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Turkish Journal of Biology

No abstract provided.

Antiatopic Dermatitis Activity Of Lissachatina Fulica Mucin: Network Pharmacology Analysis And Experimental Validation, Atin Supiyani, Wasmen Manalu, Lina Noviyanti Sutardi, Mawar Subangkit, Andriyanto Andriyanto

Turkish Journal of Biology

Background/aim: Lissachatina fulica mucin (LFM) has been used as a nutraceutical, therapeutic agent, and cosmetic ingredient. The bioactivity of mucin depends on bioactive compounds whose composition is strongly influenced by the snail’s diet. This study investigated the bioactive compounds in L. fulica mucin as potential therapeutic agents for atopic dermatitis (AD).

Materials and methods: LFM was collected from snails fed long beans and melon rinds for 4 weeks, freeze-dried, and analyzed using liquid chromatography–mass spectrometry followed by network pharmacology (NP) analysis to identify its bioactive compounds. A total of 60 BALB/c mice were sensitized on the dorsal skin with 1% …

The N-Terminal, Wd40, And C-Terminal Domains Of Wdr-31 Control Ciliary Localization And Cooperate With Elmod/Rp2 Gaps To Maintain Membrane Compartmentalization, Sebi̇ha Çevi̇k, Fatma Güzel

Turkish Journal of Biology

Background/aim: WD40 repeats are found in many ciliary proteins. Although the WD40 repeat-containing WD repeat-containing protein 31 (WDR-31) is known to regulate ciliary protein trafficking and morphology, the specific contributions of its N-terminal, WD40, and C-terminal domains to protein localization and ciliary gate integrity remain unclear. Aim of this study is to dissect the functional roles of WDR-31 domains by investigating their contributions to ciliary localization, ciliary protein trafficking, and gate integrity.

Materials and methods: Using CRISPR/Cas9 technology, we generated Caenorhabditis elegans strains with in-frame deletions that removed the N-terminus (WDR-31(ΔN)), WD40 (WDR-31(ΔWD)), and C-terminus (WDR-31(ΔC)). We next examined the …

Discovery And Functional Characterization Of Novel Programmed Death-Ligand 1 Monoclonal Antibodies, Nurşah Ersezen, Mai̇de Şeker, Arzu Aysan, Durmuş Akdoğan, Mehmet Ender Avci, Asli Kurden Pekmezci̇, Si̇bel Kalyoncu Uzunlar, Mehmet İnan, Tamer Yağci

Turkish Journal of Biology

Background/aim: Targeted therapies with monoclonal antibodies provide cancer patients with better prognosis and diseasefree survival. The blockade of immune checkpoints, including programmed cell death protein-1 (PD-1) and its ligand PD-L1, with monoclonal antibodies may boost immune responses against tumors and is regarded as an effective strategy in cancer immunotherapy. We describe the generation of anti-PD-L1 monoclonal antibodies with high affinity and specificity, and we assess their potential for therapeutic use in cancer.

Materials and methods: Hybridomas were selected for PD-L1 specificity and cross-reactivity with other immune checkpoint proteins and PD-L1 orthologs using indirect ELISA. Immunofluorescence and Western blotting assays were …

Lineage Tracing Reveals A Shared Cellular Origin For Supraclavicular Brown And Inguinal Beige Adipocytes, Yali Ran, Kai Zhang, Yi-Ting Shen, Qianxing Mo, Ziyi Wang, Hari Krishna Yalamanchili, Sharon John, Mari Kogiso, Xia Gao, Chunmei Wang, Tanvi Sinha, Brian L Black, Miao-Hsueh Chen

Duncan NRI Faculty and Staff Publications

The metabolic importance of brown adipose tissue (BAT) has been recognized, but its origins, particularly supraclavicular BAT (scBAT), remain unclear. Here, we traced scBAT to Mef2c-anterior heart field (AHF)-marked cells. Mef2c-AHF-marked cells isolated from scBAT can spontaneously differentiate into brown adipocytes, express mesenchymal stem cell markers, and can be isolated from the stromal-vascular fraction (SVF) of wild-type scBAT as [CD31

