Understanding The Epigenetic Landscape Of Barrett's Esophagus And Esophageal Cancer: A Review Of Current Findings, Caveats And Future Directions, Louise Lawless, Trevor Doherty, Carla Surlis, Niamh Gilmartin, Therese M. Murphy

Research Outputs: 2025-Present

Esophageal cancer (OC) is currently the eighth most common form of cancer worldwide with a 5-year survival rate of 10%–20%, with the primary risk factor of esophageal adenocarcinoma (OAC) being the development of Barrett's Esophagus (BO). Despite its clinical significance, the molecular pathogenesis underlying both BO and OC is not well understood. In recent years, epigenetic dysregulation, particularly aberrant DNA methylation, has emerged as a critical area of investigation, given its potential utility in the identification of diagnostic, prognostic, and therapeutic biomarkers. This review examines the evolving epigenetic landscape of esophageal cancer, including a focus on its origins in BO …

Exploring The Postpartum Recovery After Hyperemesis Gravidarum: A Qualitative Study, Zeinab El-Dirani, Sergio A. Silverio, Eleni Niarchou, Elana Payne, Pauline Dunne, Melanie Nana, Catherine Williamson, Mary F. Higgins, Eileen O'Brien, Joan Devin, Aisling Walsh, Angela C. Flynn

Research Outputs: 2025-Present

Introduction: Hyperemesis Gravidarum affects 0.3–3.6% of women during pregnancy and has a significant impact on maternal health. Investigation of both the immediate and longer-term effects remains a high research priority. However, there is limited research on postpartum recovery after hyperemesis gravidarum. Aim: To explore the postpartum recovery experiences of women who had hyperemesis gravidarum. Methods: A large descriptive qualitative study was conducted using semi-structured interviews to explore the postpartum experiences of women who had hyperemesis gravidarum within the previous 5 years in Ireland. Data were analysed using reflexive thematic analysis. Results: Forty-one women participated, and four themes were identified: (1) …

Associations Between The Planetary Health Diet In Late Pregnancy And Pregnancy Outcomes In Women With A Raised Bmi: Insights From The Pears Study, Aoife Davis, Sophie Callanan, Gillian A. Corbett, Eileen C. O'Brien, Alexander P. Douglass, Fionnuala M. Mcauliffe

Research Outputs: 2025-Present

Background: Diet quality in pregnancy is a modifiable factor with important implications for maternal and neonatal outcomes. The Planetary Health Diet (PHD), designed to promote both human health and environmental sustainability, has not been comprehensively evaluated in high-risk obstetric populations. Objectives: This study aimed to examine the PHD in a pregnant cohort with a raised body mass index (BMI) and its associations with pregnancy outcomes, hypothesizing that greater adherence is associated with more favorable pregnancy outcomes. Methods: This was a secondary analysis of data from the pregnancy exercise and nutrition research study with smartphone application support study. Pregnant women (n …

From Reactionary To Anticipatory Integrated Action: Novel Environmental Health Surveillance For Mass Gatherings, Benjamin J. Ryan, Michael Donahoo, Danielle Esler, Paul Barach, Benjamin Coghlan, Shelby Garner, Laura M. Langan, John Piispanen, Bryan W. Brooks

College of Population Health Faculty Papers

Advances in AI-driven analytics, human-in-the loop techniques, and wastewater monitoring provide the foundation needed to shift from reactive to anticipatory actions for mass gatherings. Traditional surveillance systems focus on clinical and laboratory-based notification pathways, which often result in tardy actions being implemented. Thus, traditional surveillance is becoming outdated. Mass gatherings pose heightened public health risks and hazards, including trauma; injury and substance misuse; deliberate poisoning; and infectious diseases such as food and waterborne illnesses, sexually transmitted infections, and respiratory diseases. There is also a heightened concern due to reduced vaccination coverage. As a result, future international events such as the …

The Effects Of Speak Out! On Hypokinetic Dysarthria In Individuals With Idiopathic Parkinson’S Disease, Linden King

Murray State Theses and Dissertations

The purpose of this single subject research study was to prove the efficacy of SPEAK OUT! therapy in improving loudness, rate of speech, and quality of life for individuals who have hypokinetic dysarthria due to Parkinson’s Disease. In this A-B-A design, five weeks of SPEAK OUT! therapy was provided twice a week to four individuals with a diagnosis of Parkinson’s disease. Results showed an increase in loudness in conversation and improved quality of life measured by statistical and visual analysis. These findings contribute to the research behind the use of SPEAK OUT! therapy for individuals with HKD due to PD.

