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Articles 43501 - 43530 of 50007
Full-Text Articles in Entire DC Network
Disparities In Emergency Medical Services: Examining Care Gaps For The High-Frequency User Population, Sarah Krysl Cleveringa
Disparities In Emergency Medical Services: Examining Care Gaps For The High-Frequency User Population, Sarah Krysl Cleveringa
Doctor of Psychology (PsyD)
Although many studies have illustrated healthcare disparities related to patient demographic factors in emergency medical response, few studies have examined how differences in care may be related to a patient’s identity as a high-frequency utilizer of emergency medical services (EMS). The Superuser population (higher than average utilizers of EMS) has been examined for characteristics and costs to society, but it is unknown if they receive a different type or quality of care compared to the low-frequency utilizer population. The goal of this study is to examine the EMS care that Superusers receive and possible factors that may contribute to the …
Dordt University 2026-27 Catalog, Dordt University. Registrar's Office
Dordt University 2026-27 Catalog, Dordt University. Registrar's Office
Academic Catalogs
Academic Catalog for 2026-27
Hester’S Dubious Roots And Legacy: Open Fields Doctrine Under Scrutiny, Laura K. Donohue
Hester’S Dubious Roots And Legacy: Open Fields Doctrine Under Scrutiny, Laura K. Donohue
Georgetown Law Faculty Publications and Other Works
For over a century, open fields doctrine has shaped Fourth Amendment law, denying people the right to be secure on their own property. Its application has steadily expanded, with the result that, by some estimates, the Government can now engage in warrantless surveillance of some ninety-six percent of private land and buildings regardless of fences, postings, the distance from public roads or byways, or the use to which the property is put. An originalist approach throws the doctrine into disarray: at the time of the Founding, common law protected the curtilage, which extended to the fields, barns, storehouses, and other …
Bidenomics: An Analysis, Chad Marzen
Bidenomics: An Analysis, Chad Marzen
Dickinson Law Review (2017-Present)
“What’s Bidenomics? It’s about investing in—and I feel like I’m going to—I’m going to try not to repeat some of what my colleagues have already said, but it’s about investing in America—investing in America and investing in Americans—American People” – Former President Joseph R. Biden, Jr.1 “It’s about growing the economy from the middle out and bottom up instead of the top down. Because when the middle class does well, the poor have a ladder up and the wealthy still do very well.” – Former President Joseph R. Biden, Jr.2 “The West Wing may believe Bidenomics is working …
Trained, Trusted, And Vetted, But Still Unarmed: The Army Is Bucking Congress And The Court By Continuing To Prohibit Concealed Carry, Major Jonathon L. Krisko
Trained, Trusted, And Vetted, But Still Unarmed: The Army Is Bucking Congress And The Court By Continuing To Prohibit Concealed Carry, Major Jonathon L. Krisko
Dickinson Law Review (2017-Present)
The constitutional right to bear arms in public for self-defense is not “a second-class right, subject to an entirely different body of rules than the other Bill of Rights guarantees.” We know of no other constitutional right that an individual may exercise only after demonstrating to government officers some special need. That is not how the First Amendment works when it comes to unpopular speech or the free exercise of religion. It is not how the Sixth Amendment works when it comes to a defendant’s right to confront the witnesses against him. And it is not how the Second Amendment …
Lawyering On The Eve Of War: The Role Of Law And Lawyers In Ethiopia’S Civil War, 2018–2024, Mekonnen F. Ayano
Lawyering On The Eve Of War: The Role Of Law And Lawyers In Ethiopia’S Civil War, 2018–2024, Mekonnen F. Ayano
Dickinson Law Review (2017-Present)
