Digital Commons Network^™

Not Biological, But Built: Structural And Metabolic Pathways Driving Black Maternal Health Disparities In The United States, Alexandra I. Umegboh

CMC Senior Theses

Black infants in the United States are more than twice as likely to die before their first birthday than white infants, a disparity often attributed to genetics, behavior, or individual health choices. However, this idea is challenged by a key contradiction: African immigrant women consistently experience better birth outcomes than U.S.-born Black women despite being similarly racialized. This thesis investigates the origins of this reproductive advantage and the factors contributing to its decline over time. By drawing on epidemiological data, metabolic health research, and literature on African diasporic healing traditions, it argues that the “healthy immigrant effect” is not biological, …

Balancing The Scales Of Justice: The Unconstitutionality Of Marital Rape In India, Pallavi Raju

CMC Senior Theses

Marital rape remains an unpunished crime in India, despite decades of dispute and litigation. This thesis explores the question of why the state continues to retain the marital rape exception within the Indian criminal code, even though it commits to combat gender based violence in other areas of justice. The research begins with a broader understanding of privatization of women’s rights in the international sphere and culturally sanctioned violence to protect the institution of marriage. With a focus on the legal justifications and language of Indian court cases, this thesis determines that judges adjudicate on gender justice inconsistently. Attempting to …

The Jamaica That Dreams: A Normative Application Of Developmental Theory, Tamoy Pitt

CMC Senior Theses

This thesis examines Jamaica’s persistent underdevelopment through Martha Nussbaum's normative application of the capabilities approach as per her conception in Creating Capabilities. Through this approach, the paper will argue that Jamaica’s underdevelopment is a result of the failure of its domestic institutions to provide all citizens with the substantive freedoms and capabilities necessary to live lives of dignity. Originally detailed by Amartya Sen in his book Development as Freedom, the capabilities approach posits freedom as both the means and ends to development while rejecting contemporary approaches to development such as GDP, Utilitarianism, or Rawlsian resource-based approaches as insufficient frameworks for …

Defining Consensus‐Based Components For Integrating Dietitians Into Primary Dental Care For Paediatric Populations: A Delphi Study, Lauren Hallewell, Raul Bescos, Zoe Brookes, Robert Witton, Patricia Casas‐Agustench

School of Health Professions

Background: Diet is a modifiable risk factor linking oral and systemic health, contributing to dental caries and weight-related outcomes (including underweight, overweight and obesity) in the paediatric population. However, dietary advice provided by dental professionals in primary dental care is often brief and sugar-focused, representing a missed opportunity to address shared risk factors. Integrating dietitians into primary dental care may support more holistic paediatric preventative care. Objective: To develop expert consensus on the components required to integrate dietitians into primary dental care to address diet as a common risk factor in paediatric oral health and weight-related outcomes. Methods: A three-round …

Exploring The Views Of Children With Cerebral Palsy, Their Parents And Physiotherapists On Participating In A Feasibility Randomised Controlled Trial Testing An Exergaming Device: A Qualitative Study, Rachel Rapson, Jos M. Latour, Jonathan Marsden, Bernie Carter

School of Nursing and Midwifery

Background: This study aimed to understand the experiences and views of children with cerebral palsy, their parents and physiotherapists participating in the ACCEPT feasibility randomised controlled trial, which explored a 10-week physiotherapy intervention using an interactive gaming training device. Design: Qualitative methods included semi-structured interviews, e-diary and photographs. Nine parent–child dyads and three physiotherapists participated. Children were aged between 7 and 16 years; four had co-existing additional needs. Interviews were transcribed. Reflexive thematic analysis was used. Results: Five themes covered the breadth of participants’ experiences: (1) Fitting in therapy; (2) Motivation; (3) New opportunities; (4) Physiotherapists out of their comfort …

