Digital Commons Network^™

Signaling Scaffold Shoc2 Regulates Lymphangiogenesis By Suppressing Mtorc1-Mediated Ifn Responses, Patricia Wilson, Vishakha Vishwakarma, Rebecca Norcross, Kashmira Khaire, Van N. Pham, Brant M. Weinstein, Hyun Min Jung, Emilia Galperin

Molecular and Cellular Biochemistry Faculty Publications

An interplay of growth factors and signaling pathways governs the development and maintenance of lymphatic vasculature, ensuring proper fluid homeostasis and immune function. Disruption of these regulatory mechanisms can lead to congenital lymphatic disorders and contribute to various pathological conditions. However, the mechanisms underlying the molecular regulation of these processes remain elusive. Here, we reveal a critical and previously unappreciated role for the signaling scaffold protein Shoc2 in lymphangiogenesis. We demonstrate that loss of Shoc2 results in near-complete loss of lymphatic vasculature in vivo and senescence of lymphatic endothelial cells in vitro. Mechanistically, Shoc2 is required for balancing signaling through …

Current And Emerging Therapeutic Strategies For The Treatment Of Duchenne Muscular Dystrophy, Miguel A. Lopez Perez, Noah L. Weisleder

Molecular and Cellular Biochemistry Faculty Publications

Background/Objectives: Duchenne muscular dystrophy (DMD) is a fatal, progressive neuromuscular disorder caused by mutations in the dystrophin gene, leading to the absence of functional dystrophin protein. As the largest gene in the human genome, the DMD locus is highly susceptible to mutations, contributing to a prevalence of approximately 1 in 3800–6300 live male births worldwide. This review aims to provide a comprehensive and critical synthesis of current and emerging therapeutic strategies for DMD.

Methods: We conducted a narrative review of the literature, integrating findings from clinical trials, regulatory approvals, and preclinical studies. We categorized therapeutic approaches into mutation-agnostic and mutation-specific …

The Hrt Boomerang: The Rise, Fall, And Rise Again Of Hormone Replacement Therapy For Menopause In The United States, Rachel A. Dopico

Senior Honors and Award-Winning Theses

No abstract provided.

“Medical Cannabis”: Advising Patients While Navigating Medical Ethics And Limited Evidence, Anna-Maria South, Shanna L. Babalonis, Laura C. Fanucchi, Michelle R. Lofwall

Internal Medicine Faculty Publications

Cannabis is increasingly legalized in more areas of the USA and marketed under the misnomer “medical cannabis.” Yet, there are no official dosing guidelines or approved medical uses for plant cannabis by the Food and Drug Administration. Due to significant federal barriers, research on efficacy, safety, and adverse effects of cannabis is limited. Patients are interested in cannabis as potential treatment of medical issues and/or symptoms and clinicians should include a discussion of the risks of cannabis consumption. However, many risks are not yet known, and clinicians might be unaware of the emerging literature. This perspective summarizes the potential harms …

Prevalence And Characteristics For Mental Health Disorder Before And After Childhood Cancer Diagnosis—A Statewide Population-Based Study Among Medicaid Beneficiaries, Feitong Lei, Laurie E. Mclouth, Eric B. Durbin, Thomas T. Tucker, John L. Villano, Bin Huang

Internal Medicine Faculty Publications

Introduction: Pediatric cancer patients suffer mental health deficits. Patients who are vulnerable with respect to socioeconomic or other sociodemographic factors may be at heightened risk for worse mental health outcomes during cancer for many reasons including entering treatment with an existing mental health disorder. The purpose of this study was to describe the prevalence and trajectory of mental health before and after a childhood cancer diagnosis in a socio-demographically at-risk sample.

