Digital Commons Network^™

Neighborhood-Level Social Vulnerability And Cognitive Outcomes In Older Adults With Solid Tumors, Ahmed Qaedi, Ariann Nassel, Mackenzie Fowler, Elizabeth Baker, Smith Giri, Gabriela Oates, Grant Williams, Noha Sharafeldin

UAB Huntsville Research Day - All Presentations

2026 research poster

Small Vessels, Big Consequences: It’S Not Always Lupus Nephritis, Hinal Rathi, Carlo Castillo, John Fanning

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster

Impact Of Senescence On Breast Cancer Outcomes, Gracie Sous

Honors Undergraduate Theses

Cellular senescence is a biological process in which damaged cells exit the cell cycle while remaining metabolically active and accumulating within tissues. Senescence plays a complex role in breast cancer progression, largely through the secretion of senescence-associated secretory phenotype (SASP) factors. These factors include a broad range of inflammatory cytokines, chemokines, and signaling molecules that can influence the tumor microenvironment.

Studies suggest that senescence may significantly promote cancer metastasis. Therefore, this study aims to investigate the genes involved in cancer progression and to improve understanding of how SASP is regulated, which is critical for improving breast cancer outcomes. The central …

Feasibility Of Telehealth-Delivered Gut-Directed Hypnotherapy For Managing Gastrointestinal Health: Exploring Specific Vs. Nonspecific Effects, Sabrina Romero

Honors Undergraduate Theses

This randomized controlled trial evaluated the feasibility and efficacy of telehealth-delivered Gut-Directed Hypnotherapy (GDH) compared to General Hypnotherapy (GH) for managing gastrointestinal symptoms associated with disorders of gut–brain interaction (DGBI). Eleven adults were randomized to receive four 1-hour hypnotherapy sessions over a 14-day period via Zoom (GH n = 5; GDH n = 6). Primary outcomes included PROMIS GI Belly Pain T-scores and Abdominal Pain Ratings assessed at baseline and post-treatment. Follow-up assessments were conducted at three months (n = 8). At post-treatment, participants receiving GDH demonstrated significantly lower PROMIS GI Belly Pain T-scores compared to GH, F(1, …

Investigating The Interaction Of Gram-Positive Lactobacillus Species With Mucin In The Context Of Barrett's Esophagus, Ritisha Suresh

Honors Undergraduate Theses

Gastroesophageal Reflux Disease (GERD) can progress to the precancerous Barrett’s Esophagus (BE) condition, in which the normal esophageal squamous epithelium is replaced with a columnar epithelium containing goblet cells. Mucins, sticky substances, are secreted in response to bile acid exposure during reflux episodes to protect the esophageal epithelium. Goblet cells secrete these mucins, which can also scaffold microbial colonization. Probiotic Lactobacillus bacteria can use glycosidase enzymes to process mucin and metabolize them into their component sugars (glycans). This project aims to identify the role of the Lactobacillus-mucin interaction in BE, as glycan availability could confer an advantage to Lactobacillus …

Investigating Racial And Ethnic Disparities In Cardiometabolic Outcomes Among Women With Polycystic Ovarian Syndrome: An Umbrella Review, Gianna C. Santoni

Honors Undergraduate Theses

Polycystic ovarian syndrome (PCOS) is one of the most common endocrinological disorders affecting women of reproductive age. Due to the possibility of a genetic component affecting women with PCOS, evidence supports varying health outcomes among racial and ethnic groups. This literature aims to answer the question: Does the prevalence of cardiometabolic outcomes differ among women with polycystic ovarian syndrome across racial/ethnic groups? This umbrella review was conducted in accordance with JBI Manual for Evidence Synthesis and PRIOR reporting guidelines and was registered on PROSPERO (CRD420261303872) before completion. PubMed, MEDLINE via EBSCOhost, and Web of Science via EBSCOhost were searched from …

