Digital Commons Network^™

Cognitive Dysfunction In Women With The Fmr1 Premutation During Midlife: The Lassi-L Reveals Curvilinear Cgg-Dependent Risk Buffered By College Education, Jessica Klusek, Jillian Gierman, Amanda Fairchild, Andreana M. Benitez, Elizabeth Berry-Kravis, Marsha R. Mailick

Faculty Publications

Background

The FMR1premutation (FXPM) is a common genetic variant (∼1:151 females) linked to increased risk for neurodegenerative disease. Midlife cognitive phenotypes remain poorly defined.

Objective

To characterize episodic memory performance in midlife FXPM women and examine potential risk moderation via genetic (i.e., FMR1CGG repeat expansion size) and environmental (i.e., college degree attainment) influences.

Methods

Eighty-eight FXPM women and 84 matched controls, aged 30–55, completed the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a measure of specific episodic memory processes sensitive to subtle Alzheimer's disease (AD)-related cognitive and neuropathological changes.

Results

FXPM women demonstrated deficits in proactive semantic …

The Effectiveness Of The Zig-Zag Method In Improving Dribbling Skills In High School Soccer Lessons, Muhammad Rais Hamdan, Fahrial Amiq

Journal of Innovation and Teacher Professionalism

This study aims to enhance football dribbling skills among class XI students at SMAN 2 Malang through the implementation of the zig-zag method. The research adopts a Classroom Action Research (CAR) design conducted in two cycles, each comprising four stages: planning, implementation, observation, and reflection. Data were collected through observation sheets, dribbling performance tests, and documentation to measure both skill improvement and learning engagement. The findings reveal a notable improvement in students’ dribbling ability after the intro-duction of the zig-zag method. During the first cycle, students demonstrated pro-gress in technique and coordination, although learning mastery had not yet achieved the …

Evaluating The Impact Of Lo-Fi Music On Concentration In Physics Learning Among Senior High School Students, Qotrunnada Haq, Tutut Pristiati, Ika Wahyu Widyawati

Journal of Innovation and Teacher Professionalism

Learning concentration is a key component of an effective learning process, particularly for students who frequently encounter various distractions. In the modern era, adolescents often listen to music while studying, and previous studies have shown that music may either enhance or hinder concentration. However, research on the specific influence of low-fidelity (lo-fi) music remains limited. This study employed a quantitative approach with a pre-experimental design involving Grade XI science students at SMAN 1 Dramaga, Bogor. A total of 70 students participated, divided evenly into experimental and control groups. Research instruments included observation sheets, detailed lesson plans (RPP), and questionnaires. The …

The Effectiveness Of Problem-Based Learning In Object-Oriented Programming Instruction: A Classroom Action Research Study, Elva Hidayatul Haque, Slamet Wibawanto, Winda Sulistyana

Journal of Innovation and Teacher Professionalism

This study aims to examine the implementation of object-oriented programming (OOP) instruction using a Problem-Based Learning (PBL) approach to enhance students’ programming skills at SMKN 9 Malang. The research employed a Classroom Action Research (CAR) design conducted through three iterative cycles to systematically improve the learning process. The first cycle focused on the planning stage, in which learning objectives, instructional materials, and problem-oriented learning strategies aligned with OOP concepts were developed. The second cycle involved the implementation of the PBL approach, where students actively engaged in solving contextual programming problems requiring the application of object-oriented principles. During this stage, observations …

January 20, 2026, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Data Altruism: Eu Solution And Path Of Localization In China, Teng Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Data altruism transcends the profit-seeking, monopolistic and competitive nature of the market mechanism. It is driven by innovation and encourages data subjects and holders to share information guided by the public interest. As a new type of data application and service model, it aims to achieve a virtuous cycle of the data ecosystem while optimize the utilization of data resources. Tracing back to the source, the theoretical foundation of data altruism from the ethical theory of altruism, and the concept of its budding was supported by the data for good. Analysis shows that the specific scheme of the EU data …

Effects Of Social Support Interventions On Medical Patient Survival: A Meta-Analysis Of Non-Randomized Clinical Trials, Ksenia Illinykh-Bair, Timothy B. Smith

