Digital Commons Network^™

Patent Pending: How The Current Patent Utility Requirement Hinders Biotechnological Innovation, Madison Drlik

Journal of Law and Health

The legal system is always playing catch up to adapt to new legal landscapes, doctrines, and technology; however, patent law needs help to compete with biotechnological research in the race towards innovation. Biotechnological research in the realm of human health and medicine often involves the use of therapeutic drugs. The field of healthcare biotechnology takes biological systems and processes and generates novel, creative solutions to a number of human health conditions. However, the translation process for a new drug, therapy, or process is long and expensive which requires investors to help the researchers and scientists move their creations from inception …

Evaluating The Fate And Variability Of Soil Organic Carbon And Nitrogen Species Under Conservation Practices In The Raccoon River Watershed, Zhonglong Zhang, May Wu

Civil and Environmental Engineering Faculty Publications and Presentations

This study evaluates the fate and variability of soil organic carbon (SOC) stocks and nitrogen species using the latest version of the Soil and Water Assessment Tool– Carbon (SWAT-C) and assesses how conservation practices influence their dynamics in the Raccoon River Watershed (RRW). Dominated by intensive agricultural pro- duction, the RRW is a significant contributor of sediment and nutrient loads to local rivers and the Mississippi River. This SWAT-C model simulates the export of SOC and nitrogen species and evaluates their responses under varying management scenarios. Model calibration was performed for streamflow, sediment, nitrate, total nitrogen, and organic carbon with …

Fort Hays State University Tiger Weekly, January 16, 2026, University Relations

Tiger Weekly Newsletters

No abstract provided.

Single-Cell Rna Sequencing Suggests Different Progenitor Lineages Between Idh Mutant And Idhwt Glioma, Iyad Alnahhas, Allison Kayne, Mehak Khan, Wenyin Shi

Department of Neurology Faculty Papers

Introduction Single-cell RNA sequencing has elucidated the heterogeneity in cancer. Single-cell glioblastoma (GBM) analyses have also proposed the resemblance of GBM cells to radial glia and outer radial glia (oRG) supporting the hypothesis that remnants of developmental tissue get reactivated in cancer. A recent study isolated neural progenitor cells (NPCs) from developing fetal human brain (gestational week 17-19) and classified NPCs based on their expression of THY1 (CD90), CD24 and EGFR. Ventricular radial glia are THY1⁻CD24⁻EGFR⁺ whereas oRG are THY1⁻CD24⁻EGFR⁻. Early neuron precursors are CD24⁺THY1⁻EGFR …

Where Americans Get And Trust Political Information: Traditional Media Leads, Social Media Grows, Ai Emerges, Hwayong Shin

Weidenbaum Center Survey (WCS) Reports

Where do Americans turn for political information—and which sources do they actually trust? As traditional news organizations struggle with declining public trust (Brenan 2025; Ladd 2012), social media platforms (e.g., Facebook, Instagram, X) and artificial intelligence (AI) tools (e.g., ChatGPT, Gemini, Copilot) are increasingly stepping into the information space (Bode 2016; Podimata & Cen 2025). Yet little is known about how these sources compare in citizens’ minds. This question matters because a well-functioning democracy depends not just on the availability of information, but on which sources individuals use and trust to support informed political judgments (Lupia & McCubbins 2019; Soroka …

Optimal Murine Cd4+ T Cell Priming By Mrna-Lipid Nanoparticle Vaccines Requires Endogenous Antigen Processing, Julia E. Rood, Suh Kyung Yoon, Mary K. Heard, Stephen D. Carro, Emma J. Hedgepeth, Mary E. O'Mara, Michael J. Hogan, Nhu Le, Hiromi Muramatsu, Kieu Lam, Petra Schreiner, Coral Kasden, Hansell H. Stedman, Ryan A. Langlois, James Heyes, Norbert Pardi, Laurence C. Eisenlohr

