Digital Commons Network^™

Calculus In Context: The Five College Calculus Project, James Callahan, Kenneth Hoffman, David Cox, Donal O'Shea, Harriet Pollatsek, Lester Senechal

Open Educational Resources: Textbooks

Calculus in Context: The Five College Calculus Project is a thorough reframing of what it means to learn calculus. It starts with a “clean slate;” there is no presumptive commitment to any aspect of the traditional course. Instead, the curriculum is guided by the following principles:

• Calculus is fundamentally a way of dealing with functional relationships that occur in scientific and mathematical contexts. The techniques of calculus must be subordinate to an overall view of the underlying questions.
• Technology radically enlarges the range of questions we can explore and the ways we can answer them. Computers can be engaged as …

Integrating Routine Hiv Screening Into A Sexually Transmitted Infection Panel At An Opioid Addiction Treatment Facility: A Dnp Clinical Practice Change, Stephanie Bass

Doctor of Nursing Practice (DNP)

People who use drugs are at increased risk of contracting human immunodeficiency virus (HIV) infection, hepatitis B infection, hepatitis C, and sexually transmitted infections (STIs) due to high-risk behaviors, including needle sharing, incarceration, multiple sex partners, and unprotected sex. Individuals with substance use disorders are also at increased risk for liver dysfunction, renal impairment, and other medical comorbidities associated with chronic substance use. Although many organizations, including the Centers for Disease Control and Prevention (CDC), recommend routine screening and laboratory monitoring in high-risk populations, many addiction treatment facilities in the United States lack standardized protocols for bloodborne infection, STI screening, …

Multi-Omics Analysis Of Immune-Metabolic Adaptation To Direct-Fed Microbial Supplementation In Newly Weaned Beef Steers, Adekunle Odunayo Ajiboye

Graduate Theses, Dissertations, and Problem Reports (ETD)

Immune and metabolic disruption during weaning represents a major challenge to health and productivity in beef cattle. This dissertation tested the hypothesis that supplementation with multi-strain direct-fed microbials (DFMs) modulates immune regulation and metabolic pathways associated with adaptation to weaning stress. To address this, whole-blood transcriptomics and plasma metabolomics were used to evaluate molecular and metabolic responses in newly weaned beef steers during the receiving period. Transcriptomic analysis identified differential expressions of genes associated with immune signaling and inflammatory regulation, indicating modulation of immune-related pathways without changes in growth performance. Metabolomic analysis revealed alterations in circulating metabolites related to amino …

Community Resilience Drives Change, Andrew Thomas Solt

Graduate Theses, Dissertations, and Problem Reports (ETD)

The opioid crisis has impacted many Americans. From 1999 to 2023, approximately 800,000 people have died due to opioid overdose (CDC, 2025). What began as overprescriptions of painkillers has quickly evolved into a complex social health issue that is now further worsened by stronger synthetic drugs like fentanyl. Fentanyl and fentanyl analogs (synthetic opioids that are very similar chemically to fentanyl) are often found in illegal drug supplies and in counterfeit pills (CDC, 2025). Thus, individuals who might have been initially overprescribed painkillers might now be pushed towards illegally produced drugs that are significantly more potent than what they were …

A Quality Improvement Initiative To Improve Central Line Insertion Care Using An Evidence- Based Practice Checklist, Jonathan Andre Barbour

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Central line infections in a 33-bed Cardiovascular Intensive Care Unit (CVICU) at a large academic medical center located in the northeastern United States were increasing for patients after cardiovascular surgery. These infections could, potentially, lead to longer hospital stays and lost revenues for the health system. A project explored the implementation of an evidence-based practice (EBP) sterile procedure standardized checklist during central line insertions

Purpose: A quality improvement (QI) initiative project sought to improve central line insertion compliance while monitoring the bedside implementation of an EBP checklist.

