Digital Commons Network^™

Optic Neuritis And Neuroretinitis In Cat-Scratch Disease: An Updated Systematic Review, Sara Urdiales-Sánchez, José-Ramiro González-Montaña, Pilar Alonso-Alonso, Javier Urdiales-Urdiales

Journal of Pediatric Neurology

This study provides a systematic review of optic neuritis and neuroretinitis associated with cat scratch disease (CSD) caused by Bartonella henselae. CSD, commonly transmitted through cat scratches or bites, can lead to visual complications, particularly in children, who are more frequently exposed to cats. A comprehensive literature search identified 10 relevant studies from an initial pool of 521 articles. Typical CSD manifests with regional lymphadenopathy, but severe complications like hepatosplenomegaly and encephalitis can occur, especially in younger patients. Atypical presentations, such as neuroretinitis, often begin as optic neuritis with papillary edema, progressing to a macular star pattern. Pediatric patients may …

Performance Of The Mean, Highest, And Admission Day Pediatric Sequential Organ Failure Assessment (Psofa) Scores As Outcome Predictors In A Pediatric Intensive Care Unit: A Prospective Observational Study, Debasis Maity, Moumita Samanta, Sandipan Sen, Tapan Kumar Sinha Mahapatra, Asim Kumar Mallick

Journal of Pediatric Intensive Care

Objectives: The Pediatric Sequential Organ Failure Assessment score (pSOFA) has been recently validated from its adult version having included the six clinical and biochemical parameters of organ dysfunction (respiratory, coagulation, cardiovascular, neurological, hepatic, and renal) and adapting age-adjusted cutoffs. Our goal was to find out which among the pSOFA scores (recorded on admission, highest score, and the mean score i.e., pSOFA1, pSOFAh, and pSOFAm respectively) performed better to predict mortality among the patients admitted in our pediatric intensive care unit (PICU). Methods: This prospective observational study was conducted on 104 patients (1 month to 12 years of age) admitted in …

The Expansion Of Exposure Notification Software To Enhance Disease Surveillance And Ring Vaccination, Julia Felton

URGENT Matters

No abstract provided.

Combined Glycoprotein Mutations In Rabies Virus Promote Astrocyte Tropism And Protective Cns Immunity In Mice, Mirjam Anna Rita Bertoune, Corinna Kolbe, Ann-Cathrin Werner, Maren Steinmetz, Bernhard Dietzschold, Eberhard Weihe

Department of Microbiology and Immunology Faculty Papers

Rabies virus (RABV) causes fatal encephalitis once it invades the central nervous system (CNS), and treatment options are extremely limited at this stage. We investigated the recombinant RABV variants SPBN, SPBNGA (glycoprotein substitution R333E), SPBNGAK (R333E plus N194K), SPBNGAS (R333E plus N194S), and TriGAS (three copies of the R333E/N194S glycoprotein). We evaluated their cellular tropism and immune activation in an intracerebral mouse infection model using immunohistochemistry and confocal immunofluorescence. SPBNGAK (R333E/N194K) resulted in mixed neuronal and astrocytic infection and lethal disease. In contrast, the R333E/N194S mutations in the GAS variants were associated with reduced neuronal infection and apparent astrocyte-restricted infection …

Partial Versus Full Revision In Cementless Single-Stage Exchange For Hip Periprosthetic Joint Infection: A Multicenter Comparative Study With 10-Year Survivorship Analysis, Wenbo Mu, Atthakorn Jarusriwanna, Boyong Xu, Scot A. Brown, Xiaogang Zhang, Alexander Dawes, Javad Parvizi Md, Li Cao

Rothman Institute Papers

BACKGROUND: Periprosthetic joint infection (PJI) is one of the most challenging complications following total hip arthroplasty (THA). Traditional management typically involves full revision to ensure comprehensive infection eradication. However, for patients with well-fixed implants, partial revision in a single-stage cementless approach may provide a viable alternative, potentially preserving bone stock and reducing operative time. The relative efficacy of this approach compared with full revision remains to be fully explored. This multicenter study aims to determine whether partial revision in cementless single-stage exchange surgery offers comparable infection control outcomes to full revision for select patients with well-fixed implants.

METHODS: We conducted …

The Cowl - V. 89 N. 12 - January 29, 2026

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 12 - January 29, 2026. 16 pages.

