Digital Commons Network^™

Reassessing Skeletal Stress Indicators: Implications For Changing Population Health In The Freedman’S Cemetery, Dallas, Tx, Samantha M. Mccrane, Megan Fry, Siobhan A.E. Summers

Human Biology Open Access Pre-Prints

Inferring biological stress from stature and skeletal pathological conditions is common practice in bioarchaeology. Interpretations of these data can greatly enrich knowledge about past peoples’ lifestyles, cultural practices, and socio-political constraints and shifts. However, interpretations are not always clear, are often drawn from a single skeletal indicator of stress and not always subjected to statistical testing. In this study, we reanalyze archaeological data from 742 individuals buried at Freedman’s Cemetery in Dallas, Texas. We focus on four commonly used skeletal measures of ‘stress,’ broadly defined (stature, linear enamel hypoplasia, porotic cranial lesions [e.g., cribra orbitalia & porotic hyperostosis], and bone …

Mitochondrial Ca2+ Uniporter (Mcu) Variants Form Plasma-Membrane Channels, Iuliia Polina, Jyotsna Mishra, Michael Cypress, Maria Landherr, Nedyalka Valkov, Isabel Chaput, Bridget Nieto, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, Ulrike Mende, Peng Zhang, Bong Sook Jhun, Jin O-Uchi

Center for Translational Medicine Faculty Papers

MCU, originally known as CCDC109A, is widely recognized as the gene responsible for encoding a pore-forming subunit of a Ca2+-selective channel, mitochondrial Ca2+ uniporter complex (mtCUC). While MCU expression is typically highly mitochondrial-specific, we report here a protein variant derived from the MCU gene, termed MCU-S, which lacks the mitochondria-targeting sequence (MTS) and forms a Ca2+-permeable channel outside of mitochondria. The mRNA of MCU-S was ubiquitously expressed in all cell types/tissues tested, with particularly high expression in human platelets. MCU-S protein formed Ca2+ channels at the plasma membrane, which exhibited similar channel properties to those observed in mtCUC. MCU-S channels …

The Effect Of Acute Hypoxia Exposure, With Exercise, On Bone Metabolic Biomarkers, Alyssa Bailly

Health, Exercise, and Sports Sciences ETDs

Hypoxic environments, resulting from decreased atmospheric partial pressure of oxygen, reduce oxygen availability in the blood and tissues, leading to a mismatch between supply and demand. This elicits several physiological adaptations and may influence bone metabolism. Although evidence suggests that hypoxia can modulate bone remodeling through hypoxia-inducible pathways, findings remain mixed, with most data derived from chronic hypoxic exposures in animal and cell culture models. Exercise, an essential stimulus for bone health, may exacerbate hypoxic stress; however, the skeletal response to acute hypoxic exposure combined with exercise remains unclear. We propose that intermittent exercise in hypoxia may increase negative markers …

Microtubules In Breast Cancer: Exploring The Α/Β-Tubulin Toggle Switch And Its Implications In Human Breast Cancer, Annemarie Ianos

Student Theses and Dissertations

Microtubules, composed of a/b-tubulin heterodimers, play a central role in breast cancer tumor growth by polymerizing, leading to metastasis and depolymerizing, contributing to proliferation. Human enzymes protein kinase Ca (PKC-a) and cyclin-dependent kinase 1 (Cdk-1) mediate phosphorylation at sites a:Ser165 and b:Ser172, respectively, influencing the growth of microtubules. It is possible that alternating phosphorylation at these sites contribute to an a/b-tubulin “toggle switch” that mediates microtubule instability and tumor growth.

The project investigates the influence of the toggle switch model on microtubule stability by determining the impact of mutants (a:S165D, a:S165N, a:S165S_P, b:S172S_P and a:S165S_P/b:S172S …

The Biowell System: An Integrative Framework That Connects Ecological Sustainability And Mental Wellbeing Through The Regenerative Processes Of Bioswales, Nathan A. Bussa

Hospitality Design Graduate Student Capstones

The Biowell System is an evaluative framework that connects ecological sustainability and mental well-being through the regenerative processes of bioswales.