Intervention: The Agency for Healthcare Research and Quality’s (AHRQ) Central line-associated bloodstream …

Population Dynamics And Future Viability Of The Eastern Massasauga Rattlesnake (Sistrurus Catenatus) In Southwest Michigan, Matthew John Klein

Graduate Theses, Dissertations, and Problem Reports (ETD)

Managing at-risk species or populations requires understanding the demographic and genetic drivers of long-term population trends. The eastern massasauga rattlesnake (Sistrurus catenatus) is a federally threatened species facing multiple interacting threats across its range. Habitat loss from wetland drainage and agricultural land conversion has caused range contractions and geographic isolation of populations. Because remaining populations are often small and widely separated, most are now genetically isolated, threatening their long-term viability. Reversing these declines requires understanding population dynamics, quantifying extinction risk, identifying drivers of long-term viability, and assessing the effects of inbreeding and the potential for genetic rescue to …

Improving Antibiotic Prescribing For Urinary Tract Infections In Urgent Care Centers, Alexis Alastanos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Urinary tract infections (UTIs) are one of the most common infections that require antibiotic therapy. Providers working in three urgent care clinics located in Eastern West Virginia diagnosis and treat UTIs based on their clinical judgement. Variability in clinical judgement results in inappropriate antibiotic use which has implications on antibiotic resistance and the financial burden of the patients as well as the entire organization.

Evidence Review: A total of 10 articles were evaluated to support the implementation of antibiotic stewardship initiatives that provide guidance in caring for this population. Interventions include electronic health record enhancements, provider education, and tracking …

An Assessment Of Disease Risks, Population Genetics, And Spatial Ecology Of Appalachian Cottontails (Sylvilagus Obscurus) And Snowshoe Hares (Lepus Americanus) In West Virginia, Usa, Madison Leigh Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Snowshoe hares (Lepus americanus) occupy a large range across the United States and Canada. While snowshoe hare populations are generally considered stable in the interior of their range, populations along range edges are experiencing declines, possibly driven by climate-related factors such as seasonal coat color mismatch. West Virginia represents one of the southernmost extents of the species’ range, yet little is known about the population genetic status or population sizes of snowshoe hares in the state. Appalachian cottontails (Sylvilagus obscurus) are another lagomorph species found in West Virginia. This species experienced a historical decline and currently …

Barriers To Immunity: Understanding Covid-19 Vaccine Uptake In Africa, Emilia Blechschmidt

Honors Theses

This thesis examines the factors influencing COVID-19 vaccine uptake across African countries, with a focus on structural, informational, and behavioral barriers to immunization. Drawing on cross-country data, the study analyzes how access to transportation, reliable information, and healthcare resources shape vaccination rates, alongside the effect of demographics and institutional factors in shaping individual perceptions of risk and vaccine safety.

The findings emphasize that the broader strength and preparedness of national health systems strongly influence vaccine uptake. Countries that demonstrated higher coverage of routine childhood immunizations, such as polio and hepatitis B, also tended to perform better in COVID-19 uptake efficiency …

One-Stop-Shop (Oss): Community Health Nursing: (For Undergraduate Nurses), Sarmad Muhammad Soomar

Books

No abstract provided.

Discrimination In The Trademark Id Manual, Rachael Dickson

Fordham Intellectual Property, Media and Entertainment Law Journal

Using evidence drawn from the USPTO’s treatment of 221 identifications submitted for inclusion in the Trademark ID Manual (including 43 this Author submitted on their own and as part of a team), this Article, the first ever written on the ID Manual, argues that the USPTO’s administration of the Manual systematically disadvantages trademark applicants offering lawful but socially disfavored goods or services, such as those relating to cannabis, sexual health, or “vice.”