Conventional Versus Advanced Imaging Selection For Endovascular Treatment Of Basilar Artery Occlusion Strokes., Huanwen Chen, Marco Colasurdo, Hidetoshi Matsukawa, Conor Cunningham, Ilko Maier, Sami Al Kasab, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M. Starke, Marios-Nikos Psychogios, Edgar A. Samaniego, Nitin Goyal, Shinichi Yoshimura, Hugo Cuellar, Jonathan A. Grossberg, Ali Alawieh, Ali Alaraj, Mohamad Ezzeldin, Daniele G. Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Fazeel Siddiqui, Joshua Osbun, Roberto Crosa, Charles Matouk, Min S. Park, Michael R. Levitt, Waleed Brinjikji, Mark Moss, Travis Dumont, Ergun Daglioglu, Richard Williamson, Pedro Navia, Reade De Leacy, Shakeel Chowdhry, David J. Altschul, Alejandro M. Spiotta, Peter Kan

Department of Medicine Faculty Papers

INTRODUCTION: Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed tomography perfusion (CTP) and magnetic resonance (MR) may not be necessary for selecting anterior circulation large vessel occlusion stroke patients for EVT, whether advanced imaging may be superior to conventional imaging (non-contrast CT and CT angiography) in identifying good treatment candidates among BAO patients is less clear.

PATIENTS AND METHODS: This was a multicenter retrospective cohort study of BAO EVT patients treated from 2013 to 2022 in …

Digital Cognitive Behavioral Therapy Versus Education For Chronic Pain In Adults With Sickle Cell Disease: 12-Month Randomized Trial Results, Olubusola B. Oluwole, Yi-Fan Yi-Fan Chen, Christina M. Lalama, Julia A. O’Brien, Laura M. De Castro, Charles Patrick Carroll, Darla Liles, Nirmish Shah, Santosh L. Saraf, Victor R. Gordeuk, Leshana Saint Jean, Michael Debaun, Robert M. Cronin, Tonya M. Palermo, Sherif M. Badawy, Megan E. Hamm, Jennifer N. Stinson, Chitra Lalloo, Sophie Lanzkron, Cassandra Trimnell, Lakiea Bailey, Raymona H. Lawrence, Kaleab Z. Abebe, Charles R. Jonassaint

Department of Medicine Faculty Papers

Background: Chronic pain affects up to 40% of adults with sickle cell disease (SCD), yet treatment options remain limited. While cognitive behavioral therapy (CBT) is effective in other chronic pain conditions, it is underutilized for SCD pain, and its effectiveness remains unclear. Purpose: The Cognitive Behavioral Therapy and Real-time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA) compared digital CBT to Education for chronic SCD pain in adults. At 6 months, the primary outcome (pain interference) showed no between-group difference but both groups improved (CBT: −2.13; Education: −2.66). This report presents 12-month outcomes. Methods: A total of 359 …

Politics Of A Silent Pandemic: Antimicrobial Resistance And State Capacity In India And Nigeria, Mia Kelly

CMC Senior Theses

Antimicrobial Resistance (AMR) has emerged as one of the most pressing yet widely underestimated health threats of the 21st century; this thesis explores the potentially devastating global impact of this “silent pandemic”, exposing how deeply health outcomes depend on political choices, regulatory capacity, and economic constraints. Although the danger of spreading drug-resistant pathogens is now widely acknowledged in both the scientific and political communities, states differ in their abilities to contain the issue, with low- and middle-income countries facing the greatest obstacles to national action plan implementation. This thesis investigates these disparities through a comparison of India and Nigeria, two …

Factors Correlated With State-Level Variation In Grocery Consumption Changes During The Covid-19 Pandemic, Sun Young Byun

CMC Senior Theses

In this paper, I employ a two-part empirical strategy to explore the effects of the COVID-19 pandemic on grocery consumption across U.S. states. First, I use the United States Department of Agriculture's Weekly Retail Food Sales data from 2018-2023 to estimate a time-series panel model. I use the results to test three hypotheses regarding state-level variation in consumption changes and impacts in the initial pandemic period, the remaining pandemic period, and the post-pandemic period. Second, I use the estimated state-level effects as dependent variables in cross-sectional regressions to test three hypotheses linking variation in state-level consumption patterns to economic, demographic, …

The Lipstick Effect Across Economic Crises: An Empirical Study Of Cosmetics And Luxury Spending From 2004 – 2023, Richard M. Sweeney Iii

