Digital Commons Network^™

Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton

Epidemiology and Environmental Health Faculty Publications

The Ryan White HIV/AIDS program (RWHAP) is governed by legislative and programmatic guidelines that ensure comprehensive services are provided to persons with HIV (PWH) across the United States. Comprehensive training and skill building opportunities for programmatic staff are rare. RWHAP funding recipient organizations may struggle to acquire and retain essential program-specific knowledge, with downstream impact on patient care and treatment. We designed a comprehensive 11-session videoconference learning series to improve program staff’s confidence and competence with RWHAP fundamentals. Quantitative pre-vs-post session data were analyzed using Wilcoxon Signed-Rank tests, and qualitative data using thematic analysis. We enrolled 136 staff from 23 …

Aging On The Fringes: Understanding Inequities Among Older Adults Impacted By Poverty, Mental Health Challenges, And Drug Use, William O’Leary, David Howson-Jan, Marjorie Knight, Soo Chan Carusone

Lyle S. Hallman Social Work Faculty Publications

This report provides an overview of government reports and academic literature examining aging and its intersection with poverty, homelessness, drug use, and mental health challenges. It pairs national and Ontario trends with data from Waterloo Region to illustrate how aging on the fringes is unfolding locally.

Throughout the report, “Local Lens: Waterloo Region” callouts highlight key regional indicators and their implications for programs and policy. The purpose of this report is to support discussion and action to advance equity-informed research and advocacy for people aging on the fringes. It is written for community members, service providers, and organizations seeking to …

Justice For One, Injustice For All: The Consequences Of The Legal Services Corporation’S Class Action Restriction, Elizabeth J. Lattner

Case Western Reserve Law Review

No abstract provided.

University Of Central Florida Graduate Catalog, 2025-2026, University Of Central Florida

UCF Catalogs

No abstract provided.

An Engine, Not A Vessel: Place, Politics, And Health In The United States, Philip B. Rocco

Political Science Faculty Research and Publications

Social scientists often treat places as containers for social and economic phenomena that shape health outcomes. Yet this analytic practice conceals more than it reveals. Local governments in the United States should be understood as engines of both health promotion and stratification. As the contributions to this symposium suggest, governments not only occupy a formal place in the U.S. public health system, their decisions on everything from housing to transportation infrastructure can also have profound impacts on health outcomes. Local political economies likewise renegotiate the parameters of acceptable health interventions, public understandings of health disparities, and the status of population …

Precision Metagenomics Reveals Microbial Landscape In Acute Upper Respiratory Infections: A Comprehensive Dataset, Sadia Almas, Rob E. Carpenter, Vaibhav K. Tamrakar, Anuradha Singh, Aditya Sharma, Rahul Sharma

Human Resource Development Faculty Publications and Presentations

Objectives The comprehension of the microbial composition in upper respiratory tract infections is pivotal for the progression of diagnostic and treatment methodologies. This article presents a dataset derived from Precision Metagenomic next-generation sequencing using hybridization capture-based targeted sequencing. Nasopharyngeal samples from 24 patients with acute URIs were analyzed using the Illumina®/IDbyDNA Respiratory Pathogen ID/ AMR panel. The dataset contains a wealth of information on the composition of the microbiota, including the relative abundance of known pathogens and their potential clinical significance. Data description This dataset serves as a valuable asset for future research in respiratory medicine, infectious disease epidemiology, antimicrobial …

Ebola In The Drc: A Different Problem Compounded By Violence, David Brett-Major

Journal Articles: Epidemiology

A Public Health Emergency of International Concern (PHEIC) has been declared in the Democratic Republic of Congo (DRC) due to Ebola disease from Bundibugyo virus. Non-health-focused factors should be fundamental to how DRC and its partners respond to and recover from the current emergency. Filovirus emergencies are violent in every sense-the disease experience of patients and their caregivers, the tumult in impacted communities, sometimes the physical manifestations of frustration against healthcare services, the fits and starts of concerted response, and the milieu of conflict in which this emergency occurred. Yet, interpersonal and organized violence may contribute to frequency of health …

Electrochemical Sensors Development For Bacterial Detection And Surveillance: Recent Advances And Future Directions, Baljit Singh, Kamna Ravi