Advancing Maternal Health Equity In Nebraska: Examining Prenatal Care Access Disparities, Policy Context, And Doula Integration As A Complementary Solution, Marlette Grace Dulcinee Mabiala-Maye

Theses & Dissertations

Maternal health inequities persist across the United States, with Black, Native American, and immigrant-origin women facing disproportionate barriers to timely prenatal care. This dissertation examined access to prenatal care in Nebraska, a mixed rural and urban state with extensive maternity care deserts, through three interrelated aims. Aim 1 analyzed PRAMS data using survey-weighted regression with race-by-socioeconomic-status interactions to characterize disparities in the timing and barriers to care. Aim 2 evaluated the state’s October 2020 Medicaid expansion across pre-pandemic, acute pandemic, and post-expansion periods. Aim 3 applied qualitative description and the Consolidated Framework for Implementation Research to interviews withtwenty-three maternity care …

For Weight Loss: Why Do Glp-1 Agonists Work, And How Can We Make Them Work Better?, Charlise Giang, Jieyi Meng, Mahmoud Ali Mohammad, Zhenqi Liu, Xinle Wu, Yi Zhu

Children’s Nutrition Research Center Staff Publications

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have revolutionized the management of not only type 2 diabetes but also obesity. However, even with rapid therapeutic advances in GLP-1RAs, questions regarding the fundamental principles of GLP-1-mediated weight loss and the enhanced efficacy of next-generation therapies remain. In this comprehensive review article, we first examine the milestones of GLP-1, from its initial discovery and biological characterization to its successful translation into clinical therapy. Furthermore, this review highlights the latest clinical trial data, specifically HbA1c reduction, weight-loss efficacy, and safety profiles, while exploring current pipelines of major pharmaceutical companies. Additionally, we delineate the mechanistic …

Imsa Summer Symposium 2026, Student Inquiry And Research(Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program. For the first time, we are also excited to welcome IMSA Research, Inquiry Skills, and Experimentation (RISE) students to present at the Summer Symposium.

Fort Hays State University Tiger Weekly, August 14, 2026, University Relations

Tiger Weekly Newsletters

No abstract provided.

Interpreting Title Vi: Translation Theory And The Making Of Language Policy, Olivia A. Allred

Undergraduate Honors Theses

Title VI of the Civil Rights Act provides the primary statutory basis for the development of policies supporting language access. Rather than explicitly requiring institutions to accommodate individuals with limited English proficiency (LEP), the statute establishes a broad prohibition against discrimination based on race, color, and national origin. This thesis examines the process through which that broad statutory mandate has been interpreted and applied to specific language-access policies.

To elucidate the application of language access polices at the federal level, this analysis focuses on three landmark Supreme Court decisions concerning Title VI: Lau v. Nichols, Regents of the University …

Pushed To The Edges? Electivity Patterns Of Urban Stream Homeless Encampments In Environmentally Burdened Areas, Serena Alexander, Bennett Williamson, Jeff Wootton, Costanza Rampini, Gregory Brian Pasternack, Yufang Jin, Rune Storesund, Igor Lacan

Faculty Research, Scholarly, and Creative Activity

Urban stream corridors in the San Francisco Bay Area have increasingly become locations for homeless encampments, yet little is known about the environmental conditions of these spaces. This study uses a geospatial electivity index to examine whether urban stream encampments in Santa Clara and Contra Costa counties are disproportionately located in census tracts with high pollution burdens, as measured by CalEnviroScreen 4.0. Findings show a statistically significant overrepresentation of encampments in census tracts in the top 25% of pollution and vulnerability scores, and a significant underrepresentation in lower-pollution areas. These results suggest that homeless individuals are being pushed toward environmentally …