Shingles: A Case Report, Michele White Dds, Ryan Vahdani Dds, Mha, Gary Frey Dds, Ben Warner Ms, Dds, Md

The Journal of the Michigan Dental Association

This case report details a 58-year-old male who presented at a dental urgent care clinic with oral pain and a facial rash. The report identifies the condition as shingles (herpes zoster), caused by the reactivation of the varicella-zoster virus. It explores the clinical presentation, differential diagnosis—distinguishing it from Ramsay Hunt Syndrome and Bell’s palsy—and emphasizes the importance of early antiviral treatment. Furthermore, the source highlights the role of dental practitioners in identifying infectious diseases and promoting vaccination. It serves as an educational tool for medical and dental clinicians to enhance collaborative care and expedite treatment through better recognition of shingles …

Characteristics Of One Escherichia Coli Strain Isolated From The Sick Red Panda Excreting Mucus-Like Faeces, Dongjie Cai, Lanjing Ma, Xingxin Fu, Bin Tian, David Ranucci

The Thai Journal of Veterinary Medicine

The purpose of this study is to explore the main pathogens that caused one red panda to excrete mucus-containing faeces continuously. The anal swabs of sick red panda were collected for bacterial isolation, biochemical analysis, 16SrRNA sequencing identification, antimicrobial susceptibility testing, and research on pathogenicity in Mice. An Escherichia coli (E. coli) strain was isolated and determined. This strain was resistant to ampicillin, penicillin G, ceftiofur, and highly sensitive to levofloxacin, imipenem, azithromycin, kanamycin, and compound sulfamethoxazole. All mice died within 8-14 hours after injected intraperitoneally with 6×10⁸ CFU/mL E. coli. Histopathology showed that the lungs, …

Mast Cells Promote Pathology And Susceptibility In Tuberculosis, Ananya Gupta, Vibha Taneja, Javier Rangel-Moreno, Nilofer Naqvi, Abhimanyu, Yun Tao, Mushtaq Ahmed, Kuldeep Singh Chauhan, Daniela Trejo-Ponce De Leon, Gustavo Ramírez-Martínez, Luis Jiménez-Alvarez, Cesar Luna-Rivero, Joaquin Zuniga, Deepak Kaushal, Shabaana A Khader

2020-Current year OA Pubs

Tuberculosis (TB), caused by the bacterium

Staff Education To Increase Knowledge And Awareness Of Cultural Sensitivity Among Providers, Stephanie Chiamaka Anyanwu

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project aimed to enhance cultural sensitivity among healthcare providers through an educational intervention in a local organization. With the U.S. foreign-born population exceeding 47 million, the need for culturally competent care has become paramount. The study involved nine participants who underwent a pretest and posttest assessment to evaluate their knowledge and awareness of cultural sensitivity. Results indicated a significant increase in knowledge, with pretest and posttest scores improving from a mean of 4.33 to 8.56 (p < 0.01). Awareness in key areas such as patient-provider relationships, cultural beliefs, and language barriers also showed marked improvement. These findings further support the necessity of ongoing cultural sensitivity training to enhance patient care and outcomes, highlighting the potential for broader application across healthcare institutions.

Cysteine Protease Activity In Allergen Recognition And Initiation Of Th2 Allergic Responses, Audrey Rae Meloun

ETDs from 2020-2029

Allergens are non-infectious environmental proteins that can trigger T helper 2 (Th2) cell-mediated inflammation in atopic individuals. Allergens are structurally diverse and typically lack pathogen-associated molecules patterns (PAMPs), which are recognized by pathogen recognition receptors (PRRs). PRRs are the canonical sensors of the innate immune system that typically detect PAMPs in microbes, initiating signaling pathways that drive pathogen clearance. Because allergens generally do not activate PRRs in the same way as infectious agents, alternative detection mechanisms are likely responsible for their recognition and the subsequent initiation of Th2 cell-mediated inflammation. House Dust Mite (HDM), a major indoor allergen, and other …

Beyond The Rash: Cutaneous Peripheral T-Cell Lymphoma As A Diagnostic Pitfall In Primary Care, Jared Hensley, Aura Calderon, Blake Martin, Cristina Kochi, Andres Suarez Parraga