Faculty Publications

Background: Prior research confirms that social support promotes resilience among medical patients with chronic illness. Beyond emotional benefits, research has increasingly shown the importance of social support on physical health outcomes. Therefore, identifying and evaluating interventions that increase social support among medical patients with chronic conditions is a priority for healthcare. Methods: This meta-analysis summarized data from 39,493 medical patients across 14 non-randomized trials that had been identified by a prior review of the survival benefits of social support interventions. Results: Across four studies reporting hazard ratio data, the results failed to reach statistical significance (HR = 2.10, 95% CI …

Political Economy Of Cross-Border Trade Between Indonesia And Malaysia: Local Product Opportunities And Challenges In West Kalimantan, Shanti Darmastuti, Nurfarah Nidatya, Dini Putri Saraswati, Alfiyah Nur Rahmalia

Jurnal Wacana Politik

As a key element of the political economy, cross-border trade makes a substantial contribution to community welfare while also supporting national economic growth. West Kalimantan, which borders Sarawak, Malaysia, serves as a strategic economic corridor in Indonesia, facilitating the movement of people and goods through the National Border Post. Although local products are the main commodities traded at this border, issues of product competitiveness, market stability, and border security pose major challenges to trade. Within the framework of cross-border political economy, this study examines both the opportunities and challenges in trading local products. It emphasizes how government initiatives, institutional coordination, …

The Influence Of Bapineuzumab And Semagacestat On Rapid Progressors: A Retrospective Cohort Study, Kristofer Harris, Madison Shyer, Dulin Wang, Elizabeth He, Matias Cattani, Catherine Zhang, Christine M Farrell, Xiaoqian Jiang, Yejin Kim, Paul E Schulz

Faculty, Staff and Student Publications

Background: A subset of Alzheimer's disease patients progresses much more rapidly than average. These rapid progressors exhibit accelerated cognitive and functional decline. Potential differences in Alzheimer's biomarkers for rapid progressors and their responses to disease-modifying treatments remain poorly understood, with previous clinical trials and studies producing limited biomarker data and inconsistent results.

Objectives: Examine differences in rapid progressor versus non-rapid progressor outcomes in two AD treatment trials (bapineuzumab and semagacestat) and investigate cognitive and biomarker progression in the placebo groups.

Design: Retrospective cohort study.

Setting: Four randomized, double-blind, phase 3 clinical trials from the Center for Global Clinical Research Data …

Genome-Wide Association Study Identifies Novel Variants In Olfactory, Vitamin A, Vitamin B, And Cadherin Pathways Associated With Learning And Memory, Lloyd N. Hopkins, Nesli Avgan, Heidi G. Sutherland, Francesca E. Fernandez, Emma M. Knowles, Larisa M. Haupt, John Blangero, David C. Glahn, David H. K. Shum, Rod A. Lea, Lyn R. Griffiths

Human Genetics Publications

Learning and memory, as fundamental components of human cognition, are heritable traits that are highly variable between individuals and within populations. Investigation into the genetic basis of cognition is a prominent area of research, with genetic associations being previously reported for a wide range of cognitive phenotypes. Here we utilise a genome-wide association study (GWAS) approach to evaluate the contribution of genetic variation to learning and memory phenotypes in a comprehensively phenotyped, well-characterised, healthy, and unrelated cohort of individuals (n = 613). Cognitive phenotypes were assessed using nine comprehensive test batteries consisting of twenty-one cognitive performance assessments including IQ, five …

Biopcm-Integrated Smart Façade For Hospitals: Thermal Performance Across Floor Levels In A Hot-Arid Climate, Aia A. Qindil, Esraa Elazab, Mohamed M. Shawky Abou Liela

Mansoura Engineering Journal

Hospitals are among the most energy-intensive building types because they operate around the clock and must maintain strict indoor environmental conditions, especially in hot-arid climates. Improving their performance calls for façade solutions that can store thermal energy effectively and help cut carbon emissions. This study evaluates the use of macro-encapsulated BioPCM® within the south façade of a high-rise hospital in Mansoura, Egypt, using dynamic simulations in DesignBuilder (EnergyPlus). The analysis focuses on two vertical levels, the third floor as a typical ward and the seventh floor as a rooftop ward, to investigate how elevation influences PCM performance, an aspect rarely …

Understanding Technology Integration Through Hermeneutic Interpretation: A Study Of Faculty Experiences At An Hbcu, Jill Ardley, Tamara Smith-Moyler, Keesha M. Kerns, Beatrice Darden-Woody, Priscilla Spencer, Ronald White

