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2026

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Accuracy Of Voluntary Force Modulation During The Isometric Mid-Thigh Pull, S. Alexander Long, Olivia Vadas, Stephanie Balint, Michael H. Stone, Christopher Taber Jan 2026

Accuracy Of Voluntary Force Modulation During The Isometric Mid-Thigh Pull, S. Alexander Long, Olivia Vadas, Stephanie Balint, Michael H. Stone, Christopher Taber

Exercise Science Faculty Publications

The purpose of this study was to investigate voluntary force modulation accuracy during the isometric mid-thigh pull (IMTP) and to investigate biological sex and relative strength as factors relating to error. Strength-trained males (n = 18) and females (n = 18) completed ascending (ASC) (25%, 50%, 75%) or descending (DESC) (75%, 50%, 25%) submaximal testing followed by maximal testing. Subjects rested before completing the opposite submaximal testing sequence. External feedback was not provided during testing. Measured and intended (INT) forces were analyzed with two-way repeated-measures ANOVAs with within- (ASC, DESC, and INT) and between-subject factors (male or female). Independent-samples t-tests …


Beyond Weight Loss: Effects Of Trx Suspension Training Combined With Caloric Restriction On Thyroid Function And Mental Well-Being In Obese Hypothyroid Women, Siavash Naddafha, Christopher Taber Jan 2026

Beyond Weight Loss: Effects Of Trx Suspension Training Combined With Caloric Restriction On Thyroid Function And Mental Well-Being In Obese Hypothyroid Women, Siavash Naddafha, Christopher Taber

Physical Therapy Faculty Publications

Background

The rate of metabolism decreases in hypothyroid patients; hypothyroidism is associated with body mass increases; due to this and other factors, depression, anxiety, and stress increase, which, alongside the disease state and psychological problems, causes the quality of life to suffer.

Objectives

The purpose of this research is to investigate the effect of caloric restriction along with TRX exercise on body mass, thyroid hormones, and psychological measures in obese and overweight women with hypothyroidism.

Methods

34 women aged 18–50 with hypothyroidism and a body mass index above 25 participated in this study. They were divided into three groups: a …


A Novel Superaug Adaptive Data Augmentation Strategy For Metabolic Syndrome Prediction: The First Egyptian National Cohort Study With Multi-National Comparison, Nihal Elsonny, Ashraf Elsharkawy, Abeer Tawakol, Amira Y. Haikal Jan 2026

A Novel Superaug Adaptive Data Augmentation Strategy For Metabolic Syndrome Prediction: The First Egyptian National Cohort Study With Multi-National Comparison, Nihal Elsonny, Ashraf Elsharkawy, Abeer Tawakol, Amira Y. Haikal

Mansoura Engineering Journal

Metabolic Syndrome (MetS) is a multifactorial disorder associated with an increased risk of cardiovascular disease, type 2 diabetes, and obesity-related complications. Early and accurate prediction of MetS remains challenging due to heterogeneous data sources, class imbalance, limited sample sizes in regional studies, and poor generalization across populations.

This study introduces a comprehensive machine learning framework for predicting MetS and its prognostic factors using two heterogeneous datasets: a newly collected Egyptian clinical cohort and the U.S.-based (NHANES) [CDC, 2023] dataset. For each dataset, multiple experimental pipelines are developed, integrating preprocessing, feature selection, data augmentation, hyperparameter tuning, and ensemble modeling. …


Warm Mix Asphalt: Key Issues, Performance Challenges, And Modeling Advances, Mahmoud Owais, Marwa Awad Jan 2026

Warm Mix Asphalt: Key Issues, Performance Challenges, And Modeling Advances, Mahmoud Owais, Marwa Awad

Mansoura Engineering Journal

Warm Mix Asphalt (WMA) has emerged as a sustainable alternative to conventional Hot Mix Asphalt by enabling asphalt production and compaction at reduced temperatures, thereby lowering energy consumption, emissions, and worker exposure to heat and fumes. Despite these advantages, the field performance of WMA remains influenced by technology-specific mechanisms, additive–binder compatibility, aggregate characteristics, moisture susceptibility, compaction quality, recycled material content, and climatic conditions. This review provides a critical synthesis of major WMA technologies, including foamed systems, chemical additives, organic waxes, hybrid additives, bio-based modifiers, and WMA mixtures incorporating reclaimed asphalt pavement. Particular attention is given to how these technologies affect …