Beyond The Classroom: The Continuing Impact Of Brown V Board On Equitable Access To Career And Technical Education For Historically Underrepresented Students, Shannon Hood

Murray State Theses and Dissertations

Using a qualitative phenomenological design grounded in Critical Race Theory (CRT) and Culturally Relevant Pedagogy (CRP), this study examined how institutional structures, instructional practices, and community and industry partnerships shape equitable access, engagement, and outcomes in secondary Career and Technical Education (CTE) programs serving students from historically marginalized backgrounds. Semi-structured interviews were conducted with thirteen participants, including educators, administrators, and industry partners engaged in secondary CTE implementation. Thematic analysis identified recurring patterns related to leadership decision-making, instructional relevance, culturally responsive teaching practices, relational trust and advocacy, and authentic work-based learning (WBL) experiences. Findings indicate that equitable participation in CTE extends …

Personality Assessment Inventory Profiles In Adults Seeking Autism Spectrum Disorder Assessment, Emily Kinsey

Murray State Theses and Dissertations

The current study aimed to examine differences in interpersonal functioning and response validity among adults presenting for autism spectrum disorder (ASD) assessment compared to those seeking services for other clinical concerns. The study used archival data from 238 client files collected in an outpatient clinical setting. Interpersonal functioning was assessed using the Dominance (DOM), Warmth (WRM), and Nonsupport (NON) subscales of the Personality Assessment Inventory (PAI; Morey, 1991). Response validity was evaluated using the Negative Impression Management (NIM) and Positive Impression Management (PIM) scales. A multivariate analysis of variance (MANOVA) showed no significant group differences across DOM, WRM, and NON …

Barriers To Mental Healthcare Among Men, Adrienne White

Murray State Theses and Dissertations

Men are consistently less likely than women to seek professional mental health services despite experiencing significant rates of depression and psychological distress. Traditional masculine norms and depression-related stigma have been proposed as major contributors to this disparity. The present study examined the relationships among depression stigma, conformity to masculine norms, depression severity, perceived barriers to care, and attitudes toward seeking professional mental health treatment among adult men with current or past depression. Seventy participants completed measures of depression severity (PHQ-9), conformity to masculine norms (CMNI-30), depression stigma (DSS), attitudes toward help seeking (MHSAS), and perceived barriers to care (BMHS). Contrary …

The Long-Term Effects On Youth Growing Up In Foster Care, Brittney L. Olatunde

Murray State Theses and Dissertations

Abstract

This study examined the long-term effects of the foster care system on youth, with particular focus on how early life experiences shape developmental trajectories into adulthood. Findings indicated that involvement in the foster care system significantly influences socioemotional, psychological, and life outcomes that persist across the youth life span. Understanding these enduring effects is essential for recognizing how early disruptions and transitions impact later adult functioning. Guided by life course theory, this study explored how the timing of foster care experiences, critical life transitions, and environmental contexts collectively influence individual development over time. Emphasis was on how entry and …

Tuberculosis Presenting As Multiple Pulmonary Nodules Mimicking Malignancy, Abdel Martinez Borrego, Fatimah Bello, Brandon Cantazaro, Luisa Montoya, Frank Mediola

School of Medicine Publications

Multiple pulmonary nodules often raise concern for metastatic malignancy; however, the differential diagnosis is broad and includes infectious, inflammatory, granulomatous, vascular, and benign etiologies. Tuberculosis (TB), although uncommon, can present with multiple nodules that closely mimic metastatic disease on advanced imaging, requiring careful clinicoradiologic and microbiologic correlation. We describe a woman in her 50s who presented with dyspnea and new-onset heart failure, in whom imaging revealed mediastinal lymphadenopathy and bilateral pulmonary nodules concerning for malignancy. Evaluation was limited by concurrent COVID-19 infection, and CT-guided biopsy demonstrated necrotizing granulomas without evidence of malignancy or infection. She later re-presented with fever and …