CMC Senior Theses

This paper examines whether consumers shift toward lower-cost beauty products during periods of economic uncertainty and whether this behavior moves with financial market volatility. Using household-level microdata and aggregate monthly expenditure data from the Bureau of Labor Statistics’ Consumer Expenditure Surveys (2004–2023), the study evaluates how cosmetics spending changes relative to jewelry across two major economic crises: the Global Financial Crisis and the COVID-19 pandemic. Across both datasets, cosmetics consistently become a larger share of discretionary spending when economic conditions deteriorate, supporting the presence of a lipstick-effect pattern. At the macro level, cosmetics spending is generally inversely related to market …

Maternity Leave And Women’S Leadership In A Changing Work Environment: Global Evidence, Josefine Byström

CMC Senior Theses

Family leave policies play a central role in shaping women’s participation and advancement in the labor market. This study investigates whether the relationship between maternity leave duration and women’s labor outcomes has changed before and after the COVID-19 pandemic. Using a cross-country panel spanning multiple years with fixed effects, this study examines two related outcomes: women’s labor force participation and representation in leadership. Prior to 2011, maternity leave duration displayed opposite non-linear patterns across these outcomes: an inverted U-shape for labor force participation, peaking at moderate leave lengths, and a U-shape for women’s leadership, which improved only at longer durations …

The Politics Of Russian Regional Development, Claire Moore

CMC Senior Theses

This thesis examines why Chechnya’s independence movement shifted from a secular nationalist struggle in the First Chechen War (1994–1996) to a religiously framed insurgency in the interwar period and Second Chechen War (1999–2000; 2007). Drawing on presidential speeches, interviews, archival materials, and secondary scholarship, it argues that religious radicalization cannot be explained solely by external influence or Russian military brutality. Instead, three underexplored variables–strategic economic appeals to the Islamic world, culturally-embedded practices of vengeance, and the enabling conditions of poverty and mass armament–collectively shaped this transformation. Chechen leaders increasingly emphasized Islamic identity to secure financial and military support from Middle …

The Tcja And Shareholder Payouts, Carson T. Bloom

CMC Senior Theses

Abstract

The Tax Cuts and Jobs Act (TCJA) provided corporations an estimated $233 billion in tax savings, yet relatively little is known about how firms allocated this cash windfall. This study examines whether growth and mature firms differed in whether they used these tax savings to distribute dividends and repurchase shares. Using panel data on publicly traded North American firms from 2016–2019, I classify firms as either growth or mature based on their cash-flow patterns and estimate the effects of the TCJA on their behavior using a difference-in-differences design.

The results indicate that mature firms increased shareholder payouts significantly more …

Criminalizing Motherhood: Abortion, Obstetric Emergencies, And State Power In Post-1998 El Salvador, Valery M. Reyes

CMC Senior Theses

This thesis examines how a series of regressive legal reforms in El Salvador–the 1997 Penal Code’s expansion of abortion-related punishments and the 1999 constitutional amendment defining life as beginning at conception–eliminated all exceptions to abortion and transformed a woman’s reproductive body into a site of surveillance. Rather than expanding rights, these reforms rolled back on existing protections by not recognizing obstetric emergencies, miscarriages, or cases of rape as legitimate grounds for abortion. Prosecutors and judges could treat such medical emergencies as convictions for “fetal homicide,” carrying sentences of 30-50 years in prison.

Court documents, reports from non-government organizations …

Beyond Guns And Butter: Structural Fiscal Priorities And The Politics Of Welfare In Oecd Economies, 2000-2023, Nyassa Garg

CMC Senior Theses

The “guns vs. butter” debate has long framed the tension between military and welfare spending, but this thesis reveals that the tradeoff is far more complex than traditionally assumed. This study re-examines the tradeoff in OECD economies from 2000 to 2023, using fixed-effects and within-between Mundlak models to distinguish between short-run adjustments and long-run structural patterns. My results show no clear evidence of year-to-year substitution; instead, welfare commitments in advanced OECD countries are institutionally rigid and insulated from contemporaneous military spending pressures. Crowding out primarily presents itself as a structural pattern—countries with consistently higher military burdens allocate a smaller share …

Federal Credit And Post-Disaster Economic Recovery: A County-Level Study Of Sba Lending From 2002 - 2022, Tanveer Singh Chabba