Preserving The Identity Of Historic Coptic Orthodox Monasteries In Egypt Under Contemporary Pressures: Case Studies Of St. Bishoy And St. Anthony Monasteries, George Medhat Adeeb, Mohamed Khairy Amin, Mohamed Ahmed Al-Sherbiny Jan 2026

Preserving The Identity Of Historic Coptic Orthodox Monasteries In Egypt Under Contemporary Pressures: Case Studies Of St. Bishoy And St. Anthony Monasteries, George Medhat Adeeb, Mohamed Khairy Amin, Mohamed Ahmed Al-Sherbiny

Mansoura Engineering Journal

Historic Coptic Orthodox monasteries in Egypt (HCOMEs) represent an important component of Christian heritage, integrating architectural value with enduring spiritual traditions that reflect both tangible and intangible dimensions. However, contemporary development and changing functional demands are generating transformations that may affect their identity if not carefully managed. Despite extensive scholarship, limited research has systematically examined these transformations through a structured evaluative approach. This study addresses this gap by developing and applying an analytical and evaluation framework to examine how contemporary pressures influence the historical, architectural-spatial, and spiritual identity of HCOMEs, and to assess the effectiveness of monastic responses. The framework …


The Multiwalled Carbon Nanotube-Incorporated Cfrp Laminates Interlaminar Fracture Toughness, Nikhil Janardan Rathod, Markala Karthik, Harshvardhan P. Ghongade, Javed Sikandar Shaikh, Rahul Soma Deshmukh Jan 2026

The Multiwalled Carbon Nanotube-Incorporated Cfrp Laminates Interlaminar Fracture Toughness, Nikhil Janardan Rathod, Markala Karthik, Harshvardhan P. Ghongade, Javed Sikandar Shaikh, Rahul Soma Deshmukh

Mansoura Engineering Journal

The structural integrity of carbon fibre reinforced polymers (CFRPs) suffers from damage caused by interlaminar cracking and delamination which diminishes their performance capabilities. This study provides an experimental analysis of the impact of carboxyl-functionalized multi-walled carbon nanotubes (MWCNTs) on the Mode I interlaminar fracture toughness of CFRP laminates. The researchers created composite specimens by using epoxy systems which included MWCNT loadings of 0.1 wt% 0.2 wt% and 0.3 wt% together with an unmodified control. The researchers conducted Double Cantilever Beam (DCB) testing according to ASTM standards to ascertain the rate of critical strain energy release (G_IC) of the material. The …


A Hybrid Geospatial And Remote Sensing Methodology For Drought Vulnerability Assessment In Semi-Arid Ecosystems, Kaifi Fakhir Chomani Jan 2026

A Hybrid Geospatial And Remote Sensing Methodology For Drought Vulnerability Assessment In Semi-Arid Ecosystems, Kaifi Fakhir Chomani

Mansoura Engineering Journal

The Kurdistan Region of Iraq (KRI) faced significant drought challenges due to global and environmental changes, necessitating drought assessments. Advanced techniques of remote sensing, Geographic Information Systems (GIS), and Analytic Hierarchy Process (AHP) were combined in this research to perform drought vulnerability zonation for KRI. Average annual rainfall, Average number of rainy days, Average annual temperature, slope, elevation, normalised difference water index (NDWI), normalised difference vegetation index (NDVI), land surface temperature (LST), and temperature condition index (TCI) were selected as contributing parameters for drought vulnerability assessments. The considered parameters were weighted using pairwise comparison, and thematic maps were created to …


Self-Lubricating Nano-Coatings For Tribological Applications: Materials, Mechanisms, And Ai-Driven Design Approaches, Viral Panara, Vikas Panchal, Satayu Travadi, Harmish Bhatt, Madhav Oza Jan 2026

Self-Lubricating Nano-Coatings For Tribological Applications: Materials, Mechanisms, And Ai-Driven Design Approaches, Viral Panara, Vikas Panchal, Satayu Travadi, Harmish Bhatt, Madhav Oza

Mansoura Engineering Journal

Self-lubricating coatings with nanostructured structures are becoming crucial in order to decrease friction and wear in critical tribological systems like precision tools, biomedical implants, aerospace actuators, and engines. In this review, the most representative nano-engineered solid lubricants such as transition metal dichalcogenides, diamond-like carbon, hexagonal boron nitride, graphene, MXenes and hybrid multilayer architectures are discussed. The focus of the discussion is on the most important tribological mechanisms like lamellar sliding, oxidative adaptation, tribofilm formation, transfer-film development, and nano-asperity contact evolution. It also summarizes the most significant deposition techniques, such as cathodic arc physical vapor deposition, chemical vapor deposition, plasma-based deposition, …