Methods: Data from the Kentucky Cancer Registry was utilized to identify patients aged 19 or under with a first primary childhood cancer diagnosis during 2001–2017. Linking KCR data with …

Facilitators Of And Barriers To Implementation Of A Tablet-Based Digital Health Program For Colorectal Cancer Screening In Primary Care: Qualitative Pragmatic Implementation Study, Mark Cromo, Aliza Randazzo, David P. Miller, Kristie Foley, Ajay Dharod, Anna C. Snavely, Elena Wright, Holly Brower, Mark Dignan

Internal Medicine Faculty Publications

Background: Colorectal cancer (CRC) incidence and mortality rates continue to be elevated even though effective screening methods are widely available. To increase CRC screening in primary care practices, our team developed a tablet-based digital health program (mPATH) designed to identify patients needing CRC screening, provide education, and empower patients to request a screening test via the program.

Objective: This study aimed to qualitatively assess facilitators of and barriers to implementing and maintaining mPATH in primary care clinics.

Methods: In a pragmatic implementation trial, clinics were randomized to receive only in-person training and technological support via phone or email (low touch) …

Adipose Tissue-Derived Small Extracellular Vesicles In Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance, Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang-Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep

Internal Medicine Faculty Publications

Objective: Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT-derived small extracellular vesicles (sEV^AT) change in response to glucose availability and differ by GT status.

Methods: sEV^AT were isolated from plasma of individuals with normal GT (NGT) and impaired GT (IGT) (n = 5/group) at fasting (0 h) and 1 h post glucose challenge during oral glucose tolerance test (OGTT). sEV^AT were characterized for size, concentration, surface expression of insulin receptor-α (INSRα), proteome, …

The Bigotry Of The Future: Ai Recruitment Tools & Hiring Discrimination Law, Lily Manshel

City University of New York Law Review

As one-click applications and a competitive job market result in hundreds of applicants per listing, hiring tools that use Artificial Intelligence (“AI”) promise recruiters a convenient way to sort through the crowd and find the “perfect” candidate, all while eliminating human bias. These tools—which include resume screeners, gamified assessments and personality tests, and video interviewing software—are proliferating so rapidly that their ubiquity is positioned as inevitable by both the software companies that produce them and the employers who use them. However, the use of these automated decision-making tools creates a paradox under existing antidiscrimination law: the systems clearly perpetuate and …

Review Of Bioethics: A Coursebook, Ian Werkheiser

Open Educational Resources - Reviews

No abstract provided.

Disability As A Critical Element In Exploring The Racial Wealth Gap, Nanette Goodman, Montserrat Avila-Acosta, Fitore Hyseni, Peter Blanck

The Lender Center for Social Justice

This report examines the racial wealth gap for people with disabilities in the United States. While the racial wealth gap is well-documented, with the median White household having a net worth 7-10 times higher than the median Black household, the wealth gap experienced by people with disabilities remains less explored. Recent data show that households without disabilities possess, on average, 6 times the net worth of households led by a working-age person with a disability. Wealth, defined as total household assets minus total liabilities, is a comprehensive measure of economic well-being and social stratification, and it has wide implications, including …

How The Proposed Esa Habitat Rule Harms Species On Public Lands, Sandi Zellmer

Faculty Journal Articles & Other Writings

At present, there are 1,684 federally listed endangered and threatened species in the United States. Habitat modification is the primary reason for listing. The U.S. Fish and Wildlife Service (FWS) and the National Oceanic and Atmospheric Administration (NOAA) have proposed a rule that would rescind their decades-old definition of “harm” under the Endangered Species Act (ESA). Currently, “harm” is the only term within ESA Section 9’s prohibition on “take” that encompasses habitat modification. If modifying habitat is no longer a “take,” the ESA itself would be rendered incapable of satisfying Congress’s goal: “to halt and reverse the trend toward species …

Office Of Research Compliance: Policy On Scientific Integrity And Misconduct

Academic Affairs – Policy Library

No abstract provided.