The Efficacy Of Transversus Abdominis Plane Block As An Adjunct To Spinal Anesthesia For Cesarean Delivery: An Evidence Synthesis And Implementation Toolkit, Alyssa Hebert, Alex Potts, Gabriela Robertson

Graduate Theses, Dissertations, and Capstones

Postoperative pain hinders cesarean delivery recovery and overall patient experience. Although spinal anesthesia with intrathecal opioids remains the standard of practice, associated side effects and concerns regarding opioid exposure highlight the need for effective opioid-sparing strategies. Anesthesia providers play a critical role in advancing postoperative pain management through evidence-based protocol development, provider education, and interdisciplinary collaboration to optimize maternal outcomes. The transversus abdominis plane (TAP) block provides somatic analgesia to the anterior abdominal wall by targeting the thoracolumbar nerves (T6–L1) and has increasingly been incorporated into multimodal postoperative pain management strategies for abdominal surgery. Nevertheless, a gap remains in obstetric …

Rickettsia Africae Discovered In A Short-Term Urban Traveller To South Africa: A Case Report, Zunairah Sikder

Binghamton University Undergraduate Journal

Rickettsia Africae is a pathogen that causes African tick-bite fever (ATBF). Transmission typically occurs from ticks within the Central and South African regions. Previous studies suggested that ATBF is not uncommon amongst travelers to rural sub-Saharan Africa, especially during the rainy months of November through April. However, this case report highlights a woman who contracted ATBF in novel conditions. The 70-year-old woman reported travelling strictly to and from the local church and hotel for her four-day stay in July. After returning to America, the patient experienced extreme irritation on her arm, as well as complaints of headaches. She presented to …

A Message From The Managing Editor, Carissa Bayack

Binghamton University Undergraduate Journal

A message from the 2025-2026 Managing Editor of the Binghamton University Undergraduate Journal, Carissa Bayack.

A Dosimetric Comparison Of Halcyon 6x-Fff And Truebeam 6x In Prone Left Whole Breast Radiation Therapy, Maritza Soto, Kelly Labant, M.S., Cmd, Rt(T), Kristen Vu, M.S., Cmd, Rt(T)

Masters Projects

Purpose:

This retrospective study compared dosimetric differences between prone left whole breast radiation (WBRT) treatment plans originally generated for Halcyon using 6X flattening- filter-free (FFF) beams and replanned for a conventional TrueBeam using 6X beams.

Methods:

Ten prone whole left breast treatment plans were paired and retrospectively analyzed. Clinically treated Halcyon 6X flattening filter free plans were replanned on TrueBeam using flattened 6X beams in Eclipse v16.1. Contours for all plans were generated using artificial intelligence-based autosegmentation, reviewed by a medical dosimetrist and radiation oncologist, and forward planned with a tangent technique in EZFluence to achieve identical planning objectives. Dose …

A Middle School Reading Intervention Framework, Ryan Patrick Eder

Masters Projects

Middle school students face increasing literacy demands as they transition from learning to read toward reading to learn content knowledge in science, social studies, and other subjects. However, reading intervention frameworks found in most elementary and middle schools may not fully meet the growing cognitive, academic, and affective needs of middle school students. The purpose of this project is to present a schoolwide reading intervention framework designed for middle school students. Drawing from current research, the proposed framework integrates daily, teacher-assisted intervention and enrichment with data-driven identification of students’ specific literacy growth points using rigorous, grade-level informational texts to provide …

Enhancing Algae Biofilm Quantity And Value Through Controlled Light Intensity For Treatment Of Municipal Anaerobic Digestor Effluent, Joshua D. Wintch, Ronald C. Sims

