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2026

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From Formative Policy To Performative Grading Practices : Esl Teachers’ Enactment Of Classroom-Based Assessment In Malaysian Primary Schools, Anwar Farhan Mohamad Marzaini, Shahazwan Mat Yusoff Jan 2026

From Formative Policy To Performative Grading Practices : Esl Teachers’ Enactment Of Classroom-Based Assessment In Malaysian Primary Schools, Anwar Farhan Mohamad Marzaini, Shahazwan Mat Yusoff

PASAA

No abstract provided.


The Role Of Translation In Second Language Acquisition : Relevance And Practical Applications In The 21st Century, Benjawan Tipprachaban Jan 2026

The Role Of Translation In Second Language Acquisition : Relevance And Practical Applications In The 21st Century, Benjawan Tipprachaban

PASAA

No abstract provided.


A Contextual And Work-Based Language Practice Instructional Model Development To Enhance English-Speaking Skills For Effective Customer Service Among Thai Vocational Students, Henry Yuh Anchunda, Suparada Anchunda, Wareerat Kaewurai, Pakorn Prachanban, Taweesak Sawangmek Jan 2026

A Contextual And Work-Based Language Practice Instructional Model Development To Enhance English-Speaking Skills For Effective Customer Service Among Thai Vocational Students, Henry Yuh Anchunda, Suparada Anchunda, Wareerat Kaewurai, Pakorn Prachanban, Taweesak Sawangmek

PASAA

No abstract provided.


Beyond Linguistic Accuracy : A Culturally Embedded Framework For Assessing Cross-Cultural Speaking Ability Through Performance And Reflective Inquiry, Chotiwan Yaemkhayai, Ruedeerath Chusanachoti, Theerawat Theerapojjanee Jan 2026

Beyond Linguistic Accuracy : A Culturally Embedded Framework For Assessing Cross-Cultural Speaking Ability Through Performance And Reflective Inquiry, Chotiwan Yaemkhayai, Ruedeerath Chusanachoti, Theerawat Theerapojjanee

PASAA

No abstract provided.


Competency-Based Medical Education And Entrustable Professional Activities In Dental Education: Global Perspectives And Implications For Taiwan, Johnson Hsin-Chung Cheng, Sharon Hsuan-Jung Chen Jan 2026

Competency-Based Medical Education And Entrustable Professional Activities In Dental Education: Global Perspectives And Implications For Taiwan, Johnson Hsin-Chung Cheng, Sharon Hsuan-Jung Chen

Journal of Dental Sciences

Background/purpose:

Competency-based medical education (CBME) and entrustable professional activities (EPAs) have been adopted in medical education as frameworks to align training with real-world clinical practice. Although international dental education has begun to explore EPA-based assessment, the implementation of CBME in dentistry remains inconsistent and underdeveloped, particularly in Taiwan. This narrative review aimed to summarize global and local developments in CBME and EPAs, identify current gaps in Taiwanese dental education, and clarify the rationale for examining faculty readiness in future CBME implementation.

Materials and methods:

A narrative literature review incorporating international and Taiwan-specific sources

was conducted and thematically synthesized to …


Performance Of Large Language Models In Answering Orthodontic Questions: A Scoping Review, Tu Manh Nguyen, Fang-Yu Fan, Ying-Sui Sun, Yang-Che Wu, Sheng-Wei Feng, Hao-Ting Chen, I-Ta Lee, Pao-Chang Chiang Jan 2026

Performance Of Large Language Models In Answering Orthodontic Questions: A Scoping Review, Tu Manh Nguyen, Fang-Yu Fan, Ying-Sui Sun, Yang-Che Wu, Sheng-Wei Feng, Hao-Ting Chen, I-Ta Lee, Pao-Chang Chiang

Journal of Dental Sciences

Large language models (LLMs) are increasingly explored as novel platforms for delivering orthodontic information. Although their capacity to generate rapid, structured, and accessible responses has been widely recognized, concerns persist regarding performance variability and the risk of generating inaccurate outputs. Given the heterogeneity of existing evidence, this scoping review aimed to systematically map the current research landscape and synthesize findings on the application of LLMs in addressing orthodontic queries. This review was conducted in accordance with the PRISMA-ScR guidelines. Studies were retrieved from PubMed, Scopus, and the Cochrane Library up to November 30, 2025. Twenty-six studies met the eligibility criteria …


Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, And Serum Gastric Parietal Cell Antibody Positivity In 430 Patients With Recurrent Aphthous Stomatitis, Yi-Ping Wang, Yi-Pang Lee, Yu-Hsueh Wu, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang Jan 2026

Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, And Serum Gastric Parietal Cell Antibody Positivity In 430 Patients With Recurrent Aphthous Stomatitis, Yi-Ping Wang, Yi-Pang Lee, Yu-Hsueh Wu, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found that 20.9%, 20.1%, 4.8%, 2.6%, and 7.7% of 273 recurrent aphthous stomatitis (RAS) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. This study mainly evaluated the anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in a large group of 430 RAS patients.

Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 430 RAS patients were measured and compared with the corresponding levels in 430 age- and sex-matched healthy control subjects.

Results: We …


Physico-Mechanical Properties And Streptococcus Mutans Biofilm Formation Of Bio‑Based Flexible Crowns Versus Stainless Steel And Zirconia Crowns For Pediatric Full-Coverage Restorations, Tzu-Yu Peng, Szu-Yu Lai, Yan-An Wu, Ya-Ting Yang, Yuichi Mine, Huei-Yu Huang Jan 2026

Physico-Mechanical Properties And Streptococcus Mutans Biofilm Formation Of Bio‑Based Flexible Crowns Versus Stainless Steel And Zirconia Crowns For Pediatric Full-Coverage Restorations, Tzu-Yu Peng, Szu-Yu Lai, Yan-An Wu, Ya-Ting Yang, Yuichi Mine, Huei-Yu Huang

Journal of Dental Sciences

Background/purpose: Bio‑based flexible (BFX) have recently emerged as a potential alternative to conventional pediatric full‑coverage restorations, but evidence regarding their properties and microbial behavior remains limited. Thus, this study aimed to evaluate the physico-mechanical properties and microbial behavior of BFX crown compared with stainless steel crowns (SSC) and zirconia crowns (ZRC) for pediatric full-coverage restorations.

Materials and methods: Mandibular primary molar crowns from BFX, SSC, and ZRC were assessed. Weight was measured using an electronic balance, and surface roughness and topography were evaluated using a stylus profilometer and atomic force microscopy. The arithmetic mean roughness (Ra) and root mean square …


Artificial Intelligence Assisted Multitask Framework For Dental Detection And Root Canal Filling Assessment On Periapical Radiographs, Chia-Lin Hsu, Li Wei Ou-Yang, Chih-Hao Chang, Yuan-Jin Lin, Po-Lin Huang, Kai-Syun Chiu, Heng-Chia Chen, Tsung-Yi Chen, Jia-Ching Wang, Wei-Chen Tu, Patricia Angela R. Abu Jan 2026

Artificial Intelligence Assisted Multitask Framework For Dental Detection And Root Canal Filling Assessment On Periapical Radiographs, Chia-Lin Hsu, Li Wei Ou-Yang, Chih-Hao Chang, Yuan-Jin Lin, Po-Lin Huang, Kai-Syun Chiu, Heng-Chia Chen, Tsung-Yi Chen, Jia-Ching Wang, Wei-Chen Tu, Patricia Angela R. Abu

Journal of Dental Sciences

Background/purpose: Accurate evaluation of root canal filling (RCF) quality is paramount for successful endodontic outcomes. However, conventional radiographic interpretation is often subject to subjective variability. This study developed an automated, multitask artificial intelligence (AI) framework using YOLO11 and advanced image pre-processing to identify multiple dental structures and provide quantitative assessments of RCF quality on periapical radiographs.

Materials and methods: We proposed an image enhancement pipeline, which integrate intensity normalization, white top-hat transform, and linear contrast stretching to refine dental contours for training the YOLO11 multitask model. The framework simultaneously detected primary, permanent, dental crowns, and RCFs. Quantitative metrics, including …


Active Learning-Assisted Deep Learning For Automated Maxillary Sinus Segmentation In Dental Cone-Beam Computed Tomography, Hsuan Chen, Khoa Dang Nguyen, Chih-Ling Chang, Hong Thi-Phuong Doan, Ya-Chu Chang, Thantrira Porntaveetus, Guang Hong, Wen-Liang Lo, Ding-Han Wang, Ming-Lun Hsu Jan 2026

Active Learning-Assisted Deep Learning For Automated Maxillary Sinus Segmentation In Dental Cone-Beam Computed Tomography, Hsuan Chen, Khoa Dang Nguyen, Chih-Ling Chang, Hong Thi-Phuong Doan, Ya-Chu Chang, Thantrira Porntaveetus, Guang Hong, Wen-Liang Lo, Ding-Han Wang, Ming-Lun Hsu

Journal of Dental Sciences

Background/purpose: Accurate automated segmentation of the maxillary sinus in cone-beam computed tomography (CBCT) scans is crucial for dental implant planning, sinus lift procedures, and pathological assessment, yet there remains a notable lack of publicly available models and datasets for this task. This study developed and evaluated a deep learning model for automated maxillary sinus segmentation using an active learning approach to minimize annotation effort while achieving high accuracy.