Research Outputs: 2025-Present

In today’s environment, rapid, reliable, and accurate bacterial detection is essential for protecting public health while preserving and ensuring the safety of food, water, and agricultural and environmental systems. Over the years, electrochemical sensors have gained widespread attention as viable candidates due to their rapid response, high sensitivity and selectivity, adaptability and portability, and low manufacturing cost. This facilitates their integration into various sectors, including healthcare and diagnostic applications, food safety and agriculture, and water and environmental monitoring. While these achievements represent tremendous progress, some of the challenges that need to be overcome include stability, batch-to-batch reproducibility, manufacturability, performance reliability, …

Challenging Cases In Infection Prevention And Control: Proceedings From Shea Spring 2025., Jessica Seidelman, Tsun Sheng N Ku, Anna Lafountaine, Curtis J Donskey, Edo-Abasi U. Mcgee, Rachel Pryor

PCOM Scholarly Works

Hospital epidemiologists and infection prevention professionals are frequently required to make high-stakes decisions in complex clinical scenarios where evidence-based guidance is limited or absent. These decisions often carry significant implications for patient safety, healthcare worker protection, hospital operations, and legal or financial risk. This article presents three challenging cases originally featured during the "Interesting Cases" session at the Society for Healthcare Epidemiology of America (SHEA) Spring 2025 Conference, with the goal of sharing practical lessons learned and contributing to the evolving literature in healthcare epidemiology. The first case describes the intraoperative contamination of a polyethylene liner during emergency revision total …

Ancient Immune Systems: Sensing And Signaling In Bacterial-Phage Conflict, Cameron Grace Roberts

Student Theses and Dissertations

Viruses are among the most significant selective pressures shaping the evolution of life on Earth. In the microbial world, bacteriophages (phage) are bacterial viruses and drive a continuous evolutionary arms race that has led to an extraordinary diversity of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous eukaryotic immune strategies [2]. Experimental studies have validated many of these anti-phage defense systems and revealed the mechanisms by which they disrupt phage infection [3]. Nonetheless, major gaps persist in our understanding of how bacterial immune systems recognize bacteriophage infection to trigger immunity. This dissertation …

Review Of Vampire Forensics: Uncovering The Origins Of An Enduring Legend, Elizabeth Brandt

Nebraska Anthropologist

Review of Vampire Forensics: Uncovering the Origins of an Enduring Legend (2010) by Mark Collins Jenkins.

Suing The Ghost In The Medical Machine, Jason R. Cheek

SMU Science and Technology Law Review

Devices that autonomously diagnose medical conditions, with no human interaction, have arrived. These self-operating systems incorporate artificial intelligence (AI), and include machines that diagnose preventable blindness, as well as some that write radiology reports. These devices feature AI-integrated software to make diagnosis decisions traditionally made by humans who have received extensive medical training. Soon, AI-driven devices will autonomously make treatment decisions.

What happens when these autonomous medical systems harm a patient? At the moment, most would expect product liability law to provide a path to recovery. But AI oftentimes uses multiple complex inputs and approaches, including statistical probabilities, to reach …

Filling The Network Gap In Research Ethics: Analyzing Ethical Issues At Scale In Big Team Science, Susan Wolf, Gillian H. Roehrig, Timothy L. Pruett, Korkut Uygun, Claire Colby Mcvan, Evelyn Brister, Shawneequa L. Callier, Alexander M. Capron, James F. Childress, Rosario Isasi, Andrew D. Maynard, Kenneth A. Oye, Paul B. Thompson, Terrance R. Tiersch

Articles

Scientific research increasingly involves large, multidisciplinary teams networked across multiple institutions to develop new technologies. Despite the rise of complex research networks and big team science, there has been too little analysis to date of the ethical challenges facing these networks. The extensive literature on the ethical issues confronting individual researchers and small teams (the microlevel) and on the larger societal challenges flowing from research and new technology (the macrolevel) leaves a troubling gap in between, at the mesolevel of the research network involved in big team science. Yet the ability of complex networks to conduct research ethically—which is essential …

A Systematic Review: Comparative Analysis Of Healthcare Waste Management Practices In Kenya And In The United States, Esther Nyokabi Gathungu

