Digital Commons Network^™

An Ecophysiological Approach To Improving Health Outcomes Of Ornamental Shrimp During Aquarium Trade And Transportation, Sancha Conway Holroyd, John Spicer, Robert P. Ellis, Lucy Turner

School of Biological and Marine Sciences

Ecophysiology examines the interactions between an organism’s physiology and its environment. It seeks to understand how an organism functions and adapts under changing conditions. This has direct applications to live-trade aquaculture sectors, including the ornamental aquarium trade, where traded animals experience a variety of changing, and often stressful, environmental conditions that can threaten their health and survival. This review proposes a role for ecophysiology in managing organismal health, using Hatch (1962) theoretical framework of disease and dysfunction as a foundation for defining and distinguishing health. We focus on tropical (marine and freshwater) ornamental shrimp as an exemplar group to highlight …

Impact Of Social Media-Driven Feeding Practices On The Gut Microbiome Of Captive Asian Elephants (Elephas Maximus) In Surin, Thailand, Pongpreecha Malaluang, Nuttapon Bangkaew, Jaruwan Chaiyakhot, Patinya Patikae, Nattaya Watwiengkam, Phimphanit Choklikitumnuey, Thanaphat Phupanna, Sudachanok Phowiset, Prim Chuesaard, Tarid Purisotayo

The Thai Journal of Veterinary Medicine

This study investigated the effects of social media-driven live-streaming dietary supplementation on the gastrointestinal microbial community of captive Asian elephants (Elephas maximus) at the Elephant Kingdom, Surin Province, Thailand. A hierarchical two-tier observational design was used: Tier 1 compared a minimal-supplementation control group (Group H, n = 6) with a frequent heterogeneous-supplementation group (Group L, n = 18); Tier 2 compared, within Group L, low-frequency (Group A, ≤ 3 sessions per week, n = 7) and high-frequency (Group B, > 3 sessions per week, n = 11) live-streaming sub-groups. Faecal microbial profiles were obtained by 16S rRNA gene (V3–V4) …

The Host's Immune Responses Against Viruses: How We Know Our Own Bodies And How Our Bodies Defend Themselves From Viruses, Eman A. Muhsin, Neyaf Majid Alageedi, Shahrazad Ahmed Khalaf

Maaen Journal for Medical Sciences

Background: Viral infections pose a significant threat to health worldwide, requiring a coordinated and effective immune response to limit and eventually eliminate viral infection. The purpose of this review is to examine the different ways by which the immune system responds, both by innate and adaptive pathways, against viral infections, along with the mechanisms by which viruses evade host immune responses.

Method: A systematic literature review was performed with an organized search through the following databases; PubMed, Scopus, Web of Science and ScienceDirect. The search was for studies published between 2015-2025. The final number of included articles was 45 as …

Paediatrics & Child Health | Newsletter Vol 8 Issue 1, Department Of Paediatrics & Child Health

Department of Paediatrics & Child Health Archives

• I write to you in unsettled times...
• Service | Clinics and Nursing
• World Autism Awareness Day 2025 — Understanding Autism: Myths, Challenges & Strategies
• Research | Conferences, Field Sites, Studies and Dissemination Strategies
• MoU with SHINE
• Three honours at the 23rd Annual
• Protecting infant gut health in early life
• Academics | PG, UG, CME
• The Science Behind a Paediatrician’s Quick Diagnosis
• Making Immunology Simple for Clinical Practice
• Achievements
• Behind the Systems That Build Great Doctors
• 15,000+ physical therapists. 1,440+ posters. One team from Pakistan.
• Awards and recognitions
• After hours
• Ramzan Iftar Dinner
• Alumni reunion
• PRISMA appreciation night
• In the media …

Efficacy Of A Pre-Camp Online Course For Influencing Staff Knowledge Of Ticks,Tick-Borne Illness, And Tick Practices, Barry A. Garst, Alexandra Skrocki, David Lawrence White, Tracey Gaslin, Ashley Dehudy

CompassPoint

No abstract provided.