Biological Engineering Student Research

Rotating algae biofilm reactors (RABRs) have been shown to remove nutrients from wastewater and to cultivate algae for bioproducts. Another key variable in RABR technology for cultivating microalgae biomass is light intensity. The goal of this study was to address a gap in the design and operation of algae biofilm reactors by analyzing the effects of light intensity on biomass quality and quantity, chemical precipitation of phosphorus, and phosphorus uptake into biomass. This study utilized a triplicate laboratory-scale experiment with PAR intensities from 10 to 2000 µmol m⁻²·s⁻¹. Municipal wastewater anaerobic digester effluent (ADE) was utilized …

Self-State Shifts During Nonsuicidal Self-Injury: Associations With Trauma History And The Functions Of Self-Harm, Katie E. Callahan

Dissertations, 2020-current

Nonsuicidal self-injury (NSSI) is a clinically significant behavior associated with substantial psychological distress and elevated suicide risk. Despite considerable research on the emotional triggers and functional implications of NSSI, the internal relational states activated during self-harm remain poorly understood. This study examined shifts in self-directed relational patterns during NSSI episodes using the Structural Analysis of Social Behavior (SASB) model and Interpersonal Reconstructive Therapy (IRT) theory. A cross-sectional secondary data analysis was conducted with 125 participants who reported current or past NSSI. Residualized change scores were computed to index shifts in self-state between general and NSSI conditions. Measures included the SASB-based …

Fall Risk In Community-Dwelling Adults: A Comparison Of English And Spanish-Speaking Individuals, Jesus D. Gomez

Dissertations, 2020-current

Falls are a leading cause of injury-related mortality among middle-aged and older adults. Although vestibular dysfunction, hearing loss, behavioral factors, and social determinants of health have been associated with increased fall risk, few studies have examined these relationships. Furthermore, limited research in audiology and vestibular science has investigated fall-risk vulnerability among Spanish-speaking individuals.

This study aimed to: (1) estimate the prevalence of fall risk among community-dwelling adults and compare prevalence between English-speaking and Spanish-speaking participants; (2) assess the prevalence of previously undiagnosed benign paroxysmal positional vertigo (BPPV) and compare prevalence between language groups; and (3) develop predictive models of fall …

African American Gold Star Mothers: Race, Black Motherhood, Loyalism And European Superiority In The First World War, Giovanni Nickolette Gibbs

Masters Theses, 2020-current

This thesis examines the US government’s pilgrimages for Gold Star Mothers of the First World War. It focuses on the Jim-Crowing of black Gold Star Mothers. Through the analysis of archival records, letters, telegrams, newspaper articles, poems, and secondary literature, the thesis explores how two domineering forces, the National Association for the Advancement of Colored People and the federal government of the United States of America, captured dissension when seeking to send black Gold Star Mothers on segregated pilgrimages to Europe. The War Department’s announcement that the widows’ pilgrimages to Europe in the 1930s would be segregated caused a great …

Imsa Summer Symposium 2026, Student Inquiry And Reserach Reserach (Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program. For the first time, we are also excited to welcome IMSA Research, Inquiry Skills, and Experimentation (RISE) students to present at the Summer Symposium.

Cover Design

Luke Berryman

Brain Perivascular Macrophages Regulate Endothelial Cell Function Via A Cmaf-Dependent Transcriptional Program In Mouse And Human, Simone Brioschi, Julia A Belk, Steffen E Storck, Yue Wu, Zhuoying Wang, Ziang Feng, Lynn Van Olst, Josie L Emery, Raki Sudan, Junjie Wu, Siling Du, Marco Genua, Federica La Terza, Alex J Edwards, Khai M Nguyen, Jessie Sanford, Daniel D Lee, Mattia Bugatti, Arnold J Federico, Yun Chen, Zuoxu Wang, Silvia Penati, Patrick Fernandes Rodrigues, Alina Ulezko Antonova, Hui Qi Loo, Igor Smirnov, Susan Gilfillan, Carmen M Halabi, Jennifer Ponce, Jun Yan, Howard Y Chang, Gwendalyn J Randolph, William Vermi, Marina Cella, Michael Meers, Renato Ostuni, David Gate, Aivi T Nguyen, Carlos Cruchaga, Song Hu, Jonathan Kipnis, Marco Colonna