Using Low-Cost Sensors For Source Attribution And Health Assessment: An Air Quality Study In Brownsville, Texas, Sai Deepak Pinakana, Kabir Bahadur Shah, Daniel Jaffe, Juan L. Gonzalez, Owen Temby, Gabriel Ibarra-Mejia, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Air quality monitoring remains a challenge in areas lacking or having sparse federal monitoring infrastructure, posing significant barriers to public health research. This study demonstrates the usage of low-cost sensors in addressing gaps in air quality monitoring, source attribution, and health risk assessment in a Brownsville, TX neighborhood impacted by emissions from a barite and celestite mineral processing unit. PM2.5 concentrations were measured using PurpleAir sensors deployed across three residential locations, with the site nearest to the processing unit recording a 24-h averaged PM2.5 concentration of 25.12 μg/m3—approximately 2.79 times higher than the nearest Texas Commission of Environmental Quality (TCEQ) …

Sustainable Healthcare In Action: Six Practice Changes That Make A Difference, Christine Catling, Carol Crevacore, Melisa Young, Wayne Varndell, Jack Cornish, Sue Sheppard-Law, Elaine Correia Moll

Research outputs 2022 to 2026

Problem: Planetary health, linking the well-being of human populations with the stability of Earth's natural systems, is increasingly recognised as essential for all organisations. Healthcare is a major contributor to environmental harm, responsible for an estimated 4.4% of global net emissions. As a result, healthcare workers have an important role in driving sustainable, low-waste practices within clinical settings. Aim: This paper outlines six practical, evidence-informed changes that can be introduced within healthcare organisations: adopting reusable tourniquets, reducing unnecessary glove use, recycling medication blister packs, promoting reusable nappies, using reusable or compostable blueys, and reintroducing stainless steel holloware. Discussion: These examples …

Proactive Safety Reasoning In Human-Robot Collaboration In Disassembly Through Llm-Augmented Stpa And Fmea, Morteza Jalali Alenjareghi, Fardin Ghorbani, Samira Keivanpour, Yuvin Adnarain Chinniah, Sabrina Jocelyn

Études primaires

Disassembly tasks in human–robot collaboration (HRC) environments present safety challenges due to hazardous materials, control system variability, and physically demanding operator tasks. To address these challenges, we propose an AI-augmented risk assessment framework integrating System-Theoretic Process Analysis (STPA) and Failure Mode and Effects Analysis (FMEA). This framework is implemented in four configurations: Term Frequency– Inverse Document Frequency (TF-IDF), Fine-tuned Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), and RAG with a structured Knowledge Graph (KG) built from safety standards. The system supports real-time, standards-compliant safety reasoning by generating interpretable, context-specific recommendations. We evaluate these configurations across GPT-3.5 TURBO, GPT-4o, GPT-4.1, and …

Analysis Of The Functional And Acoustical Comfort Of Earplugs Experienced By A Group Of Workers In Canadian Companies And Identification Of The Influencing Variables, Bastien Poissenot-Arrigoni, Olivier Doutres, Alessia Negrini, Djamal Berbiche, Franck Sgard

Études primaires

Earplugs are essential for hearing protection in noisy workplaces, but their effectiveness depends heavily on user comfort, which influences proper and consistent use. This study explores functional and acoustical comfort experienced by 173 workers across Canadian companies, each testing different ’disposable or reusable’ earplug models over seven weeks. Comfort is assessed using detailed questionnaires covering six subdimensions: ease of insertion and removal, noise protection, impact on work, and discomfort related to internal and external noise perception. Linear mixed-effects models are applied within a triad framework encompassing person-, earplug-, and environment-related characteristics in order to identify those with a significant influence …

A Scalable Magnetic Field Mapping Approach For Pouch-Type Lithium-Ion Batteries, Luiz G.C. Melo, Chun H. Law

Études primaires

Ensuring safety in energy storage systems increasingly relies on advanced diagnostic tools, among which magnetic field mapping plays a critical role. This work aims to develop and validate a high-sensitivity magnetic field sensor array for accurate field mapping and preliminary battery diagnostics. We present a 4 × 4 array of magnetic sensors integrated with a calibration procedure to ensure accurate output. The system was experimentally tested by characterizing the magnetic field generated by two planar copper conductors. Finite element simulations were performed for comparison and validation. Experimental measurements exhibited strong agreement with the simulation results, confirming the reliability of the …

Advancing Greenhouse Air Filtration: Biodegradable Nanofiber Filters With Sustained Antimicrobial Performance, Amirali Bajgholi, Reza Jafari, Alireza Saidi