College of Life Sciences Faculty Papers

Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines elicit robust CD4+ T cell responses, yet the mechanisms underlying this T cell priming remain unknown. Antigens presented to CD4+ T cells on major histocompatibility complex class II (MHC II) are traditionally acquired by antigen presenting cells (APCs) from extracellular sources. Here we show that vaccine specific CD4+ T cell responses instead rely on antigen directly expressed within APCs, without extracellular transit. Murine APCs treated with mRNA-LNP vaccines activate T cells more efficiently when presenting antigen produced internally, rather than acquired externally. Immunization with mRNA-LNP vaccines engineered to inhibit antigen expression in APCs results …

Institutional Practices Drive Antibiotic Variability In Neonatal Intensive Care Units: Baseline Evidence To Inform National Stewardship Interventions In Oman, Abdullah Alqayoudhi, Manoj Malviya, Sathiya Murthi, Mohammed Rasik Nv, Adil Said Al-Wahaibi, Raya Al-Habsi, Said Al-Balushi, Talal Alwardi, Agha Hatif Shamsi, Halah Bait Raidan, Aamera Al-Majrafi, Preethi Kiran, Eyad Hani Abu Abu Alhaijaa, Kawther Al Amri, Khalfan Al Abdali, Mohammed S. Al Reesi, Nasser Al-Shafouri, Amal Al-Jabri, Sachin Shah, Said Al-Kindi, Zubair H. Aghai, Mohammed Al-Yahmadi, Amal Al-Maani

Department of Pediatrics Faculty Papers

Background: Antibiotic overuse in Neonatal Intensive Care Units (NICUs) is a major contributor to antimicrobial resistance and adverse neonatal outcomes. This study aims to evaluate baseline antibiotic utilization (AU), identify factors influencing variability, and assess the impact of neonatal characteristics and sepsis incidence. Methods: A multicenter retrospective analysis examined AU in seven NICUs from 2019 to 2023, involving 25,532 neonatal admissions during national antibiotic stewardship program implementation. Data encompassed neonatal clinical parameters, sepsis incidence, and AU metrics, including days of therapy (DOT) per 1000 patient-days. Statistical analyses included correlation assessments and multivariate regression to identify determinants of antibiotic use. Results: …

The Ethical Limits Of Physician Autonomy In Reproductive Medicine, Isabel Martens

Honors Theses

In vitro fertilization is a relatively new medical practice that helps people who face infertility be able to reproduce. Reproductive medicine providers face ethical dilemmas often in their field, only some of which have standards of care. There are questions in the medical landscape pertaining to physician autonomy versus patient autonomy, which heavily apply to reproductive medicine providers. Patient autonomy is highly valued in medical ethics; however, physician autonomy should also be considered. When a physician decides who can and cannot reproduce, ethical considerations must be followed to maintain the practice of reproductive autonomy. Limited policies exist that manage reproductive …

Minutes (1-16-2026), California State University, San Bernardino - Associated Students, Incorporated

Associated Students, Incorporated records

No abstract provided.

Elevated Trna Halves In Olfactory Epithelial Cells Of Patients With Schizophrenia, Justin T. Gumas, Megumi Shigematsu, Karin E. Borgmann-Winter, C. G. Hahn, Yohei Kirino

Computational Medicine Center Faculty Papers

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

Human Capital And Development, Philippe Aghion, Ingvild Almås, Costas Meghir

Cowles Foundation Discussion Papers

Human capital is central to efforts to promote growth, convergence, and the elimination of poverty. Drawing on seminal macroeconomic frameworks by Nelson-Phelps, Lucas, and subsequent developments, alongside macro and microeconomic evidence, the chapter examines the role of human capital in driving innovation and growth, emphasizing how different types of human capital matter at different stages of development, and discussing obstacles to accumulation and evidence from policy interventions.

