Digital Commons Network^™

A Poly-L-Lysine-Functionalized Electrochemical Immunosensor Enables Highly Sensitive Detection Of Tumor Necrosis Factor Receptor-Associated Protein 1, Berfi̇n Vural, Mustafa Kemal Sezgi̇ntürk

Turkish Journal of Chemistry

Tumor necrosis factor receptor-associated protein 1 (TRAP-1), a member of the mitochondrial heat shock protein family (HSP90), is essential for protein homeostasis, stress response, and cell cycle. TRAP-1 not only optimizes cellular energy production but also prevents cell death, thereby supporting the survival and proliferation of tumor cells. In addition to cancer, TRAP-1 has been associated with Parkinson’s disease, certain autoimmune disorders, and abnormalities in the kidney and urinary tract. In this study, a unique and useful indium tin oxide-polyethylene terephthalate (ITO–PET)-based electrochemical biosensor is described for detecting the biomarker TRAP-1. The ITO–PET electrode, selected as the working electrode, is …

August 18, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Software Tools And Simulation Exercises For Radiation Oncology Cyber-Attack Resiliency, Yevgeniy Vinogradskiy, James Lamb

Department of Radiation Oncology Faculty Papers

This review summarizes the rationale for radiation oncology cyberattack simulation exercises, recent results from multi-institutional resiliency drills, and the landscape of software tools developed to help clinics resume radiotherapy treatments rapidly and safely during a cyberattack or other major clinical software outage. Simulation exercises using record-and-verify (R&V) downtime and File Mode treatment delivery have identified failure modes not apparent in theoretical planning alone, including risks related to treatment documentation, repeated fractions, patient setup, and missed safety checks. Available software tools emphasize insulated backup of DICOM-format planning data and clinical notes, treatment-state dashboards, File Mode treatments, redundant R&V installations, and human-readable …

141 Macdonough St. Hous. Dev. Fund Corp. V. Rhodes-Wiggins

All Decisions

Companion case to LT-306940-25/KI—same building, same HDFC, same judge (Grant, J.). The same Grimmet analysis applies. The notice of termination is identically deficient, alleging only 'failed to pay rent' without specifying the period or arrears amount. The same predicate notice inadequacy compels dismissal. Additionally, 34 HPD violations exist against the premises (29 pre-notice) including 3 rent-impairing violations that have not been certified as corrected, which are relevant to the adequacy of notice because uncorrected rent-impairing violations could implicate an MDL §302-a abatement defense. Proceeding dismissed.

Selective Loss Of Primary Cilia And Neurotrophic Signaling In G51d Α-Synuclein Mice Highlights A Common Pathway To Parkinson’S Disease, Yu-En Lin, Ebsy Jaimon, Youngdoo Kim, Annabeth Loftman, Aaran Vijayakumaran, Benjamin D W Belfort, Claire Y Chiang, Benjamin R Arenkiel, Huda Y Zoghbi, Suzanne R Pfeffer

Duncan NRI Faculty and Staff Publications

Parkinson's disease is characterized by dopaminergic neuron loss and accumulation of α-synuclein aggregates in the brain. G51D α-synuclein knock-in mice provide a genetically and clinically relevant model of disease, exhibiting early olfactory deficits, age-dependent motor impairment, and progressive phospho-α-synuclein accumulation. In multiple Parkinson's disease models, striatal cholinergic and parvalbumin interneurons, as well as astrocytes, lose primary cilia and the neurotrophic signaling needed to sustain dopaminergic neurons. We show here that G51D α-synuclein mice share these phenotypes. Phospho-Ser129 α-synuclein accumulation correlates with cilia loss in cholinergic interneurons but not in spiny projection neurons that accumulate higher phospho-α-synuclein levels. In the piriform …

Exploring Elite Athletes’ Perceptions Of The Practice Of Mindfulness For Mental Health And Optimal Performance, Omar A. Sesay