What role do lawyers play when a nation stands at the brink of war? This Article examines how Ethiopia’s legal profession navigated escalating political instability in the years leading up to the country’s devastating civil war (2018–2022). It traces how private attorneys, judges, prosecutors, government legal advisors, human rights advocates, consultants, and law academics engaged with shifting power dynamics, ethical dilemmas, and political tensions, revealing their complex positioning as both actors and intermediaries in the unfolding crisis. Some resisted factional political pressures and sought to uphold legal principles, while others adapted to the fragile conditions and aligned with prevailing currents, …
Suppressing The Surge: Starbucks And The Limits Of Labor Rights, Ivan Garcia
Suppressing The Surge: Starbucks And The Limits Of Labor Rights, Ivan Garcia
Dickinson Law Review (2017-Present)
In the wake of the 2020 COVID-19 pandemic, Starbucks workers launched an unprecedented movement to organize workers at each store. Starbucks management responded to this movement with an unlawful union busting campaign. The National Labor Relations Board found that the Starbucks campaign violated workers’ rights to engage in union activity under the National Labor Relations Act. Starbucks’ efforts allowed them to stave off any collective bargaining agreement between the stores and the union. The company adopted aggressive tactics in the run-up to worksite elections which the Board found amounted to unlawful interference. The endeavor to organize workers at Starbucks stores …
Complying With Title Ix In The Nil Era, Benjamin Moyer
Complying With Title Ix In The Nil Era, Benjamin Moyer
Dickinson Law Review (2017-Present)
On July 1, 2021, college athletics forever changed when the NCAA allowed college athletes to receive financial compensation for the use of their Name, Image, and Likeness (NIL) in endorsements and other marketing engagements. While NIL has empowered college athletes and enabled them to profit from their athletic abilities, it has also thrown the college sports industry into chaos. The House v. NCAA settlement agreement, which was officially approved on June 6, 2025, was expected to establish better guardrails for universities. However, the agreement’s approval may only increase universities’ exposure under Title IX. Part of the House settlement agreement enables …
It’S Gone To The Dogs: The Need For Regulation In Professional Service Dog Training, Crystal J. Elsner
It’S Gone To The Dogs: The Need For Regulation In Professional Service Dog Training, Crystal J. Elsner
Dickinson Law Review (2017-Present)
Currently, no state requires professional service dog trainers to pass any test or obtain any occupational licensure to prove their competency. While the Americans with Disabilities Act and its implementing regulations do not require that dogs complete a professional training program to be considered service dogs, many individuals with disabilities choose to use such programs. The unregulated nature of the industry allows inexperienced individuals to market themselves as professionals, which can harm not only the dogs receiving training but also the humans that will eventually take them home. Further, the lack of industry oversight leaves room for bad actors to …
Envisioning Antiracist Legal Education In Aotearoa New Zealand: The Role Of Leadership, Mele T. Vaitohi
Envisioning Antiracist Legal Education In Aotearoa New Zealand: The Role Of Leadership, Mele T. Vaitohi
Dickinson Law Review (2017-Present)
This Essay presents a comprehensive examination of antiracism within Aotearoa New Zealand’s legal education, underscoring the critical need to embed antiracist principles across both the curriculum and the legal profession. It highlights the imperative for systemic change to dismantle structural inequities and advocates for an educational framework that prepares future lawyers to address and challenge racial injustice. Additionally, the Essay demonstrates how visionary leadership can spearhead transformative initiatives that amplify Pacific voices, cultivating a legal landscape that is both inclusive and equitable. Through these insights, this Essay aims to contribute to ongoing dialogues on creating a justice system reflective of …
The Future Of Title Ix After House V. Ncaa, Abigail Perkiss
The Future Of Title Ix After House V. Ncaa, Abigail Perkiss
Dickinson Law Review (2017-Present)