Impact Of Exercise And Cognitive Behavioral Therapy On Anxiety And Depression, Ranjita Subedi, Rachel Affeldt, Abigail Bentley, Gavin Gump, Madison Mitchell, Taylor Rodgers, Bayley Mullins, Libbie Woodland, Sophia Rubenkoenig Jan 2026

Impact Of Exercise And Cognitive Behavioral Therapy On Anxiety And Depression, Ranjita Subedi, Rachel Affeldt, Abigail Bentley, Gavin Gump, Madison Mitchell, Taylor Rodgers, Bayley Mullins, Libbie Woodland, Sophia Rubenkoenig

Nurse Residency Posters

OhioHealth Grant Medical Center


Impact Of Fast Track On Emergency Department Length Of Stay, Kayce Carrick Bsn, Rn, Kelsey Richmond Rn, Stacy Duncan Rn Jan 2026

Impact Of Fast Track On Emergency Department Length Of Stay, Kayce Carrick Bsn, Rn, Kelsey Richmond Rn, Stacy Duncan Rn

Nurse Residency Posters

Facilitator: Melissa Harper, BSN, RN

OhioHealth O'Bleness Hospital


Impact Of Intentional Leadership Styles On Staff Nurse Satisfaction And Retention, Monica Patrick Rn, Camie Mitchell Rn, Amelia Kennedy Rn, Rachel Geiger Rn, Zachary Foster Rn, Katherine Leahy Rn Jan 2026

Impact Of Intentional Leadership Styles On Staff Nurse Satisfaction And Retention, Monica Patrick Rn, Camie Mitchell Rn, Amelia Kennedy Rn, Rachel Geiger Rn, Zachary Foster Rn, Katherine Leahy Rn

Nurse Residency Posters

Facilitator: Tess Wagner, BSN, RN

OhioHealth Riverside Methodist Hospital


A High-Stakes Landing: Traumatic Innominate Artery Injury After A Skydiving Accident, Claire G. Lewis Ms, Sarah Burki Md, Mahmound Alhusseini Md, Caroline K. Scruggs Md, Margaret L. Jackson Md, Steven Eisenberg Md, Anthony Estrera Md Jan 2026

A High-Stakes Landing: Traumatic Innominate Artery Injury After A Skydiving Accident, Claire G. Lewis Ms, Sarah Burki Md, Mahmound Alhusseini Md, Caroline K. Scruggs Md, Margaret L. Jackson Md, Steven Eisenberg Md, Anthony Estrera Md

Summer Research Program Abstracts

No abstract provided.


Educational Attainment And Symptom Improvement In Treatment-Resistant Depression: A Longitudinal Cohort Analysis Across Treatment Modalities, Marjorie Harrison, Giselli Scaini Msc, Phd, Aspen Viamontes Jan 2026

Educational Attainment And Symptom Improvement In Treatment-Resistant Depression: A Longitudinal Cohort Analysis Across Treatment Modalities, Marjorie Harrison, Giselli Scaini Msc, Phd, Aspen Viamontes

Summer Research Program Abstracts

No abstract provided.


Quantifying Hemodynamics In Implantable Cardiac And Renal Support Devices Using Computational Modeling, Alexander D. De Oliveira Jan 2026

Quantifying Hemodynamics In Implantable Cardiac And Renal Support Devices Using Computational Modeling, Alexander D. De Oliveira

Summer Research Program Abstracts

No abstract provided.


Reference-Point Indentation Captures Age-Related Material-Quality Changes In Human Infant Rib Cortical Bone, Kush Patel Jan 2026

Reference-Point Indentation Captures Age-Related Material-Quality Changes In Human Infant Rib Cortical Bone, Kush Patel

Summer Research Program Abstracts

No abstract provided.


Neurodevelopmental Outcomes After Posthemorrhagic Hydrocephalus Of Prematurity, Mekal S. Mathew, Rene Leal, Caroline L. Hanan, David J. Sun, Hasan K. Mubarak, Amelie D. Perrier, William E. Johnson, Micolette R. Mardik, Trevor R. Alwell, Christian Amezquita Contreras, Chance E. Hatfield, Peter H. Yang Jan 2026

Neurodevelopmental Outcomes After Posthemorrhagic Hydrocephalus Of Prematurity, Mekal S. Mathew, Rene Leal, Caroline L. Hanan, David J. Sun, Hasan K. Mubarak, Amelie D. Perrier, William E. Johnson, Micolette R. Mardik, Trevor R. Alwell, Christian Amezquita Contreras, Chance E. Hatfield, Peter H. Yang

Summer Research Program Abstracts

No abstract provided.