Probability Cueing In Large-Scale Environmental Search: The Role Of Landmark Cues In Statistical Learning, Shaun Dordoy, Rory Baxter, Alastair Smith

School of Psychology

Efficient environmental search is an important and adaptive everyday skill. A particular feature of theoretical interest is whether large-scale search is informed by the spatial statistics of the environment - probability cueing is a robust effect in two-dimensional visual search tasks, but studies of large-scale search have generated equivocal findings. Here, we examined whether sensitivity to a statistical cue specified within an allocentric reference frame is modulated by the presence and location of environmental landmarks. Participants explored fully immersive virtual environments, wherein they were presented with an array of locations (columns) and required to search them for a hidden target …

Exploring The Experience Of Co-Designing Mental Health Services In The National Health Service As An Expert By Experience, Annabelle Mccall, Peta Temple, River Rose, Pete Keohane, Lealah Hewitt-Johns

School of Psychology

PurposeThe number of Experts by Experience (EbE) working in mental health services has grown in recent years. The National Health Service (NHS) five-year plan states EbE should be used across different levels, including service delivery, design and commissioning. While current research explores the role of EbE in service delivery, little is known about their experiences of co-designing services. This study aims to explore EbE experiences of co-designing NHS mental health services.Design/methodology/approachThis research used qualitative semi-structured interviews with ten participants who had worked on projects focused on co-designing NHS mental health services as an EbE. Data were analysed using reflexive thematic …

Masthead, Cleveland State Journal Of Law And Health

Journal of Law and Health

No abstract provided.

Fda's New Approval Plan For Covid-19 Vaccines: An Inquiry Of "Benefit" Rather Than The Statutory Scope Of "Safety, Purity, And Potency"?, Henry Yat-Shing Kwan

Journal of Law and Health

This article analyzes the FDA's proposed policy plan issued in May 2025 regarding the approval of Covid-19 boosters for different groups of persons. It offers two constructive recommendations that will help prevent constitutionality challenge on impermissible intrusion of the freedom of health.

The first is to avoid using the confusing term "benefit" but instead focus on the statutory parameters of "safety, purity, and potency." The affected group can make a strong case that their free choice of vaccination should not be deprived, as long as the vaccine qualifies for the statutory thresholds of being safe, pure, and potent. They are …

Clinicopathological Features Of Colorectal Cancer In Young Patients In Comparison With Older Patients, Bahaa Al-Neama, Wasam Al-Asadi

Iraqi National Journal of Medicine

Background:  Colorectal cancer (CRC) has traditionally been considered a disease of older adults; however, recent evidence shows an increasing incidence among younger patients. Understanding the differences in clinicopathological features between young and older individuals is essential for improving early diagnosis, treatment strategies, and outcomes. Aim: The primary objective of this study is to compare the demographic profiles and clinicopathological characteristics of younger patients (aged <40 years) with those of older patients (aged ≥40 years) diagnosed with colorectal cancer. Methods: Eighty-five consecutive patients admitted to our hospital were prospectively followed for their entire hospital stay or up to 7 days, whichever came first. Each patient's blood glucose measurement was recorded according to ward protocol. Indices included total blood glucose per ward, per patient-day, or patient stay, and percentage blood glucose levels per predefined cut points to assess the incidence of hypo-, eu-, and hyperglycemia. The trial registration number at Clinicaltrials.org is NCT04800861. Results: Total data consisted of 645 blood glucose tests from 85 patients and 284 patient-day results, with an average of 2.27 tests per patient-day and 7.59 measurements per patient stay. The percentage of blood glucose in the range (80–180 mg/dL) varied by model, with patient-day showing the highest results at 48.24%, while the percentage of patients with hypoglycemia (blood glucose <60 mg/dL) was highest per patient stay at 1.18%. Conclusions: Younger colorectal cancer patients in this study presented more frequently with rectal tumors, poor differentiation, and advanced disease stages. Despite similar symptom profiles, delayed diagnosis may contribute to worse pathological features. These findings support the need for greater awareness and consideration of earlier screening in younger populations.

Distribution System Reliability Evaluation Considering Protection Coordination Using Petri Nets, Rani Kumari, Bhukya Krishna Naick

Turkish Journal of Electrical Engineering and Computer Sciences

Maintaining reliable and high-quality power delivery becomes increasingly complex with expanding power grids. The lack of protection coordination poses a significant threat, compromising overall system reliability. This research addresses this challenge by proposing a method for coordinating protective devices within the distribution system, specifically during network faults. The proposed approach utilizes a stochastic timed Petri net (STPN) based methodology to model protective device coordination across various fault scenarios. This technique effectively captures the dynamic behavior and interactions of protective equipment, allowing for the anticipation of potential disturbances. This proactive insight facilitates preventative measures to address prewarning situations, thereby preventing cascading …

