When Drug Repurposing Backfires: Antagonistic Effects Of Ivermectin On Cisplatin Therapy In Oral Cancer, Dalia Ghalwash, Rana Tantawy, Shereen Nader, Ayman Elgawish

Dentistry

Abstract

Background

Cisplatin (CIS) remains the gold standard chemotherapeutic agent for the management of oral cancer. However, its clinical efficacy is frequently limited by chemoresistance and dose-dependent toxicities. Ivermectin (IVM), a well-established antiparasitic agent with emerging anticancer properties, has been proposed as a potential adjuvant capable of enhancing the antitumor efficacy of CIS.

Methods

In vitro experiments were conducted on HN9 oral squamous cell carcinoma cells, while OEC normal epithelial cells served as control. The experimental evaluation comprised the MTT assay for cell viability, Annexin V/propidium iodide (PI) staining for apoptosis detection, cell cycle distribution analysis, quantitative real-time PCR (RT-qPCR) …

Neuromuscular Adaptations Following Eight Weeks Of French Contrast Training In Elite Youth Football Players: Implications For Athletic Performance, Okan Demir, Tolga Altug, Christopher B. Taber, Mehmet Bayansalduz

Exercise Science Faculty Publications

Neuromuscular training is increasingly recognised for enhancing football performance and athletes’ capacity to tolerate the repetitive high-intensity demands of match play. The French Contrast Method (FCM) combines heavy resistance, plyometric, and ballistic exercises within a post-activation performance enhancement framework, yet evidence in elite youth players during the competitive season remains limited. This study examined the effects of an eight-week in-season FCM program on reactive strength, neuromuscular performance, maximal strength, anaerobic performance, and short-distance sprint ability. Twenty-eight elite male youth football players were randomly assigned to an experimental group (FCM plus regular football training; n = 14) or a control group …

Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib

ASEAN Journal on Science and Technology for Development

The review article demonstrates the importance of power electronics in propelling the increase of renewables and increasing the efficiency of contemporary electrical grids. In particular, it highlights the need for bidirectional converters for effective energy management in vehicle-to-grid (V2G) systems with two-way power transfer. The paper examines the series of complications offered by the significantly large integration of power electronic converter-interfaced renewables, such as those related to system steadiness, power quality, and resignation bottlenecks. Also, it recognizes a mix of new technologies, such as wide bandgap (WBG) semiconductors like silicon carbide (SiC) and gallium nitride (GaN), that deliver superior performance …

Design Of An Economic Order Quantity–Based Dashboard For Vaccine Packaging Inventory Management, Hadi Susanto, Susmitha Canny, Alexandra Elizabeth Callistha, Shakira Dwi Purwandari, Naila Davina Aurelia

ASEAN Journal on Science and Technology for Development

Background: Timely availability of vaccine packaging is critical to pharmaceutical supply chain reliability, as packaging materials play a key role in maintaining cold chain integrity during distribution. Inadequate availability of packaging materials can disrupt vaccine delivery even when finished vaccines are ready for shipment. The case company faces frequent delivery delays, insufficient safety stock, and irregular replenishment of vaccine packaging materials, which have jeopardized the organization’s target of achieving a 90% on-time delivery rate.

Objective: To design and evaluate an Economic Order Quantity (EOQ)–based inventory dashboard for vaccine packaging that standardizes ordering decisions and strengthens stock visibility in pharmaceutical distribution …

Multiclass Skin Lesions Classification And Early Skin Cancer Detection Using An Attention-Enhanced Xception Architecture, Shamira Arshad Shaikh, Yogita Mistry

ASEAN Journal on Science and Technology for Development

Skin disorders are considered one of the major healthcare problems globally and need proper, prompt, effective and early diagnosis to enhance clinical practice. Traditional machine learning and deep learning approaches often exhibit limited generalization capability and reduced effectiveness in extracting discriminative features from complex multiclass dermatological datasets. For this purpose, an interpretable attention-enhanced Xception framework for automatic multiclass skin disease diagnosis based on dermoscopic images has been designed through the use of the International Skin Imaging Collaboration (ISIC) dataset. The dataset includes 2,357 dermoscopic images that belong to nine classes of skin lesions. The proposed framework integrates channel attention and …

Mending The Broken Heart: Applying Selective Spiritual Practices To Navigate The Grief Process At Reeder Memorial Baptist Church Charlotte, North Carolina, Kathryn A. Bonapart

Doctor of Ministry Projects

This Doctor of Ministry capstone examined how guiding congregants through intentional spiritual disciplines can foster grief healing at Reeder Memorial Baptist Church in Charlotte, NC. Many members face grief related to death, illness, relational loss, or communal trauma. The project integrated the biblical narrative of Jesus in Gethsemane (Matthew 26:36–46) with group practices such as prayer, silence, solitude, lament, and journaling. Quantitative pre- and post-surveys and qualitative data from journals, field notes, and interviews revealed growth in emotional awareness, spiritual endurance, consistent grief practices, deeper faith during mourning, greater awareness of God’s presence in suffering, and stronger community connections.  The …