Walden Dissertations and Doctoral Studies

Elite athletes experience physical, cognitive, and emotional demands that affect athletic performance and personal well-being, increasing the risk for anxiety, depression, burnout, attentional difficulties, and maladaptive coping strategies. Mindfulness-based stress reduction (MBSR) has been examined for its effect on attentional control, emotional regulation, cognitive flexibility, and stress resilience, but limited qualitative research has examined how elite athletes experience the practice of mindfulness. The purpose of this generic qualitative study was to explore elite athletes’ perceptions of the practice of mindfulness for mental health and optimal performance. The theoretical framework draws from mindfulness theory and MBSR principles. Semistructured interviews were conducted …

Learning Challenges And Their Correlation Among Nursing Students Using Artificial Intelligence Bots, Sofia Magdalena Norbe Robles, Francine Isabel M. Adarne, Astrid Jaide Arellano, Charlene Azucenav, Ianne Jasmine A. Bayan, Luis Manuel M. Caudal, Angelica S. De Guzman, Jan Philip Dela Cruz, Gweneth E. Gabon, Adrian Paolo P. Mabahague, Rebeka L. Ricabierta, Andru Nicolas P. Rosal, Jodi Darla S. Taroc, Sheena Margaret B. Valera

International Nursing Research Congress (INRC)

The rise of Artificial Intelligence (AI) has profoundly transformed the digital age, bringing notable implications for nursing education. AI, defined as the simulation of human intelligence in machines (Duggal, 2023), has revolutionized nursing, where students face various challenges related to Knowledge, Skills, and Attitudes (KSA) when using AI bots for academic purposes. This study examines the learning challenges encountered by nursing students in the domains of knowledge, skills, and attitudes (KSA) when using AI bots for academic purposes, particularly in relation to ethical considerations.

A descriptive-correlational research design was employed, using structured questionnaires to analyze the relationship between demographic profiles, …

Immigration Stress And Inequities Driving Diabetes Distress In Hispanic Adults: A Scoping Review, Rachell Nguyen

International Nursing Research Congress (INRC)

Background: Hispanic adults in the United States experience disproportionately high rates of type 2 diabetes mellitus (T2DM) and co-occurring mental health conditions. These disparities are intensified by immigration-related stress, acculturation challenges, and minority stress, all of which contribute to heightened diabetes distress and reduced self-management capacity.

Purpose: This scoping review examined how immigration stressors, acculturation processes, and minority stress influence diabetes distress and mental health outcomes among Hispanic adults with T2DM.

Methods: Using Arksey and O’Malley’s six-step scoping review framework and PRISMA-ScR guidelines, a comprehensive search of PubMed, CINAHL Complete, MEDLINE (OVID), and ScienceDirect identified studies published between 2015 and …

Risk Stratification And Screening For Sleep Apnea In Cardiology Outpatient Setting, Ma Vanessa Simoy Mabazza, Tanya Tanzillo, Paul H. Nguyen, Rubina D. Nguyen

International Nursing Research Congress (INRC)

Background: Obstructive sleep apnea (OSA) is the most prevalent sleep disorder and is strongly associated with cardiovascular disease (CVD), but remains widely underdiagnosed due to inconsistent and non-standardized screening practices in outpatient settings.

Local Problem: Patients with CVD were reported to be diagnosed with OSA following sleep studies at an outpatient cardiology clinic. The need for a consistent, evidence-based approach to risk-stratification and screening was recognized.

Aim: The aim of this project was to increase the sleep apnea risk stratification rate among new adult cardiology patients from 53% to at least 85% over a 16-week implementation period by incorporating the …

Bridging Theory And Innovation: Cultivating Nursing Scholars Through Research, Ai And Mentorship, Charlene Whitaker-Brown, Judy Cornelius

International Nursing Research Congress (INRC)

As a newly R1 Carnegie Classification institution, in the Southeastern part of the United States, there is renewed emphasis on expanding research opportunities for undergraduate and graduate students. In response, the Research Explorer Program commencing in Winter 2025 is being launched as a pilot initiative to enhance student research engagement within the School of Nursing.