School of Medicine Publications

Cutaneous manifestations of T-cell lymphomas may resemble common dermatologic or infectious conditions, increasing the risk of delayed recognition. We report a 78-year-old woman with known peripheral T-cell lymphoma (PTCL) who presented with a rapidly progressive, diffuse erythematous rash accompanied by cervical lymphadenopathy. Initial evaluation prioritized more common etiologies; however, inpatient medicine broadened the differential diagnosis, prompting early hematology and oncology consultation. Contrast-enhanced CT of the neck demonstrated multiple enlarged, partially necrotic left cervical lymph nodes consistent with disease progression. After multidisciplinary discussions and consideration of prognosis, the patient elected palliative-focused management with oncology follow-up. This case underscores the importance of …

Anorectal Complications In Acute Leukaemia: A Retrospective Analysis Of Clinical Characteristics, Management And Outcomes In A Tertiary Care Setting In Oman, Najwa Al Himali, Murtadha Al Khabori, Mohamed Al Huneini

Sultan Qaboos University Medical Journal

Objectives: Anorectal complications are common and serious issues among patients with haematological malignancies, leading to significant morbidity and mortality. Limited data are available on their incidence, microbiology screening and management. This study aimed to improve the understanding of these complications in patients diagnosed with acute leukaemia in Oman. Methods: This retrospective study was conducted at Sultan Qaboos University Hospital, Muscat, Oman and included patients diagnosed with acute leukaemia who developed anorectal complications over the past decade (2015–2024). Results: A total of 100 patients were included in this study; 50% had acute myeloid leukaemia (AML), 35% had acute lymphoblastic leukaemia (ALL) …

Hepatitis C Virus Treatment Outcomes Using A Family Medicine Interdisciplinary Team., Megan Hull

Ambulatory and Primary Care Articles

No abstract provided.

Routine Admission Urinalysis Has Low Clinical Utility In Psychiatric Hospitalizations, Tri Pham, Devanshi Patel, Ana Berce, Alice Bewley, Sena Sayood

2020-Current year OA Pubs

We examined the diagnostic utility of urinalyses (UAs) in psychiatric admissions. Admission UAs led to diagnosis of clinical urinary tract infections in 1.7% of cases. Among those treated with antibiotics, inappropriate prescriptions occurred in 71.3% of cases, with increased odds in older age, female sex, positive cultures, and certain psychiatric diagnoses.

Description Of Services Per Conception, Conception Rate And Pregnancy Rate In Dairy Cattle Post Foot And Mouth Disease At Kpsbu Lembang, Maulyda Miftahuljannah, Septiyani Septiyani, Nucholidah Solihati

Jurnal Ilmu Ternak Universitas Padjadjaran

The availability of dairy cow milk in Indonesia is still insufficient to meet domestic needs, one of which is caused by the declining dairy cow population due to infectious diseases, namely FMD (Foot and Mouth Disease). Not only does it cause economic losses, FMD also results in a decline in the reproductive status of dairy cows. To assess whether a cow's productivity level is good or not, it can be determined quantitatively by calculating several reproductive efficiency parameters, namely Service per Conception (S/C), Conception Rate (CR) and Pregnancy Rate (PR). The aim of this research is to describe the reproductive …

Study Of The Implementation Of Health Management For Pig Breeding In Cv Roku, Manggarai, East Nusa Tenggara, Korbinianus Rinca, Roselin Gultom, Maria Luju, Yohana Febrizki Bollyn

Jurnal Ilmu Ternak Universitas Padjadjaran

The application of health management is a determining factor for the success of a pig farm business. This research was conducted to find out the implementation of pig health management in CV. Roku, Manggarai, East Nusa Tenggara. The data used in this research was secondary data. The secondary data was reconfirmed to the owner using the direct interview method using questionnaires. Secondary data that has been confirmed using the interview method, was then analyzed descriptively. The practice of health management studied was the application of medication, biosecurity, and vaccination to gilts, sows, and piglets. The results of the study showed …

Review Efek Ekstrak Tanaman Berbeda Sebagai Anti-Toxocara, Gosha Parugrug, Desy Widianingrum, Listya Purnamasari, Himmatul Khasanah

