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2026

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The Wto Is Dead, Long Live The Wto: The Lingering Interpretive Problem Of Article 27.1 Of The Trips Agreement, Faisal Chaudhry Jan 2026

The Wto Is Dead, Long Live The Wto: The Lingering Interpretive Problem Of Article 27.1 Of The Trips Agreement, Faisal Chaudhry

Fordham International Law Journal

No abstract provided.


A Council Of Europe Tribunal To Prosecute Putin For The Crime Of Aggression In Ukraine, Erin A. Kenny Jan 2026

A Council Of Europe Tribunal To Prosecute Putin For The Crime Of Aggression In Ukraine, Erin A. Kenny

Fordham International Law Journal

No abstract provided.


Promise, Progress, Or Posturing? India And The Intellectual Property Chapter In The United Kingdom-India Comprehensive Economic And Trade Agreement, Pratyush Nath Upreti, Virender Chandel Jan 2026

Promise, Progress, Or Posturing? India And The Intellectual Property Chapter In The United Kingdom-India Comprehensive Economic And Trade Agreement, Pratyush Nath Upreti, Virender Chandel

Fordham International Law Journal

No abstract provided.


Spatiotemporal Dynamics Of Mountain Front Recharge Flow Paths And Their Contribution To Alluvial Aquifer Water Supply, Mikaela Bollag-Miller Jan 2026

Spatiotemporal Dynamics Of Mountain Front Recharge Flow Paths And Their Contribution To Alluvial Aquifer Water Supply, Mikaela Bollag-Miller

Graduate Student Theses, Dissertations, & Professional Papers

Mountain Front Recharge (MFR) is a critical recharge source for alluvial basin aquifers throughout the Intermountain West, yet the spatial and temporal dynamics of distinct recharge pathways remain poorly constrained. This study investigates the seasonal and spatial dynamics of MFR pathways and evaluates their impact on the Missoula Aquifer, a sole-source alluvial aquifer in western Montana, USA. MFR includes both surface-water inflows from mountain areas and Mountain Block Recharge (MBR), the groundwater contribution to the basin aquifer. A valley-scale water balance was employed to estimate first-order contributions and temporal fluctuations of MBR flow paths. A three-layer steady-state MODFLOW groundwater model …


Infected Intra-Abdominal Hematoma Post-Laparoscopic One-Anastomosis Mini Gastric Bypass: Case Report And Literature Review, Musa Machibya, Hellen Mram, Jackline Gabone, Ally Mwanga, Tanseer Asghar, Authar Ali Jan 2026

Infected Intra-Abdominal Hematoma Post-Laparoscopic One-Anastomosis Mini Gastric Bypass: Case Report And Literature Review, Musa Machibya, Hellen Mram, Jackline Gabone, Ally Mwanga, Tanseer Asghar, Authar Ali

General Surgery, East Africa

Introduction: Laparoscopic one-anastomosis gastric bypass (OAGB) is a widely performed bariatric procedure with favorable outcomes; however, it carries a risk of postoperative complications. An infected intra-abdominal hematoma is a rare but potentially serious complication, often presenting with nonspecific features that can delay diagnosis.

Case presentation: A 29-year-old female with class II obesity (BMI 36 kg/m2 ) underwent elective laparoscopic OAGB. The immediate postoperative course was uneventful, and she was discharged in stable condition. Eleven days later, she presented with fever and systemic symptoms without significant abdominal findings. Laboratory investigations suggested sepsis. Imaging revealed a large perigastric collection consistent with …


Reversible Hemi-Parkinsonism Syndrome Secondary To Bilateral Subdural Hematomas: Case Report And Literature Review, Musa Machibya, Godlove Mlay, Kelvin Sawe, Zainab Ali, Mugisha Clement, Philip Adebayo Jan 2026

Reversible Hemi-Parkinsonism Syndrome Secondary To Bilateral Subdural Hematomas: Case Report And Literature Review, Musa Machibya, Godlove Mlay, Kelvin Sawe, Zainab Ali, Mugisha Clement, Philip Adebayo

General Surgery, East Africa

Introduction: Chronic subdural hematoma (CSDH) is a rare but reversible cause of secondary parkinsonism. Bilateral CSDH presenting with unilateral parkinsonian features is exceptionally uncommon.