This program introduces a cohort of 10 undergraduate nursing students to the fundamentals of nursing research through mentorship with graduate nursing students. Grounded in the belief that early exposure to research strengthens clinical reasoning, evidence-based practice, and leadership, the initiative will provide undergraduates with hands-on …

Fmea-Based Risk Assessment And Improvements For Vascular Access Education In Hemodialysis, Nai-Hua Hsiao

International Nursing Research Congress (INRC)

This study evaluates and improves the patient education and care process before and after arteriovenous fistula surgery in hemodialysis patients. Inadequate implementation of this process may lead to multiple clinical risks. Currently, Southern X Hospital lacks a standardized patient education protocol, resulting in duplicated, omitted, or inconsistent content. These deficiencies negatively affect patients' comprehension and adherence, potentially leading to resource waste and reduced dialysis quality. To address these issues, this study applies Failure Mode and Effects Analysis (FMEA) to systematically identify potential failure modes within the education and care continuum. The CRITIC (Criteria Importance Through Intercriteria Correlation) method is used …

Multi-Interactive Teaching For Clinical Nursing Preceptors: Impact On Learning Styles And Competence, Shui-Tao Hu, Shu-Ling Yeh, Yi-Ling Chang

International Nursing Research Congress (INRC)

Background: Newly recruited nurses face high turnover and adaptation challenges, requiring clinical preceptors to possess diversified teaching competencies. Multi-interactive teaching, integrating simulation, discussion, and immediate feedback, can enhance teaching reflection and professional development.

Purpose: To examine the effects of multi-interactive teaching on clinical preceptors’ learning styles and teaching competence.

Design: Quasi-experimental, one-group pretest-posttest design.

Methods: Six multi-interactive workshops were conducted for experienced clinical preceptors, covering preceptor characteristics, learner learning styles, teaching competence, and strategies for coaching difficult learners. Workshops included seminars and real-time interactive communities. Participants were registered nurses (clinical ladder 3 or above, or ladder 2 with >5 years’ …

Rewilding Health: A Global Nursing Framework For Nature-Based Interventions And Planetary Well-Being, Amber Lea Vermeesch, Mary Rockwood Lane, Erica Timko Olson

International Nursing Research Congress (INRC)

Purpose: Rewilding—defined as restoring natural ecosystems and reconnecting humans to nature—offers a scalable, evidence-informed strategy to advance global health goals identified by the World Health Organization and United Nations Sustainable Development Goal (SDG) 3. This project examines how nurses can operationalize rewilding and nature-based interventions (NBIs) as ethical, clinical, and policy actions supporting universal health coverage, mental health promotion, non-communicable disease prevention, and global well-being.

Background: Growing evidence demonstrates that exposure to nature reduces stress, improves immune function, decreases depression and anxiety, enhances cancer survivorship outcomes, and promotes social connectedness. Aligning with Watson’s Unitary Caring Science and Chinn’s Emancipatory Nursing, …

Trends And Characteristics Of Behavioral Trials On Hpv Vaccination: A Systematic Review (2006-2025), Jutamas Suwannawat, Megan Whaley, Tsui-Sui Annie Kao, Angela Chia-Chen Chen

International Nursing Research Congress (INRC)

Background: Although human papillomavirus (HPV) vaccination has effectively prevented HPV-related cancers and infections since 2006 (Rosenblum et al., 2022; Semprini et al., 2025), uptake remains suboptimal (Franco et al., 2019; Guo et al., 2025; Han et al., 2025). Behavioral clinical trials have increasingly sought to enhance HPV uptake, yet few have examined overall trends. This study examined trends and characteristics of behavioral HPV vaccine trials between 2006 and 2025.

