paper- and computer-based text composing performance among early primary children (N = 544 Grade 2 students). Multilevel analyses revealed significant differences between boys and girls in both compositional quality and productivity across writing modalities. Specifically, boys consistently exhibited lower scores in both compositional quality and productivity compared to girls. Gender differences were notably influenced by various student-level factors such as handwriting automaticity, spelling …

The Role Of Participant–Clinician Relationality And Intervention Source In A Violence Reduction Trial: A Qualitative Study, Paul Leslie Simpson, Freya Stephenson, Patricia Morgan, Emaediong I. Akpanekpo, Jocelyn Jones, Peter William Schofield, Lee Knight, Tony Butler

Research outputs 2022 to 2026

Violence and domestic violence are global public health problems with prevention programs showing limited effectiveness. The form of delivery of such programs can influence their utility yet delivery characteristics are often poorly described. We analysed interviews with clinicians (n = 5) and participants (n = 12) involved in ReINVEST, a violence reduction clinical trial, to identify key elements of delivery. Three themes were identified: (1) clinician accessibility; (2) clinicians as participant advocates; and (3) humane care, reflecting participant–clinician ‘relationality’ as a central component of program delivery. We propose that this relationality is more likely to emerge in interventions delivered independently …