Case presentation: A 61-year-old male from Comoros developed a right-hand tremor, intermittent dystonia, and mild right-sided motor deficits months after a motor vehicle accident. Medical therapy was ineffective. Imaging revealed bilateral frontoparietal subdural collections with a right hematoma causing a midline shift. Bilateral burr-hole evacuation led to marked improvement, with the UPDRS Part III score improving from approximately 7 to 1–2 points and near-complete hematoma resolution on follow-up.

Discussion: This case demonstrates the variable …


Oil Palm (Elaeis Guineensis) Leaf Extract-Mediated Green Synthesis Of Tio2 Nanoparticles And Their Optical Characteristics, Nofrijon Sofyan, Andriayani, Yetria Rilda, Fiona Angellinnov, Mouna M'Rad, Muhammad, Aga Ridhova, Akhmad Herman Yuwono, Donanta Dhaneswara Jan 2026

Oil Palm (Elaeis Guineensis) Leaf Extract-Mediated Green Synthesis Of Tio2 Nanoparticles And Their Optical Characteristics, Nofrijon Sofyan, Andriayani, Yetria Rilda, Fiona Angellinnov, Mouna M'Rad, Muhammad, Aga Ridhova, Akhmad Herman Yuwono, Donanta Dhaneswara

Baghdad Science Journal

This work aims to explore the characteristics of TiO2 NPs green-synthesized via an environmentally friendly method using oil palm (Elaeis guineensis) leaf extract as a green medium and capping agent by utilizing titanium tetra isopropoxide (TTIP) as precursor. The oil palm leaves were extracted with different solvent concentration variations. The natural extract was characterized using liquid chromatography-mass spectroscopy (LC-MS) and infrared spectroscopy for active chemical contents and functional groups. The obtained TiO2 NPs were also characterized using infrared spectroscopy (FTIR) for the functional groups, ultraviolet spectroscopy (UV-DRS) for the optical characteristics, and X-ray diffraction (XRD) for the phase …


Clinical Subtypes Of Co-Morbid Insomnia And Obstructive Sleep Apnea (Comisa): Results Of A Cluster Analysis, Yuan Shi, Xujun Feng, Fengyi Hao, Yuru Nie, Yihui Zhang, Zhaohua Chen, Siqi Guan, Larry D. Sanford, Michael V. Vitiello, Xiangdong Tang Jan 2026

Clinical Subtypes Of Co-Morbid Insomnia And Obstructive Sleep Apnea (Comisa): Results Of A Cluster Analysis, Yuan Shi, Xujun Feng, Fengyi Hao, Yuru Nie, Yihui Zhang, Zhaohua Chen, Siqi Guan, Larry D. Sanford, Michael V. Vitiello, Xiangdong Tang

Department of Pathology & Anatomy Faculty Publications

Background

Variations in the bidirectional relationship between obstructive sleep apnea (OSA) and insomnia in co-morbid insomnia and OSA (COMISA) may form distinct subtypes of COMISA, which have not been previously characterized. This study aims to identify and characterize subtypes of COMISA.

Methods

From a community-recruited COMISA cohort 256 individuals who met diagnosis for COMISA were used to identify subtypes using a two-step clustering methodology. Demographics and multidimension clinical characteristics were collected and compared among obtained subtypes. Logistic models were used to evaluate whether these subtypes were associated with cardiometabolic and mental disorders. A clinical cohort of 1816 COMISA patients was …


The Rna-Binding Protein Pumilio Limits Polymodal Noiception In Drosophila Larvae, Sara Palega, Hannah Davenport, Rebeccah K. Stewart, Jessica Horton, Andrew Bellemer Jan 2026

The Rna-Binding Protein Pumilio Limits Polymodal Noiception In Drosophila Larvae, Sara Palega, Hannah Davenport, Rebeccah K. Stewart, Jessica Horton, Andrew Bellemer