Social Support As An Effect Modifier Of The Assocation Between Drug-Use Related Stigma And History Of Substance Use During Pregnancy Among Women Who Use Unprescribed Opioids In New York City: A Cross-Sectional Study, Isabelle C. Lynch

Graduate Studies Theses and Dissertations 2026

Substance use and misuse among women who are pregnant is a growing public health concern in the United States. Overdose deaths are now a leading cause of death among pregnant and postpartum women, and neonatal abstinence syndrome rates have increased to 23 per 1000 births. A barrier addressing substance use among these women is social stigma, which in part is driven by punitive drug policies that criminalize substance use during pregnancy and societal gender roles and norms surrounding women’s substance use. Social support, including emotional, instrumental, and informational support, can serve to mitigate the negative impacts of stigma on health …

Numerical Simulation Of Micro-Cutting Processes For The Estimation Of Material Fracture Toughness, Juan J. Lainez

Graduate Studies Theses and Dissertations 2026

Accurate determination of plane-strain fracture toughness is essential for structural integrity assessments of engineering components, yet conventional ASTM standardized testing methods require large, notched specimens that are impractical in many industrial and research contexts. This thesis presents a finite element method-based approach for estimating the mode I plane-strain fracture toughness of engineering materials from orthogonal micro-cutting simulations if the continuum damage mechanics-based fracture locus is calibrated. This method will eliminate the need for pre-cracked specimens while maintaining physically grounded fracture mechanics principles. The methodology applies to the Atkins energy-based cutting force model, in which the depth-independent intercept of the specific …

Black Widow Optimization Of Hybrid Renewable-Hydrogen Microgrids For Cost-Effective Water Pumping In Off-Grid Systems, Ayodeji Akinsoji Okubanjo, Ignatius Kema Okakwu, Samson Oladayo Ayanlade, Abayomi Temitope Layeni, Etinosa Noma-Osaghae, Christian Chukwuemaka Ike, Olufemi Peter Alao, Ayodeji Joseph Akinremi, Ayo Isaac Oyedeji

Trends in advanced sciences and technology

The intermittent nature of renewable energy resources, together with limited infrastructure in off-grid communities, presents major obstacles to sustainable water supply. To overcome these challenges, this study develops a Black Widow Optimization (BWO)-based framework for the optimal sizing of a hybrid renewable–hydrogen microgrid integrating photovoltaic (PV) systems, wind turbines, battery energy storage, and hydrogen storage for reliable and cost-effective water pumping applications. The optimization goals are to reduce the Levelized Cost of Water (LCOW), Levelized Cost of Hydrogen (LCOH), and Net Present Cost (NPC), while system reliability and energy efficiency are quantified using the probability of unmet water demand (PUWD) …

Neuroprotective Effects Of Flaxseed And Purslane Extracts Against Cerebral Ischemia/Reperfusion Injury: Modulation Of Apoptotic, Neurotrophic, And Neurotransmitter Signaling, Fatma M. Attia, Ahmed E. Abdel Moneim, Rehab E. El-Hennamy, Inas S. M. Elsayed, Gehad E. Elshopakey, Nabil A. El-Yamany

Trends in advanced sciences and technology

Background: Cerebral ischemia/reperfusion (I/R) injury is a serious pathological condition that leads to permanent neurological impairment. Plant-derived bioactive compounds are gaining attention as promising neuroprotective therapeutic alternatives with relatively low adverse effects. Aims: This study aimed to investigate the neuroprotective effects of flaxseed extract (FE) and purslane extract (PE) on I/R injury in rats.

Methods: Seventy adult male rats were divided into seven groups: control, sham, I/R model, FE, FE-pretreated I/R, PE, and PE-pretreated I/R. Cerebral ischemia was induced by occlusion of the bilateral common carotid arteries for 60 min, followed by 120 min reperfusion. Rats were treated orally with …

Investigating The Relationship Between College Students’ Sense Of Belonging And Graduation Rates At A Private, Predominantly White Institution, Jamie Symonette

All Electronic Theses and Dissertations

This quantitative research analyzed the association between a sense of belonging and academic achievement among 514 undergraduates in a small, all-white institution (PWI), based on the 2025 Campus Life Survey and institutional data. Although national graduation disparities persist (64% of White students graduate within six years versus 54% of Latinx, 44% of Black, and 39% of Native American students), limited quantitative research has investigated belonging in private PWI settings. Variables were perceived sense of belonging, institutional climate, demographic factors (race/ethnicity, sex), academic advancement signs (cumulative GPA, earned credit hours), and seriously considered leaving. Multi-Regression (hierarchical and binary) and binary logistic …

Bridging The Gap Between Function-Based And Iddsi Standards In Dysphagia Care, Chien-Hui Cheng

Rehabilitation Practice and Science

No abstract provided.