Delphi Study To Explore The Organizational Characteristics, Conditions, And Infrastructures Needed To Integrate Professional Development With A Career Advancement Framework In The Form Of Career Lattice, Shelly Yu-Tze Tze Shelly Wang

Dissertations

Purpose: The purpose of this policy Delphi study was to identify, prioritize, and build expert consensus on the organizational characteristics, conditions, and infrastructures that support employee access to professional development (PD) opportunities embedded within a career advancement (CAd) framework. Specifically, this study aimed to: (a) identify key organizational components necessary to support professional development within a career lattice structure, (b) determine the relative importance of these components as rated by experts, and (c) establish expert-recommended strategies for implementation.

Methodology: This study used a Delphi method, consisting of three rounds, to collect data from experts with the titles of manager, directors, …

Retention Of Elementary Special Education Teachers: A Phenomenological Study Of Retention Factors And Work-Life Balance In Brick-And-Mortar And Virtual, Independent Study Educational Environments, Meredith Clark-Lewis

Dissertations

Purpose: This phenomenological study aimed to identify the factors that influence the retention of elementary special education teachers in virtual, independent study environments and brick-and-mortar environments, and to explore similarities and differences in how elementary special education teachers experience work-life balance across educational settings.

Methodology: Purposeful sampling was used to identify 10 elementary special education teachers in California who worked in brick-and-mortar and virtual independent study settings and met the study's inclusion criteria. Semi-structured, open-ended interviews were conducted virtually, recorded, transcribed, and analyzed using NVivo qualitative data analysis software. Both deductive and inductive coding strategies were employed, guided by the …

Student Wellness: Exploring The Role Of Faculty In Implementing Effective Supports For Mental Well-Being And Academic Performance In Community College Dental Hygiene Education, Bernadette Heather Smith

Dissertations

Purpose: The purpose of this phenomenological, comparative study was to identify and describe effective supports used by dental hygiene faculty and their role in the mental well-being and academic performance of community college dental hygiene students.

Methodology: Two Southern California community college dental hygiene programs were selected for this phenomenological study to identify the use of faculty supports. A purposeful sampling strategy was applied to these populations to identify participants in specific selection criteria. Twenty-one participants, who consisted of five faculty members and five or six 2nd-year students from each school, were selected. Data were collected by conducting individual interviews …

Smarter Nutrition: Right-Sizing Nutritional Monitoring In Patients On Crrt, David Zolezzi, Elizabeth Journey, Jayne Walters

2026

No abstract provided.

Asset Forfeiture As An Animal Welfare Law: A Case Study On South Carolina's Bond-Or-Forfeit Statute, Morgan Mercer

Animal Law Review

This Comment examines South Carolina’s 2024 bond-or-forfeit statute (H.B. 3682) as a case study in the growing trend of extending existing legal frameworks to promote animal welfare. Traditionally, asset forfeiture treats animals purely as property subject to seizure. However, by shifting the costs of caring for seized animals from public agencies to the animals’ owners, H.B. 3682 embeds a concern for animal well-being into a framework historically focused on economic and property interests. This Comment argues that bond-or-forfeit statutes are part of a broader trend toward recognizing animals as sentient beings with welfare interests distinct from their owners’ property rights. …

A Mandate With Teeth: Biting Back At The Neglect Of New York's Humane Education Law, Mei Brunson

Animal Law Review

New York passed its compulsory humane education law in 1917, which obligates school districts to provide weekly instruction in the “humane treatment and protection of animals” to all elementary school students. Though this mandate is clear, New York school districts routinely ignore it and deprive students of the humane education that they are statutorily entitled to. To make matters worse, the New York Commissioner of Education has abdicated their responsibility to enforce this minimum educational standard. Over the years, the laudable efforts of advocacy groups, educators, and legislators have brought about some instances of district compliance. Nevertheless, widespread district noncompliance …

Toward Interspecies Reproductive Justice, Asha A. Ramakumar

Animal Law Review

Reproductive justice discourse has largely overlooked non-human animals, despite the parallel forms of biopolitical control exercised over human women and female animals’ reproductive labor. By examining the shared logics underlying the subordina-tion of both human women and dairy cows, this Article argues that any genuine conception of reproductive justice must inter-rogate reproductive exploitation beyond the human experience. Drawing from Michel Foucault’s theory of biopower and Carol J. Adams’ framework of the “absent referent,” this Article elucidates how powerful institutions control those with the capacity for preg-nancy by perpetuating narratives of biological essentialism and obligation.