By deliberately refusing to include identifications of goods and services relating to entire categories of commerce in the ID Manual, the USPTO imposes higher costs, greater uncertainty, and …

A Transdisciplinary Approach To Advancing Water Security And Public Health: The “Nurse + Engineer” Model For Achieving Sustainability In Wash Systems Using Community-Based Participatory Research, Daniel B. Oerther, Sarah Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Human health is linked to the health of the environment, a concept referred to as planetary health. As environmental challenges become increasingly complex, single-disciplinary approaches are insufficient to achieve sustainable solutions. This article presents a transdisciplinary framework, termed the "Nurse + Engineer" model, as a novel methodology for addressing complex problems at the nexus of environmental engineering and public health. The model integrates the technical design and systems-level thinking of environmental engineering with the community-based, patient-centered care of nursing. This work details the key lessons learned from the retrospective application of this framework to a series of multi-year, community-based participatory …

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a widespectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33 ) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (− 72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Development Of A Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model For Beta-Lactam Antibiotic Combination Against Enterococcus Faecalis Based On Time-Kill Assays To Predict Drug Disposition And Guide Dosing Strategy In A Severe Renal Impairment Population, Ruhma Zia Khan

Selected Full-Text Dissertations 2020-

Bacterial resistance to antibiotics continues to be a global health problem, limiting antibacterial therapy against infective endocarditis caused by Enterococcus faecalis. To overcome increasing resistance, dual beta-lactam therapy has been advocated as an alternative regimen for treatment – the synergistic activity against E. faecalis demonstrated to be effective. Currently, ampicillin plus ceftriaxone is the standard of care, but the practical application of this therapy is limited by ampicillin’s poor stability in solution at room temperature. A synergistic combination of penicillin plus ceftriaxone shows promise due to penicillin’s superior stability at ambient temperature, but ceftriaxone’s potential to cause hepatoxicity further limits …

Massive Upper Extremity Neurofibroma Treated With Limb-Sparing Debulking: A Case Report, Danielle Cummings, Tomas Holy, Nathan Morrell

Western Journal of Orthopaedics

Surgical management of neurofibromas in Neurofibromatosis type 1 (Von Recklinghausen’s disease), can be challenging because tumor size, location, hypervascularity, and tissue friability pose the risk for significant intraoperative and postoperative blood loss. Despite these risks, surgery is often necessary because of functional losses or cosmetic concerns. The authors present a 31-year-old woman with a massive neurofibroma on her right distal forearm, wrist, and hand, who ultimately underwent surgical resection because of functional impairment of her hand. She required postoperative hospitalization and blood transfusion for management of acute blood loss anemia. Because of concerns regarding blood loss and surgical morbidity, the …

A Living Epidemic: The Persistence Of Tuberculosis In Contemporary Indigenous Alaska, Sharon Kim , ‘26

Senior Theses, Projects, and Awards

No abstract provided.

Identifying And Prioritizing Essential Healthcare Services For A Private Start-Up Healthcare Hub In Laxmipasha, Bangladesh, Ferdous Ara Mostofa

Dissertations

This quantitative study identifies and prioritizes essential healthcare services for developing a private start-up healthcare hub in Laxmipasha, Bangladesh, a rural community with significant gaps in healthcare access. Using secondary data from national and international sources, the research analyzed disease burden, population characteristics, and service availability to determine the most urgent health priorities. A structured, evidence-based framework was used to evaluate services based on mortality and morbidity, service gaps, and potential health impact. The findings indicate that Maternal and Child Health (MCH), Non-Communicable Disease (NCD) management, and infectious disease control represent the most critical priorities for initial implementation. The study …

The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the strategic role of Corporate Social Responsibility (CSR) in helping small businesses recover from crises, with a specific focus on the COVID-19 pandemic. Different from many traditional studies that highlight the ethical or reputational aspects of CSR, this research will examine its practical effects: how CSR initiatives during crises influence business success by enhancing consumer trust, particularly by examining the differential impact of Internal CSR versus External CSR. The study suggests that, compared with internally focused CSR, external CSR activities will have a greater impact on consumer trust. In addition, the dissertation suggests that this effect is …

Dielectrophoretic Biomarkers For Cancer Detection And Cell Analysis: Integrating Microfluidics And Ai, Raphael Olumide Oladokun