International Journal of Teaching and Learning in Higher Education

This study explores how six education faculty members in the School of Education at a Historically Black College and University (HBCU) in the southeastern United States interpret and implement instructional technology instruction through a hermeneutic theoretical lens. Grounded in the HBCU’s School of Education vision statement, the research investigates how faculty members’ understanding of human learning behaviors shapes their pedagogical choices within School of Education courses. The qualitative analysis revealed three key themes: (1) Technology as a Tool for Equity and Inclusion, (2) Alignment with the School of Education Vision, and (3) Student-Centered, Practice-Oriented Use of Technology. Rather than employing …

Doctoral Students’ Perceived Academic Research Reading Ability: A Mixed-Methods Study, Ryan Glaman

International Journal of Teaching and Learning in Higher Education

Empirical research is useful for informing educational policy and practice. However, doctoral students often struggle with reading and evaluating empirical research papers. The present study examined doctoral students’ perceptions of their ability to read and evaluate empirical research articles, both before and after an educational research methods course, as well as which course components students perceived as most impacting their ability to read and evaluate research articles. The study used a convergent mixed methods design, involving pre- and post-course survey data. Results indicated students felt they improved in their experience levels, comfort levels, interpretation ability, and evaluation ability regarding reading …

Engaging Asl-English Interpreting Undergraduates In Research: A Model For Student Engagement And Faculty Productivity, Kimberly J. Hale, Valerie Freeman

Journal of Interpretation

Engaging undergraduate ASL-English interpreting students in research yields multiple benefits beyond enhancing faculty scholarly productivity. In this innovative practices article, we first summarize scholarly literature showing that including undergraduates in research experiences supports development of career-readiness skills while simultaneously building the pipeline of future faculty. We then discuss the benefits of undergraduate research experiences and argue that research activities can be integrated throughout an interpreter education program curriculum. Using a detailed description of a course-based undergraduate research experience (CURE) and course-embedded project examples, we demonstrate how structured research experiences can be integrated into programs without creating additional burden for faculty …

The Effects Of A Nurse-Led Peace Program On Perceived Peaceful End-Of-Life And Quality Of Life Among Head And Neck Cancer Patients Undergoing Concurrent Chemoradiation, Sirinya Pimvichai, Yaowarat Matchim, Tanadej Sinthusake, Kiratiya Wongkalasin

Journal of Health Research

Background: Evidence indicates that peaceful end-of-life care programs benefit terminally ill patients, with nurses playing a central role in program delivery. However, no structured end-of-life care programs currently exist for patients with head and neck cancer (HNC), who often experience profound physical and psychological distress. A nurse-led Peaceful End-of-Life Care (PEACE) program was therefore developed. This study aimed to evaluate the effects of the PEACE program on perceived peaceful end-of-life (PEOL) and quality of life (QoL) among HNC patients undergoing concurrent chemoradiotherapy (CCRT).

Methods: A quasi-experimental, two-group time-series design was conducted with 64 HNC patients recruited from oncology wards at …

Preventive Health Behaviors Among Vegetable Farmers In Indonesia: An Application Of The Extended Theory Of Planned Behavior, Aria Gusti, Wira Iqbal, Fitrahul Afifah

Journal of Health Research

Background: Farmers in low- and middle-income countries face serious occupational and environmental health risks, including pesticide exposure, musculoskeletal disorders, and skin diseases. In Indonesia, limited evidence exists on the psychosocial factors that shape preventive health behaviors, hindering the design of effective interventions. This study applies an extended Theory of Planned Behavior (TPB) framework to analyze preventive practices among vegetable farmers.

Methods: A cross-sectional survey was conducted among 254 vegetable farmers in Koto Laweh Village, West Sumatra, Indonesia, during July–August 2025. Data were collected using a validated TPB-based questionnaire and analyzed with Partial Least Squares Structural Equation Modelling (PLS-SEM).