In October 2025, attorneys representing current and former Division I college athletes filed preliminary briefs in the Ninth Circuit, calling on the appellate court to reverse the settlement in House v. NCAA,1 which in April 2025 turned intercollegiate athletics on its head. The brief argued that the terms of the settlement stand in violation of Title IX of the 1972 Educational Amendments, the legislation that prohibited sex-based discrimination in education programs and related activities that receive federal funding. According to the settlement terms, 90 percent of the backpay is earmarked to fund men’s football and basketball players, 5 percent …
Advocating For Cause: The California Recall Process Needs A Purpose, Mary-Beth Moylan
Advocating For Cause: The California Recall Process Needs A Purpose, Mary-Beth Moylan
Dickinson Law Review (2017-Present)
Democratic systems and the tools that sustain them need to operate by the people and for the people with consideration to the realities of the era in which they exist. The use of direct democracy, and in particular the recall process, in recent decades suggests that what was once a progressive reform intended to ensure good government has now become a political tool for stoking partisan disruption. It is time for a close look at how and why some states continue to allow for recall and the circumstances under which a recall election should be called. During the COVID-19 pandemic, …
“You’Re Denying God”: Thoughts On Institutional Homophobia From Lgbtq-Affirming Staff And Faculty At Christian Colleges, Kaytlin Epperly
“You’Re Denying God”: Thoughts On Institutional Homophobia From Lgbtq-Affirming Staff And Faculty At Christian Colleges, Kaytlin Epperly
Doctor of Psychology (PsyD)
Over 4 million adults identify as LGBTQ Christians in the United States (Conron et al., 2020). Yet, despite increasing support in secular and religious circles alike, the LGBTQ community continues to face prejudice and discrimination in evangelical Christian spaces (Jones, 2026; Public Religion Research Institute, 2023). Unfortunately, much of this is experienced on Christian college campuses. During a crucial period of identity development, many emerging adults on these campuses struggle between their queer identities and Christian faith, leading to psychological distress, shame, and marginalization. However, previous research illustrates the integral role that social support plays in LGBTQ students’ wellbeing (Cook …
Relationships Between Substance Use, Adverse Childhood Experiences, Psychological Functioning, And Use Of Positive Coping, Jade Binford
Relationships Between Substance Use, Adverse Childhood Experiences, Psychological Functioning, And Use Of Positive Coping, Jade Binford
Doctor of Psychology (PsyD)
Clinicians have attempted to understand substance abuse for years, and theories attempting to explain substance abuse have evolved. Theories have ranged from viewing the issue as a moral failure to interpreting it through a disease-oriented viewpoint. The self-medication hypothesis has been used to understand substance abuse and describes the issue as deriving from individuals seeking relief from psychological distress (e.g., emotional dysregulation, behavioral impairment, painful memories). Substance abuse has been linked to the experience of depression, anxiety, exposure to adverse experiences in childhood and adulthood, and trauma-related clinical diagnoses. The role of positive coping has been considered a function that …
Iere Annual Report 2026, Erin Largo-Wight, Heather Barnes Truelove, Kelly Rhoden, Jessica Barnes, Lauren Canady, Nicole Lowe, Ruby Cox, Sydney Barrett, Kathleen Hutton
Iere Annual Report 2026, Erin Largo-Wight, Heather Barnes Truelove, Kelly Rhoden, Jessica Barnes, Lauren Canady, Nicole Lowe, Ruby Cox, Sydney Barrett, Kathleen Hutton
Annual Reports
2026 Annual Report of the Institute for Environmental Research and Education
Administrative Self-Constitutionalism, Brian Lipshutz
Administrative Self-Constitutionalism, Brian Lipshutz
Public Law and Legal Theory Working Papers
Since the days of the Interstate Commerce Commission, federal agencies have generally refused to address the constitutionality of statutory provisions. They have offered little reasoning to justify that refusal, yet scholars have generally accepted it. This Article explains why agencies can—and should—address constitutional challenges to statutory provisions.