Reducing No-Show Rates In A Rural Family Medicine Clinic Through Personal Phone Call Reminders, Joyce Bumgardner Jan 2026

Reducing No-Show Rates In A Rural Family Medicine Clinic Through Personal Phone Call Reminders, Joyce Bumgardner

Doctor of Nursing Practice Projects

Background: Missed patient appointments cost the healthcare industry billions annually, reducing provider accessibility and practice revenue. At a rural family medicine office in western Lincoln County, North Carolina, new patient no-show rates exceeded 10%, surpassing the healthcare system’s goal of 5% or less. Automated appointment reminders via text, phone, and email were already in place, but did not adequately address the problem. New patient appointments occupy a 40-minute time slot, twice that of established patients, increasing the impact of each missed appointment.

Purpose: The purpose of this quality improvement project was to determine whether personal phone call reminders made with …


The Role Of Healthcare Leaders’ Perceived Emotional Intelligence In Staff Acceptance Of Artificial Intelligence Tools, Daniel Brian Mcswain Jan 2026

The Role Of Healthcare Leaders’ Perceived Emotional Intelligence In Staff Acceptance Of Artificial Intelligence Tools, Daniel Brian Mcswain

Doctor of Business Administration Dissertations

Artificial intelligence tools are increasingly used in healthcare, but successful implementation depends on more than technical deployment. Staff acceptance is one important factor that influences whether AI tools are used in practice. Traditional technology acceptance research has emphasized perceived usefulness, ease of use, social influence, and facilitating conditions. Less attention has been given to the role of emotional intelligence and trust during an AI-related change. The purpose of this research was to examine the relationship between healthcare leaders’ perceived emotional intelligence and their clinical team’s behavioral intention to use AI tools. The study also examined whether age moderated this relationship …


Gratitude Journaling And Mindfulness To Mitigate Burnout In Mental Health Staff, Jennifer Davis Jan 2026

Gratitude Journaling And Mindfulness To Mitigate Burnout In Mental Health Staff, Jennifer Davis

Doctor of Nursing Practice Projects

Burnout among mental health professionals in inpatient behavioral health settings negatively affects staff well-being, job satisfaction, and patient care quality. This Doctor of Nursing Practice (DNP) quality improvement project evaluated the effectiveness of an 8-week mindfulness and gratitude journaling program implemented on a rural behavioral health unit in North Carolina. Guided by Jean Watson’s Theory of Human Caring, the intervention aimed to enhance resilience and workplace wellness through daily mindfulness and reflective journaling practices. A repeated cross-sectional design using anonymous pre- and post-intervention surveys was conducted with 30 staff participants. Thirty participants enrolled in the study, and 24 completed the …


Enhancing Clinical Judgement In Pre-Licensure Nursing Students Through Active Learning Strategies Of Unfolding Case Studies And Simulations For Postpartum Hemorrhage, Lisa M. Alley Jan 2026

Enhancing Clinical Judgement In Pre-Licensure Nursing Students Through Active Learning Strategies Of Unfolding Case Studies And Simulations For Postpartum Hemorrhage, Lisa M. Alley

Doctor of Nursing Practice Projects

New graduate nurses lack the appropriate clinical judgement to provide optimal, safe, quality care, as evidenced by the report of errors in health care (Rodziewicz et al., 2024). The purpose of this project was to provide an evidence-based intervention that used an unfolding case study and simulation to further develop clinical judgement among undergraduate nursing students in a rural ADN program. The project used a pre-test and post-test to measure students' improvement prior to versus after the learning experience and debrief. This project also introduced a DASH tool, which is a debriefing assessment for simulations in healthcare, to help students …


Enhancing Mass Casualty Incident Preparedness: Bridging The Gap Between Education And Practice, Emily M. Coggins Jan 2026

Enhancing Mass Casualty Incident Preparedness: Bridging The Gap Between Education And Practice, Emily M. Coggins