The Brown Foundation: Institute of Molecular Medicine

Brain perivascular macrophages maintain brain physiology, yet their transcriptional regulators and functions in health and disease remain unclear. Using single-cell multi-omics and functional experiments, we identify cellular musculoaponeurotic fibrosarcoma oncogene (cMAF) as a key transcription factor for brain perivascular macrophages, and conditional deletion of cMAF disrupts their phenotype in vivo. Functionally, cMAF drives insulin-like growth factor-1 (IGF1) expression in perivascular macrophages, enabling communication with endothelial cells. Consistently, cMAF deletion in perivascular macrophages causes transcriptional alterations in cerebral arteries, affecting vascular functions. Notably, cMAF emerges as the main transcription factor for human perivascular macrophages, suggesting conservation of this transcriptional module. During …

Establishing Partnerships Between Families, Schools, And Communities To Support Family Involvement In Literacy Education, Matraca Bourdo

Masters Projects

As the percentage of fourth grade students reading at a proficient level continues to decline, schools are seeking effective ways to improve literacy education and student achievement. Research emphasizes the importance of early literacy development in supporting academic success and lifelong learning. However, not all families have the same background knowledge of literacy skills and how to develop them with their children. Partnerships between schools, families, and communities can provide the support and resources needed while working toward the goal of improving student achievement.

The purpose of this project is to implement a team that partners with families to educate …

Retired Doctors As Users Of Patient-Facing Electronic Health Records: A Mixed-Methods Survey In The Uk And Spain, Ray Jones, Shang-Ming Zhou, Angeles Lazcoz, Brian Mcmillan, Olanrewaju Bamidele, Richard Fitton, Brian Fisher, Mar Soler-Lopez, Charlotte R. Blease

School of Nursing and Midwifery

BackgroundOnline patient access to electronic records is expanding internationally but remains contested. Although practising clinicians’ concerns are well documented, less is known about the views of retired doctors who are more likely themselves to be patients. We explored the experience of retired doctors in accessing their own medical records as patients in the UK and Spain.MethodsWe conducted an anonymous mixed-methods online survey of retired doctors aged 60 years and over in the UK and Spain. Participants reported their experiences of accessing their own medical records and their views on whether online access should be available to all patients. Quantitative analyses …

The Parkinson's Pathway: Enhancing Knowledge And Care Management In Skilled Nursing, Kaitlyn Chau

Master's Projects and Capstones

Parkinson’s disease (PD) is commonly diagnosed among the older population, contributing to high utilization of skilled nursing facility (SNF) services. Objective: SNF A’s current onboarding and training program for staff discussed general geriatric topics but failed to include structured PD-specific education. This may lead to gaps in competence, confidence, and workflow related to PD care and management, resulting in low quality of patient care, poor health outcomes, and decreased safety and satisfaction. Aim: The project aimed to establish and incorporate a structured PD-specialized education program within a SNF located in Northern California, to increase employees’ self-reported confidence, competence, …

Cardozo Law News Brief: August 14, 2026, Benjamin N. Cardozo School Of Law

Cardozo Law News Briefs

Highlights from the August 14, 2026 Cardozo Law News Brief include:

• Professor Saurabh Vishnubhakat spoke to Forbes about Buc-ee’s aggressive trademark enforcement strategy and the potential reputational costs of pursuing weaker infringement cases.
• Professor Zalman Rothschild was quoted in The Nation’s Health about the potential impact of a Supreme Court ruling on childhood vaccine mandates and religious exemptions.
• Professor Stewart Sterk spoke to the Associated Press about anticipated legal challenges to New York City’s pied-à-terre tax.
• Adjunct Professor Gary Galperin spoke to People about concerns surrounding Luigi Mangione supporters and their potential influence on the case, and also discussed the …