Agencies have the power to assess the constitutionality of statutory provisions. They already exercise a similar authority when they apply the canon of constitutional avoidance and consider the constitutionality of individual actions. There is no basis for stopping short of addressing challenges to statutes. And many scholars have recognized that, as a formal …
Counseling Professionals' Perspectives On Ai Integration In Education And Supervision: A Concept Mapping Study, Hank Crofford, Elif Bor, Gülşah Kemer
Counseling Professionals' Perspectives On Ai Integration In Education And Supervision: A Concept Mapping Study, Hank Crofford, Elif Bor, Gülşah Kemer
Counseling & Human Services Faculty Publications
The rapid emergence of artificial intelligence (AI) has raised important questions about how new technologies will shape professional norms and practices in counseling. The purpose of this study was to understand how counseling professionals expect AI to be integrated into counselor education and supervision (CES). Using a mixed‐methods concept mapping design, 31 participants generated and sorted statements about the potential roles, benefits, and concerns associated with AI in the profession. Participants represented diverse counseling roles, including counselor educators, licensed professional counselors, supervisors, master's‐ and doctoral‐level trainees, and other counseling‐related professionals. Standard concept mapping procedures were conducted using R, resulting in …
Legislative Debate-Attributed Suicidality Among Lgbtq+ Adults: The Buffering Effect Of Community Belongingness, Keith J. Watts, Shawndaya S. Thrasher, Laneshia R. Conner, Nicole Campbell, Louis G. Baser, Dekeitra Griffin, Sydney P. Howard, Missy Spears, Justin X. Moore
Legislative Debate-Attributed Suicidality Among Lgbtq+ Adults: The Buffering Effect Of Community Belongingness, Keith J. Watts, Shawndaya S. Thrasher, Laneshia R. Conner, Nicole Campbell, Louis G. Baser, Dekeitra Griffin, Sydney P. Howard, Missy Spears, Justin X. Moore
Counseling & Human Services Faculty Publications
Background: In recent years, the sociopolitical landscape in the United States has shifted due to an increase in state-level legislation regarding LGBTQ+ rights, a trend that has been particularly pronounced in the Commonwealth of Kentucky. While the mental health impacts of enacted laws are increasingly documented, a critical gap remains in understanding the psychological toll of the legislative debates themselves—the prolonged periods of public discourse surrounding the restriction of rights. Methods: Utilizing data from the 2025 Queer Kentucky Survey (N = 817), this exploratory study examined the association between LGBTQ+ community belongingness and acute suicidality attributed specifically to anti-LGBTQ+ legislative …
Asynchronous Lgbtq+ Affirming Counseling Training With Early Career Counselors: A Mixed Methods Program Evaluation, Amber L. Pope, Kelli Hartzell, Matt B. Siroty, Jeff Moe, Noelle St. Germain-Sehr, Bianca R. Augustine, Amanda St. Germain-Sehr, Tai Lexumé
Asynchronous Lgbtq+ Affirming Counseling Training With Early Career Counselors: A Mixed Methods Program Evaluation, Amber L. Pope, Kelli Hartzell, Matt B. Siroty, Jeff Moe, Noelle St. Germain-Sehr, Bianca R. Augustine, Amanda St. Germain-Sehr, Tai Lexumé
Counseling & Human Services Faculty Publications
A growing body of research shows that training in LGBTQ+ affirming counseling (LGBTQ+ AC) positively impacts counselors’ perceived knowledge and skills in providing mental health services to LGBTQ+ communities. Existing program evaluations of LGBTQ+ AC, however, have primarily used synchronous delivery formats and cultural competency models for the training design. This study is part of an action research agenda to develop an introductory training in LGBTQ+ AC, using asynchronous online delivery and cultural humility as the conceptual framework for the training design. We used a fixed convergent parallel mixed methods quasi-experimental design to examine the impact of our LGBTQ+ AC …