Pediatric Both Bone Fracture Leading To Median Nerve Entrapment: A Case Report, Joshua Lyndon Dale, Frank Gerold

School of Medicine Publications

Introduction: Both-bone forearm fractures are common in pediatric patients and most often result from a fall onto an outstretched hand. Although rare, nerve entrapments, particularly of the median nerve, can occur, especially following closed reduction.

Case report: We present the case of a 13-year-old male who sustained a both-bone forearm fracture while on vacation in Mexico. The injury was managed with closed reduction and casting. Despite appropriate treatment, the patient developed progressive numbness, tingling, and thenar atrophy in the median nerve distribution. Electromyography and nerve conduction studies confirmed significant median nerve dysfunction. Surgical exploration revealed the median nerve entrapped in …

Jack, Regis Dean

Mighty Pen Project Anthology & Archive

An Army veteran recounts a fellow soldier's struggle with estrangement and alcoholism after saving a wounded Iraqi during the Gulf War. Decades later, he finds himself trying to support the man who once promised to have his back.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in …

Research Initiative For Northeast Grazing Soils (Rings) Soil Carbon Data Report, Karla M. Jarecke, Joseph P. Amsili, Alexandra Contosta, Caitlin Hicks Pries, Kelsey H. Jensen, Morgan Mcclure, Alexander Steiner, Eric Von Wettberg, Mojtaba Zeraatpisheh

Faculty Publications

The Research Initiative for Northeast Grazing Soils (RINGS) is a multi-institutional collaboration with a mission to advance the understanding of soil organic carbon (SOC) dynamics in grazing systems across the northeastern United States. RINGS distributed a survey between October 2025 and June 2026 to researchers and practitioners across the Northeast to identify where SOC data has been collected and the basic field and lab methods used. The survey asked participants to describe existing soil datasets collected on land directly or indirectly impacted by grazing livestock. The survey was distributed to colleagues of RINGS researchers that work at university, corporate and …

Hosts, Scouts, And Female Indentured Sexual Servitude In Contemporary Japan, Caroline Norma, Seiya Morita

Dignity: A Journal of Analysis of Exploitation and Violence

This article sweeps away glossy abstractions obscuring the indenturing of women in sexual servitude in Japan. These abstractions were generated by anthropologists writing in English in the first two decades of the 21^st century who inverted the relationship between perpetrator and victim to suggest that female customers exploited hosts. To overturn this view and expose the ‘gendered reality that [i]s really going on’ in Japan, this article differently explains from a feminist perspective how present-day host and scout businesses indenture Japanese women in sexual servitude. This role is one of both procuring victims as well as keeping young women …

Examining Reproductive Equity In The Post-Roe United States, Yali Pang, Anna Grace Causey, Nakeina E. Douglas-Glenn, Research Institute For Social Equity Rise

Research Institute for Social Equity

Four years after the U.S. Supreme Court overturned Roe v. Wade, state-level variation in reproductive rights policy is associated with substantial geographic inequities in access to abortion and reproductive health care across the United States. The adoption of restrictive or protective reproductive rights policies is closely tied to legislative control, underscoring the political drivers of reproductive inequity. The evidence suggests that advancing reproductive equity will require coordinated national, state, and local response to strengthen healthcare infrastructure, reduce economic barriers, and establish durable legislative protections for reproductive rights.