Études primaires

Air quality management in greenhouses is critical to safeguarding plant health and occupational safety, yet conventional filtration methods often fall short in performance and sustainability. These enclosed environments are prone to the accumulation of bioaerosols, including fungi, bacteria, pollen, and dust particles, which can compromise crop productivity and pose health risks to workers. This review explores recent advancements in air filtration technologies for controlled environments such as greenhouses, where airborne particulate matter, bioaerosols, and volatile organic compounds (VOCs) present ongoing challenges. Special focus is given to the development of filtration media based on electrospun nanofibers, which offer high surface area, …

If Only Pickups And Vans Could Fly: Vehicle Maintenance And The Challenge Of Safely Lifting Large Vehicles On A Two-Post Lift, Damien Burlet-Vienney, Sylvie Beaugrand, Maud Gonella, Bertrand Galy, Élise Ledoux

Études primaires

The use of automotive lifts requires mechanics to work under or near a multi-ton load. Based on consultation with stakeholders, pickups and vans appear to pose problems when raised using two-post above-ground lifts (2PAG lifts), the most common type of automotive lift in garages. The aim of this study is therefore to highlight the work activity performed by mechanics when raising pickups and vans on 2PAG lifts and to describe the factors they take into account to ensure vehicle stability. Data collection took place under actual conditions in five garages. A total of 108 lifting situations were filmed and analyzed, …

Lung Inflammation From Daily Exposure To Airborne Particulate Matter In A Trade School, Kynda Tinawi, Céline Plante, Alan Da Silveira Fleck, Édith Giasson, Isabelle Valois, Caroline Couture, Eva Suarthana, Maximilien Debia, Audrey Smargiassi

Études primaires

Background Workers are exposed daily to various airborne chemical agents, however, associations between daily exposures to particulate matter and lung inflammation in occupational settings have been little explored. Objective To estimate the association between daily occupational exposure to respirable (PM4 and PM2.5), ultrafine particles, their oxidative potential, and fractional exhaled nitric oxide within apprentices in a school of construction trades. Methods We used a repeated measures design over 5 consecutive days in 56 apprentices from 3 construction trade sectors (bricklaying, welding, and carpentry). Fractional exhaled nitric oxide was measured each day post-work. Personal and work area daily PM4 were collected …

Early Drowsiness Detection Via Second-Order Derivative Analysis Of Heart Rate Variability: A Non-Contact Ecg Approach With Machine Learning, Fabrice Vaussenat, Abhiroop Bhattacharya, Julie Payette, Alireza Saidi, Victor Bellemin, Geordi-Gabriel Renaud-Dumoulin, Sylvain G. Cloutier, Ghislain Gagnon

Études primaires

Drowsy driving contributes to roughly 20% of traffic fatalities, yet most detection systems rely on behavioral cues that appear only after impairment has set in. Here we ask whether first and second derivatives of heart rate variability (HRV) can detect pre-crash states earlier than conventional approaches. Twenty-five participants completed 49 driving simulator sessions while we recorded cardiac activity through capacitive ECG electrodes embedded in the seat backrest—a non-contact method that avoids the privacy concerns of camera-based monitoring. To prevent circular evaluation, ground truth labels were based solely on crash proximity rather than HRV-derived scores. The combined HRV feature set (conventional …

Managing Complexity: Manager-Stakeholder Communication, Relational Dynamics, And The Dual Nature Of Rtw Communication, H. Bertolini, Marc Corbière, Alessia Negrini, Nadine Larivière, Patrizia Villotti, Dominic Prévost, Meryl Caiada, Jason Amorim, Fergal O'Hagan

Études primaires

Purpose

The return to work (RTW) process of worker absent due to common mental disorders (CMD) or musculoskeletal disorders (MSD) represents a complex challenge that involves multiple stakeholders. The aim of this study was to examine how managers perceive the factors that facilitate or hinder communication with other stakeholders during the RTW process.

This qualitative study was based on four focus groups conducted in Canada (Quebec and Ontario) with 18 managers.