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pancreatic ductal adenocarcinoma (PDAC) carries a five-year survival rate of 13%, driven largely by late-stage diagnosis and the absence of sensitive noninvasive screening tools. Current diagnostic methods lack the sensitivity to detect disease-associated systemic changes at early and precancerous stages, representing a critical clinical gap. This dissertation addresses the central hypothesis that PDAC and its pathological subtypes induce measurable, disease-associated electrophysiological changes in circulating PBMCs that can serve as correlative liquid-biopsy biomarkers. To test this hypothesis, this work asks: can dielectrophoresis (DEP), impedance and zeta potential analysis with AI-assisted classification distinguish benign pancreatic conditions (non-malignant control), precancerous lesions (primarily IPMNs), …

How Do Individual And Environmental Covariates Impact The Immune Response Of Deer Mice In Western Montana?, Rachel A. Throckmorton, Angela Luis

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Sin Nombre Virus (SNV) is an exceptional model system for studying wildlife disease because of how simple it is to capture, take samples, and obtain disease status from the primary host. Immune response is an important factor to consider when testing for SNV because it can affect susceptibility of the host as well as transmission of the virus. We examined individual and environmental conditions that may predict immune response and therefore possibly SNV transmission in wild populations. We investigated whether SNV infection status, reproductive status, sex, and season correlate with immune response through examining total white blood cell (WBC) counts …

Prospective Validation And Comparison Of Laboratory Risk Indicator For Necrotizing Fasciitis (Lrinec) And Site Other Than Lower Limb, Immunosuppression, Age, Renal Impairment, And Inflammatory Markers (Siari) Scoring Systems For Necrotizing Fasciitis In Critically Ill Patients., Talal Ibrahim Mostafa Hagag, Shimaa Mohamed Kalama

Journal of Medicine in Scientific Research

Background Necrotizing soft tissue infections (NSTIs) are rapidly progressive infections that are dangerous to life, with high morbidity and mortality. Prompt surgical and medical management is necessary and stands mostly on precise identification as well as risk stratification. In order to enhance diagnostic as well as prognostic accuracy, prognostic scoring systems like the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) as well as the most recent Site, Immunosuppression, Age, Renal impairment, and inflammatory markers (SIARI) score, were introduced. Methods A prospective observational cohort study was carried out during June-August 2024 in Shebin Elkom Teaching Hospital among 60 patients who had …

A Comparison Of Haemodialysis And Renal Transplantation On Male Sexual Function And Hormonal Abnormalities, Hala Ibrahim Mohamed, Ahmad Mohamad Abbas Elseasi

Journal of Medicine in Scientific Research

Background Sexual dysfunction and hormonal imbalance are common in males with end-stage renal disease (ESRD), particularly among those on chronic hemodialysis. Kidney transplantation may restore endocrine homeostasis and improve sexual function. This study aimed to compare the effects of hemodialysis and renal transplantation on male sexual function and related hormonal profiles. Methods This cross-sectional study was conducted on 40 married men (≥18 years) with ESRD at National Institute of Urology and Nephrology from October 2024 to October 2025. Participants were divided into two groups: Group I (hemodialysis) and Group II (renal transplantation). Clinical evaluation, laboratory tests, and hormonal assays (Folliclestimulating …

Response Efficacy And Discrete Emotions In Message Design: Testing Emotional Pathways To Help-Seeking Intentions And Engagement, Marian Jaitto-Jeffrey

Theses and Dissertations--Communication

Research on fear appeals shows that threat-framed messages promote adaptive outcomes when accompanied by efficacy information. According to the extended parallel process model (EPPM), danger-control responses, including message acceptance, positive attitudes toward recommended behaviors, and help-seeking intentions, are most likely to occur when efficacy appraisals, particularly perceptions of response efficacy, are sufficient to meet perceived threat. When efficacy appraisals fall short of perceived threat, fear-control responses, such as message derogation, denial, or resistance to seeking help, are most likely to emerge. Beyond reducing defensive processing, response efficacy cues may also evoke positive emotions such as hope. Whereas fear is often …

The Covid-19 Pandemic: Predictors Of Inpatient Admission For People With Severe Mental Illnesses, Ashley Killoren

PCOM Psychology Dissertations

The purpose of the study was to identify differences in patterns of demographic and psychiatric symptoms among individuals with severe mental illnesses admitted to an inpatient psychiatric hospital 1 year before the quarantine shelter-in-place restriction order issued by a governor in the Northeastern United States, during the restriction order, and 1 year starting when all COVID-19 restrictions were lifted. A second goal of the study was to determine whether psychiatric admission rates changed by comparing admission rates before and during the quarantine order, and 1 year after all COVID-19 restrictions were lifted. This quantitative, retrospective, observational study was achieved by …

Balancing Inquiry Based Learning And Direct Instruction, Sharon Liu , '26

Senior Theses, Projects, and Awards

No abstract provided.