Beyond Income Deprivation: Assessing The Compounding Impacts Of Fixed Costs And Broadband Equity On Food Security, Aemro Worku, Morgan Woodle Phd, Nakeina E. Douglas-Glenn, Research Institute For Social Equity Rise

Research Institute for Social Equity

Nearly 47 million people in the United States, including 14 million children, are considered food insecure by the U.S. Department of Agriculture. These nutritional deficiencies are often considered problems of uniform economic hardships. Analyzing 50-state data, this report reveals two distinct structural challenges: financial cash flow and physical geography. First, absolute food insecurity is driven by high costs of living, fueled by housing rent burdens, and is mitigated by strong broadband internet access that connects families to benefits. Second, physical access to healthy food shows no independent relationship with household budgets; rather, it is a problem of corporate grocery placement …

Connecting The Dots - Recognition Of Artificial And Natural Shapes Relies On Representing Points Of High Information, Gunnar Schmidtmann, Nicholas Baker, Kevin J. Lande, Filipp Schmidt

School of Health Professions

Physiological and psychophysical evidence suggests that the visual system represents object outlines using prominent curvature features, particularly regions of extreme curvature (convex maxima and concave minima). These curvature extrema often coincide with points of high informational content (“surprisal”), but this relationship is only correlational. It remains unclear whether the visual system explicitly encodes curvature extrema or instead prioritizes the most informative contour locations. To address this, we conducted two shape-matching experiments comparing the roles of curvature extrema and surprisal in shape representation. Observers performed match-to-sample tasks in which smooth reference shapes were matched to simplified polygonal versions created by connecting …

Reduced Threat-Related Neural Efficiency: A Possible Biomarker For Pediatric Anxiety Disorders, Julia O. Linke, Reut Naim, Simona P. Haller, Parmis Khosravi, Beck Scheinberg, Meghan E. Byrne, Anita Harrewijn, Ellen Leibenluft, Melissa A. Brotman, Anderson M. Winkler, Daniel Samuel Pine

School of Medicine Publications

Objective: Pediatric anxiety disorders are common and predict adult psychopathology, yet current treatments, such as cognitive-behavioral therapy (CBT), produce lasting remission in less than 50% of affected youths. To support the search for improved, mechanistically grounded interventions, this study evaluated neural efficiency, defined as similarity in functional connectivity between a threat task and rest, as a potential biomarker. The study evaluated neural efficiency in relation to anxiety diagnosis and treatment response.

Methods: The authors compared 103 youths with an anxiety disorder diagnosis (mean age, 12.5 years [SD=2.91], 62% female) to 103 youths with no psychiatric diagnosis (mean age, 13.4 years …

Accuracy Of The Phenotypic 1g Test To Detect Mycobacterium Tuberculosis And Drug Resistance From Sputa In The Us-Mexico Border, Mia Aguirre, Doris Ayala, Juan Ignacio Garcia, Yoscelina Estrella Martinez-Lopez, Amberlee Hicks, Nadine M. Chacon, Ashley Gay-Cobb, Alyssa Schami, Selena Zavala-Perez, Blanca I. Restrepo

School of Medicine Publications

Background: With >10 million new tuberculosis (TB) cases/year, a limitation to TB control is the lack of simple and accurate tests for TB diagnosis and drug-susceptibility testing (DST) in endemic regions. We evaluated the accuracy of the first-generation, low-complexity phenotypic TB test (1G test), designed for simultaneous Mtb detection and resistance to isoniazid, rifampicin and moxifloxacin, suitable for resource-limited settings.

Methods: A cross-sectional study was conducted using sputa from 426 possible pulmonary TB subjects from two small Mexican cities bordering Texas. The 1G test was compared against phenotypic TB detection tests in the region [acid fast bacilli smear microscopy and …

Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib

ASEAN Journal on Science and Technology for Development

The review article demonstrates the importance of power electronics in propelling the increase of renewables and increasing the efficiency of contemporary electrical grids. In particular, it highlights the need for bidirectional converters for effective energy management in vehicle-to-grid (V2G) systems with two-way power transfer. The paper examines the series of complications offered by the significantly large integration of power electronic converter-interfaced renewables, such as those related to system steadiness, power quality, and resignation bottlenecks. Also, it recognizes a mix of new technologies, such as wide bandgap (WBG) semiconductors like silicon carbide (SiC) and gallium nitride (GaN), that deliver superior performance …