Methods: We searched ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, and the International Standard Randomized Controlled Trial Number for behavioral HPV vaccination trials registered between 2006 and 2025. Inclusion criteria …

Mindful Parenting And Toddlers' Food Responsiveness: The Role Of Controlling Feeding Practices, Qingyu Jiang, Holly Wilhite, Natalie A. Williams, Dipti A. Dev, Caron A. C. Clark, Pearl Avari, Sarah B. Ladd

Journal of Extension

Controlling feeding practices may negatively impact children's eating behaviors. Mindful parenting may offer a promising way to reduce the use of these practices. This study examined the mediating role of pressuring children to eat and using food as a reward in the association between mindful parenting and toddlers' food responsiveness. Results indicated that higher levels of mindful parenting were associated with lower pressuring to eat, which was related to lower food responsiveness in toddlers. The results may inform Extension professionals providing mindfulness strategies for mothers of young children to improve feeding practices, ultimately reducing children's unhealthful eating behaviors.

The Role Of Green Competence In Enhancing Green Performance Among Healthcare Workers In Indonesian Community Health Centers, Dewi Susanna, Tris Eryando, Dwi Agustina, Artha Prabawa, Rabiatul Adawiah, Lusianah Lusianah, Ratna Sari Dewi

Media Kesehatan Masyarakat Indonesia

Climate change poses increasing risks to population health and healthcare systems worldwide. Primary healthcare facilities, partic-ularly community health centers, play a critical role in climate change mitigation and adaptation through environmentally sustainable practices. This study aimed to assess the level of green competency of Puskesmas staff and analyze relationship in the green behavior. A cross-sectional study was conducted among 102 personnel at the Community Health Center in East Jakarta, Indonesia, using a total sampling approach. Green competence was measured across five dimensions (knowledge, skills, abilities, attitudes, awareness) involving a structured questionnaire. Data were analyzed using descriptively and inferentially using chi-square …

Remarkable Seizure Reduction With Trofinetide Treatment In An Adult With Rett Syndrome: A Case Report, Semihan Adegbite, Pooneh Memar Ardestani, Maromi Nei

Department of Neurology Faculty Papers

No abstract provided.

God's Will Or Man's? The Power Of Religious Rhetoric In Shaping Wartime Domestic Policy Preferences, Claire E. Brimhall

Undergraduate Honors Theses

How do individuals represent their religious beliefs in the political sphere? Is this impacted by levels of conflict in a given society? In times of war, people of faith often rally behind leaders and policies that diverge from the values upheld by their religious institutions. In fact, in many such cases, religious affiliation and church attendance are among the strongest predictors of support for these political actors.

This thesis examines two such cases where religious voters support policies that contradict the moral teachings of their faith, advancing a theory that a state’s appeals to religion can fundamentally reshape how believers …

Are 2d:4d Finger-Length Ratios Related To Bdsm Power Play Roles? An Exploratory Study, Phoenix R. Crane

Psychology and Neuroscience Faculty Publications

This study explored the relationships between 2D:4D ratio, a biological marker influenced by prenatal androgen exposure, and personality traits among members of the BDSM community. The 2D:4D ratio, calculated by dividing the length of the second (index) finger by the length of the fourth (ring) finger, is a non-invasive measure of prenatal exposure to androgens, with a smaller 2D:4D ratio associated with higher levels of testosterone exposure. Previous, albeit conflicting, research suggests that higher levels of testosterone are associated with dominance, aggression, risk-taking, and sensation-seeking. The present study draws on these findings to propose an androgenization of power play roles. …

Improved Foraminal Expansion And Pain Scores Following Placement Of Novel Expandable Interlaminar Stabilization Device For Lumbar Spinal Stenosis, Robert P. Norton, Ian Koch, Kendra Primavera, Roy Y. Miloh, Alex R. Vaccaro, Mitchell K. Ng

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Retrospective cohort study.