A Narrative Review Of The Central Neural Control Of Swallowing And Its Implications For Dysphagia Rehabilitation, Kuo-Chang Wei, Tyng-Guey Wang, Ming-Yen Hsiao

Rehabilitation Practice and Science

Swallowing is controlled by a distributed neural network spanning the brainstem central pattern generator, subcortical modulatory circuits, and cortical regions responsible for volitional planning and sensorimotor integration. Evidence from lesion studies, neuroimaging, and neurophysiology demonstrates that dysphagia arises from disruptions at different nodes of this network, producing lesion-specific impairment profiles rather than a uniform swallowing deficit. This network-based perspective has shifted rehabilitation from predominantly compensatory management toward mechanism-driven interventions aimed at restoring physiological function. Behavioral skill-training and resistance-based exercises harness motor learning and cortical plasticity, whereas neuromodulatory approaches—including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), pharyngeal electrical …

Experience And Barriers In Pediatric Dysphagia Rehabilitation: A Quantitative Survey Study, François-Xavier Brajot, Ai-Ju Wu, Pao-Chuan Torng

Rehabilitation Practice and Science

Purpose: Despite an important need for health care services targeting pediatric dysphagia, there exist a number of barriers to doing so, including workforce competence. The current study surveyed practicing Speech-Language Pathologists to determine (1) the importance of pediatric dysphagia in their caseload, (2) the adequacy of existing educational resources, and (3) perceived barriers to providing quality care in Taiwan.

Methods: An anonymous survey was completed by Speech-Language Pathologists working in Taiwan. Responses were analyzed with respect to current work setting, experience, preparation, and perceived barriers.

Results: Survey results from 122 respondents indicated that the pediatric dysphagia caseload is unexpectedly low …

Dysphagia And Rehabilitation In Patients With Parkinson’S Disease, Jong Mi Park, Seo Yeon Yoon

Rehabilitation Practice and Science

Dysphagia is one of the most clinically important complications of Parkinson's disease (PD). It impairs nutrition and quality of life and is closely linked to aspiration pneumonia, a leading cause of death in this population. It is often underrecognized, partly because subjective complaints underestimate the impairment found on objective testing, and partly because silent aspiration progresses without a protective cough. This review examines dysphagia in PD from a rehabilitation perspective, covering its pathophysiology, clinical features, assessment, and the evidence for rehabilitative interventions. Parkinsonian dysphagia arises from dopaminergic, non-dopaminergic, and peripheral mechanisms, and because it responds inconsistently to levodopa, rehabilitation has …

A Scoping Review Of Non-Instrumental Dysphagia Screening Tools: Building Flowcharts To Guide Tool Selection, Yu-Chun Chang, Ming-Jhuan Wang, Shu-Fen Siao, Yu-Juan Xu, Meng-Shan Wu, Tyng-Guey Wang, Cheryl Chia-Hui Chen

Rehabilitation Practice and Science

Selecting an appropriate non-instrumental dysphagia screening tool is a complex process. This scoping review aimed to identify dysphagia screening tools with established reliability and validity, and to develop administrator-based flowcharts to guide tool selection across different clinical populations. A scoping review was conducted using studies identified in CINAHL, Embase, PsycINFO, PubMed, and Web of Science. Our search was guided by five keywords: “dysphagia,” “deglutition,” “screening,” “test,” and “measure.” Original studies about the development and validation of non-instrumental dysphagia screening tools were selected. Six reviewers were involved in the review process, and at least two reviewers independently completed each step of …

Capacity-Building Project To Progress The Implementation Of International Instruments To Combat Iuu Fishing (Capfish) : Summer Academy : Southeast Asia, World Maritime University

Reports

No abstract provided.

An Anatomy-Aware Efficientnetb0 And Cbam Framework For Suppressing Hard Boundary Bias In Mri Brain Tumor Classification, Ali Abdulzahraa Jalil, Ahmad Fatlawi, Hussein Ali Hussein Al Naffakh, Umar Farooq Khattak

Polytechnic Journal

The accurate classification of brain tumors from Magnetic Resonance Imaging (MRI) is important for prognosis and treatment planning in neuro-oncology. Although Convolutional Neural Networks (CNNs) dominate medical image analysis and achieve high scores, many rely on a clinically dangerous shortcut that we call Hard Boundary Bias (HBB). When an MRI slice is saved with zero padding, the boundary between the bright skull and the dark background forms the strongest gradient in the image, and the network fixes on this artificial edge instead of the tumor. To address this, we propose a lightweight framework that combines an EfficientNetB0 backbone with a …