Doctor of Nursing Practice Projects

The increasing amount of mass casualty incidents (MCIs), such as natural disasters, large-scale emergencies, and active shooter events, has emphasized the need for healthcare professionals to respond effectively. Traditional undergraduate nursing curriculum often offers limited opportunities for students to practice disaster preparedness through simulated experiences. This DNP project was created to evaluate the effectiveness of implementing an MCI training simulation to increase the confidence and competence of senior pre-licensure nursing students when responding to a mass casualty event. The project implemented a 1-day, simulation-based MCI event for senior nursing students enrolled in an Adult Health II course. The event included …


Senior Heart Health Facilitating Hypertension Management, Heather Hodgens Lupo Jan 2026

Senior Heart Health Facilitating Hypertension Management, Heather Hodgens Lupo

Doctor of Nursing Practice Projects

Hypertension affects approximately 70% of adults aged 65 years and older and remains a leading contributor to cardiovascular morbidity and mortality in the United States, highlighting the need for effective community-based hypertension management interventions. Despite the availability of evidence-based guidelines, gaps in education and self-management persist among older adults. This Doctor of Nursing Practice (DNP) quality improvement project, Senior Heart Health: Facilitating Hypertension Management, was designed to improve hypertension-related knowledge among adults aged 55 years and older through a structured, community-based health coaching intervention.

The project was implemented in a rural community and consisted of four weekly educational sessions delivered …


Hands-Free Tech For Fall Prevention, Sierra Dixon Rn, Jessica Gillam Rn, Bryan Hatheway Rn, Taightam Hicks Bsn, Rn, Kelsey Tignor Bsn, Rn, Hailie Tomsik Rn, Jeremiah Waworoendeng Rn Jan 2026

Hands-Free Tech For Fall Prevention, Sierra Dixon Rn, Jessica Gillam Rn, Bryan Hatheway Rn, Taightam Hicks Bsn, Rn, Kelsey Tignor Bsn, Rn, Hailie Tomsik Rn, Jeremiah Waworoendeng Rn

Nurse Residency Posters

Facilitator: Kasey Gillen, MHA, BSN, RN, NPD-BC

OhioHealth Mansfield Hospital


Women Are Discriminated Against On The Basis Of Sex: Anti-Trans Epistemologies In Australian Universities, Emily M. Gray, Jacqueline Ullman, Mindy Blaise Jan 2026

Women Are Discriminated Against On The Basis Of Sex: Anti-Trans Epistemologies In Australian Universities, Emily M. Gray, Jacqueline Ullman, Mindy Blaise

Research outputs 2022 to 2026

This article offers an analysis of qualitative data from a multi-phased project entitled Understanding and Addressing Everyday Sexisms in Australian Universities. The project’s key aim was to improve the ways in which gender-based discrimination is understood and addressed in Australian universities. It achieved this aim through adopting a situated, intersectional, and creative approach to data generation and analysis. The authors examine data from phase three of the project, a large-scale survey that was distributed across 12 of Australia’s 39 public universities, yielding 1257 responses. The survey was designed to encourage academic staff of all genders to participate and aimed to …


Patent Law's Trade Remedy, Michael Doane Jan 2026

Patent Law's Trade Remedy, Michael Doane

Akron Law Faculty Publications

Although a trade remedy, not an intellectual property rights statute, Section 337 of the Tariff Act of 1930 plays an important and controversial role in the enforcement of intellectual property rights in the United States. As a trade remedy, Section 337 is designed and intended to promote innovation and investment in the United States through support of statutorily defined domestic industries against unfair competition from infringing imported products. This Article analyzes Section 337 as a trade remedy from the perspective of intellectual property rights owners and innovators such as start-up companies, universities, individual inventors, and other research and development-focused entities. …


Just Prosecution, G. Ben Cohen Jan 2026

Just Prosecution, G. Ben Cohen

Akron Law Faculty Publications

Prosecutors were once envisioned as the heroes of the criminal legal system, wielding immense power to secure justice. Yet their role remained largely untethered to a coherent, principled framework. Without clear guardrails, traditional prosecution contributed to mass incarceration, racial disparities, and punitive excesses. Progressive prosecution sought to redress these deficiencies, but a lack of cohesive theoretical grounding, accompanied by a divestiture of power, left prosecutions weak. Reform was fragmented by electoral pressures but remained subject to abolitionist critiques. This article asks readers to consider the idea of Just Prosecution as a way of reimagining the prosecutor’s role—raising the question of …


Neurotensin Drives Theca Cell Migration During Ovulation In Primates, Jessica S. Miller, Megan A. G. Sage, Thomas E. Curry Jr., Diane M. Duffy Jan 2026