Broaching The Intersectionality Of Race And Disability In School Counseling, Aaron Albright, Emily Goodman-Scott, Jenna Alvarez, Rawn Boulden
Broaching The Intersectionality Of Race And Disability In School Counseling, Aaron Albright, Emily Goodman-Scott, Jenna Alvarez, Rawn Boulden
Counseling & Human Services Faculty Publications
Students of color with disabilities experience compounded inequities. This conceptual article details these compounded inequities. The authors provide a review of the literature related to inequities in education, culturally affirming antiracist school counseling, intersectionality, and broaching. Next, the authors provide a rationale for implementing Day-Vines and colleagues’ multidimensional model of broaching behaviors (MMBB) in school counseling with students of color with disabilities. Then, the authors use the MMBB heuristic to conceptualize practical guidelines for school counselors to engage in direct broaching with their students. These guidelines are tabulated with a description of the four broaching dimensions and their aim within …
"Oh, You've Come To Visit The Yard?": Phenotypic Capital, Intragroup Marginalization, And The Gated Sanctuary In Black Lgbtq+ Communities, Keith J. Watts, Shawndaya S. Thrasher, Nicole Campbell, Laneshia R. Conner, Julian K. Glover, Janet K. Otachi, Dekeitra Griffin
"Oh, You've Come To Visit The Yard?": Phenotypic Capital, Intragroup Marginalization, And The Gated Sanctuary In Black Lgbtq+ Communities, Keith J. Watts, Shawndaya S. Thrasher, Nicole Campbell, Laneshia R. Conner, Julian K. Glover, Janet K. Otachi, Dekeitra Griffin
Counseling & Human Services Faculty Publications
Identity-based communities that share common characteristics, beliefs, and experiences (e.g., Black LGBTQ+ communities) have historically been conceptualized as protective bubbles that buffer Black LGBTQ+ individuals against the deleterious effects of systemic racism and cisheterosexism. However, this monolithic narrative often masks the internal power dynamics that divide belonging. This study explores the exclusionary dynamics embedded within these safe spaces, examining how internal hierarchies of skin tone, socioeconomic status, and gender performance function as proximal stressors. Guided by a critical constructivist paradigm, this study utilized Reflexive Thematic Analysis to analyze open-ended survey responses from 74 Black LGBTQ+ adults. Data were drawn from …
Editorial For Issue 20(2), Jeff Moe, Peighton Corley, Aaron Albright
Editorial For Issue 20(2), Jeff Moe, Peighton Corley, Aaron Albright
Counseling & Human Services Faculty Publications
[Introduction] Hello to the readers of the Journal of LGBTQ Issues in Counseling. Like many counselors, counselors-in-training, scholars, and other individuals you may be coming to the journal looking for insights into your counseling work. Along with publishing original research that creates space for exploring LGBTQ+ lifeways from an open and affirmative perspective, the manuscripts published in the journal have always been grounded in application.
Contemporary Approaches To Group Psychotherapy Supervision, Michelle A. Collins-Greene (Ed.), Molyn Leszcz, Nina W. Brown, Ellen Wright, Scott Giacomucci, Les R. Greene, Susan P. Gantt, Leah M. Niehaus, Francis Kaklauskas, Tony L. Sheppard
Contemporary Approaches To Group Psychotherapy Supervision, Michelle A. Collins-Greene (Ed.), Molyn Leszcz, Nina W. Brown, Ellen Wright, Scott Giacomucci, Les R. Greene, Susan P. Gantt, Leah M. Niehaus, Francis Kaklauskas, Tony L. Sheppard
Counseling & Human Services Faculty Publications
This chapter captures the work of contemporary supervisors of group psychotherapy, all of whom have practiced many years and have trained and supervised innumerable group leaders. They demonstrate the diversity of settings and theoretical orientations that are prominent in the current era. Their essays speak for themselves and provide wonderful illustrations and models for supervisors-in-training and consultation to emulate. They also talk about who influenced, mentored, and supervised them.