Enhancing Tea Productivity Through Integrated Fertilization And Pruning Management: A Review, Intan Ratna Dewi Anjarsari, Murgayanti, Muhamad Kadapi, Syariful Mubarok, Uum Umiyati, Salsabilah, Alifatul Azmi, Afifah Putri Ramadhan, Trifani Hana Husniah, Rosita, Azkal Azkiya

Jurnal Kultivasi

Tea productivity is strongly influenced by agronomic management practices, particularly fertilization and pruning, which play critical roles in regulating plant growth, physiological performance, and shoot regeneration. This review aims to synthesize current scientific evidence on how integrated fertilization and pruning management can sustainably enhance tea productivity. A narrative review approach was employed by collecting and analyzing peer-reviewed articles published between 2015 and 2025 from reputable databases, including Google Scholar and major international journals. The review highlights that balanced fertilization strategies, combining inorganic, organic, and biofertilizers, significantly improve nutrient availability, photosynthetic efficiency, and shoot yield. Pruning, when properly timed and executed, …

Differential Effects Of Thiamine, Bap, And Thidiazuron Combinations On Shoot Multiplication And Phenolic-Flavonoid Accumulation In Pineapple In Vitro Cultures, Dinda Septia Rachman, Erni Suminar, Anne Nuraini, Fiky Yulianto Wicaksono, Suseno Amien, Syariful Mubarok, Hermanto

Jurnal Kultivasi

The demand for high-quality pineapple (Ananas comosus (L.) Merr.) planting materials continues to increase, while conventional propagation methods are limited in multiplication rate, uniformity, and production efficiency. In vitro culture offers an alternative approach for rapid and large-scale seedling production. However, information on the effects of thiamine and cytokinin combinations on both shoot multiplication and phenolic-flavonoid accumulation in pineapple in vitro remains limited. This study evaluated ten defined combinations of thiamine and cytokinin for shoot multiplication and total phenolic-flavonoid contents of pineapple explants. The experiment employed a completely randomized design with 10 treatment combinations of thiamine (0.1 and 0.4 mg/L), …

Performance Of Dual-Form Terminalia Catappa Organic Fertilizers On Sweet Corn Yield And Economic Viability In Tropical Highlands, Stefina Liana Sari, Eso Solihin, Rahmat Budiarto

Jurnal Kultivasi

Recycling underutilized plant biomass into organic fertilizers underpins low-input cropping strategies, but liquid and solid formulations derived from a common feedstock have seldom been evaluated side by side under field conditions. This study aimed to (i) characterize the physicochemical properties and safety profile of a liquid organic fertilizer (LOF) and a crumb-type organic fertilizer (COF) co-produced from Terminalia catappa leaf compost, (ii) compare their effects on sweet corn growth and yield, (iii) determine relative agronomic effectiveness (RAE), and (iv) evaluate economic feasibility of the most promising organic–inorganic combinations. We produced LOF and COF through aerobic composting of Terminalia catappa leaves …

Metabolic Dynamics Of Secondary Metabolites In Arabica Coffee (Coffea Arabica): From Biosynthesis To Post-Harvest Transformations, Kamilrashid Hadi Dwitama, Yudithia Maxiselly, Cucu Suherman, Santi Rosniawaty

Jurnal Kultivasi

Coffee (Coffea arabica) is a globally significant beverage whose sensory profile and physiological effects derive from a complex matrix of secondary metabolites. This review presents a comprehensive "lifecycle" perspective of three pivotal classes: the alkaloid caffeine, phenolic chlorogenic acids (CGA), and the diterpenoids cafestol and kahweol. Here, 'lifecycle' defines a metabolite's continuous biochemical trajectory, tracking its genetic origin and ecological function in the plant through structural modifications during fermentation, drying, storage, and roasting. These classes are highlighted because they serve as the primary drivers of bitterness, acidity, and health bioactivities with fundamentally distinct transformational pathways. Following a systematic methodology, this …