Neurotensin Drives Theca Cell Migration During Ovulation In Primates, Jessica S. Miller, Megan A. G. Sage, Thomas E. Curry Jr., Diane M. Duffy

Department of Biomedical and Translational Sciences Faculty Publications

Theca cells are a critical steroidogenic cell type of the ovarian follicle and corpus luteum. The ovulatory luteinizing hormone (LH) surge (or human chorionic gonadotropin (hCG)) stimulates theca cell relocation from the stroma surrounding the dominant follicle to full integration into the developing corpus luteum. Luteinizing hormone/human chorionic gonadotropin also stimulates granulosa cells to produce local mediators of ovulation, including the peptide neurotensin (NTS). To determine if hCG-stimulated NTS regulates theca cell relocation within the ovulatory follicle, vehicle or an NTS receptor antagonist was injected into a macaque dominant follicle, and ovaries were removed 48 h after hCG administration. Additional …


P38 Mapk Is Involved In Epigenetic Regulation Of Fibrotic Genes In Replication Induced Senescence In Lung Fibroblasts, Shan Zhu, Jennifer Q. Zhou, Kan Wang, Ming-Lei Guo, Yan Sanders Jan 2026

P38 Mapk Is Involved In Epigenetic Regulation Of Fibrotic Genes In Replication Induced Senescence In Lung Fibroblasts, Shan Zhu, Jennifer Q. Zhou, Kan Wang, Ming-Lei Guo, Yan Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Fibroblast activation is essential for tissue repair following injury; however, prolonged activation drives pathological fibrosis. Idiopathic pulmonary fibrosis (IPF), a progressive and age-associated lung disease, is characterized by aberrant fibroblast activation, with increasing evidence implicating senescent and near-senescent fibroblasts in its pathogenesis. However, the underlying mechanisms remain poorly defined. In this study, we investigated whether histone modification is involved in TGF-β1 treated lung fibroblasts and contributes to the fibrotic phenotype. Human IMR90 lung fibroblasts at low and high population doubling levels (LPDL and HPDL), as well as primary IPF fibroblasts, were used in this study. In response to TGF-β1, both …


Dysregulation Of Alternative Splicing Patterns In The Ovaries Of Reproductively Aged Mice, Adnan T. Alsamaraee, Vanessa L. Correll, Julius O. Nyalwidhe, Pavla Brachova, Nehemiah S. Alvarez Jan 2026

Dysregulation Of Alternative Splicing Patterns In The Ovaries Of Reproductively Aged Mice, Adnan T. Alsamaraee, Vanessa L. Correll, Julius O. Nyalwidhe, Pavla Brachova, Nehemiah S. Alvarez

Department of Biomedical and Translational Sciences Faculty Publications

Female reproductive aging is characterized by progressive deterioration of ovarian function, yet the molecular mechanisms driving these changes remain incompletely understood. Here, we used long-read direct RNA-sequencing to map transcript isoform changes in mouse ovaries across reproductive age. Comparing young and aged mice after controlled gonadotropin stimulation, we identified widespread alternative splicing changes, including shifts in exon usage, splice site selection, and transcript boundaries. Aged ovaries exhibited increased isoform diversity, favoring distal start and end sites, and a significant rise in exon skipping and intron retention events. Many of these age-biased splicing events altered open reading frames, introduced premature stop …


Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht Jan 2026

Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht

Department of Biomedical and Translational Sciences Faculty Publications

Background

Suppressing estradiol (E₂) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin-mediated glucose uptake, and induces insulin resistance. We examined whether E₂ deprivation also impairs microvascular flow and cardiac function.

Methods

Offspring of untreated baboons, letrozole-treated baboons, or letrozole plus E₂ (maternal s.c. injections during the second half of gestation) underwent contrast-enhanced microbubble ultrasonography to quantify microvessel flow and echocardiography to assess cardiac performance.

Results

Letrozole reduced maternal serum E₂ by 95% (p <  0.01). In letrozole offspring, microbubble flux rate (β) fell 55% (p <  0.02), replenishment was 5 s slower (p <  0.03), and microvessel flow declined 40% (p = 0.05); all were restored by added E₂. Indices of systolic (isovolumic contraction), diastolic (isovolumic relaxation), global performance (Tei index), and cardiac output were unchanged.

Conclusion

Prolonged gestational E₂ deprivation programs a reduction in microvascular flow without altering cardiac function; maternal E₂ prevents this, supporting E₂'s role in …