Design Of An Economic Order Quantity–Based Dashboard For Vaccine Packaging Inventory Management, Hadi Susanto, Susmitha Canny, Alexandra Elizabeth Callistha, Shakira Dwi Purwandari, Naila Davina Aurelia

ASEAN Journal on Science and Technology for Development

Background: Timely availability of vaccine packaging is critical to pharmaceutical supply chain reliability, as packaging materials play a key role in maintaining cold chain integrity during distribution. Inadequate availability of packaging materials can disrupt vaccine delivery even when finished vaccines are ready for shipment. The case company faces frequent delivery delays, insufficient safety stock, and irregular replenishment of vaccine packaging materials, which have jeopardized the organization’s target of achieving a 90% on-time delivery rate.

Objective: To design and evaluate an Economic Order Quantity (EOQ)–based inventory dashboard for vaccine packaging that standardizes ordering decisions and strengthens stock visibility in pharmaceutical distribution …

Multiclass Skin Lesions Classification And Early Skin Cancer Detection Using An Attention-Enhanced Xception Architecture, Shamira Arshad Shaikh, Yogita Mistry

ASEAN Journal on Science and Technology for Development

Skin disorders are considered one of the major healthcare problems globally and need proper, prompt, effective and early diagnosis to enhance clinical practice. Traditional machine learning and deep learning approaches often exhibit limited generalization capability and reduced effectiveness in extracting discriminative features from complex multiclass dermatological datasets. For this purpose, an interpretable attention-enhanced Xception framework for automatic multiclass skin disease diagnosis based on dermoscopic images has been designed through the use of the International Skin Imaging Collaboration (ISIC) dataset. The dataset includes 2,357 dermoscopic images that belong to nine classes of skin lesions. The proposed framework integrates channel attention and …

Mending The Broken Heart: Applying Selective Spiritual Practices To Navigate The Grief Process At Reeder Memorial Baptist Church Charlotte, North Carolina, Kathryn A. Bonapart

Doctor of Ministry Projects

This Doctor of Ministry capstone examined how guiding congregants through intentional spiritual disciplines can foster grief healing at Reeder Memorial Baptist Church in Charlotte, NC. Many members face grief related to death, illness, relational loss, or communal trauma. The project integrated the biblical narrative of Jesus in Gethsemane (Matthew 26:36–46) with group practices such as prayer, silence, solitude, lament, and journaling. Quantitative pre- and post-surveys and qualitative data from journals, field notes, and interviews revealed growth in emotional awareness, spiritual endurance, consistent grief practices, deeper faith during mourning, greater awareness of God’s presence in suffering, and stronger community connections.  The …

Social Support As An Effect Modifier Of The Assocation Between Drug-Use Related Stigma And History Of Substance Use During Pregnancy Among Women Who Use Unprescribed Opioids In New York City: A Cross-Sectional Study, Isabelle C. Lynch

Graduate Studies Theses and Dissertations 2026

Substance use and misuse among women who are pregnant is a growing public health concern in the United States. Overdose deaths are now a leading cause of death among pregnant and postpartum women, and neonatal abstinence syndrome rates have increased to 23 per 1000 births. A barrier addressing substance use among these women is social stigma, which in part is driven by punitive drug policies that criminalize substance use during pregnancy and societal gender roles and norms surrounding women’s substance use. Social support, including emotional, instrumental, and informational support, can serve to mitigate the negative impacts of stigma on health …

Numerical Simulation Of Micro-Cutting Processes For The Estimation Of Material Fracture Toughness, Juan J. Lainez

Graduate Studies Theses and Dissertations 2026

Accurate determination of plane-strain fracture toughness is essential for structural integrity assessments of engineering components, yet conventional ASTM standardized testing methods require large, notched specimens that are impractical in many industrial and research contexts. This thesis presents a finite element method-based approach for estimating the mode I plane-strain fracture toughness of engineering materials from orthogonal micro-cutting simulations if the continuum damage mechanics-based fracture locus is calibrated. This method will eliminate the need for pre-cracked specimens while maintaining physically grounded fracture mechanics principles. The methodology applies to the Atkins energy-based cutting force model, in which the depth-independent intercept of the specific …