Materials and methods: We utilized 249 CBCT scans from the publicly available CTooth+ and STS-Tooth datasets. Ground truth annotations were generated through semi-automated segmentation in 3D Slicer with validation by five expert …


Artificial Intelligence In Dentistry: A Cross-Domain Bibliometric Analysis Of Technologies, Functional Applications, And Dental Specialties, Yinghui Yang, Cheng-Chia Yu, Min Yee Ng Jan 2026

Artificial Intelligence In Dentistry: A Cross-Domain Bibliometric Analysis Of Technologies, Functional Applications, And Dental Specialties, Yinghui Yang, Cheng-Chia Yu, Min Yee Ng

Journal of Dental Sciences

Background/purpose: Artificial intelligence is increasingly applied in dentistry across diagnosis, prediction, treatment planning, education, and patient communication. This study aimed to provide a structured cross-domain overview of dental AI research by integrating AI technologies, functional applications, and dental specialties within one bibliometric framework.

Materials and methods: AI-related dental publications from 2016 to 2026 were retrieved from the Web of Science Core Collection. Original and review articles were screened and classified by AI technology, functional application, and dental specialty. Bibliometric mapping, collaboration analysis, keyword co-occurrence, and heatmap-based cross-domain visualization were performed.

Results: A total of 920 publications were included. Publication …


A Scientometric Study On Research Trends And Characteristics Of Lymph Node Metastasis In Oral Cancer, Linjian Huang, Xiaocui Tong, Wei Liu, Xinyu Zhang Jan 2026

A Scientometric Study On Research Trends And Characteristics Of Lymph Node Metastasis In Oral Cancer, Linjian Huang, Xiaocui Tong, Wei Liu, Xinyu Zhang

Journal of Dental Sciences

Background/purpose: Cervical lymph node metastasis (LNM) is the most critical prognostic factor in oral cancer (OC) patients. The purpose of this study was to analyze the scientometric characteristics and research trends of LNM in OC.

Materials and methods: All the papers on LNM in OC were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2016 and after 2016 in the analysis of research trends.

Results: There were 946 papers on LNM in OC, with total citations of 21,154 and the h index of 70. The trend of clinical aspect including lymph …


Exploring Exhibited Works On Dentistry-Related Topics At The Student Science Fair Projects In Taiwan From 1970 To 2025, Mei-Huei Li, Feng-Chou Cheng, Kun-Ming Lien, Chun-Pin Chiang Jan 2026

Exploring Exhibited Works On Dentistry-Related Topics At The Student Science Fair Projects In Taiwan From 1970 To 2025, Mei-Huei Li, Feng-Chou Cheng, Kun-Ming Lien, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.


Negative Pulp Sensibility Responses Do Not Necessarily Indicate Pulp Necrosis In Teeth Associated With Cystic Or Cyst-Like Lesions, Le Lu, Xiang Zhang, Ya Shen, He Liu Jan 2026

Negative Pulp Sensibility Responses Do Not Necessarily Indicate Pulp Necrosis In Teeth Associated With Cystic Or Cyst-Like Lesions, Le Lu, Xiang Zhang, Ya Shen, He Liu

Journal of Dental Sciences

No abstract provided.


Comparative In Vivo Study Of 3d-Printed Composite Bioceramic Scaffolds Fabricated By Distinct Pre-Processing Methods, Yu-Ting Li, Ju-Hsuan Yang Jan 2026

Comparative In Vivo Study Of 3d-Printed Composite Bioceramic Scaffolds Fabricated By Distinct Pre-Processing Methods, Yu-Ting Li, Ju-Hsuan Yang

Journal of Dental Sciences

No abstract provided.


Artificial Intelligence-Powered Chatbots’ Responses To Orthodontic Questions From The Dentistry Specialization Examination: Accuracy And Source Evaluation, Berrak Çakmak, Tevhide Sökmen, Burcu Balos‚ Tuncer Jan 2026

Artificial Intelligence-Powered Chatbots’ Responses To Orthodontic Questions From The Dentistry Specialization Examination: Accuracy And Source Evaluation, Berrak Çakmak, Tevhide Sökmen, Burcu Balos‚ Tuncer

Journal of Dental Sciences

No abstract provided.