CMC Senior Theses

The United States Small Business Administration (SBA) is a government organization founded in 1953 that plays a central role in disaster response by providing capital contracts and low-interest loans to affected firms and households. This thesis will examine whether the SBA’s disaster lending program supports county-level economic recovery in the aftermath of a disaster period. My initial hypothesis is that after a natural disaster, an increase in SBA loan activity should help mitigate income losses and support economic recovery, leading to a consistent level of county-level Adjusted Gross Income (AGI) growth in future years. Using a constructed dataset that links …

Loan-Heavy Aid: Consequences On Academic And Early-Career Outcomes, April Zhang

CMC Senior Theses

This study examines how the composition of financial aid, specifically the balance between loans and grants, shapes students’ academic performance, major selection, and early career outcomes. Using administrative data from the University of California system (2007-2019) and post-graduation records from UC Irvine, I analyze how loan reliance influences both educational trajectories and labor-market results. The key measure, loanshare, captures the fraction of total aid financed through loans rather than grants. This allows for comparisons among students with similar financial need, expected family contribution, and total aid levels. Results show that students with more loan-heavy aid packages earn significantly lower …

Overview Of The Ergonomic Model Of Soccer And The Training Process, James J. Collins, Shane Malone, Kieran D. Collins

Research Outputs: 2025-Present

Soccer is a complex sport with significant physical, physiological, psychological, technical, and tactical demands on players. This review presents an ergonomics-based model of soccer performance, emphasizing that no single component operates in isolation. Building on the foundational ergonomic framework, this review integrates contemporary evidence on training load monitoring, ecological dynamics, and cognitive-perceptual performance dimensions not systematically addressed in prior frameworks. Elite outfield players cover 9–14 km·h⁻¹ per match, with high-speed running (19.8–24.8 km·h⁻¹) making up about 20% of total distance and sprinting (>25 km·h⁻¹) around 2%. These outputs vary by playing position, tactical formation, …

Am I Top Of The Pops? Does Feedback Of Live Gps Between Sets Of Hurling-Specific Small-Sided Games Improve Subsequent Running And Physiological Performance?, Shane Malone, John Keane, Tom Hargroves, Conor P. Clancy, John David Duggan, Damien Young, Kieran D. Collins

Research Outputs: 2025-Present

The investigation aimed to determine if live feedback of team- and player-specific global positioning system (GPS) running performance data between bouts of hurling small-sided games (SSGs) altered the physical and physiological responses during subsequent bouts of SSGs during a 6-week hurling pre-season period. Twenty-four (n = 24) hurling players (age 25.5 ± 3.2 years; height 177.9 ± 3.2 cm; body mass 83.5 ± 4.5 kg) received either feedback or no feedback during hurling-specific SSGs across a 6-week pre-season period. Teams were assigned to two specific groups, a) GPS live feedback or b) no GPS live feedback (control) for each session, …

Efficacious Anti-Cancer Drugs Targeting Nicotinamide N-Methyltransferase (Nnmt) In Cultured Human Oral Squamous Cell Carcinoma (Oscc), Brian Maloney, Martyna Kubisztal, Ziqian Ge, Yin Lu, Lisa Strotmann, Adrianna Budziňska, Mary F. Rooney, Marilena Karavyraki, Andrew Knox, Richard K. Porter

Research Outputs: 2025-Present

Background/Objectives: Oral squamous cell carcinoma (OSCC) is a major cause of human cancer. The enzyme, nicotinamide N-methyltransferase (NNMT), is overexpressed in a variety of human cancers, including OSCC. Our objective was to target NNMT with novel inhibitors and determine their anti-cancer efficacy while shedding light on their possible mechanism of action. Methods: We identified two small molecule inhibitors of NNMT (AG-670 and AO-022) based on a pharmacophore of the in silico nicotinamide binding site. These inhibitors were investigated for (i) potency to inhibit the activity of the isolated NNMT enzyme (EC₅₀ values), (ii) cytotoxicity (IC₅₀ values) against the …

Alignment Of The Planetary Health Diet With Pregnancy Dietary Guidelines: Insights From Two Cohorts, Aoife Davis, Sophie Callanan, Gillian A. Corbett, Eileen C. O’Brien, Alexander Douglass, Fionnuala M. Mcauliffe