Microbiology & Molecular Cell Biology Faculty Publications

Nociception is the process by which the nervous system detects and processes information about potentially harmful environmental stimuli to generate behavioral and physiological responses. The process of nociception undergoes plasticity in response to injury, inflammation, and infection to shape the sensitivity of nociceptive circuits and the behavioral responses they control. We are increasingly aware that post-transcriptional regulation of gene expression shapes the sensitivity and plasticity of nociceptive sensory neurons and nociceptive behavior. In Drosophila, the Pumilio RNA-binding protein interacts with diverse target mRNAs to regulate their abundance and translation in a wide range of contexts including the establishment of …


Sae For All: Curriculum Guide, Emily Carpenter Jan 2026

Sae For All: Curriculum Guide, Emily Carpenter

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

Supervised Agricultural Experience (SAE) is a critical component of agricultural education, designed to provide students with hands-on learning opportunities that extend beyond the classroom. The SAE for All model ensures that every student participates in meaningful experiential learning tailored to their interests and career goals. By integrating SAE into the curriculum, students develop technical skills, career readiness competencies, and an understanding of real-world agricultural applications. This guide includes a teaching plan and a comprehensive set of assignments.


Branches Etched Across The Sky Jan 2026

Branches Etched Across The Sky

Theatre and Performance Studies Programs

Branches Etched Across The Sky by Addae Moon


How Parents & Children Talk About Technology Rules, Elisha Seoyoon Bae , '26 Jan 2026

How Parents & Children Talk About Technology Rules, Elisha Seoyoon Bae , '26

Senior Theses, Projects, and Awards

No abstract provided.


A Living Epidemic: The Persistence Of Tuberculosis In Contemporary Indigenous Alaska, Sharon Kim , ‘26 Jan 2026

A Living Epidemic: The Persistence Of Tuberculosis In Contemporary Indigenous Alaska, Sharon Kim , ‘26

Senior Theses, Projects, and Awards

No abstract provided.


Identifying And Prioritizing Essential Healthcare Services For A Private Start-Up Healthcare Hub In Laxmipasha, Bangladesh, Ferdous Ara Mostofa Jan 2026

Identifying And Prioritizing Essential Healthcare Services For A Private Start-Up Healthcare Hub In Laxmipasha, Bangladesh, Ferdous Ara Mostofa

Dissertations

This quantitative study identifies and prioritizes essential healthcare services for developing a private start-up healthcare hub in Laxmipasha, Bangladesh, a rural community with significant gaps in healthcare access. Using secondary data from national and international sources, the research analyzed disease burden, population characteristics, and service availability to determine the most urgent health priorities. A structured, evidence-based framework was used to evaluate services based on mortality and morbidity, service gaps, and potential health impact. The findings indicate that Maternal and Child Health (MCH), Non-Communicable Disease (NCD) management, and infectious disease control represent the most critical priorities for initial implementation. The study …


Histopathological Effects Of The Intrathecal Chondroitinase Abc Administration In Spinal Cord Injured Rats: A Systematic Review, Mohammad Amin Habibi, Ali Anjomshoa, Mohsen Sadeghi-Naini, Zahra Ghodsi, Samuel Berchi Kankam, Erfan Razavi, Armin Aryannejad, Seyed Mohammad Piri, Akam Ramezani, Rasha Atlasi, Kawthar Mohamed, Sina Shoo, Meysam Kaveh, Akbar Fotouhi, Arman Zeinaddini, James S. Harrop, Alex R. Vaccaro, Michael G. Fehlings, Vafa Rahimi-Movaghar Jan 2026

Histopathological Effects Of The Intrathecal Chondroitinase Abc Administration In Spinal Cord Injured Rats: A Systematic Review, Mohammad Amin Habibi, Ali Anjomshoa, Mohsen Sadeghi-Naini, Zahra Ghodsi, Samuel Berchi Kankam, Erfan Razavi, Armin Aryannejad, Seyed Mohammad Piri, Akam Ramezani, Rasha Atlasi, Kawthar Mohamed, Sina Shoo, Meysam Kaveh, Akbar Fotouhi, Arman Zeinaddini, James S. Harrop, Alex R. Vaccaro, Michael G. Fehlings, Vafa Rahimi-Movaghar

Department of Orthopaedic Surgery Faculty Papers

Introduction: Chondroitinase ABC (ChABC) has been considered a potential treatment for spinal cord injury (SCI). We aim to identify and evaluate the histopathological effects of intrathecal ChABC administration in SCI rat models.