Craniofacial And Airway Changes After Skeletal Class Iii Orthognathic Surgery: A Machine Learning Study, Zay Yar Linn, Johnson Hsin-Chung Cheng Jan 2026

Craniofacial And Airway Changes After Skeletal Class Iii Orthognathic Surgery: A Machine Learning Study, Zay Yar Linn, Johnson Hsin-Chung Cheng

Journal of Dental Sciences

No abstract provided.


A Novel Method For The Precise Second Mesiobuccal Canal Orifice Location: A Combined Strategy For Enhanced Clinical Practice, Yuhan Wang, Lingyun Li, Jan 2026

A Novel Method For The Precise Second Mesiobuccal Canal Orifice Location: A Combined Strategy For Enhanced Clinical Practice, Yuhan Wang, Lingyun Li,

Journal of Dental Sciences

No abstract provided.


Postoperative Conductive Hearing Loss After Full-Arch-Implantation Surgery Under General Anesthesia In An Oral Submucous Fibrosis Patient: A Case Report, Hao-Chen Wang, Fu-Chuan Tsai, Chia-Che Wu, Chih-Yuan Fang Jan 2026

Postoperative Conductive Hearing Loss After Full-Arch-Implantation Surgery Under General Anesthesia In An Oral Submucous Fibrosis Patient: A Case Report, Hao-Chen Wang, Fu-Chuan Tsai, Chia-Che Wu, Chih-Yuan Fang

Journal of Dental Sciences

No abstract provided.


Factors Influencing Dental Career Decision-Making Among High-Achieving Students In Taiwan, Chien-Hong Yu, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang Jan 2026

Factors Influencing Dental Career Decision-Making Among High-Achieving Students In Taiwan, Chien-Hong Yu, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.


Clinical Red Flags And Referral Strategies For Odontogenic Deep Neck Space Infections: The Primary Care Dentist’S Role As The First Line Of Defense, Sih-Yi Wu Jan 2026

Clinical Red Flags And Referral Strategies For Odontogenic Deep Neck Space Infections: The Primary Care Dentist’S Role As The First Line Of Defense, Sih-Yi Wu

Journal of Dental Sciences

No abstract provided.


From Domestic Science To Dental Science: The Hidden Pathway For Talented Taiwanese Women During The Japanese Colonial Period, Hung-Lun Pan, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang Jan 2026

From Domestic Science To Dental Science: The Hidden Pathway For Talented Taiwanese Women During The Japanese Colonial Period, Hung-Lun Pan, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.


Effects Of Cleaning Protocols On The Material Properties Of Clear Aligners And Retainers: A Systematic Review, Yao-Chang Chiang, Tu Manh Nguyen, Thuy-Trang Thi Ho, Loc Minh Lu, Yang-Che Wu, Tong-Hsien Chow, Chiang-Wen Lee, Fang-Yu Fan, Li-Nai Chen, I-Ta Lee Jan 2026

Effects Of Cleaning Protocols On The Material Properties Of Clear Aligners And Retainers: A Systematic Review, Yao-Chang Chiang, Tu Manh Nguyen, Thuy-Trang Thi Ho, Loc Minh Lu, Yang-Che Wu, Tong-Hsien Chow, Chiang-Wen Lee, Fang-Yu Fan, Li-Nai Chen, I-Ta Lee

Journal of Dental Sciences

Clear aligners and retainers are widely used in contemporary orthodontics because of their esthetic appearance, removability, and patient-centered advantages. However, repeated exposure to dietary pigments and cleaning procedures may alter their optical, surface, mechanical, and chemical properties, potentially affecting appliance appearance, hygiene, and performance. This systematic review evaluated changes in the material properties of clear aligners and retainers following different cleaning protocols. Electronic searches were performed in PubMed, Scopus, LILACS, and the Cochrane Library from inception to February 28, 2026. Twenty studies were included, comprising 18 in vitro studies and 2 randomized clinical crossover studies. Cleaning protocols were categorized as …


International Comparison Of Oral Hypofunction Among Community-Dwelling Older Adults In Three Asian Countries: A Cross-Sectional And Multi-National Study, Ryosuke Yanagida, Kohei Yamaguchi, Kazuharu Nakagawa, Chantaramanee Ariya, Patcharaphol Samnieng, Megan F Liu, Nai-Chia Teng, Ting-Yi Renn, Rieko Moritoyo, Sirinthip Amornsuradech, Kanako Yoshimi, Haruka Tohara Jan 2026