Thematic analysis identified five themes related to facilitators and seven themes related to communication obstacles. Among the main facilitators, trust, clarity, and collaboration emerged as key elements …

On The Use Of Hearing Aid Algorithms In Industrial Noise: Balancing Speech Intelligibility And Hearing Protection, Solenn Ollivier, Fabien Bonnet, Alexis Pinsonnault-Skvarenina, Christian Giguère, Jérémie Voix, Hugues Nélisse

Études primaires

Hearing protection devices (HPDs) are widely used to mitigate the risks of noise-induced hearing loss in industrial environments. However, conventional HPDs can often hinder communication for workers with hearing loss. While those workers may rely on hearing aids in their daily lives, the potential benefits and associated risks of using such devices in noisy workplaces remain unexplored. This study evaluated the effects of different hearing aid signal processing algorithms on speech intelligibility and estimated noise exposure under industrial noise conditions to characterize the balance between communication and protection needed to develop solutions for workers with hearing loss. A digital hearing …

Tracking Vigilance While Driving: Pilot Study Of Heart Rate Variability Classification Under A Controlled Sleep-Deprivation Protocol, James Elber Duverger, Eli Moser, Philippe Boudreau, Marie Claude Ouimet, Diane B. Boivin, Alireza Saidi

Études primaires

Decreased vigilance associated with drowsiness is a major cause of motor vehicle crashes, but its physiological characterization and detection remain difficult due to behavioral and environmental confounding factors. This study presents an original experimental framework combining a highly controlled sleep-deprivation protocol, repeated driving simulations, and a machine-learning-based heart rate variability (HRV) analysis to study the physiological and behavioral changes in vigilance during a prolonged period of wakefulness while driving. Twelve healthy young adults participated in a 30-h sleep-deprivation constant routine protocol that included driving simulations every two hours, with data collection: electrocardiography (ECG), subjective ratings of drowsiness, psychomotor vigilance test, …

Understanding The Potential Biogeochemical Effects Of Alternative Restoration Materials: A Study Of Basalt And Other Materials, Cadie L. Barnes

Graduate Studies Theses and Dissertations 2026

Concern over the effects of microplastics on estuarine ecosystems and public health has prompted many restoration practitioners to switch from plastic materials to more “natural” substrates. These natural (BESE-biopolymer, cement-jute structures) and non-plastic (basalt fiber) materials should not contain harmful substances; however, their chemical composition is unknown. Natural materials may degrade faster in subtropical environments and release nutrients into surrounding waters, which is concerning for eutrophic restoration areas. Basalt fiber bags, made from melted basalt rock spun into fibers, have not been evaluated for biogeochemical impacts within estuaries. To address this knowledge gap, two field experiments and two laboratory experiments …

Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand

Graduate Studies Theses and Dissertations 2026

Emergency physicians work in a high-demand environment requiring irregular, around-the-clock schedules, which can contribute to elevated work-home conflict and burnout. While previous research has focused on objective schedule characteristics such as length of shift or time of day worked, less attention has been given to how emergency physicians perceive the fairness of the scheduling process itself. Drawing on Work-Home Resources Theory and Personal Resource Allocation Theory, this study examines whether perceptions of schedule justice influence work-home conflict via schedule satisfaction. I propose that perceived fairness in schedule creation functions as a contextual resource that shapes whether a schedule is experienced …

Professional Quality Of Life Among Medical Surgical And Telemetry Registered Nurses, William Lim, Emy-Lee Marie Anglo Ricafrente, Jenny Carrillo

Publications 2026-present

No abstract provided.

Endometriosis From Initiation To Innovation: Immune Microenvironments, Clonal Lesion Biology, And The Emerging Therapeutic Pipeline, Bindu Santhamma, Jessica Chacon, Eva Deemer, Dorota Stary, Shayla A. Hernandez, Ramadevi Subramani, Rajkumar Lakshmanaswamy, Klaus J. Nickisch, Surinder K. Batra, Hareesh B. Nair

Journal Articles: Biochemistry & Molecular Biology

Endometriosis is a chronic, estrogen-dependent inflammatory disease that, despite its benign histology, displays several cancer-relevant features, including clonal expansion, somatic alteration-associated lesion evolution, tissue invasion, apoptosis resistance, immune evasion, angiogenesis, fibrosis, and metabolic adaptation. These features are particularly important in ovarian endometriosis, where recurrent hemorrhage, iron-driven oxidative stress, and chronic inflammatory remodeling may promote malignant transformation. This review examines endometriosis through an oncologic framework by integrating current evidence on disease initiation, clonal lesion evolution, and the peritoneal, ovarian, and deep-infiltrating microenvironments. We discuss how epithelial, stromal, immune, endothelial, mesothelial, and neural components cooperate to support lesion survival, dissemination, vascularization, fibrosis, …