A Programmable Genetic Platform For Engineering Noninvasive Biosensors, Asish N Chacko, Kaamini M Dhanabalan, Jinyang Wan, Roy Chien, Nolan T Anderson, Binzhi Xu, Katie Pham, Ritu Tiwari, Arnab Mukherjee

Faculty, Staff and Student Publications

Creating genetic sensors for noninvasive visualization of biological activities in optically opaque tissues holds immense potential for basic research and the development of genetic and cell-based therapies. Magnetic resonance imaging (MRI) stands out among deep tissue imaging methods for its ability to generate high-resolution images without ionizing radiation. However, the adoption of MRI as a mainstream biomolecular technology has been hindered by the lack of adaptable methods to link molecular events with genetically encodable contrast. Here, we introduce modular aquaporin-based protease-activatable probes for enhanced reporting (MAPPER), a platform for the systematic creation of genetic sensors for MRI. To develop MAPPER, …

Selective Deletion Of Slc2a1 From The Rpe Reveals That Rods But Not Cones Depend On Glucose Transport Across The Outer Blood-Retinal Barrier, Lauren L. Daniele, John Y.S. Han, Minzhong Yu, Ravi A. Sangani, Craig D. Beight, Cyrus Rostami, Philip D. Kiser, Neal S. Peachy, Nancy J. Philp

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

GLUT1 facilitates a continuous flow of glucose across the inner and outer blood-retinal barriers (BRBs) to support vision. To understand the extent to which photoreceptors rely on glucose transport across the outer BRB, we generated a tamoxifen-inducible conditional knockout of Slc2a1 in the retinal pigment epithelium (RPE) (RPE-iΔGlut1). In the RPE-iΔGlut1 mice, rod photoreceptors exhibited impaired outer segment renewal and decreased the expression of proteins involved in phototransduction and ciliary transport. Proteins regulating the retinal stress response increased. Cone photoreceptors were functional and viable 15 months post-tamoxifen treatment in the RPE-iΔGlut1 mice, while 70% of the rods died. …

Leadless Versus Transvenous Dual-Chamber Pacemakers: Real-World Evidence From Aveir Dr Coverage With Evidence Development Study., Monica Lo, Anish K Amin, Marcin Kowalski, Anne Kroman, Dilip Mathew, Valay Parikh, Stanislav Weiner, Jennifer M Joseph, Leonard Ganz, Mohammed Mortada

Heart and Vascular Articles

BACKGROUND: AVEIR DR, an industry-first dual-chamber leadless pacemaker (LP), provides continuous atrioventricular synchrony through implant-to-implant (i2i) communication between atrial and ventricular LP devices. It is important to evaluate the early real-world comparative safety of AVEIR DR LP.

OBJECTIVE: To compare complications and mortality between AVEIR DR LP and dual-chamber transvenous pacemakers (TP).

METHODS: De novo LP and TP patients were identified in Medicare Fee-for-Service claims (October 2023 and December 2024). Outcomes were 30-day and 6-month complications, reinterventions, heart failure hospitalizations, and all-cause mortality. Comparisons were adjusted for demographics, comorbidities, and hospital encounter characteristics.

RESULTS: Compared to TP (N = 77 …

Differential Blood-Brain Barrier Permeability Driven By Asymmetric Hypoperfusion In A Vascular Dementia Model, Mengjun Dai, Kuizhi Qu, Ying Jiang, Song Gao, Yan-Ning Rui, Zhen Xu

Faculty, Staff and Student Publications

Introduction: Blood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cerebral hypoperfusion. This study aimed to investigate the effects of asymmetric hypoperfusion on BBB permeability using a mouse model of VaD.

Methods: Asymmetric bilateral common carotid artery stenosis (ACAS) was induced using ligature rings. BBB integrity was assessed on 3 days post-surgery using Evans blue, IgG, and albumin extravasation. A modified tissue processing protocol optimized endogenous marker detection. Regional and sex-based differences in BBB permeability were analyzed.