International Comparison Of Oral Hypofunction Among Community-Dwelling Older Adults In Three Asian Countries: A Cross-Sectional And Multi-National Study, Ryosuke Yanagida, Kohei Yamaguchi, Kazuharu Nakagawa, Chantaramanee Ariya, Patcharaphol Samnieng, Megan F Liu, Nai-Chia Teng, Ting-Yi Renn, Rieko Moritoyo, Sirinthip Amornsuradech, Kanako Yoshimi, Haruka Tohara

Journal of Dental Sciences

Background/purpose: In aging Asian societies, oral hypofunction among older adults has gained importance, with most epidemiological studies conducted in Japan. We aimed to compare oral function in community-dwelling older adults in Japan, Taiwan, and Thailand.

Materials and methods: Community-dwelling older adults aged ≥ 60 years who participated in Yokohama, Taipei, and Phitsanulok health surveys (May 2022–September 2024) were included. Age, sex, body mass index (BMI), and denture use data were recorded. Using the Japanese Society of Gerodontology diagnostic framework, seven oral hypofunction components were evaluated: oral hygiene, oral dryness, occlusal force, tongue–lip motor function, tongue pressure, masticatory function, …


Development And Clinical Validation Of An Artificial Intelligence–Assisted Radiographic System For Predicting Periodontal Pocket Severity Using Full-Mouth Radiographs., Yi-Tai Ho, Tsui-Hsien Huang, Cheng-Han Shie, Tao-Wei Chang, Chun-Te Ho, Chia-Tze Kao Jan 2026

Development And Clinical Validation Of An Artificial Intelligence–Assisted Radiographic System For Predicting Periodontal Pocket Severity Using Full-Mouth Radiographs., Yi-Tai Ho, Tsui-Hsien Huang, Cheng-Han Shie, Tao-Wei Chang, Chun-Te Ho, Chia-Tze Kao

Journal of Dental Sciences

Background/purpose: Conventional periodontal probing is the gold standard for evaluating periodontal disease severity; however, it is time-consuming and susceptible to operator-dependent variability. This study developed and clinically validated an artificial intelligence (AI)-assisted radiographic system for automated periodontal disease severity assessment using full-mouth radiographs, and investigated its association with clinical periodontal probing depth.

Materials and methods: A total of 655 full-mouth radiographs were retrospectively collected: 151 (3,962 teeth) for AI model training and 504 (13,809 teeth) for validation. Periodontal bone loss was quantified using the periodontal bone loss (PBL) ratio and classified as mild, moderate, or severe. Clinical validation used 31 …


Avian Mesenchymal Stem Cell-Derived Extracellular Vesicle Alleviates The Porphyromonas Gingivalis Lipopolysaccharide Induced Gingival Fibroblast Senescence, Han-Chieh Yang, Earl Fu, Yu-Tang Chin, Ju-Sheng Shieh, Wei-Ni Lin, Cheng-Yang Chiang Jan 2026

Avian Mesenchymal Stem Cell-Derived Extracellular Vesicle Alleviates The Porphyromonas Gingivalis Lipopolysaccharide Induced Gingival Fibroblast Senescence, Han-Chieh Yang, Earl Fu, Yu-Tang Chin, Ju-Sheng Shieh, Wei-Ni Lin, Cheng-Yang Chiang

Journal of Dental Sciences

Background/purpose: We have shown that extracellular vesicles (EVs) derived from Polygonum multiflorum extract bio-pulsed avian mesenchymal stem cells exhibit anti-inflammatory and proliferation-promoting properties. A significant association has been identified between periodontitis, higher biological age, and accelerated biological aging. This study investigated whether the bio-pulsed EVs could alleviate Porphyromonas gingivalis lipopolysaccharide (Pg-LPS)-induced senescence in human gingival fibroblasts (hGFs).