Results: Knowledge …

Hidden Malignancy: Ileocecal Intussusception As An Atypical First Presentation Of Diffuse Large B-Cell Lymphoma In Adulthood, Komal Harisinghani, Parth Adrejiya, Mohammad Abubaker, Oluchi Idenyi, Raman Babayeuski, Noor Qureshi, Ashok Kanugula, Sara Assaf, Daniel Assaf, Srikanth Maddika

Journal of Community Hospital Internal Medicine Perspectives

Intussusception is predominantly a pediatric condition, with only about 5% of all intussusception cases occurring in adults with primary intestinal lymphomas comprising 1%–4% of gastrointestinal malignancies, 90% of which are B-cell non-Hodgkin lymphomas (NHL). Diffuse large B-cell lymphoma (DLBCL), the most common subtype of NHL, often leads to intussusception without classical B symptoms. We present the case of a 33-year-old male with ileocolonic intussusception caused by a 4.8 × 5.3 × 5.5 cm enhancing mass. Histopathology and FISH confirmed DLBCL without MYC, BCL2, or BCL6 rearrangements, ruling out double- or triple-hit lymphoma. Following a right ileo-colectomy, R-CHOP(rituximab, cyclophosphamide, doxorubicin, vincristine, …

Disguised And Dangerous: A Case Of Cervicofacial Actinomycosis Presenting With Hemoptysis, Tharun Shyam, Shamanth M Reddy, Saumya Nanda, Yan Naing Tun, Rohan Pinto, Navjot Somal, Ravi Karan Patti

Journal of Community Hospital Internal Medicine Perspectives

Actinomycosis is a rare, chronic, suppurative bacterial infection caused by Actinomyces spp with an incidence of 0.3 cases per million people annually. The cervicofacial area is the most common site of infection and accounts for approximately 50 percent of all cases. Most cases of cervicofacial actinomycosis are odontogenic in origin.

Hemoptysis in the setting of actinomycosis commonly occurs from pulmonary involvement. Hemoptysis secondary to isolated cervicofacial actinomycosis has seldom been documented in literature. We hereby present a case of cervicofacial actinomycosis presenting with hemoptysis likely secondary to an oro-cervical fistula. We aim to highlight the challenges in diagnosis of this …

Losartan-Induced Angioedema: A Case Report And Review Of Literature, Leila C. Tou, Audrey Nourse, Rachel Cox, Spencer Stanford

Journal of Community Hospital Internal Medicine Perspectives

Angiotensin receptor blockers (ARBs) are frequently prescribed as alternatives to angiotensin-converting enzyme inhibitors (ACEIs), particularly in patients who experience ACEI-induced adverse effects including cough. Although ARBs are associated with a lower incidence of angioedema, rare cases have been reported in patients without prior ACEI exposure. Here, we describe a 58-year-old Black male who developed lip and facial swelling six months after starting losartan. His symptoms did not improve with antihistamines or corticosteroids but resolved after discontinuation of losartan, which was replaced with amlodipine without recurrence. This case emphasizes the need for clinician awareness of ARB-induced angioedema and the importance of …

Slipping Through The Chasm Of Multicenter Hand-Offs - Rare Incidence Of Nintedanib Induced Renal Failure: Case Report, Abid Mm, Khan Mi, Jain T, Daniel A, Flack T, Posner J

Journal of Community Hospital Internal Medicine Perspectives

Introduction: Nintedanib, a receptor tyrosine kinase inhibitor (TKI), is approved for idiopathic pulmonary fibrosis (IPF). While its common adverse effects include gastrointestinal symptoms and elevated liver enzymes, renal toxicity is rare. We report a case of nintedanib-induced kidney failure. Case: An 82-year-old man with IPF and no prior kidney disease developed acute kidney injury (AKI), nephrotic-range proteinuria, volume overload, metabolic acidosis, and hyperkalemia 10 days after starting nintedanib. Extensive serologic investigations were unremarkable. Kidney biopsy showed acute tubular injury, minimal change disease (MCD), focal global glomerulosclerosis, and interstitial fibrosis. Nintedanib and other potential nephrotoxins were stopped, and the patient was …

A Comparison Of Biological Therapies Vs Traditional Immunosuppressant In The Management Of Inflammatory Bowel Diseases: A Narrative Review, Umme Farwah Tahir Dr, Sadaf Noureen, Fnu Partab, Muhammad Waqas Afzal, Maham Afzal, Asad Mehmood, Fatima Afzal, Kaynat Hasan, Fnu Sameeha, Seerat Riaz, Sumyya Tariq, Abida Perveen