Jurnal Ilmu Ternak Universitas Padjadjaran

Toxocara canis and Toxocara cati are important zoonotic parasites of dogs and cats. The increasing use of medicinal plants as anti-parasitic agents are attributed to its advantages like less side effects, with lower risk of anthelmintic resistance, and as cheaper alternatives. Although there are still no reports of anthelmintic resistance in Toxocara spp, the tendency of it happening should always be anticipated. This review summarized the in vitro and in vivo studies of the anti-Toxocara activity of plants, to enumerate the different plant extracts and the isolated active compounds in relation to their activity. In vitro studies investigated …

Effectiveness Of Pineapple Waste (Ananas Comosus) As Natural Disinfectant In Milk Cans, Eulis Tanti Marlina, E. Harlia, Y Hidayati

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aims to study the effectiveness of pineapple fruit waste (peelsand hump) as a natural source of disinfectant in the disinfection process of milk can. The study was conducted descriptively with three treatments, namely ethanol 96% (P1), pineapple peelsextract 100% (P2), and pineapple hump extract 100% (P3). The parameters measured were bacterial inhibition zones, decrease of total bacteriaand Coliform. The results showed that ethanol 96%was very effective in reducing total and Coliform bacteria by producing a inhibition zone of 25.75 mm, while pineapple peelsand hump extracts were included in the medium category disinfectant by producing inhibition zones of 9.05 …

Antibacterial Activities Of Methylating Cowpea Globulins, Seham Abdel-Shafi, Ali Osman, Eman Tartour, Mahmoud Sitohy, Gamal Enan

Al-Farahidi Biomedical Journal

Background: Cowpea (Vigna unguiculata) is a nutritionally important legume rich in storage proteins, mainly 7S and 11S globulins. These proteins have gained recent attention due to their potential bioactive properties, including antimicrobial effects. Chemical modification such as methylation may enhance their functional and biological activities.

Objectives: This study aimed to extract and characterize cowpea protein isolate (CPI) and its globulin fractions (7S and 11S), evaluate their antibacterial activities, and investigate the effect of methylation on enhancing their potency.

Materials and Methods: CPI was extracted from cowpea seeds, and 7S and 11S globulins were purified and designated as P7S …

Vaccines For Pandemics: Lessons From Covid-19 For H5n1 And Beyond, Alison Mccarthy, Michael S. Sinha

University of Chicago Legal Forum

The COVID-19 pandemic brought unprecedented challenges to vaccine development and distribution. Never before has a vaccine been developed so quickly and distributed so rapidly. But compared to past pandemics and public health crises—like polio or even the more recent H1N1 pandemic—the United States government’s COVID-19 vaccine strategy depended greatly on the private sector.

COVID-19 vaccines were credited with saving millions of lives worldwide, but private companies reaped these rewards, retained their patent rights, and profited from the vast and pressing need for their vaccines. Now, five years later, not every company views its vaccine work as a success. Financial hits …

Realizing The World Health Organization’S Constitutional Mission: Equitably And Everywhere, Sam Halabi, Lawrence Gostin

University of Chicago Legal Forum

COVID-19 revealed deeply embedded inequalities in countries’ capacity to respond to public health disasters. From 2020 to 2024, the content and scope of international health law expanded to address these deep inequities, including a new pandemic agreement and significant changes to the International Health Regulations (IHR). Recent moves by the Trump Administration leveled significant losses on this new global health law infrastructure. At the heart of this infrastructure is the World Health Organization (WHO)—the UN’s specialized agency, which for 77 years has led the world toward realizing the human right to the highest attainable standard of mental and physical health. …

Crisis And The Constitution: The Role Of Civil Liberties In Times Of National Security Threat, Michele Goodwin, Allison M. Whelan

University of Chicago Legal Forum

In this Article, we contribute to the unfolding debate around civil liberties and civil rights in times of political, cultural, and health crises. As this Article was drafted, the National Guard was deployed in Los Angeles, California and Washington, D.C. by the President of the United States. In Oregon, a federal judge issued a final order barring the Trump administration from deploying troops to Portland. These events renew questions related to federalism, states’ rights, individual civil rights, and civil liberties. As chaos unfolds, what is the rule of law and role of civil liberties in times of real or purported …

The Disaster Management Complex: Law’S Adaptations In Times Of Climate Disaster, Michael Burger, Jeffrey Schlegelmilch, Lucia Bragg