OBJECTIVE: To evaluate radiographic durability and clinical outcomes following placement of a novel expandable interlaminar stabilization device for single-level lumbar spinal stenosis. Specifically, we aimed to: 1) quantify immediate postoperative posterior column distraction; 2) determine whether foraminal expansion is improved postoperatively without radiographic subsidence; and (3) assess potential improvements in patient-reported pain/clinical outcomes.

METHODS: A retrospective review was performed of adult patients undergoing single-level decompression supplemented by an interlaminar device for symptomatic lumbar spinal stenosis by a single surgeon from 2024 to 2025. Radiographic parameters included anterior, middle, and posterior disc height, foraminal height, and …

Parents’ Perceptions Of Their Children With Disabilities’ Mental Health During The Rapid Transition To Online Learning At The Time Of The Covid-19 Pandemic, Arnell Rorie Footman

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic prompted an abrupt shift to online learning, raising significant concerns about the mental health of children with disabilities. Existing research highlights increased rates of anxiety, depression, and social isolation during due to the disruptions in structured routines and in-person support systems. This generic qualitative study, guided by Bronfenbrenner’s EST was conducted to explore parents’ perceptions of the mental health challenges experienced by their students with disabilities during the rapid transition to online learning at the time of COVID-19 pandemic. Data was obtained through semi-structured interviews in which parents voiced their perceptions and experiences concerning their children’s mental …

Using Posters To Increase Vegan Entrées Chosen At Classics In Wmu’S Student Dining Center, Sarah Schneider

Honors Theses

The following experiment tested the use of specifically designed posters to see the effect on eating habits of those who ate entrées from WMU’s food counter called Classics in the Student Dining Center. The independent variable was a poster with humorous and factual elements displayed at the point of choice in the dining center. The primary dependent variable was the percentage of vegan entrees chosen out of the total number of vegan and meat entrees served. The secondary dependent variables were the number of vegan entrees prepped and served, and the percentage of each entree that was served out of …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

141 Macdonough Street Hdfc V. Reid

All Decisions

Grimmet government-entwinement test satisfied: HDFC operates under Private Housing Finance Law Article XI, its deed and certificate of incorporation carry HPD approval requirements and low-income use covenants, and Board of Estimate resolutions provide a partial tax exemption running through July 2029. Constitutional due process therefore requires the HDFC to demonstrate 'cause' to evict. The notice of termination states only that the tenant 'failed to pay rent'—no period, no rate, no arrears balance. This is legally insufficient: vague and conclusory. Additionally, 16 HPD violations exist against the premises (15 served before the notice) and 40 building-wide violations, 2 of which are …

Emerging Aiot-Based Approaches For Early Detection Of Cardiac Diseases: A Review, Balqees Talal Hasan, Zaid J. Al-Araji, Zainab Al-Badrany, Sarah Kanaan Hamzah, Abdulmajeed Sulaiman

Mesopotamian Journal of Artificial Intelligence in Healthcare

Cardiovascular disease continues to pose a serious global health burden, emphasizing the need for smart, ongoing, and clinically trustworthy systems for early detection of this condition. The convergence of IoT-enabled sensing technologies with AI has led to the rise of an innovative paradigm known as AIoT, integrating technologies such as machine learning, deep learning, edge and fog computing, and cloud-based analytics with the aim of real-time cardiac monitoring and diagnostic decision support. Despite rapid expansion, current literature appears disparate in its coverage of sensing modalities, learning algorithms, system architectures, data sets, evaluation criteria, and clinical applications. To remedy this, a …

Experiencing God Firsthand, Joseph Khabbaz

The Main Thing Devotional

Why settle for a secondhand faith when you can have a firsthand experience with God?