Call To Action: A Telebehavioral Health Framework For Counselor Development, Brittany G. Suggs, Brittany J. Bice-Urbach, Marlene M. Maheu, Kenneth P. Drude, Donna Ford, Jocelyn Novella, Bradford Felker, Donald M. Hilty
Call To Action: A Telebehavioral Health Framework For Counselor Development, Brittany G. Suggs, Brittany J. Bice-Urbach, Marlene M. Maheu, Kenneth P. Drude, Donna Ford, Jocelyn Novella, Bradford Felker, Donald M. Hilty
Counseling & Human Services Faculty Publications
The widespread implementation of telebehavioral health (TBH) services, accelerated by the COVID-19 pandemic, created an urgent need for standardized competencies in counselor education. Many practitioners report minimal formal training, leading to significant variability in competence and a concerning gap between their confidence and actual preparedness. This article issues a call to action for counseling programs to adopt the interprofessional TBH competency framework from the Coalition for Technology in Behavioral Science (CTiBS). This structured, evidence-based roadmap outlines knowledge and skills for competent, ethical TBH practice across seven domains and three progressive levels: novice, proficient, and authority. Adopting this framework will enhance …
Intersectionality Of Race And Disability: The School Counselors' Role In Policy Reformation, Jenna M. Alvarez, Rachel Saunders, Vanessa Sinclair, Stephanie Smith-Durkin, Emily Goodman-Scott
Intersectionality Of Race And Disability: The School Counselors' Role In Policy Reformation, Jenna M. Alvarez, Rachel Saunders, Vanessa Sinclair, Stephanie Smith-Durkin, Emily Goodman-Scott
Counseling & Human Services Faculty Publications
The United States K-12 education system is riddled with inequities within the intersection of race and disabilities; relatedly, the school counseling literature also demonstrates a similar gap in the literature. As a result, through three case illustrations highlighting the unique experiences of historically marginalized students of color with disabilities, we illustrate the multiplex intersection of race and disability and how a school counselor can utilize leadership, advocacy, and social justice for systemic change. Further, the three cases are structured through the ADDRESSING framework, to systematically consider the complexities of identity, overlapping cultural influences, and the connections to practice (Hays, 2022). …
Optimizing Kidney Allograft Years: Underutilization Of Pediatric Donors, Nicholas Herrera, Ana Cortez, Diane Cibrik, Bradley A. Warady
Optimizing Kidney Allograft Years: Underutilization Of Pediatric Donors, Nicholas Herrera, Ana Cortez, Diane Cibrik, Bradley A. Warady
Manuscripts, Articles, Book Chapters and Other Papers
Background.
The Kidney Donor Profile Index (KDPI) score drives kidney allocation in the United States for both adult and pediatric donors, despite the calculation being primarily derived from adult donor data. A KDPI of ≤20% is considered to have the longest graft survival potential and is typically prioritized for recipients who have a low Estimated Posttransplant Survival (EPTS) score. Using KDPI to assess pediatric donor quality may underestimate graft survival and result in underutilization of these kidneys for recipients with a low EPTS score.
Methods.
Using Scientific Registry of Transplant Recipients data, we analyzed 5-y posttransplant death-censored graft survival of …
Pharmacogenetic Hslco1b1*14-Guided Dosing Of Methotrexate In Transgenic Arthritic Mice Normalizes Exposure And Response., Felicia Gooden, Brennan D. Meier, Griffin D. Shaffer, Kim Gibson, Paul Toren, Nieko C. Punt, Sandhya Subash, Dilip K. Singh, Bhagwat Prasad, Laura Ramsey, Zachary L. Taylor
Pharmacogenetic Hslco1b1*14-Guided Dosing Of Methotrexate In Transgenic Arthritic Mice Normalizes Exposure And Response., Felicia Gooden, Brennan D. Meier, Griffin D. Shaffer, Kim Gibson, Paul Toren, Nieko C. Punt, Sandhya Subash, Dilip K. Singh, Bhagwat Prasad, Laura Ramsey, Zachary L. Taylor
Manuscripts, Articles, Book Chapters and Other Papers
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease that negatively affects ~100,000 children under the age of 16 in the United States. About ~30% of these patients fail first-line drug therapy with low-dose methotrexate (MTX) due to poor tolerability or lack of efficacy. The SLCO1B1*14 allele is associated with increased MTX clearance and has been linked to reduced overall drug exposure and nonresponse to MTX in JIA patients. Herein, we describe transgenic hSLCO1B1*14 and hSLCO1B1*1 DBA1/J mSlco1b2 knock-out mice, which we used to assess arthritic response to MTX using the collagen-induced arthritis model. Mass spectrometry-based proteomics analysis revealed that …
Association Of N-Terminal Pro-Brain Natriuretic Peptide With Ckd Progression In The Ckd In Children Study., Alexander Kula, David K. Prince, Joseph T. Flynn, Susan L. Furth, Bradley A. Warady, Tamara Isakova, Derek Ng, Jeese Seegmiller, Rob Christenson, Nisha Bansal
Association Of N-Terminal Pro-Brain Natriuretic Peptide With Ckd Progression In The Ckd In Children Study., Alexander Kula, David K. Prince, Joseph T. Flynn, Susan L. Furth, Bradley A. Warady, Tamara Isakova, Derek Ng, Jeese Seegmiller, Rob Christenson, Nisha Bansal
Manuscripts, Articles, Book Chapters and Other Papers
No abstract provided.
