Digital Commons Network^™

Molecular Heterogeneity Of Hpv-Associated Cancers And Strategies To Overcome Treatment Resistance, Danyal Daneshdoust, Anam Khan, Rani Mahyoob, Chongwen Cao, Zihao Yu, Nagireddy Putluri, Gennady Shvets, Haichang Li, Bo Zhao, Xuefeng Liu, Jenny Li

Faculty, Staff and Students Publications

Human papillomavirus (HPV) is a major driver of global cancer incidence, responsible for nearly all cervical cancers and a significant proportion of oropharyngeal, anal, and other anogenital cancers. Despite the availability of effective vaccines, HPV-associated cancers persist due to persistent infection, immune evasion, and the virus's ability to integrate into the host genome, contributing to molecular heterogeneity and therapeutic resistance. Here, we summarize molecular heterogeneity and the emerging combined therapeutic strategies. High-risk HPV types, notably HPV16 and HPV18, initiate carcinogenesis through persistent infection of epithelial basal cells and through the actions of the E6 and E7 oncoproteins, which disrupt the …

Case Series Of Nizon-Isidor Syndrome By Heterozygous Variants In Med12l With Further Evidence Of Mitotic Instability In One Case With Diploid-Triploid Mosaicism, Brian Corner, Ashley Mcminn, Joy D Cogan, Rizwan Hamid, Lynette Rives, John A Phillips, Nina Paddu, Gitanjali Srivastava, Ronit Marom, Farah A Ladha, Claudia Soler-Alfonso, Rachel Franciskovich, Mary Koziura, Sumit Pruthi, Gabriele Richard, Christina B Sheedy, Undiagnosed Diseases Network, Thomas Cassini

Faculty, Staff and Students Publications

Nizon-Isidor syndrome is a rare disorder caused by heterozygous variants in MED12L, with only eight documented cases in the literature. Here, we present three additional cases of this syndrome. Proband 1 was a 7-year-old female who presented with developmental delay, right-leg hemihypertrophy, laryngeal cleft, esotropia, abnormal skin pigmentation, sectoral iris hypopigmentation, dysphagia, periventricular nodular heterotopia, seizures, morbid obesity, and a pelvic kidney. Genome sequencing (GS) revealed a MED12L variant, NM_053002.5:c.3559+2T>G. Both computational models and transcriptomic analysis confirmed that this variant induced splice loss of MED12L exon 25. Probands 2 and 3 presented with overlapping phenotypes of developmental delay; sequencing …

Transition To Tenecteplase Is Associated With Shorter Door-To-Puncture Times: A Retrospective Study From The Lone Star Stroke Consortium Tnk Registry, Mark P Goldberg, Andrew Slusher, Reza Behrouz, Alibay Jafarli, Siddarth Prasad, Daiwai Olson, Maria Denbow, Mehari Gebreyohanns, Asmiet Techan, Chethan P Venkatasubba Rao, Jane A Anderson, Barbara Kimmel, Anette Ovalle, Michele Patterson, Sean I Savitz, Salvador Cruz-Flores, Steven Warach, Lee Birnbaum

Faculty, Staff and Students Publications

Background: Intravenous thrombolytic (IVT) and mechanical thrombectomy (MT) therapies are the current standard of care for large vessel occlusion (LVO) stroke. Multiple studies emphasized the impact of time metrics on patient outcomes, particularly door-to-needle (DTN) and door-to-puncture (DTP) times. Tenecteplase (TNK) offers potential advantages over alteplase (ALT), including a simplified one-time bolus administration, which may reduce DTP time. Results suggest TNK is non-inferior to ALT in terms of clinical outcomes, but few large cohort studies have compared DTP time for patients receiving TNK vs. ALT prior to thrombectomy. This real-world study aimed to compare DTP times and discharge outcomes in …