Part II examines several examples of …

Front Matter, Lewis & Clark Law Review

Animal Law Review

Front Matter contains Table of Contents, masthead, and faculty advisers for Animal Law Review Volume 32, Issue 1.

Disability Studies And Disability Evaluation In Healthcare—Themes And Challenges Moving Forward, Debra A. Harley, Si-Yi Chao

Early Childhood, Special Education, and Counselor Education Faculty Publications

No abstract provided.

Special Tribute To Dean R. Tyndall, Ma, Otrl, Faota

OJOT Sponsor Profiles

No abstract provided.

A Golden Age For Us . . . Or For The Airlines? Ensuring Robust Federal Consumer Protections To Make Flying Great Again For Everyone, David S. Nahmias, Julian Sanghvi

Journal of Law and Mobility

Flying today is not meaningfully better for passengers than it was twenty years ago—and the airlines are largely to blame. Airlines leverage opaque pricing practices and junk fees to extract greater revenue from passengers, while the quality of air travel has deteriorated. Despite its mandate to protect the flying public and the air travel market from deceptive and anticompetitive practices, the Department of Transportation has been largely captured—adopting industry-favorable regulations and procedures while cutting commonsense consumer protections. This Essay examines the airlines’ coordinated campaign to circumvent and dismantle consumer protections, and how the industry have largely captured the federal agency …

Discrimination Distress And Current Combustible And Non-Combustible Tobacco Product Use Among Us Youth, 2023, Meman Diaby, Osayande Agbonlahor, Maggie K. Richardson, Joy L. Hart, Shyanika W. Rose, Delvon T. Mattingly

Markey Cancer Center Faculty Publications

Introduction: Discrimination is the unfair treatment of people based on their identity. Youth who experience discrimination may cope with associated distress by using tobacco products, with amplified health consequences depending on the type of product.

Methods: We used data from the 2023 National Youth Tobacco Survey (n = 22 069) and derived an overall continuous measure from the 15-item Adolescent Discrimination Distress Index, as well as three continuous discrimination distress sub-indices: educational, institutional, and peer (range for each: 0–5). We defined current tobacco use as two outcomes: any past 30-day use of combustible (cigarettes, cigars, hookah, roll- your-own, pipe, bidis) …

Poppers, Apps, And Pleasure: From Set To Setting Among Sexually Diverse Men In Mexico, Juan Carlos Mendoza-Pérez, Keith J. Watts

Social Work Faculty Publications

Background: Poppers (alkyl nitrites) are widely used among sexually diverse men to enhance sexual pleasure. However, research has historically been dominated by risk-centered frameworks such as associations with HIV or other STIs, overlooking user motivations related to hedonic reward, intimacy, and agency. This conceptual oversight is particularly evident in the Global South. This study explores the benefits, motivations, and social meanings of poppers consumption among sexually diverse men in Mexico, emphasizing its relationship with dating applications.   Methods: A mixed-methods cross-sectional study used an electronic survey administered in 2023 to sexually diverse cisgender men. The analytic sample included participants who reported …

Rethinking Behavior - Winter 2026, Midwest Symposium For Leadership In Behavior Disorders

ReThinking Behavior Magazine

A magazine for professionals serving children and youth with behavioral needs.

Winter 2026, Volume 9, Issue 2

Epilepsy, Children's Health School Services

School Guides

Educator guide about how to support students with epilepsy.

Cystic Fibrosis, Children's Health School Services

School Guides

Educator guide about how to support students with cystic fibrosis.

Early Childhood Special Education (Ecse), Children's Health School Services

School Guides

Parent guide about the Texas Early Childhood Special Education (ECSE) program.

End Stage Renal Disease, Children's Health School Services

School Guides

Educator guide about how to support students with end stage renal disease.