Materials and methods: Pg-LPS was used to induce cellular inflammation and senescence in hGFs. The cytokines IL-1β, IL-6, and TNF-α were assessed by quantitative polymerase chain reaction (qPCR), and cytotoxicity was assessed with MTS. Senescence after repeated stimulations was evaluated …


Developing An Automated Cytology-Based Dna Ploidy Test For Detecting Oral Squamous Cell Carcinoma In Taiwan: A Feasibility Study, Pei Hsuan Lu, Kelly Yi Ping Liu, Julia Yu Fong Chang, Long‐Wei Lin, Hao-Hung Chang, Chen-Han Chang, Shang Hsuan Peng, Catherine F. Poh Jan 2026

Developing An Automated Cytology-Based Dna Ploidy Test For Detecting Oral Squamous Cell Carcinoma In Taiwan: A Feasibility Study, Pei Hsuan Lu, Kelly Yi Ping Liu, Julia Yu Fong Chang, Long‐Wei Lin, Hao-Hung Chang, Chen-Han Chang, Shang Hsuan Peng, Catherine F. Poh

Journal of Dental Sciences

Background/purpose: Oral squamous cell carcinoma (OSCC) remains a global health issue, particularly in underserved settings such Taiwan where access to early diagnosis is limited. DNA ploidy-based oral cytology has shown strong diagnostic performance, but its applicability across populations require evaluation.

Materials and methods: In this prospective feasibility study, brush and oral rinse samples were collected from patients with OSCC, low-grade dysplasia, reactive lesions, and normal mucosa. DNA cytometry was performed to quantify ploidy profiles. Diagnostic performance was evaluated using published algorithm and cohort-specific thresholds derived from stratified 10-fold cross-validation.

Results: A total of 118 patients were included (50 OSCC, 41 …


A Bibliometric Evolution Of Molecular Mechanisms And Emerging Research Trends Of Therapeutic Resistance In Oral Cancer, Chu-Yen Chien, Ying-Chen Chen, Jia-Rong Wu, Hsu-Hua Chu, Yi-Jen Hung, Yi-Shing Shieh Jan 2026

A Bibliometric Evolution Of Molecular Mechanisms And Emerging Research Trends Of Therapeutic Resistance In Oral Cancer, Chu-Yen Chien, Ying-Chen Chen, Jia-Rong Wu, Hsu-Hua Chu, Yi-Jen Hung, Yi-Shing Shieh

Journal of Dental Sciences

Background/purpose: Drug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.

Materials and methods: A comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional …


Anemia, Hematinic Deficiencies, And Hyperhomocysteinemia In Gastric Parietal Cell Antibody-Positive And -Negative Recurrent Aphthous Stomatitis Patients, Yu-Hsueh Wu, Yi-Ping Wang, Yi-Pang Lee, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang Jan 2026

Anemia, Hematinic Deficiencies, And Hyperhomocysteinemia In Gastric Parietal Cell Antibody-Positive And -Negative Recurrent Aphthous Stomatitis Patients, Yu-Hsueh Wu, Yi-Ping Wang, Yi-Pang Lee, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found the serum gastric parietal cell antibody (GPCA) positivity in 12.8% of 430 recurrent aphthous stomatitis (RAS) patients. This study assessed whether GPCA-positive RAS (GPCA+RAS) patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects or GPCA-negative RAS (GPCAˉRAS) patients.

Materials and methods: The mean corpuscular volume, blood hemoglobin (Hb), and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels were measured and compared between any two of three groups of 55 GPCA+RAS patients, 375 GPCAˉRAS patients, and 430 healthy control subjects.

Results: We found …


Blood Vessels Expressing Cd31 And Endomucin Contribute To The Formation Of New Hard Tissue Via Osterix-Expressing Cells During The Healing Process Of Pulp Revascularization In Mice, Takatoshi Ikarashi, Keisuke Mitomo, Kentaro Tashiro, Mayuka Haketa, Toshihide Mizoguchi, Akira Yamaguchi, Takashi Muramatsu Jan 2026

Blood Vessels Expressing Cd31 And Endomucin Contribute To The Formation Of New Hard Tissue Via Osterix-Expressing Cells During The Healing Process Of Pulp Revascularization In Mice, Takatoshi Ikarashi, Keisuke Mitomo, Kentaro Tashiro, Mayuka Haketa, Toshihide Mizoguchi, Akira Yamaguchi, Takashi Muramatsu

Journal of Dental Sciences

Background/purpose: Niche for osteogenesis forms near specialized blood vessels that highly express both CD31 and endomucin (Emcn). However, localization of the vessels remains unknown during wound healing process after pulp revascularization. We investigated the localization of both CD31 and Emcn-expressing vessels and osterix (Osx)-expressing cells after pulp revascularization. Materials and methods: Five-week-old male C57BL/6J mice underwent pulp revascularization in the mesial root canal of the right first maxillary molar. The mice were sacrificed at 1 hour, 7 days, 14 days, and 21 days post-surgery, and immunofluorescence for CD31, Emcn, and Osx was performed. Additionally, calcein labeling was used to visualize …