New Products, New Ideas, Paula Lauer

CompassPoint

No abstract provided.

Spring 2025 - Volume 35, Number 1, Full Issue

CompassPoint

No abstract provided.

Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence-based artificial intelligence (AI) models. We present a protein language model (PLM)-guided approach complemented by the energy landscape frustration analysis as a dual-stream framework to investigate the relationship between AI prediction of binding sites and biophysical organization of regulatory pockets across the human kinome. By probing a fine-tuned residue-level PLM classifier across 453 kinase structures, a clear performance gap is discovered between highly predictable orthosteric pockets (Types I, I.5, and II) and poorly resolved distal allosteric sites (Type …

Licensed Social Workers’ Perceived Structural And Systemic Treatment Barriers For Clients With Severe Mental Illness, Myron Curtis White

Walden Dissertations and Doctoral Studies

There was a gap in the existing strategies in social work practice regarding the structural and systemic barriers to health care treatment for clients with serious/severe mental illness (SMI). The Centers for Disease Control and Prevention documented that addressing mental health destabilization in the United States is important and requires an understanding of the mental illness to be addressed, including its causal factors, the relationships between the mentally ill and their community/environment, and the methodology for effecting care. This general qualitative study explored what licensed social workers perceived as structural and systemic barriers to health care treatment access for their …

A Glimpse Into Classrooms: Teachers’ Experiences Pre- And Post-Covid, Sam Hilbert, Katherine Wheeler, Robin H. Lock, Janna Brendle, Kassi Gregory

Journal of Educational Research and Practice

The COVID-19 pandemic forced many schools to pause in-person learning. Prior research indicates that these closures affected overall mental health and student academic performance. Mental health concerns, particularly anxiety and depression, were exacerbated for many school-aged children during these closures. Research has linked disorders, such as anxiety and depression, with changes in behaviors. Academic gaps have also been linked with negatively displayed behaviors in school settings. COVID school closures resulted in a 25% increased global prevalence of anxiety and depression diagnoses and an estimated 1-year academic loss in student learning. Although both variables have been shown to contribute to changes …

Treatment, Recognition, And Prevention Of Communicable Conditions In The Summer Camp Setting, Matthew Labkovski

CompassPoint

No abstract provided.

Mitigating An Influenza Outbreak At A Residential Youth Summer Camp, Sandra D. Shapiro, Rachel Thomas, Stacey A. Hobbick, Bretta Weissman, Erica Gottlieb, Rebecca Spielman

CompassPoint

No abstract provided.

Fall 2024 - Volume 34, Number 2, Compass Point

CompassPoint

No abstract provided.

Your Camp Health Services Essential Tips For Success, Bev Unger

CompassPoint

Camp health services are the cornerstone of health and safety. From managing small injuries to medical emergencies, it is the area of camp that encompasses care, safety, health promotion, injury prevention, illness and injury management, and the overall “make you feel better” place. Hiring the right health staff and setting them up for success with appropriate tools, staff training, and solid processes are key to the success at summer camp. When there is a crisis, an injury, or an illness, the outcome can be devastating if not managed in a timely and effective way. Creating the best health center experience …

Addressing Tick And Tick-Borne Illnesses At Camp, Lynne Rodrigues, Alexsandra Dubin, Ashley Dehudy, Alexandra Skrocki

CompassPoint

No abstract provided.

Spring 2024 - Volume 34, Number 1, Compass Point

CompassPoint

No abstract provided.