Validation Of The Norwegian Version Of The Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Michaela Dreetz Gjerstad, Anders Ledaal Bjørnestad, Jodi Maple-Grødem, Elin Bjelland Forsaa, Ylva Hivand Hiorth, Karen Herlofson, Espen Benjaminsen, Kari Anne Bjørnarå, Espen Dietrichs, Roberta Balestrino, Carmen Gasca-Salas, Chi-Ying R Lin, Alvaro Sanchez-Ferro, Michelle H S Tosin, Tiago A Mestre, Monica M Kurtis, Pablo Martinez-Martin, Sheng Luo, Luowen Yu, Glenn T Stebbins, Christopher G Goetz, Mds Coa Translation Steering Committee

Faculty, Staff and Students Publications

Introduction: The Movement Disorder Society-revised version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is the gold standard assessment for evaluating Parkinson's disease (PD) symptoms and severity, but a validated Norwegian version is not yet available. We translated the original English MDS-UPDRS into Norwegian and tested the clinimetrics of the translated version following the MDS-established protocol for non-English language translations.

Methods: Two independent teams translated the English version of the MDS-UPDRS into Norwegian. After review of the back-translated English version, cognitive pretesting was performed in twelve PD patients at one study site. This was followed by large-scale testing completed by …

At The Crossroads Of Law And Society: Understanding The World Of Immigration Attorneys., Elvis Ariri

Senior Independent Study Theses

This independent study examines the professional experiences of immigration attorneys working with immigrant clients in the United States. Through qualitative, semi-structured interviews, the research explores how immigration law operates in practice, emphasizing systemic complexity, administrative delay, and discretionary decision-making. Findings reveal that attorneys navigate a fragmented legal framework shaped by shifting policies, inconsistent adjudication, and high emotional stakes. Beyond technical expertise, immigration practice requires emotional resilience, ethical judgment, and strategic adaptability. By centering attorneys’ perspectives, this study highlights immigration law as a lived social system that structures belonging, exclusion, and stability, illuminating the gap between statutory intent and human consequence.

On Procedures And Democracy, Nicholas Bagley

Book Chapters

Something broke in America around 1970. The persistence of Jim Crow had given the lie to America’s promise of equality under the law. The environmental movement burst onto the scene with a blistering indictment of the wanton destruction of the natural world, the befouling of the air and of waterways, and the indiscriminate use of DDT. Urban planners recklessly destroyed neighborhoods in the name of redevelopment and rammed highways through Black communities. Lies and half-truths served to justify sending tens of thousands of young men to their deaths in Vietnam.

Entrenching Incumbent Power: Medicare Advantage, Part D, And The Politics Of Health Reform, Samuel R. Bagenstos

Other Publications

During each of the past three Democratic presidential administrations, health policy has been a key domestic priority. President Clinton unsuccessfully sought to pass comprehensive health reform, before settling for important incremental expansions of health insurance coverage during his second term. President Obama successfully pushed the Affordable Care Act to enactment, though perhaps at the cost of losing Congress decisively in his first midterm election. And President Biden both dealt with the health-policy consequences of the COVID emergency and enacted a major reform of the Medicare prescription drug program, including the first-ever provision for the government to negotiate prices, in the …

A Behaviour Analysis Of Nutrition Behaviours And Technology Use In Individuals With Severe Mental Illness, Ciara O'Sullivan, Tara Coppinger, Alison Merrotsy, Indika Dhanapala

Publications

No abstract provided.

Dnp Final Report: Advancing Mental Health Care Through Self-Guided Cbt For Ptsd, Maureen Balcazar

DNP Final Reports

Background: Trauma-related symptoms are associated with impaired functioning, increased distress, and limited access to timely evidence-based care in rural communities. Local Problem: In a rural Permian Basin outpatient mental health setting, patients with trauma-related symptoms experienced barriers to structured coping support while awaiting or engaging in trauma-focused care. Intervention: This quality improvement project implemented a self-guided cognitive behavioral therapy (CBT) workbook supported by four planned biweekly provider check-ins during an eight-week period. Methods: Ten adults enrolled. Feasibility was evaluated using provider reachability, workbook engagement, participant feedback, and available PTSD Checklist for DSM-5 (PCL-5) scores. Quantitative findings were summarized descriptively; three …