Black Widow Optimization Of Hybrid Renewable-Hydrogen Microgrids For Cost-Effective Water Pumping In Off-Grid Systems, Ayodeji Akinsoji Okubanjo, Ignatius Kema Okakwu, Samson Oladayo Ayanlade, Abayomi Temitope Layeni, Etinosa Noma-Osaghae, Christian Chukwuemaka Ike, Olufemi Peter Alao, Ayodeji Joseph Akinremi, Ayo Isaac Oyedeji

Trends in advanced sciences and technology

The intermittent nature of renewable energy resources, together with limited infrastructure in off-grid communities, presents major obstacles to sustainable water supply. To overcome these challenges, this study develops a Black Widow Optimization (BWO)-based framework for the optimal sizing of a hybrid renewable–hydrogen microgrid integrating photovoltaic (PV) systems, wind turbines, battery energy storage, and hydrogen storage for reliable and cost-effective water pumping applications. The optimization goals are to reduce the Levelized Cost of Water (LCOW), Levelized Cost of Hydrogen (LCOH), and Net Present Cost (NPC), while system reliability and energy efficiency are quantified using the probability of unmet water demand (PUWD) …

Neuroprotective Effects Of Flaxseed And Purslane Extracts Against Cerebral Ischemia/Reperfusion Injury: Modulation Of Apoptotic, Neurotrophic, And Neurotransmitter Signaling, Fatma M. Attia, Ahmed E. Abdel Moneim, Rehab E. El-Hennamy, Inas S. M. Elsayed, Gehad E. Elshopakey, Nabil A. El-Yamany

Trends in advanced sciences and technology

Background: Cerebral ischemia/reperfusion (I/R) injury is a serious pathological condition that leads to permanent neurological impairment. Plant-derived bioactive compounds are gaining attention as promising neuroprotective therapeutic alternatives with relatively low adverse effects. Aims: This study aimed to investigate the neuroprotective effects of flaxseed extract (FE) and purslane extract (PE) on I/R injury in rats.

Methods: Seventy adult male rats were divided into seven groups: control, sham, I/R model, FE, FE-pretreated I/R, PE, and PE-pretreated I/R. Cerebral ischemia was induced by occlusion of the bilateral common carotid arteries for 60 min, followed by 120 min reperfusion. Rats were treated orally with …

Capacity-Building Project To Progress The Implementation Of International Instruments To Combat Iuu Fishing (Capfish) : Summer Academy : Southeast Asia, World Maritime University

Reports

No abstract provided.

Investigating The Relationship Between College Students’ Sense Of Belonging And Graduation Rates At A Private, Predominantly White Institution, Jamie Symonette

All Electronic Theses and Dissertations

This quantitative research analyzed the association between a sense of belonging and academic achievement among 514 undergraduates in a small, all-white institution (PWI), based on the 2025 Campus Life Survey and institutional data. Although national graduation disparities persist (64% of White students graduate within six years versus 54% of Latinx, 44% of Black, and 39% of Native American students), limited quantitative research has investigated belonging in private PWI settings. Variables were perceived sense of belonging, institutional climate, demographic factors (race/ethnicity, sex), academic advancement signs (cumulative GPA, earned credit hours), and seriously considered leaving. Multi-Regression (hierarchical and binary) and binary logistic …

Cytocompatibility, Osteogenic Potential, Antibacterial And Antibiofilm Efficacy Of A Calcium-Silicate-Based Intracanal Medication, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

This study assessed the biological and antimicrobial properties of a calcium silicate-based material and calcium hydroxide (CH) when used as intracanal medications. MTT assay, osteogenic differentiation of human periodontal stem cells (hPDLSCs), cell mineralization-assay, and determination of ALP activity were assessed to investigate the biological properties. While the agar well diffusion, crystal violet (CRV) assay and LIVE/DEAD staining of dentin slices infected with a mature E. faecalis biofilm were used to assess the antimicrobial properties. Normally distributed data were analyzed using one and two-way ANOVA and post hoc Tukey test, while for non-normally distributed data Kruskal Wallis and Dunn's tests …