2019g_Nhp32_Approved_Bc_Pt-Curricular-Sequence-Change-Revision1, Graduate Council

All Approved Curriculum

No abstract provided.

2019g_Nhp28_Approved_Bc_Pt-Curricular-Sequence-Change, Graduate Council

All Approved Curriculum

No abstract provided.

2026 Phi Beta Kappa Induction Ceremony Program, Phi Beta Kappa, Psi Of California Chapter At Chapman University

Phi Beta Kappa Induction Ceremony Programs

The 2026 Induction Ceremony for the Psi of Chapter California was held on May 12, 2026 at the Hilbert Museum of California Art at Chapman University. In this ceremony, 27 outstanding students and one honorary member were inducted into Phi Beta Kappa.

Please click here to view photos from the ceremony.

Simultaneous Multielectrode Recordings Along The Human Scala Tympani: Evidence For Level-Dependent Place Coding, Amit Walia, Matthew A Shew, Shannon M Lefler, Amanda J Ortmann, Patrick Ioerger, Jordan Varghese, Jacques A Herzog, Craig A Buchman

2020-Current year OA Pubs

The cochlea systematically encodes sound frequency and intensity via a precisely organized tonotopic map, in which traveling waves peak at specific cochlear locations. A fundamental but incompletely understood aspect of auditory coding involves how stimulus intensity shapes this tonotopic organization. In animal models, increasing intensity shifts the cochlear traveling wave peak basally; however, physiological evidence for such intensity-dependent shifts in human cochlear processing is limited. Here, we performed simultaneous multielectrode electrocochleography recordings along the human scala tympani to characterize how cochlear place coding varies as a function of stimulus intensity. In subjects with preserved cochlear mechanics, including individuals with auditory …

The Echo: May 11, 2026, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Data-Driven Approaches To Investigate Cardiotoxicity Using Hipscs High Throughput Screening, Danny Vu

Theses - ALL

Recent advances in human induced pluripotent stem cell (hiPSC) technology have enabled the development of high-throughput platforms for cardiotoxicity screening. However, conventional analytical approaches remain limited by time-intensive processing, manual annotation requirements, and reduced scalability for large datasets. To address these challenges, calcium fluorescence signals from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC CMs) were analyzed using a high-throughput imaging platform and complementary machine learning frameworks. First, a feature-based supervised learning approach using engineered waveform descriptors and low-dimensional signal embeddings enabled rapid and interpretable screening of large chemical datasets, with combined features improving predictive performance relative to engineered features alone. …

A Review Of Video Game Effects And Uses, David Corso

Caravel Undergraduate Research Journal

Video games are versatile in their form and function. Whether they’re training doctors or offsetting Alzheimer’s disease, video games can exercise both mental and physical features, train specific skills for a number of jobs, educate players about events and phenomenon in our world, research and understand natural human processes, and they can be designed for a number of other purposes. Multiple studies have demonstrated the effects of video games on physiological and cognitive levels—positive, negative, and everything in between. This paper identifies various physical and psychological effects that video games produce, and it suggests ways in which video games can …

Phi Beta Kappa Membership Roster, Phi Beta Kappa, Psi Of California Chapter At Chapman University

Phi Beta Kappa Membership Roster

No abstract provided.

Illuminating Success: Student And Teacher Perception On Media Center Brainlit Lighting, Jase M. H. Ide

Undergraduate Honors Thesis Collection

Lighting plays a critical role in shaping learning environments, yet its influence on students’ cognitive, emotional, and physiological functioning is often overlooked in educational research. This study examined the perceived impact of BrainLit’s biocentric lighting, a daylight-simulating system designed to support circadian rhythms, within an educational setting. The research focused on Sycamore School, the first early childhood through eighth-grade school in the United States to implement BrainLit biocentric lighting. Using a qualitative research design, data were collected through interviews with third- and eighth-grade students and faculty members in the school’s Media Center. Transcribed interviews were analyzed thematically to identify patterns …