Prosthetic Knee Joint Infection Caused By Gemella Morbillorum, Nataly Echevarria-Castro, Shaleen Duhra, Leonor Echevarria

Western Journal of Orthopaedics

Gemella morbillorum is a gram-positive coccus found in the gastrointestinal tract, and is an uncommon cause of human infections, including prosthetic joint infections (PJI). Reported risk factors include immunosuppression, recent gastrointestinal procedures, and poor dental hygiene. This report describes a case of knee PJI caused by G. morbillorum, likely due to hematogenous seeding following a colonoscopy three months earlier. The patient is a 70-year-old man with well-controlled diabetes mellitus who had undergone total knee arthroplasty three years prior. He presented with three weeks of left knee swelling. Synovial fluid culture revealed G. morbillorum. The patient was treated with debridement, antibiotics, …

Substance Abuse: Causes, Effects, And Treatment Approaches, Ambrea A. Watkins

Integrated Studies

Abstract

Substance abuse continues to be one of the most significant public health and social challenges facing the United States. Substance use disorders affect millions of individuals each year and have serious consequences for families, communities, and public systems such as healthcare and criminal justice. Addiction is widely recognized as a chronic brain disease that can alter behavior, decision making, and impulse control. Many individuals who struggle with substance abuse also experience related issues such as mental illness, homelessness, poverty, and involvement in the criminal justice system.

This research paper examines the causes, impacts, and treatment approaches related to substance …

Advancing Nanotechnology For Hematological And Osteological Disorders, Chase K. Hamilton

Integrated Studies

When people think of medicine, they often picture stethoscopes, routine clinical checkups, surgeries, and standard prescriptions. One field that needs more acknowledgement is the technological side. As technology continues to evolve, healthcare advances alongside it, with nanotechnology emerging as a substantial area of innovation. This paper reflects the expanding role of nanotechnology in modern medicine, focusing on its potential applications in trauma and internal medicine care and in the treatment of blood and bone disorders as well as bone and blood related cancers. By working at an extremely small scale, nanotechnology allows for more precise and targeted treatment, reducing damage …

Effect Of Jet Lag And Nighttime Shifts On The Circadian Rhythm Of Humans, Mahd Adrees

Williams Honors College, Honors Research Projects

This project reviews the circadian rhythm and its disruption by jet lag and nighttime shifts. It discusses the effects on melatonin, sleep quality, and physiological symptoms using articles from Google Scholar. Key studies, mechanisms, and statistics will support these points. A discussion follows, comparing and contrasting the various literature sources. This review aims to raise awareness and summarize strategies to reduce jet lag and nighttime shift effects, improving wellbeing.

Examining The Pre-Columbian Use Of Psychotropic Plants In The South American Andes: Tobacco, Coca, And Ayahuasca, Jalayne Allison

Distinguished Undergraduate Researcher Program

This thesis offers a literature review that traces the origins and variations in the use of tobacco (Nicotiana sp.), coca (Erythroxylum coca spp.), and ayahuasca (Banisteriopsis caapi) in the Andean highlands and Amazon region along the western coast of South America. This mountainous region stretches across seven countries: Venezuela, Colombia, Ecuador, Peru, Bolivia, and Argentina. Diverse South American Indigenous groups and ancient civilizations, such as the Inca Empire, have inhabited this area. This review delves into key concepts of Andean cosmology, especially those related to ecology and hydrology as interpreted through Inca beliefs. These concepts are pivotal in the application …