Identification Of Active Compounds And Antidiabetic Activity Of Red Shoot (Syzygium Myrtifolium) Leaves Extract With In Vitro And In Silico Methods, Muhamad Iqbal Prakoso, Siti Warnasih

Pharmaceutical Sciences and Research

Diabetes mellitus (DM) is a chronic metabolic disease that affects approximately 537 million people worldwide (1 in 10 individuals), and its prevalence is projected to reach 783 million by 2045. One of the plants that has the potential to be an antidiabetic is red shoots (Syzygium myrtifolium) since it contains various secondary metabolite compounds such as flavonoids, triterpenoids, steroids, saponins, phenolics, and anthocyanins. This study aimed to evaluate the antidiabetic properties of red shoot leaves extract and to identify and predict interactions between its active compounds and the α-glucosidase receptor. Ethanol, ethyl acetate, and n-hexane extracts of red …

Synthesis, Characterization, And In Vitro And In Silico Antibacterial Evaluation Of 5-(3-Nitrophenyl)-1, 3, 4-Thiadiazol-2-Amine, Abdelghani Sehmi, Farouk Boudou, Ahcene Keziz, Amal Belakredar, Huda Alsaeedi, Mikhael Bechelany, Gemma K. Kinsella, Ahmed Barhoum

Research Outputs: 2025-Present

Introduction – This study reports the synthesis, structural characterization, and antibacterial evaluation of 5-(3-nitrophenyl)-1, 3, 4-thiadiazol-2-amine (NPTA), a commercially available thiadiazole derivative with potential antimicrobial activity. Methods – NPTA was synthesized through a green, one-pot condensation reaction between thiosemicarbazide and 3-nitrobenzoic acid in absolute ethanol, affording a pale-yellow crystalline solid with a melting point of 110 °C–112 °C. The compound was characterized using Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy, confirming its structure. In vitro antibacterial assays, in silico ADMET and toxicity profiling, molecular docking, frontier molecular orbital (FMO) analysis, and 200 ns molecular dynamics simulations were performed. …

Advances In Gene Editing Strategies For Viral Disease Resistance In Pigs: Knock-Out, Knock-In, And Overexpression Approaches, Zhao Namula, Takeshige Otoi, Aya Nakai, Megumi Nagahara, Maki Hirata, Fuminori Tanihara

The Thai Journal of Veterinary Medicine

Highly contagious viral pathogens—such as porcine reproductive and respiratory syndrome, classical swine fever, and African swine fever—continue to pose serious threats to the swine industry and cause major global economic losses. Conventional disease control approaches, such as vaccination and biosecurity, are limited by viral heterogeneity and immune escape mechanisms. Gene editing technologies, most notably the CRISPR/Cas9 system, offer an innovative means of introducing innate viral disease resistance or resilience in pigs. The continuous improvement of these tools can provide a sustainable strategy to enhance animal welfare and global food security and reduce reliance on traditional control measures. This review provides …

Hemidiaphragmatic Segmental Zoster Paresis, Terrence Sanvictores, Johnson Ukken

School of Medicine Faculty Research

The reactivation of latent varicella-zoster virus within infected neurons can lead to common clinical manifestations, including rash, acute neuritis, post-herpetic neuralgia, herpes zoster ophthalmicus, and Ramsay–Hunt syndrome. Segmental zoster paresis is an unusual neurologic complication of shingles that is defined by focal asymmetric motor weakness in the myotome corresponding to skin lesions of the dermatome. This case is a presentation of a patient who developed chronic hypoxia and severe atelectasis attributed to right-sided phrenic nerve paralysis secondary to herpes zoster infection.

Pneumococcal Colonization In Pediatric Patients Undergoing Hematopoietic Cell Transplantation., Liset Olarte, Jennifer E. Schuster, Ibrahim Ahmed, Kristina G. Hulten

Manuscripts, Articles, Book Chapters and Other Papers

Despite the increased risk of invasive pneumococcal disease among pediatric hematopoietic cell transplant (HCT) recipients, pneumococcal colonization has not been evaluated in this population. We prospectively assessed longitudinal pneumococcal colonization in 22 pediatric HCT recipients from conditioning therapy to 100 days post-HCT. A higher likelihood of pneumococcal colonization was observed in the late post-HCT period (weeks 9-14) compared with the early post-HCT period (weeks 1-8), with odds increasing with each additional week after conditioning.IMPORTANCEThis is the first study to longitudinally evaluate pneumococcal colonization in pediatric hematopoietic cell transplant (HCT) recipients from the onset of conditioning therapy to 100 days post-HCT. …