Impostor Thoughts At Work: Examining The Relationship Between Impostor Thoughts, Employee Well-Being, And Coworker Support, Nikitha Sara Mohan

Theses, Dissertations and Culminating Projects

Most individuals experience impostor thoughts; however, limited construct clarity has hindered efforts to effectively examine their relationship with employee outcomes (Gullifor et al., 2021). To address this limitation, the present study adopts a sociocognitive perspective, conceptualizing impostor thoughts as beliefs that others overestimate one’s competence at work (Clance & Imes, 1978; Tewfik, 2022). Specifically, this research investigates workplace impostor thoughts and their associations with indicators of employee well-being, including job-related negative affect, burnout, physical symptoms, and perceived self-competence. Additionally, the study examines coworker support as a potential moderating factor in these relationships. A mixed-methods approach was employed. Quantitative data were …

The Physical, Chemical, And Emotional Discourse Of Hormonal Disruption By Microplastics And Nanoplastics, Lily Warken

Theses & ETDs

Microplastics (MPs)1 and nanoplastics (NPs) are emerging as a growing concern within the health field as plastic use continues to rise. These particles have been increasingly recognized for their potential to act as endocrine-disrupting chemicals (EDCs), interfering with normal hormonal signaling and receptor function. This study examines the molecular, hormonal, and reproductive impacts of MPs and NPs on the human body, with particular attention to the importance of endocrine homeostasis and its sensitivity to disruption. In some cases, MPs and NPs and their adsorbed contaminants may mimic endogenous hormones and interact with hormone receptors, further complicating regulatory processes. Special emphasis …

2026 Workshop On Bridging The Gaps: Tackling Microplastics And Nanoplastics Challenges In Coastal Ecosystems, Shenghua Wu, Kaushik Venkiteshwaran, Melike Dizbay-Onat, Alexandra Stenson, Jinhui Wang, Tina Miller-Way, Ebenezer Nyadjro, Bhuvnesh Bharti, John Weinstein, Yi Bao, Shihui Shen, Valerie Longa, Shenghua Zha, John Cleary, Marty Lind

Workshops

This report presents the findings from the 2026 Workshop on Tackling Microplastics and Nanoplastics (MNPs) in Coastal Ecosystems, which took place in Mobile, Alabama. More than 140 experts from universities, government, industry, and community organizations gathered to address the increasing issue of MNPs in coastal regions.

The Implications Of Music Therapy On The Human Mind, Mckayla Martin

Senior Honors Theses

Music therapy harnesses the power of music in clinical settings. It is primarily used to support mental health. Music affects areas such as anxiety, memory, and brain plasticity. Therapeutic music practices can reduce stress and anxiety, enhance specific types of long-term memory, and encourage neuroplasticity. It is an effective, non-invasive treatment for those experiencing mental distress. Ongoing research on the effectiveness of music therapy in clinical settings has the potential to significantly improve the treatment of mental illness, disorders, and disabilities.

Transforming Theory Into Action: Feminist Frameworks In Reproductive Justice Organizing, Ella R. Mitchell

Honors Program: Senior Projects (Public)

This honors thesis examines how feminist theoretical frameworks can be translated into practical strategies for reproductive justice organizing. Grounded in a reproductive justice framework and drawing on three key feminist frameworks, intersectional feminism, queer feminist theory, and feminist ethics of care, this paper explores how each provides critical tools for understanding and responding to reproductive oppression. Intersectional feminism illuminates how overlapping systems of inequality structure reproductive experiences and political marginalization. Queer feminist theory challenges heteronormative assumptions about family, gender, and reproduction, expanding reproductive justice discourse to include LGBTQ+ communities and diverse forms of kinship. Feminist ethics of care emphasizes relational …

The Impact Of Glucose Exposure On Organic Cation Transporters (Oct) Function In A Corneal Epithelial Cell Line, David A. Garza