Electronic Theses and Dissertations

This comparative study used a systematic literature review to explore waste management practices in Kenya and the USA, examining predefined concepts to identify new patterns relevant to sustainable healthcare waste management (HCWM) practices. The study aimed to understand sustainable practices in healthcare waste management and how developing nations such as Kenya can benchmark from practices in developed nations such as the USA. While the study identified challenges in waste management across Kenya and the USA, it also identified sustainable practices that could be adopted across contexts. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines …

Improving Nasal Decolonization Rates In The Inpatient Medical-Surgical Setting, Francesca Annunziato Royer

DNP Projects

Background/Significance

Hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) remains a significant cause of morbidity, mortality, and increased healthcare costs. Alcohol-based nasal decolonization is an evidence-based strategy to reduce MRSA transmission; however, staff compliance with decolonization protocols is often suboptimal, limiting effectiveness in inpatient medical-surgical settings.

Purpose

The purpose of this evidence-based quality improvement (EBQI) project was to evaluate whether implementing a structured, evidence-based nasal decolonization protocol improved staff compliance and reduced missed administrations and patient refusals among eligible medical-surgical inpatients.

Methods

This EBQI project was implemented on five inpatient medical-surgical units at a large academic medical center. Interventions included standardized staff education, …

Beyond The Bars: Reimagining The Dc Correctional System As The Frontline For Hepatitis C Elimination, Rahimatu Jalloh, Amber Munoz, Riyan Lee, Kristen Martinez, Malia Allen, Gerard Lin

DC Health and Academic Prep Program (DC HAPP)

Hepatitis C is a major public health concern among incarcerated populations, who are infected at rates approximately 10 times higher than the general U.S. population. In Washington, D.C., an estimated 12,700 people are living with hepatitis C, and the District has one of the highest HCV prevalence and mortality rates in the nation. Although hepatitis C is highly curable, many incarcerated individuals do not receive treatment despite having enough time to complete therapy while incarcerated.

This project proposes a comprehensive hepatitis C program for the D.C. prison system that addresses HCV through prevention, intake screening, treatment during incarceration, and post-release …

Longitudinal Implementation Of A Neurodevelopmental Screening Program For Children Born To Mothers Living With Hiv In Maternal–Child Clinics In Kenya: A Mixed Methods Study, Megan S. Mchenry, Eren Oyungu, Amina Abubakar, Ananda Roselyne Ombitsa, Micaela Gaviola, Cleophas Cherop, Beatrice Kaniaru, Carolyne Jerop, Alan Mcguire, Rachel C. Vreeman

Institute for Human Development, East Africa

Background: Children with perinatal HIV exposure are at increased risk for neurodevelopmental (ND) delays, yet little is known about ND screening implementation for this population.

Methods: This longitudinal study evaluated ND screening implementation at a health clinic in Kenya, from 9/2021 to 8/2023. Children aged 18-36 months with perinatal HIV exposure were screened using a 12-item general ND tool. Implementation outcomes—acceptability, feasibility, fidelity, and sustainability—were assessed through time-motion observations, clinic records, and semi-structured interviews with caregivers and staff.

Results: Of 507 eligible children, 405 (80%) were screened. Screening rates were consistent over 24 months, with average time …

Outbreak Preparedness And Response In A Globalized World: Are We Ready?, Francesca F. Norman, David Brett-Major, Chiara Sepulcri, Emmanuel Bottieau, Theresa Sepulveda, Federica Toscanini, Laura A. Nicolini, Jesse J. Waggoner, Sami Alcedo, Davidson H. Hamer, Ralph Huits, Michael Libman, Geosentinel Network, Tropnet Network, Kevin O'Laughlin

Journal Articles: Epidemiology

BACKGROUND: Recent global epidemics and pandemics have highlighted the need for adequate diagnostic capacities to respond to emerging threats. Strengthening operational capacities can lead to improved preparation; investing in emergency response infrastructure may diminish progression of outbreaks and prevent escalation.

METHODS: An email-linked survey was sent January-March-2025 to two global infectious disease surveillance networks' (GeoSentinel and TropNet) participating clinics assessing capacity for Oropouche virus (OROV) diagnostic testing. Data on testing capacity for other arboviruses was also requested.