Longitudinal Genomic Surveillance Of Sars-Cov-2 In A University Microcosm Reflects Global Evolutionary Trends, Sankar Prasad Chaki, Melissa M Kahl-Mcdonagh, Benjamin W Neuman, Loni A Taylor, Rebecca S B Fischer, Blake M Hanson, Marlisa S Hardy, Jo Ann Culpepper, Eric Boerwinkle, Kurt A Zuelke

Faculty, Staff and Student Publications

SARS-CoV-2 transmission has declined, yet ongoing viral evolution continues to pose public health challenges. This study conducted long-term (2020-2024) genomic surveillance within a large and globally diverse university community. Viral genomes obtained from clinical (n = 1,786) and surveillance (n = 888) testing samples were classified under clade, lineage, and variant systems, and compared with global genomic data sets. Local patterns broadly paralleled global evolutionary trends, including the phased emergence of major variants, episodic introductions of new lineages, and shifts in dominant clades. Lineage diversity peaked during fall semesters and was highest among undergraduate-aged individuals, with similar distributions …

Cytoskeletal Protein Expression In Autism Spectrum Disorder: A Psychoneuroimmunological Perspective On Sars-Cov-2, James Birch

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic heightened concerns about health disparities among individuals with autism spectrum disorder (ASD). Limited understanding of the biological factors underlying health variability may hinder efforts to reduce disparities and improve care for neurodivergent populations. Guided by the psychoneuroimmunology framework, this quantitative study investigated whether cytoskeletal gene expression was associated with neuroimmune variability in ASD and SARS-CoV-2 populations. Three genes –Nck-associated protein 1 (NCKAP1), WAS/WASL-interacting protein family member 1 (WIPF1), and actin-related protein 2/3 complex subunit 1B (ARPC1B)—were evaluated using two publicly available Gene Expression Omnibus datasets GSE212645 (ASD vs. sibling-matched controls, N = 40) and GSE152641 (SARS-CoV-2-positive vs. …

Playing For The Planet: Gamified Learning And Global Health Education, Michael Dillon, Laura Bowater

Peninsula Medical School

Dr Michael J Dillon and Professor Laura Bowater emphasise the significance of gamification in global health education amidst increasingly complex challenges

Pneumococcal Colonization In Pediatric Patients Undergoing Hematopoietic Cell Transplantation, Liset Olarte, Jennifer E Schuster, Ibrahim Ahmed, Kristina G Hulten

Faculty, Staff and Students Publications

Despite the increased risk of invasive pneumococcal disease among pediatric hematopoietic cell transplant (HCT) recipients, pneumococcal colonization has not been evaluated in this population. We prospectively assessed longitudinal pneumococcal colonization in 22 pediatric HCT recipients from conditioning therapy to 100 days post-HCT. A higher likelihood of pneumococcal colonization was observed in the late post-HCT period (weeks 9-14) compared with the early post-HCT period (weeks 1-8), with odds increasing with each additional week after conditioning.IMPORTANCEThis is the first study to longitudinally evaluate pneumococcal colonization in pediatric hematopoietic cell transplant (HCT) recipients from the onset of conditioning therapy to 100 days post-HCT. …

Al Kuwait Hospital Dubai, Emirates Health Services 1st Research Week 2025: Research Abstracts Of Clinical And Scientific Advances, Suad Hannawi, Linda Saf Eldin, Alaa Abuquta, Yusra Abdulrahman, Maryam Yaslam, Sabaa Saleh Al-Hemyari, Maimouneh Qazi, Noor Majed Al Mheiri, Ahmed Alamadi, Alia Aljasmi, Sondos Al Salmi, Maria Al-Salmi, Moza Aljamri, Ahmed Ibrahim Abdulrahman, Sharifa Alamadi, Haifa Hannawi

Saudi Medical Journal

No abstract provided.