Theses & Dissertations

Organic cation transporters (OCT) facilitate the movement of neurochemicals and medications, contribute to the removal of cellular waste, and facilitate neuronal communication. Three subtypes of these high-capacity, low-affinity transporters (OCT1, OCT2, and OCT3) are differently expressed in peripheral tissues such as the liver, kidneys, as well as the central nervous system. OCTs are also expressed in ocular tissues. Chronic hyperglycemia is a complication commonly associated with diabetes that can lead to ocular diseases such as diabetic keratopathy, which affects the cornea. In this project, we expose immortalized human corneal epithelial cells (HCE-S) to various glucose concentrations to study their impact …

Design And Development Of A Perfusable Hydrogel Platform With Bioprinted Human-Endothelialized Microvascular Channels, Calvin A. Chernyatinskiy

All Theses

We developed an integrated bioprinting and perfusion platform to generate vascularized hydrogel constructs that support perfusable microchannel networks. Multiple hydrogel formulations, sacrificial ink systems, device geometries, and perfusion conditions were systematically evaluated to optimize print fidelity, mechanical stability, and cellular compatibility. Internally gelling alginate–calcium carbonate hydrogels were identified as a robust matrix, providing tunable gelation kinetics and structural stability during embedded printing. In parallel, Pluronic F-127 fugitive ink enabled reliable fabrication of continuous hollow channels due to its shear-thinning behavior and efficient post-print removal.

The finalized platform integrates stereolithographically fabricated perfusion chambers with extrusion-based bioprinting to produce three-dimensional, perfusable vascular …

Effects Of Tourist Feeding On The Gut Microbiome And Ecophysiology Of Endangered Northern Bahamian Rock Iguana (Cyclura Cychlura), Erin Lucy Lewis

All Graduate Theses and Dissertations, Fall 2023 to Present

The lifespan and reproduction of an animal depends on maintaining a healthy physiology. The proportion of individuals that survive to an age at which procreation can occur is important to long-term stability of populations and contributes to species survival. Health in an animal is measured in a variety of ways, including through monitoring of the body’s physiological systems, as well as its ability to respond to invading pathogens, and through the different types of bacteria present in the gut. Relationships among those different health metrics have been discovered in recent years and have been found to play important roles in …

Characterizing Metabolic Flux Of Plant Secondary Metabolites From Diverse Animal-Source Foods To Humans, Muhammad Ahsin

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a popular saying: “You are what you eat.” But does this also mean, “You are what your food eats”? This dissertation explores that question by examining how farming practices shape the nutritional quality of meat—and what, if anything, those differences mean for the people who consume it. While modern livestock production and nutrition research often emphasize protein and fat, this work tests the idea that animals function as biological mediators, linking soil and plant conditions to human diets through the chemical composition of meat and milk. To evaluate this hypothesis, we tracked health-relevant plant compounds— phytonutrients—across the soil–plant–animal–human …

Beyond The First Bout: Adaptations To Repeated Injuries Across Physiological And Pathological Conditions, Cory W. Baumann, Christopher P. Ingalls, Kazunori Nosaka, Jarrod A. Call

Research outputs 2022 to 2026

Skeletal muscle exhibits remarkable plasticity following injury, yet most research has focused on responses to a single bout of eccentric contractions. This review addresses adaptations to repeated eccentric contraction–induced injuries across physiological and pathological conditions, with emphasis on insights from preclinical rodent models. In healthy muscle, the repeated bout effect (RBE) reduces strength loss and accelerates recovery after subsequent bouts. However, these adaptations are highly condition dependent. Aging can attenuate the RBE, while dystrophic muscle remains vulnerable to repeated injury despite compensatory remodeling. Other factors, including but not limited to, chronic alcohol intake and malignant hyperthermia can influence these responses, …

Medical Simulation In Toxicology: Enhancing Clinical Competence, Decision Making And Patient Care In Resource-Limited Settings, Rakesh Ghimire, Anjana Thapa, Sanjeev Kharel, Shristi Kharel Ghimire, Rabin Basnet, Farshad Mazda Shirazi, Allan J. Hamilton