Slc22a3/Oct3 Drives Serotonin-Mediated Stemness In Pancreatic Cancer, Nivedeta Krishna Kumar, Venkatesh Varadharaj, Neelanjana Gayen, Annant Bir Kaur, Kirtana Arikath, Ashu Shah, Poompozhil Mathivanan, Palanisamy Nallasamy, Zahraa Wajih Alsafwani, Bhuvaneshwari Seshadri, Pratima Raut, Sanchita Rauth, Jimmie Persinger, Sandipan Brahma, Micah Schott, Rebecca E. Oberley-Deegan, Geoffrey A. Talmon, Jesse L. Cox, Surinder K. Batra, Moorthy P. Ponnusamy

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is a highly aggressive malignancy, with cancer stem cells (CSCs) playing a critical role in metastasis, therapy resistance, and recurrence, thereby presenting significant treatment challenges. Emerging evidence suggests that normal embryonic and adult progenitor stem cells share common gene signatures with CSCs. However, the early pluripotency-associated factors and stemness programs that become aberrantly reactivated during oncogenic transformation remain poorly defined. Here, we identify SLC22A3/OCT3 (Solute Carrier Family 22 Member 3) as a reactivated embryonic-associated signature that regulates PC stemness. SLC22A3 is markedly upregulated in CSC-enriched populations, and its silencing in PC cells grown in both 2D cultures …

Rac1 Gtpase Regulates The Scfβtrcp-Mediated Degradation Of Claspin And The Cellular Response Of Pancreatic Cancer Cells To Gamma Rays, Neha Chaudhary, Tabbatha N. Somers, Surinder K. Batra, Ying Yan, Michel M. Ouellette

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND/OBJECTIVES: Pancreatic ductal adenocarcinomas (PDACs) are lethal tumors exhibiting resistance to most cancer therapeutics, particularly DNA-damaging agents. The

METHODS: Western blot analyses were used to assess the impacts of Rac1 inhibition on the components of the ATR/Chk1 cascade.

RESULTS: Here, we show that Rac1 inhibition disrupts ATR/Chk1 signaling by promoting degradation of Claspin, a key component of the fork protection complex needed for the Ser345-phosphorylation of Chk1 by ATR. In PDACs and normal pancreatic ductal cells, Rac1 inhibition (via inhibitors or siRNA) decreased Claspin protein levels without affecting its mRNA, reflecting a >3-fold reduction in Claspin's half-life. Claspin contains a …

Acceptability, Usability, And Clinical Integration Of A Clinic-Based Digital Game For Hpv Education: Qualitative Perspectives From Adolescents, Parents, And Healthcare Providers, Elizabeth Reifsnider, Satya Subedi, Nouran Ghonaim, Megan Whaley, Angela Chia-Chen Chen

Ellmer School of Nursing Faculty Publications

Background/Objectives: HPV vaccination is safe, effective, and recommended at ages 11–12, yet uptake remains suboptimal. Serious video games may offer an innovative strategy to deliver brief, engaging education during clinic visits. This qualitative paper, embedded within a mixed-methods study, examined adolescents’, parents’, and healthcare providers’ (HCPs’) perceptions of the acceptability, usability, and perceived clinical applicability of HPV Detective, a tablet-based digital game designed to provide HPV-related education to parent–child dyads during pediatric clinic wait times. Methods: Eight adolescent–parent dyads (N = 16) and three HCPs from university-affiliated pediatric clinics participated in 30–60-min semi-structured Zoom interviews. Interviews were audio-recorded, transcribed, and …

Increasing Hpv Vaccination Among Early Adolescents Using A Game-Based Digital Intervention: A Randomized Controlled Trial, Angela Chia-Chen Chen, Lihong Ou, Elizabeth Reifsnider, Kimberly Arcoleo, Ashish Amresh, Michael Todd