Research Outputs: 2025-Present

The Planetary Health Diet (PHD) is a mostly plant-based diet that aims to optimise human health whilst minimising the environmental impact of food production. Limited data exists on whether the PHD fulfils key nutritional requirements during pregnancy. This research aimed to examine the PHD in early pregnancy and how it aligns with daily nutrient intake and European Food Safety Authority (EFSA) dietary guidelines. Pregnant women (n=678) from two Irish cohorts (ROLO and MicrobeMom) were analysed. Dietary intakes in early pregnancy were determined using a 3-day food diary and used to calculate PHD Index (PHDI) scores. Women were dichotomised by the …

Physique Development And Management Shape Experiences Of Low Energy Availability Risk In Elite Professional Male Rugby Union Players, Gary Sweeney, Siobhain Mcardle, Nessan Costello, Kieran Collins

Research Outputs: 2025-Present

This study aimed to explore elite male rugby union players’ perceptions and lived experiences of physique development and management in relation to low energy availability risk. Semi-structured interviews (29 ± 8 min) were conducted with 18 players (senior: n = 9; academy: n = 9; mean age: 23 ± 3) across four professional rugby union clubs in Ireland. Through reflexive thematic analysis, the following themes were constructed. Players had limited awareness of low energy availability, yet described experiences consistent with symptoms, including fatigue, low mood and reduced libido. A pervasive physique culture, characterised by body composition ‘ideals’ and weight or …

From Platelets To Particles: Optimizing Extracellular Vesicle Isolation In A National Blood Centre, Y. Chintala, A. Waters, F. Mcgrath, A. Lorusso, C. Wynne, S. Meaney

Research Outputs: 2025-Present

Background and Objectives: Platelet-derived extracellular vesicles (PEVs) are submicron, membrane-bound particles released upon platelet activation, with a recognized role in haemostasis, inflammation and immunoregulation. PEVs remain insufficiently characterized in blood products. This study compared four isolation methods to evaluate their impact on PEV yield, purity and characteristics, aiming to identify a practical approach for transfusion service workflows. Materials and Methods: PEVs were isolated from expired single-donor aphaeresis platelet concentrates (n = 12) using methods based on different isolation principles: ultracentrifugation (UC), size exclusion chromatography (SEC), mixed size/charge separation (hybrid) and an affinity-based spin column method (affinity). Size, number and biochemical …

Developing Forensic Entomology Practice In Ireland: Case Applications And Operational Considerations, Claudio Tersaruolo, Yiyang Sun, Sally Anne Collis, Jesus Frias, Linda Mulligan, Orla Howe

Research Outputs: 2025-Present

Forensic entomology is valuable in legal investigations for estimating the minimum post-mortem interval (minPMI) by insect species and their lifecycles on decomposing remains. While forensic entomology is well established in central-northern Europe and the UK, it has been rarely practiced in Ireland due to a lack of demand and practical expertise. Office of the State Pathologist (OSP) provides the national forensic pathology service; however specialised forensic entomology services are outsourced and instructed on a case-by-case basis. A collaboration was established between the OSP, Technological University Dublin (TU Dublin) and University of Strathclyde over the past two years. This collaboration enabled …

Understanding The Epigenetic Landscape Of Barrett's Esophagus And Esophageal Cancer: A Review Of Current Findings, Caveats And Future Directions, Louise Lawless, Trevor Doherty, Carla Surlis, Niamh Gilmartin, Therese M. Murphy

Research Outputs: 2025-Present

Esophageal cancer (OC) is currently the eighth most common form of cancer worldwide with a 5-year survival rate of 10%–20%, with the primary risk factor of esophageal adenocarcinoma (OAC) being the development of Barrett's Esophagus (BO). Despite its clinical significance, the molecular pathogenesis underlying both BO and OC is not well understood. In recent years, epigenetic dysregulation, particularly aberrant DNA methylation, has emerged as a critical area of investigation, given its potential utility in the identification of diagnostic, prognostic, and therapeutic biomarkers. This review examines the evolving epigenetic landscape of esophageal cancer, including a focus on its origins in BO …