Methods: We searched PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library for studies published from the inception of each database until November 22, 2022.

Results: Of 3857 screened citations, 17 studies met eligibility criteria and were entered into the qualitative analysis. Sixteen studies were of high quality, and one study was of medium quality. The four main rat strains used in studies were Sprague-Dawley, Wistar, Lister hooded, …


Reframing Faces: Brief Cognitive Restructuring And Emotion Recognition In Depression, Disha Sharma Jan 2026

Reframing Faces: Brief Cognitive Restructuring And Emotion Recognition In Depression, Disha Sharma

Student Scholarship

No abstract provided.


The Institutionalization Of Nuclear Sharing: A Happy Medium For Asymmetric Alliances, Masanao Goto Jan 2026

The Institutionalization Of Nuclear Sharing: A Happy Medium For Asymmetric Alliances, Masanao Goto

Student Scholarship

No abstract provided.


Why Person-Environment Fit Matters When Addressing Homelessness: An Intersectional Analysis Of King County, Washington’S Coordinated Entry System, Cori L. Cafaro Jan 2026

Why Person-Environment Fit Matters When Addressing Homelessness: An Intersectional Analysis Of King County, Washington’S Coordinated Entry System, Cori L. Cafaro

Theses and Dissertations from DePaul University

Coordinated Entry (CE) systems aim to address homelessness by allocating resources based on need and prioritizing the most vulnerable individuals. However, system success depends on appropriately matching people to housing. This study examined person-environment fit (P-E fit) and associated housing outcomes for single adults matched to permanent supportive housing through King County, Washington's CE for All system, with intersectionality as a secondary lens. This was a secondary analysis using Qualitative Content Analysis of interview and focus group transcripts from tenants (n = 18), staff (n = 27), and policy leaders (n = 11). Five dimensions of fit emerged as consequential …


Bone Healing During A Dysregulated Inflammatory Phase: Comparative Skeletal Features In 5-Lipoxygenase Knockout And Wild Type Mice, Marco Hernandez, Nidhin John, Bhuvana L. Chandrashekar, Mariza A. Matsumoto, Naohiro Shibuya, Claudia Biguetti Jan 2026

Bone Healing During A Dysregulated Inflammatory Phase: Comparative Skeletal Features In 5-Lipoxygenase Knockout And Wild Type Mice, Marco Hernandez, Nidhin John, Bhuvana L. Chandrashekar, Mariza A. Matsumoto, Naohiro Shibuya, Claudia Biguetti

School of Podiatric Medicine - Student Research

Background: High-risk patients, such as those with diabetic neuropathy, often experience prolonged and dysregulated inflammation during bone healing. The 5-lipoxygenase (5LO) pathway is a key mediator of inflammation and bone resorption and may influence these outcomes. Therefore, understanding the skeletal features associated with 5LO genetic deletion may help identify therapeutic opportunities to improve healing in high-risk patients.

Objective: To determine how genetic deletion of 5LO affects skeletal structure and macrophage phenotypes, with the goal of identifying therapeutic targets to improve bone healing in high-risk patients.

Materials and Methods: A total of 10, adult (3 months old), 129/SvEv male mice were …


The Resilient Educator: Examining The Role Of Resilience On A First-Year Rural Music Educator’S Job Satisfaction, Isaac Price Jan 2026

The Resilient Educator: Examining The Role Of Resilience On A First-Year Rural Music Educator’S Job Satisfaction, Isaac Price

Graduate Theses, Dissertations, and Problem Reports (ETD)

The future of music education in schools is largely determined by educators' resilience in their positions. Resilience is the process of adapting to adversity by accessing and utilizing intrinsic and extrinsic resources available (Gu & Day, 2007; Squires et al., 2023). Resilience affects various aspects of an educator’s personal and professional life, including job satisfaction (Li, 2023). Job satisfaction can affect teacher health, teacher performance, and teacher retention, which in turn may affect student performance (Huysman, 2008; Lu et al., 2024; Robison & Russell, 2022). The circumstances and events that occur during a teacher’s first year in the profession can …