Results: Increased BBB permeability was observed in both corpus callosum …

Role Of The Etv5/P38 Signaling Axis In Aggressive Thyroid Cancer Cells, Jerry H Houl, Rozita Bagheri-Yarmand, Muthusamy Kunnimalaiyaan, Paola Miranda Mendez, Joseph L Kidd, Ali Dadbin, Andrea Ruiz-Jurado, Parag A Parekh, Ying C Henderson, Nikhil S Chari, Aatish Thennavan, Reid T Powell, Clifford C Stephan, Xiao Zhao, Anastasios Maniakas, Roza Nurieva, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mark Zafereo, Jennifer R Wang, Stephen Y Lai, Marie-Claude Hofmann

Faculty, Staff and Student Publications

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops. The exact cause of this resistance remains unclear. We previously found that in PDTC and ATC cells, the BRAFV600E mutation is strongly linked to the expression of ETV5, a transcription factor downstream of the MAPK pathway. In the current study, we …

Integrative Spatial Multi-Omics Reveal Niche-Specific Inflammatory Signaling And Differentiation Hierarchies In Aml, Enes Dasdemir, Ivo Veletic, Christopher P Ly, Andres E Quesada, Christopher D Pacheco, Fatima Z Jelloul, Pamella Borges, Sreyashi Basu, Sonali Jindal, Zhiqiang Wang, Alexander Lazar, Khalida M Wani, Dinler A Antunes, Patrick K Reville, Preethi H Gunaratne, Robert J Tower, Padmanee Sharma, Hussein A Abbas

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a clonal disorder characterized by immature blasts and arrested differentiation that primarily affects the bone marrow (BM) and occasionally presents as extramedullary (EM) disease. EM manifestations highlight AML's adaptability to distinct microenvironments, which we examined using spatial analyses of medullary and EM tissues. We describe a workflow for Visium-based spatial transcriptomics in medullary and EM AML, revealing insights into cell-cell communication and the spatial organization of AML hierarchies. In BM, monocytes and granulocyte-monocyte progenitors colocalized with leukemic populations, sharing molecular signatures with those in EM sample. CXCL12-CXCR4-mediated communication correlated with PI3K/AKT/mTOR signaling in inflammatory niches.

Opioid Use After Screw Fixation Of Slipped Capital Femoral Epiphysis., Jonathan R. Warren, Stephanie Coupal, Colleen M. Moreland, Mckenna C. Noe, George E. Quaye, Lisa Berglund, Caleb W. Grote

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common pediatric hip disorder primarily managed with transphyseal screw fixation. Opioid pain medication is often used postoperatively, but there is little evidence to guide prescribing practices. The purpose of this study was to describe opioid utilization and prescribing practices for patients after screw fixation of SCFE.

METHODS: This was a prospective observational study of patients with SCFE who underwent transphyseal screw fixation. Patients and guardians were contacted on postoperative days 1, 3, and 5 for data collection. Postdischarge analgesic use, pain severity using a parental proxy, and pain control satisfaction were recorded. …

The Effectiveness Of Respiratory Syncytial Virus Prophylaxis Programme Using Palivizumab In Preterm Infants: A Single Institute Retrospective Study, Hilal Al Mandhari, Saif Al Kendi, Noura Al-Balushi, Aqeela Bintaqi, Abdulrahman Al Saadi, Mohamed Abdellatif

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate the effectiveness of an established respiratory syncytial virus (RSV) prophylaxis programme by assessing RSV-related hospitalisations (RSVH) and identify associated risk factors among preterm infants born at <32 weeks’ gestation. Methods: This retrospective cohort study was conducted at Sultan Qaboos University Hospital, Muscat, Oman. Eligible participants were preterm infants <32 weeks’ gestation, born between January 2015 and December 2020, who received RSV prophylaxis. Data were extracted from electronic medical records and analysed. Results: A total of 282 infants were included. The mean gestational age was 28.56 ± 2.03 weeks and the mean birth weight was 1.23 ± 0.35 kg. A total of 5 infants (1.8%) experienced RSV-related hospitalisation while receiving palivizumab prophylaxis. Infants with RSVH were significantly more likely to be …

College Students' Barriers To Mental Health Support Services: A Practitioner's Perspective, Rebecca C. Johnson