Indirect Treatment Comparison Of Tezepelumab Versus Other Biologics In Severe Chronic Rhinosinusitis With Nasal Polyps: A Systematic Literature Review And Network Meta-Analysis, Joseph K. Han, Joaquim Mullol, Claire Hopkins, Oliver Pfaar, Martin Desrosiers, Jason Steenkamp, Danny Gibson, Santiago Zuluaga Sanchez, Andrew Foster, Christopher S. Ambrose
Indirect Treatment Comparison Of Tezepelumab Versus Other Biologics In Severe Chronic Rhinosinusitis With Nasal Polyps: A Systematic Literature Review And Network Meta-Analysis, Joseph K. Han, Joaquim Mullol, Claire Hopkins, Oliver Pfaar, Martin Desrosiers, Jason Steenkamp, Danny Gibson, Santiago Zuluaga Sanchez, Andrew Foster, Christopher S. Ambrose
Department of Otolaryngology (ENT) Faculty Publications
Introduction
This study compared the efficacy of tezepelumab with other approved biologics and endoscopic sinus surgery (ESS) using indirect treatment comparisons (ITCs) in adults with severe, uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).
Methods
Randomized controlled trials (RCTs) identified via a systematic literature review (SLR) were synthesized in a network meta-analysis (NMA). Outcomes included change from baseline in nasal polyp score (NPS), nasal congestion/obstruction score (NCS/NOS), difficulty with sense of smell (DSS), Sino-Nasal Outcome Test-22 (SNOT-22) score, Lund Mackay score (LMS), time to nasal polyposis (NP) surgery decision, proportions requiring NP surgery or systemic corticosteroids (SCS), time to SCS use, …
Expanding The Genetic And Phenotypic Spectrum Of Polrmt-Related Mitochondrial Disease., Mahmoud R. Fassad, Sebastian Valenzuela, Monika Oláhová, Jack J. Collier, Charlotte V Y Knowles, Eleni Mavraki, Miriam Elbracht, Nergis Güzel, Thomas Herberhold, Ingo Kurth, Andrea Maier, Larissa Mattern, Carol J. Saunders, Helen Mccullagh, Katrin Õunap, Saskia B. Wortmann, Andre Reis, Lei Zhang, Claes M. Gustafsson, Robert Mcfarland, Robert W. Taylor
Expanding The Genetic And Phenotypic Spectrum Of Polrmt-Related Mitochondrial Disease., Mahmoud R. Fassad, Sebastian Valenzuela, Monika Oláhová, Jack J. Collier, Charlotte V Y Knowles, Eleni Mavraki, Miriam Elbracht, Nergis Güzel, Thomas Herberhold, Ingo Kurth, Andrea Maier, Larissa Mattern, Carol J. Saunders, Helen Mccullagh, Katrin Õunap, Saskia B. Wortmann, Andre Reis, Lei Zhang, Claes M. Gustafsson, Robert Mcfarland, Robert W. Taylor
Manuscripts, Articles, Book Chapters and Other Papers
Mitochondrial diseases are a complex group of conditions exhibiting significant phenotypic and genetic heterogeneity. Genomic testing is increasingly used as the first step in the diagnostic pathway for mitochondrial diseases. We used next-generation sequencing followed by bioinformatic data analysis to identify potentially damaging variants in the POLRMT gene (NM_005035.4) in six new affected individuals. Structural protein analysis predicted the detrimental impact of variants on POLRMT protein structure. Patients show extended phenotypic abnormalities often presenting early in life with features including global developmental delay, cognitive impairment, short stature and muscular hypotonia. This study expands the genetic and phenotypic landscape of mitochondrial …