The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy Jan 2026

The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the strategic role of Corporate Social Responsibility (CSR) in helping small businesses recover from crises, with a specific focus on the COVID-19 pandemic. Different from many traditional studies that highlight the ethical or reputational aspects of CSR, this research will examine its practical effects: how CSR initiatives during crises influence business success by enhancing consumer trust, particularly by examining the differential impact of Internal CSR versus External CSR. The study suggests that, compared with internally focused CSR, external CSR activities will have a greater impact on consumer trust. In addition, the dissertation suggests that this effect is …


Disaster Exposure, The Perception Of Physiological Pain, And Psychological Distress Across Adulthood, Esha Azhar Jan 2026

Disaster Exposure, The Perception Of Physiological Pain, And Psychological Distress Across Adulthood, Esha Azhar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Climate change brings with it an increase in the occurrence of natural disasters, such as hurricanes, wildfires, severe storms, etc. In the aftermath, afflicted individuals may suffer adversely, especially in their physical and mental health. Previous research has found older adults to be faring better after experiencing a disaster compared to younger adults, which has been attributed to their better mental health associated with aging and gaining experience with adversities (Strough et al., 2023; 2025). The current study examined the psychological distress and physiological pain of individuals across the adult lifespan after experiencing a disaster. Participants were part of the …


Posttraumatic Growth In Appalachian Youth: Findings From An Outpatient Pediatric Trauma Specialty Clinic, Marinne M. Morgan Jan 2026

Posttraumatic Growth In Appalachian Youth: Findings From An Outpatient Pediatric Trauma Specialty Clinic, Marinne M. Morgan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Childhood traumatic event exposure (CTE) involves exposure to extreme events that overwhelm one’s ability to cope. Childhood traumatic event exposure has been linked to a wide range of adverse mental and physical health consequences, including posttraumatic stress symptoms (PTSS). Fewer studies have examined positive trajectories following childhood traumatic event exposure, such as posttraumatic growth (PTG), especially in understudied regions such as Appalachia. The current study used a cross-sectional design to examine posttraumatic growth in 14 youths aged 9 to 15 years seeking trauma-focused therapeutic services at an outpatient pediatric trauma specialty clinic in West Virginia. In line with previous research, …


Empowered Choices: A Quality Improvement Women’S Health Initiative In Faith-Based Nursing For Women Recovering From Substance Use Disorder, Jennifer Mewshaw Jan 2026

Empowered Choices: A Quality Improvement Women’S Health Initiative In Faith-Based Nursing For Women Recovering From Substance Use Disorder, Jennifer Mewshaw

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Women with substance use disorder (SUD) face higher rates of unplanned pregnancy, reproductive infections, and delayed prenatal care. Faith community nurses (FCNs) often already serve within this community and have a long history of promoting public health interventions. However, they lack the knowledge and confidence in sexual and reproductive health (SRH) education.

Evidence Review: A literature review identified barriers to SRH care for women with SUD and the role of FCNs in community and public health interventions. Evidence supports providing FCNs with the knowledge and skills to deliver SRH education and support for women with SUD using trauma-informed and …


Improving Access To Treatment For Alcohol Use Disorder For Veterans: An Evidence-Based Practice Policy Analysis, Mary Rizzo Jan 2026

Improving Access To Treatment For Alcohol Use Disorder For Veterans: An Evidence-Based Practice Policy Analysis, Mary Rizzo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Alcohol use disorder (AUD) is common among veterans and is associated with poor health outcomes. Although extended-release naltrexone (XR-NTX) is an effective treatment, maintenance injections at the VA Pittsburgh Healthcare System are only available at the main medical center, requiring many veterans to travel long distances each month.

Purpose: The purpose of this evidence-based practice policy analysis was to evaluate the feasibility of offering XR-NTX injections at Community-Based Outpatient Clinics (CBOC) and develop a policy recommendation to improve access to care.