Research outputs 2022 to 2026

Medical simulation has emerged as a transformative approach in toxicology education. By providing immersive, hands-on experience, simulation enhances learner engagement, critical thinking, and long-term knowledge retention while offering a safe environment to practice clinical decision-making without jeopardizing patient safety. Despite these advantages, the integration of simulation-based training remains limited in low-and middle-income countries (LMICs) due to resource constraints, lack of standardized curricula, and limited access to high-fidelity simulators. Additionally, little research has explored its optimal application in these settings. This review explores available evidence regarding the effectiveness of medical simulation in the diagnosis and treatment of toxicological emergencies in LMICs. …

Urban Illumination And Circadian Disruption: Examining Artificial Light At Night, Caitlin Mcmasters

Theses

Artificial light at night is increasingly prevalent in dense urban environments, yet it remains unclear how often typical city lighting conditions likely exceed recommended nighttime limits for residential circadian health. This thesis evaluates nighttime light exposure in two contrasting urban districts, Back Bay in Boston and Times Square in New York City, using satellite derived nighttime radiance, GIS based urban morphology, and documented lighting infrastructure characteristics. Rather than relying on calibrated photometric simulations, the study employs a qualitative, evidence based comparative approach to assess relative façade exposure and interpret conditions against established benchmarks, including the WELL Building Standard and ILP …

Hemispheric Processing Of Words And Unfamiliar Symbol Strings, Karoline Curlo

Celebrating Scholarship and Creativity Day (2018-)

This study investigates the role of each cerebral hemisphere in processing word forms to better understand how the brain decodes letter strings. Participants completed a same-different judgment task for four-character word and symbol (Orkhon) pairs presented unilaterally. On different trials, a single character was substituted at the first, second, third, or fourth position in the string. Results showed a sameness advantage in the left hemisphere (LH) and a difference advantage in the right hemisphere (RH) - effects only observed with word stimuli. Performance was best when the substituted character occurred at the beginning or end of words and symbols, rather …

Unleashing Stress: The Effects Of Training, Bond Strength, And Stress On Pet Dog Behaviors And Health, London Maria Wolff

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Humans and dogs have formed a unique ability to communicate with each other through evolutionary and developmental mechanisms. This increased communication serves to form dynamic interspecies bonds by facilitating learning and training over the lifetime of a dog. However, it is not known what factors permit the unique capacity of dogs to form bonds with, and learn from, their human companions. Odor is a notable candidate for interspecies communication about emotional states, with studies showing that both dogs and humans use odor information to detect human emotions (Calvi et al., 2020). Possibly, this may include detection of both acute and …

A Treatise On Tool Development: The Arthroscope’S Cultural, Technological, And Metascientific Translation, Montgomery F. Waterer

Honors Theses

The arthroscope was a revolutionary development in the fields of medicine, engineering, and ethics. There are many valuable lessons to be learned from the story of its development and translation that are relevant to the future of medicine and society. Beginning with a brief description of the tool’s design, this paper will examine a period within the history of the arthroscope. This window contains multiple innovators and ends with the life and work of Dr. Robert Jackson. In examining the relevant historical facts of its development, this paper will then briefly address the importance of sports medicine in the development …

Iron-Based Nanoparticles As Delivery Tools, Keykavous Parang, Rajesh Vadlapatla, Ajoy Koomer, Victoria Moran, Lanie Jackson, Amir Nasrolahi Shirazi

Pharmacy Faculty Articles and Research

Iron-based nanoparticles, particularly iron oxide nanostructures (IONPs), have emerged as versatile and clinically relevant platforms for drug delivery and theranostic applications. Among these, superparamagnetic iron oxide nanoparticles (SPIONs), including magnetite (Fe₃O₄) and maghemite (γ-Fe₂O₃), are the most extensively investigated due to their biocompatibility, magnetic responsiveness, and established safety profiles. Their unique superparamagnetic behavior enables external magnetic-field-guided targeting, magnetic resonance imaging (MRI) contrast enhancement, and magnetically triggered hyperthermia, enabling simultaneous diagnosis and therapy. Surface functionalization with polymers, silica, lipids, peptides, and biomolecules further improves colloidal stability, circulation time, targeting specificity, and controlled drug …