Multidimensional Predictors Of Disease Severity And Health Outcomes In Patients With Sickle Cell Disease: A Data-Driven Clinical Insight, Hind A. Alzahrani, Ruba Omar Mohammed Almaghrabi, Raed Alharbi, Abdulaziz Saleh Alghamdi, Mohammad A. Albanghali, Hanan E. Alyahyawi, Abdulmohsen M. Alruwetei, Besma Garah, Mohammed Alzahrani, Samar Hassan Hjar, Sana Shaker

Saudi Medical Journal

Objectives: To describe the clinical, hematologic, and therapeutic characteristics of hospitalized adults with sickle cell disease (SCD) in the Al-Baha region and to identify factors that predict hospitalization as well as transfusion frequency. Methods: A retrospective observational analysis was conducted on 117 adults with confirmed SCD who were admitted to King Fahad Hospital-Al-Baha during 2022–2024. Demographic information, hematologic parameters, clinical features, hospitalization rate, transfusion history, and treatment protocols were collected from the electronic medical records. Statistical analyses (ANOVA, Kruskal-Wallis test, Chi-square tests, and Fisher's exact Test) were performed to compare between groups where applicable. Results: The cohort had a mean …

Healthcare-Associated Infection Causes And Mitigation Strategies: A Systematic Review, Mohammad Irfan, Nahed Alquwez

Saudi Medical Journal

Objective: To describe the landscape of healthcare-associated infections (HAI) and, in particular, to pay attention to the types of infection that are usually seen, the most common infectious agents involved and the effective prevention strategies. Methods: A detailed search was performed using Google and PubMed, and studies that exclusively addressed healthcare associated infections or their mitigation. Studies published since 2000 were included. Data from individual articles were extracted and categorized by study focus, type of infection, causes and contributing factors, and documented mitigation strategies. Editorials, reviews, case studies, meta-analyses, and systematic reviews were excluded. Results: The analysis showed that infections …

Global Trends In School Disaster Preparedness Research: Bibliometric Analysis Impacts On Public Health And Safety, Muhammad Farid, Muhammad Agita Hutomo, Oktomi Wijaya, Dian Ika Puspitasari

Chulalongkorn Medical Journal

Background: Disasters disrupt daily human activities, arising from natural or artificial triggers, with varying impacts based on community vulnerability and resource capacity. Effective disaster management involves a cycle of mitigation, preparedness, response, and recovery. One of the mitigation measures is to establish school disaster preparedness that integrate education and capacity building.

Objective: The aim of this research is to conduct a bibliometric analysis based on Scopus publications regarding school disaster preparedness.

Methods: A bibliometric analysis was performed on publications indexed in Scopus from 1965 to 2024. Data were processed and visualized using VOSviewer to explore trends in annual outputs, contributing …

Ecorxchoice.Com— An Sidp-Funded Calculator Integrating Environmental Metrics With Antimicrobial Stewardship, Pamela S. Lee, Hugh Gordon, Theresa Ferguson, Tien Dinh, Misty Vu, Marina Nguyen, Chaynor Hsiao, Gary Fong

Pharmacy Faculty Articles and Research

Healthcare sustainability is a multidisciplinary field that seeks to mitigate healthcare’s environmental consequences. Antimicrobial stewardship and healthcare sustainability both aim to reduce wasteful resource use while maximizing patient safety. However, a strong partnership between antimicrobial stewardship and healthcare sustainability has yet to develop. To facilitate environmentally sustainable decision-making in antimicrobial prescribing, we developed a web-based calculator (EcoRxChoice (www.ecorxchoice.com)) where users can enter different antimicrobial regimens and compare how much plastic waste each regimen creates. This work was supported in part by the Society of Infectious Diseases Pharmacists (SIDP), reflecting SIDP’s commitment to strengthening sustainability as a practical extension of antimicrobial …