Intervention: This project examined the current XR-NTX administration process and compared it with alternative approaches used within the …


Fairness Without Demographic Attributes In Medical Vision–Language Models, Ahsan Habib Akash Jan 2026

Fairness Without Demographic Attributes In Medical Vision–Language Models, Ahsan Habib Akash

Graduate Theses, Dissertations, and Problem Reports (ETD)

Vision–language models (VLMs) and the embedding models that underlie them have become the default representation layer for multimodal artificial intelligence. Trained by contrastive alignment over enormous, loosely curated image–text corpora, they inherit the demographic skew of that data, and they encode it in the geometry of the shared embedding space itself. The consequence is a model that performs unevenly across demographic groups even when no protected attribute is ever supplied as an input. In consumer applications this is an equity problem; in medicine it is a safety problem, because an embedding that is systematically less discriminative for one subpopulation translates …


Effect Of Yoga On Non-Invasive Measures Of Cardiovascular Functioning And Health, Alexis Nicole Thrower Jan 2026

Effect Of Yoga On Non-Invasive Measures Of Cardiovascular Functioning And Health, Alexis Nicole Thrower

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Cardiovascular disease (CVD) has been the number one cause of death worldwide and within the United States (US) for decades. Effective and practical prevention modalities are needed to reduce the burden of this often-preventable condition. Physical activity is an effective and modifiable behavior for CVD risk management; however, only one in four adults meet current physical activity guidelines. Some types of yoga, including vinyasa yoga, are a form of physical activity, and vinyasa yoga efficiently incorporates moderate-intensity aerobic activity, muscular-strengthening movements, and flexibility components. Yet, minimal rigorous research evaluates yoga’s effects on health. The purpose of this dissertation is …


Dielectrophoretic Biomarkers For Cancer Detection And Cell Analysis: Integrating Microfluidics And Ai, Raphael Olumide Oladokun Jan 2026

Dielectrophoretic Biomarkers For Cancer Detection And Cell Analysis: Integrating Microfluidics And Ai, Raphael Olumide Oladokun

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pancreatic ductal adenocarcinoma (PDAC) carries a five-year survival rate of 13%, driven largely by late-stage diagnosis and the absence of sensitive noninvasive screening tools. Current diagnostic methods lack the sensitivity to detect disease-associated systemic changes at early and precancerous stages, representing a critical clinical gap. This dissertation addresses the central hypothesis that PDAC and its pathological subtypes induce measurable, disease-associated electrophysiological changes in circulating PBMCs that can serve as correlative liquid-biopsy biomarkers. To test this hypothesis, this work asks: can dielectrophoresis (DEP), impedance and zeta potential analysis with AI-assisted classification distinguish benign pancreatic conditions (non-malignant control), precancerous lesions (primarily IPMNs), …


Landscape As Expo: Reimagining Desert Landscapes As Climate-Adaptive Cultural Infrastructure In Las Vegas, Parinaz Baradaran Anaraki Jan 2026

Landscape As Expo: Reimagining Desert Landscapes As Climate-Adaptive Cultural Infrastructure In Las Vegas, Parinaz Baradaran Anaraki

Graduate Theses, Dissertations, and Problem Reports (ETD)

Contemporary desert cities face increasing environmental and social challenges driven by climate change, including extreme heat, water scarcity, fragmented ecological systems, and limited access to high-quality public open space. In many rapidly urbanizing regions, conventional urban development has marginalized desert landscapes, treating them as vacant land rather than valuable ecological and cultural assets. This thesis proposes Landscape as Expo as a new framework for transforming desert landscapes into climate-adaptive cultural infrastructure, where ecological processes become both functional systems and public experiences.

The project focuses on a 140-acre site within the Tule Springs Planning District in North Las Vegas, Nevada, identified …


The Histamine-3 Receptor In Cardiac Fibrosis: A Novel Role In Fibroblast Function, Heather Linsky Jan 2026

The Histamine-3 Receptor In Cardiac Fibrosis: A Novel Role In Fibroblast Function, Heather Linsky

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, heart failure affects approximately 6.7 million individuals. Despite a number of available therapies, heart failure prevalence continues to grow, suggesting the need for a broader range of effective therapies. More specifically, heart failure with preserved ejection fraction comprises approximately 50% of all heart failure cases and, as the name suggests, is a disease of diastolic dysfunction as opposed to systolic dysfunction. A hallmark of heart failure with preserved ejection fraction is myocardial fibrosis, which is a key contributor to diastolic dysfunction, and is the major focus of this dissertation work. In the heart, histamine-3 receptor activation …