Campus-Wide Assessment Of Indoor Air Quality At A University In The United Arab Emirates, Nida Qafisheh, Hani Kour

All Works

In educational institutions with the use of mechanical ventilation especially in arid climates indoor air quality (IAQ) has significant implications to health and cognitive performance of occupants. The present study examined 35 different sites’ IAQ at Abu Dhabi University, United Arab Emirates (UAE), in January-February 2024 comparing the observations with 2024 IAQ Guideline in Dubai Municipality (DM-HSD-GU119-IAQ). Portable instruments were used to measure eleven parameters: temperature, relative humidity, CO 2 , CO, ozone, formaldehyde, total volatile organic compounds (TVOC), PM 10 and PM 2 . 5 . The count of viable bacteria and fungi was determined by 15-min passive sedimentation …

Immune Reconstitution And Tolerance-Inducing Therapies As Promising Therapeutic Approaches In Multiple Sclerosis, Alireza Beheshti Maal, Mandana Kazem Arki, Seyed Massood Nabavi, Mostafa Rezaei-Tavirani, Elham Rismani, Massoud Vosough, Gholamreza Azizi, Nikoo Hossein-Khannazer

Department of Neurology Faculty Papers

OBJECTIVES: Multiple sclerosis (MS) is a complex, progressive neurodegenerative autoimmune disease and a major cause of neurological disability worldwide. MS affects approximately 2.8-3 million people, predominantly presenting as relapsing-remitting MS (RRMS) that frequently converts to secondary progressive disease, while effective options for progressive phenotypes remain limited.

METHODS: This review reframes MS immunotherapy through a tolerance-centric paradigm, distinguishing continuous maintenance disease-modifying therapies (DMTs) from immune reconstitution therapies (IRTs) and emerging antigen-specific tolerance strategies.

RESULTS: Classical immune reconstitution therapies, including alemtuzumab, cladribine, and autologous hematopoietic stem cell transplantation (aHSCT), have demonstrated durable disease control and prolonged periods of no evidence of disease …

First Evidence Of Clinical Protection From An Eehv1a Mrna Vaccine In Naturally Infected Juvenile Elephants, Michael Wenninger, Lauren Farris, Jessica Heinz, Rongsheng Peng, Gary S Hayward, Jessica Watts, Jeroen Pollet, Jenny Nollman, Paul D Ling

Faculty, Staff and Students Publications

Juvenile Asian elephants who have lost maternal antibodies are particularly susceptible to fatal hemorrhagic disease caused by primary infection with elephant endotheliotropic herpesvirus 1A (EEHV1A). To address this vulnerability, a multi-antigen EEHV1A mRNA vaccine has been administered to EEHV1A seronegative calves at four institutions. However, the extent to which this vaccine confers protective immunity remains an open question. In November 2023, two juvenile male calves (aged 6 and 7 years) were transferred from Dublin Zoo to the Cincinnati Zoo and Botanical Garden and confirmed to be seronegative for EEHV1A. Both calves received an experimental EEHV1A mRNA vaccine in October 2024, …

Evaluation Of A Multiantigen Mrna Vaccine Against Eehv1a In Asian Elephants, Lauren Farris, Jessica Watts, Jeroen Pollet, Christine Molter, Sarah Cannizzo, Michael Wenninger, Jessica Heinz, Rebecca Eddy, Jessica Emerson, Dewey Maddox, Paul D Ling

Faculty, Staff and Students Publications

Elephant endotheliotropic herpesvirus (EEHV) is endemic in Asian elephants and can cause fatal hemorrhagic disease (HD) in juveniles, with calves aged 1-8 years being most vulnerable, particularly following the decline of maternal antibodies. Current supportive treatments, which commonly include fluids, plasma infusions, and human anti-herpesvirus drugs, are not consistently effective, highlighting the urgent need for preventative strategies. To address this challenge, we generated an EEHV1A multi-antigen mRNA vaccine targeting four conserved herpesvirus entry proteins (gB, gH, gL, and gO), which elicited robust humoral and cellular immune responses in mice without adverse effects. Based on these preclinical findings, a vaccine trial …