Ellmer School of Nursing Faculty Publications

Background/Objectives: Human papillomavirus (HPV) vaccination coverage among adolescents remains below public health targets despite strong evidence of vaccine effectiveness in preventing HPV-related cancers. Digital interventions (e.g., serious games) may improve HPV vaccine uptake, but evidence for effects on vaccination behavior remains limited. Methods: This secondary analysis of a randomized controlled trial evaluated a co-designed, game-based digital intervention to increase HPV vaccine initiation among unvaccinated youth aged 11-14 years and their parents. The sample included 64 parent-adolescent dyads (33 intervention and 31 usual care dyads). The primary outcome was HPV vaccine initiation at 2-month follow-up. Results: A significantly greater proportion of …

The Asymmetric Effect Of Social Connection And The Cumulative Damage Of Comorbidities On Physical And Mental Health Of Older Virginians, Newton Ochoki, Lynn Wiles, Peijia Zha, Vince Falco, Carielle Joy Rio, Jonathan Romero, Leorey N. Saligan

Ellmer School of Nursing Faculty Publications

Objectives

This study explored relationships of social connection with physical and mental health in older adults, specifically examining the effects of comorbidities on these relationships and the influence of sociodemographic variables on the strength of these associations.

Methods

This cross-sectional study enrolled 174 community-dwelling adults aged 60 years and older residing in Hampton Roads, Virginia, USA. Data were collected from April to August 2025. Hierarchical linear regression analyses examined the associations of social connection with physical and mental health. Moderated mediation analysis examined if comorbidities mediated these relationships and whether sociodemographic factors moderate the strengths of these associations.

Results

In …

Feeding Mode Is Associated With Infant Night Sleep Trajectories During The First Postnatal Year, Magdalena Olson, Li Liu, Elizabeth Reifsnider, Dean V. Coonrod, Sarada S. Panchanathan, Megan E. Petrov, Corrie M. Whisner

Ellmer School of Nursing Faculty Publications

Background: Short sleep and formula feeding during infancy are associated with increased risk of childhood obesity. Feeding practices and sleep arrangements vary during infancy and may also be dynamic, yet their impact on infant night sleep duration remains unclear. Understanding these relationships is crucial for formulating recommendations to support breastfeeding and address sleep concerns. Objective: We examined the association between feeding mode and parent-reported infant night sleep duration during the first postnatal year, while additionally evaluating night-weaning and bedsharing as contextual sleep-related practices. Methods: Infants in the Phoenix Metropolitan Area (n = 193) were followed up at 3, 8, 13, …

Skeletal Muscle Myofiber Development In Non-Human Primate Offspring Deprived Of Estrogen In Utero, Phillip J. Gauronskas, Terrie J. Lynch, Eugene D. Albrecht, Gerald J. Pepe

Department of Biomedical and Translational Sciences Faculty Publications

Introduction: We previously showed that baboon offspring born to mothers deprived of estrogen during the second half of gestation exhibited insulin resistance prior to and after the onset of puberty. Moreover, the size of skeletal muscle myofibers and the number of microvessels important for delivery of insulin/glucose to myofibers were lower in near-term fetuses deprived of estrogen during pregnancy, and myofiber capillarization remained reduced in post-pubertal offspring deprived of estrogen in utero. However, it remains to be determined whether skeletal muscle size is restored to normal in animals deprived of estrogen in utero after the onset of puberty/gonadal estrogen production. …

Hu308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates Sars-Cov-2 Spike Protein-Induced Acute Lung Injury In Mice, Janette Lockett, Gregory Nicholson, Nicholas Richards, Ryan Washington, Nagaraja Nagre

Department of Biomedical and Translational Sciences Faculty Publications

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to pose major health challenges despite effective vaccination efforts. The sustained occurrence of breakthrough infections and emerging variants of the virus highlights the need for additional therapeutic strategies. Given the anti-inflammatory role of the cannabinoid type 2 receptor (CB2R), we examined the effect of CB2R activation in SARS-CoV-2 spike protein subunit 1 (S1SP)-induced acute lung injury (ALI).

Methods

ALI was induced in mice by intratracheal (i.t.) administration of S1SP, followed by treatment with the CB2R agonist HU308 (5 mg/kg, intraperitoneal: i.p.) 1 h …