University of Chicago Legal Forum

The Anthropocene is marked by constant climate-related disasters and defined by the urgent need to foster and implement adaptations to future climate impacts that reduce disaster risk. The intensity, frequency, and severity of extreme weather events continue to rise even as nations and corporations alike miss their emissions targets, all promising a hotter, wetter, and more extreme future. A number of federal agencies, including the Federal Emergency Management Agency (FEMA), have, at times, sought to adapt their own famously fragmented responses to these changing circumstances. However, federal disaster response is conducted against a backdrop of authorizing legislation that is designed …

The Consequences Of Attempted Human Perfection: Genetic Enhancement And Why It Is Immoral, Kiran S. Sajnani

Mako: NSU Undergraduate Student Journal

In the field of biomedical ethics, genetic enhancement—the alteration of human DNA to increase characteristics beyond normal function—is a highly contested topic. Genetic enhancement presents serious ethical issues, especially when gene therapy seeks to treat or prevent disease. This paper makes the consequentialist case that genetic enhancement, whether somatic or germline, is intrinsically unethical because of its ethical, societal, and systemic ramifications. The autonomy of future persons is violated by germline enhancement, which also runs the risk of deepening socioeconomic gaps and escalating intergenerational inequity. Even though it only affects the individual, somatic augmentation undermines human diversity and agency by …

A Prospective Analysis Of Pediatric Emergency Department Revisits: Insights And Strategies For Enhanced Care, Jumeena Shahanaz, Tania Alhuwalia, Uma Gonchigar, Molly Ruttenberg, Fady Ebrahem, Venugopalan Poovathumparambil

URGENT Matters

No abstract provided.

Community And Individual Risk Factors Associated With Tuberculosis Treatment Outcomes: Ca, Md, And Oh, [2017-2021]., Kadiatu Banjoko

Walden Dissertations and Doctoral Studies

There are unsuccessful treatment outcomes with Tuberculosis (TB) disease, although effective therapies exist. This study aimed to identify predictors of unsuccessful treatment using the socioecological model. A quantitative cross-sectional study and multinomial logistic regression analysis were used to measure the associations between long-term care (LTC), homelessness, correctional facility, Human Immunodeficiency Virus (HIV), diabetes, excess alcohol, illicit drug use, and TB treatment outcomes of death, lost to follow-up, and treatment refusal. The sample consisted of 7,589 individuals aged 15 and older with pulmonary TB between 2017 and 2021, residing in California, Ohio, and Maryland. Findings indicated a correlation between community factors …

Tick Incidence Across Midwestern Summer Camps: Associations With Landscape Characteristics In Year 2 Of Fight The Bite, Alexandea Skrocki, Barry A. Garst, Tracey Gaslin

ACA National Camp Research Forum Abstracts

No abstract provided.

Assessing Abuse And Neglect In U.S. Nursing Homes: A Comparative Analysis Across Pre-, During, And Post-Pandemic Periods, Katherine Gane

Theses and Dissertations

Nursing homes are among the most closely regulated providers in the U.S. healthcare system, with both federal and state agencies working together to monitor care and help protect residents. The COVID-19 pandemic, however, introduced unprecedented challenges for facilities and survey agencies alike, disrupting normal operations, limiting in-person visits, and temporarily shifting regulatory priorities. The purpose of this study was to examine how these pandemic-related disruptions were reflected in the severity and reporting patterns of substantiated abuse and neglect deficiencies in U.S. nursing homes. Using publicly available data from the Centers for Medicare & Medicaid Services (CMS), this study analyzed 39,607 …

Creative Arts To Enhance Cervical Cancer Awareness Using Art-Based Messages From A Nigerian Crowdsourcing Open Call: Qualitative Thematic Analysis, Abdulhammed O Babatunde, Olufunto A Olusanya, Peter Kalulu, Temitope Ojo, Onyekachukwu Anikamadu, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: Cervical cancer is a leading cause of cancer deaths among women in Nigeria, yet awareness is low. Historically, art has served as a medium for processing emotions and sharing experiences, which can be effective in promoting health and behavior change.

OBJECTIVE: This study aimed to examine art submissions and social media engagement from a Nigerian crowdsourcing open call to inform co-designed strategies for cervical cancer prevention among women.

METHODS: This study reported following the SRQR (Standard Reporting for Qualitative Research) guideline. From October to November 2023, we launched an open call for art on social media, inviting adult women …