Dissertations, Theses, and Projects

The purpose of this study was to identify barriers to accessing mental health support for college students from the perspective of college faculty counselors. In 2022, research indicated that over 60% of college students met the criteria for one or more mental health conditions (Lipson et al., 2022), though data published in the same year revealed that practitioners employed at colleges and universities are only supporting an average of 12.2% of the student population (Bruns et al., 2023). While college counseling centers have reported increasing usage rates, there remains a gap in the number of students utilizing services versus those …

Prevalence And Factors Associated With Regular Fast-Food Consumption Among The Adult Population In Qatar: Cross-Sectional Analysis From Qatar Biobank Cohort, Alaa Zuhair Massarweh, Lynne Alexandra Kennedy, Asayel Saleh, Aljazi Al-Thani, Ala Al Rajabi

All Works

Background The Eastern Mediterranean Region has undergone a rapid nutrition transition over the last three decades, with healthier traditional table diets displaced by energy-dense convenience foods. To the best of our knowledge, this is the first large cohort-based estimate of regular fast-food consumption (RFFC >= 1 time/week) and its correlates among the adult population in Qatar using Qatar Biobank, a volunteer prospective cohort of Qataris and long-term residents.Methods A cross-sectional study using a simple randomized sample of 2,000 adult participants from the Qatar Biobank (QBB) longitudinal cohort. Dietary intake was assessed using a validated food-frequency questionnaire. RFFC was modeled as …

Ai Derivation And Exploration Of Antibiotic Class Spaces, Adam Bess, Sean Rowland, Chris Alvin, Supratik Mukhopadhyay

Open Access Fund Publications

Purpose The rapid evolution of antibiotic-resistant bacteria poses an urgent global health crisis. A key gap in current antibiotic discovery approaches is the absence of automated chemical synthesis methods designed to systematically generate and evaluate compounds within specific antibiotic classes. We address this gap through fragment-based computational experiments that systematically explore antibiotic chemical spaces.

Methods Our computational methodology consists of three steps: fragmentation of known compounds (eMolFrag), generating new molecular structures by recombining fragments (eSynth), and filtering of candidates based on desired properties (eFilter). eFilter combines structural analysis, pathway information, and protein targets …

Access Is The Outcome: Rethinking Metrics, Worthiness, And Human Rights Across Philanthropy And Development, Stephanie Zabriskie

Faculty Publications

This thought paper examines how philanthropic evaluation frameworks misclassify access to basic human rights as a preliminary step rather than a complete outcome. In competitive funding environments, post-access behavioral metrics such as utilization and compliance are often elevated to outcome status and used to assess program worthiness. Drawing on rights-based and systems-level evaluation frameworks, the paper argues that access itself constitutes a sufficient and legitimate outcome, and that post-access data should function as program management inputs rather than legitimacy or financial thresholds. Reframing access as the outcome has implications for philanthropic accountability, administrative burden, and the ethical consistency of funding …

Combining Dna Methylation Features And Clinical Characteristics Predicts Ketamine Treatment Response For Ptsd, Amir Valizadeh, John D Roache, Xinyu Zhang, Ying Hu, Ralitza Gueorguieva, Lynnette A Averill, Mohini Ranganathan, Zuoheng Wang, Douglas E Williamson, Paulo R Shiroma, Matthew J Girgenti, Ismene L Petrakis, Argelio L López-Roca, Stacey Young-Mccaughan, Terence M Keane, Alan L Peterson, Chadi G Abdallah, John H Krystal, Ke Xu

Staff and Researcher Publications

Post-traumatic stress disorder (PTSD) exhibits extensive clinical and biological variability, making treatment challenging. The Consortium to Alleviate PTSD (CAP)-ketamine trial, the largest randomized study of ketamine for PTSD, found no overall benefit of ketamine over placebo, underscoring the necessity to identify responsive subgroups. Using pre-treatment blood DNA methylation profiles and clinical measures from the CAP-ketamine trial, we applied machine learning to predict treatment response. A model based on 1,208 methylation sites achieved higher predictive accuracy than models using clinical variables alone, and combining both data types further improved performance. The methylation-derived score distinguished responders with 92.9% accuracy. The predictive CpGs …