RESULTS: Responses were obtained for 58 GeoSentinel/TropNet sites (58/104, 55.8%): 50% responding sites (29/58) had OROV diagnostic testing available at a public reference …

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a wide-spectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (−72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

A Meta-Narrative Review: Advancements In Mycobacterium Tuberculosis And Their Impact On Healthcare Professionals, Nadine Duran, Mehwish Khalil, Alexandria Ramirez, Link Summers-Perry, Mary Coolbaugh-Murphy, Denise Juroske Short

Research Methods Poster Session 2026

No abstract provided.

Meta-Narrative Review: The Role Of Pen-A And Other Genetic Mutations In Ceftriaxone-Resistant Neisseria Gonorrhoeae, Elizabeth Calderon, Alejandra D. Coreas, Bereniz A. Esmeralda, Jianne A. Peregrino, Denise M. Jursoke Short, Mary Coolbaugh-Murph

Research Methods Poster Session 2026

No abstract provided.

Fecal Microbiota Transplantation Modulates Gut Microbiota And Lipid Metabolism To Reduce Diarrhea In Low-Birth-Weight Neonatal Calves, Zhanhe Zhang, Duo You, Donglin Wu, Xintong Li, Yang Jia, David L. Harmon, Ming Xu

Animal and Food Sciences Faculty Publications

This study aimed to elucidate the mechanism by which colonic fecal microbiota transplantation (FMT) improves lipid metabolism in low-birth-weight neonatal calves via modulation of the gut microbial ecosystem. In a completely randomized design, seventy newborn Holstein calves (1 day old, 32.63 ± 3.13 kg BW) were assigned to two groups (35 calves/treatment; 30 females and 5 males per group). A healthy calf was used as a fecal donor. A 10% fecal bacterial suspension was prepared and administered colonically (50 mL, twice daily for 5 days). All calves were fed the same milk replacer and weaned using a step-down protocol at …

Type Ii Diabetes Treatment Comparison Via Compartment Modeling, Abigail M. Collins

Theses and Dissertations

Type II diabetes mellitus affects one in ten adults worldwide, yet the effects of treatment type and adherence level on developing complications and quality of life have not been well characterized at the population level, and mathematical modeling offers a structured way to examine these dynamics. This thesis adapts the Boutayeb et al. (2004) model to incorporate dynamic treatment types and levels of adherence, producing nine scenarios in which complication development rate and complication recovery rate differed, to compare peak complications and quality of life across treatment and adherence conditions. Using a system of ordinary differential equations and compartment modeling, …

Oral N-Acetylcysteine In Hepatitis C - Induced Acute Liver Injury: A Case Report, Mohammed Irfan Khan, Shuchita Jhaveri, Renu Thomas, Kevin Garnepudi, Galvin Dhaliwal, Ahmed Ouni, Shane P. Sweeney, Julian Nguyen

Gulf Coast Division GME Research Day 2026

No abstract provided.

A South Texas Mousetrap: A Case Report Of Murine Typhus And Diagnostic Dilemmas, Arjun Kamath, Jose Garza, Matthew Wagner, Deekshita Valiveti, Percy Thomas, Christopher Ganson, Abhay Vakil, Zuhair Ali

Gulf Coast Division GME Research Day 2026

No abstract provided.

Right Upper Quadrant Pain With Perihepatitis, Morgan D. Homan, Jake Valentine, Edwin R. Malone Ii

Gulf Coast Division GME Research Day 2026

No abstract provided.

More Than A Scratch: Capnocytophaga Bacteremia Induced Severe Sepsis With Multi-Organ Failure With Occupational Dog Exposure, Cristina Lee, Alex Craig, Dmitriy Scherbak

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

How Robotics Can Reduce Occupational Injuries In Hospitals: Is Hipaa A Barrier?, Uwa Maher

Student Works

No abstract provided.

The Great Imitator: A Subtle Case Of Syphilis In The Emergency Department Amid Rising National Incidence, Jyotirmaya Jain, Michael Flanders, Manzoor Bevinal

Gulf Coast Division GME Research Day 2026

No abstract provided.

From Susceptible To Stubborn: Fluconazole Resistant Candida Albicans Bacteremia, Mackenzie Elias, Denise Balcacer-Estevez, Trent Percy

West Florida Division GME Research Day 2026

No abstract provided.