Exploring The Postpartum Recovery After Hyperemesis Gravidarum: A Qualitative Study, Zeinab El-Dirani, Sergio A. Silverio, Eleni Niarchou, Elana Payne, Pauline Dunne, Melanie Nana, Catherine Williamson, Mary F. Higgins, Eileen O'Brien, Joan Devin, Aisling Walsh, Angela C. Flynn

Research Outputs: 2025-Present

Introduction: Hyperemesis Gravidarum affects 0.3–3.6% of women during pregnancy and has a significant impact on maternal health. Investigation of both the immediate and longer-term effects remains a high research priority. However, there is limited research on postpartum recovery after hyperemesis gravidarum. Aim: To explore the postpartum recovery experiences of women who had hyperemesis gravidarum. Methods: A large descriptive qualitative study was conducted using semi-structured interviews to explore the postpartum experiences of women who had hyperemesis gravidarum within the previous 5 years in Ireland. Data were analysed using reflexive thematic analysis. Results: Forty-one women participated, and four themes were identified: (1) …

Health And Environmental Consequences Of Blue Light Exposure And Mitigation Strategies: A Review, Dr Hani Alkhatib, Brian Norton

Research Outputs: 2025-Present

Blue light is a natural component of the visible spectrum that has a fundamental role in regulating circadian rhythms, visual performance, mood, and daytime alertness. In modern environments, however, exposure patterns have shifted due to widespread use of artificial lighting and digital devices. Artificial blue light exposure can be mistimed relative to the biological night. This literature review examines the consequences of inappropriately timed artificial blue light exposure. Specifically, the review covers: (i) the spectral biology of blue light and its role in circadian entrainment; (ii) the timing-, intensity-, and duration-dependent effects on human sleep, ocular health, mood, and metabolic …

Imperfections And Scars: The Aesthetics Of Curated Decay In Urban Conservation: The Aesthetics Of Curated Decay In Urban Conservation, Ioana Moldovan, Connell Vaughan, Michael O’Hara, Silivan Moldovan, Ioana Cecălășan

Research Outputs: 2025-Present

This paper explores the value of imperfections and curated decay in the conservation of architecture and public art as vehicles of cultural memory. While conventional heritage practice treats physical degradation as a threat, newer conservation ethics argue for embracing material impermanence within an aesthetics of care. We examine how acknowledging patina, weathering, and even structural decline can become an act of care, maintaining the “spirit” and authenticity of a place. The theoretical framework integrated the aesthetics of imperfection, including concepts like the Japanese wabi-sabi, which finds beauty in the incomplete and impermanent, critical heritage theory (which questions whose memories and …

Immigration Federalism And The Promise Of State Constitutions, Joanne Gottesman

Lewis & Clark Law Review

This Article explores state constitutions’ promises and pitfalls for immigrant rights advocacy. This is a particularly urgent endeavor, given the anti-immigrant measures of President Trump’s second term and a U.S. Supreme Court that is willing to reverse longstanding precedent. Even cases like Plyler v. Doe, with its guarantee of free public education to undocumented children, could be vulnerable. While U.S. Supreme Court opinions protecting immigrant rights are the gold standard because they apply nationwide, state courts and state constitutions provide critical alternative avenues for relief that should not be overlooked.

This Article considers some state constitutional provisions that may help …

Constraining Citizenship: Presidential Threshold In Indonesia’S Judicial Framework, Arfan Yanayir Akbar Sabillilah

Jurnal Hukum & Pembangunan

This research critically evaluates the constitutionality of Indonesia's Presidential Threshold as regulated by Article 222 of Law No. 7/2017, requiring political parties or coalitions to secure 20% of DPR seats or 25% of national valid votes for presidential nominations. The term “Presidential Threshold” follows Constitutional Court jurisprudence, distinguishing it from the election threshold in Article 6A(3) requiring 50%+1 votes to win the presidency and the parliamentary threshold in Article 414 requiring 4% of votes for legislative seat allocation. Through normative legal analysis of Constitutional Court decisions No. 51-52-59/PUU-VI/2008, 53/PUU-XV/2017, and 62/PUU-XXII/2024, this study examines 33 judicial reviews from 2017 to …