Journal of Community Hospital Internal Medicine Perspectives

Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is a chronic immune-mediated condition requiring long-term management. Traditional immunosuppressants, such as corticosteroids, thiopurines, and methotrexate, have been widely used but are associated with broad immunosuppressive effects and significant adverse events. The advent of biological therapies, including tumor necrosis factor (TNF) inhibitors, integrin inhibitors, and interleukin (IL)-12/23 inhibitors, has revolutionized IBD treatment by offering targeted immune modulation. Biologics have demonstrated superior efficacy in achieving and maintaining remission compared to traditional immunosuppressants, particularly in moderate to severe IBD. They provide targeted immune suppression, reducing systemic side effects, but are associated with …

Statin Induced New-Onset Diabetes Mellitus A Narrative Review, Jasvin K Manha, Sumanth Kumar Bandaru

Journal of Community Hospital Internal Medicine Perspectives

Statins are widely used to lower LDL cholesterol and prevent cardiovascular disease. Although generally safe, there is increasing evidence that they may increase the risk of new-onset diabetes mellitus (NODM). Recent studies show a modest but consistent rise in diabetes risk associated with statin use, especially among individuals with prediabetes, obesity, or other metabolic risk factors. High-intensity statins like atorvastatin and rosuvastatin carry a greater risk compared to agents such as pravastatin or pitavastatin. Proposed mechanisms include increased insulin resistance, impaired insulin secretion, and changes in hepatic glucose production. Despite the diabetes risk associated with statins, their well-established cardiovascular benefits …

Short Term Outcomes And Resource Utilization In Patients Admitted For Infective Endocarditis Who Develop Pericardial Effusion: A Retrospective Cohort Study, Nameer Ascandar, Sajog Kansakar, Waqas Qureshi, Aakash Patel, Ahmed O. Farooq, Brett Milford, Suman Pasupuleti, Eduardo J. Lazaro

Journal of Community Hospital Internal Medicine Perspectives

Background: Pericardial effusion (PCE) development in the context of infective endocarditis (IE) may negatively impact clinical outcomes leading to intense resource utilization. Limited contemporary studies exist that examine clinical outcomes, resource utilization and readmission rates in patients admitted for IE who develop PCE.

Methods: We utilized the Nationwide Readmissions Database years 2016-2022 to tabulate all adult admissions for IE. We compared clinical outcomes in patients who developed PCE to those who did not. Survey weighted logistic and linear regression analysis was performed to predict in-hospital mortality, clinical outcomes, costs, and 30-day non-elective readmission in association with PCE.

Results: Of an …

A Strategy For Surge Management: Senior Residents On The Admitting Frontlines, Hamza Saifuddin, Oliver Yockey, Rachelle Pichot, Gwendolyn Brainard, Samantha Labay, Michael S. Wang

Journal of Community Hospital Internal Medicine Perspectives

Hospitals adapt to surges in a variety of ways, including expediting admitting and discharge procedures, hiring temporary staff and locums to meet increased demand, and temporarily expanding or creating facilities. To mitigate negative effects associated with surges, a small community-based hospital’s Internal Medicine (IM) residency program and hospitalist program collaborated by shifting senior residents into admitting physician roles with indirect supervision to meet increased surge needs. This shift allowed an admitting attending physician to shift to a newly created rounding service and, on average, the number of rounding services was increased from seven to nine. Over a fifteen-month period (five …

Empowering Residents In Community-Based Internal Medicine Programs: A Structured Framework Integrating Simulation Labs, Ai, And Gamification, Nirmay Sonar, Zaynah Sadiq, Bernie Sergent

Journal of Community Hospital Internal Medicine Perspectives

Community-based internal medicine residencies train nearly half of all U.S. IM residents and are essential for staffing underserved areas. These programs often face educational gaps due to limited resources, faculty development, and procedural training opportunities. We designed a 12-month quality initiative for 27 residents at a small community hospital blending new high-fidelity simulation drills (e.g. in-situ rapid-response and procedural labs), restructured didactics (gamified quizzes, NEJM Resident 360™, HumanDx cases), enhanced orientation (“intern survival guide”), research education, wellness retreats, community outreach and AI-driven, individualized case feedback. New interventions were implemented alongside existing activities, with targeted outcomes including clinical competency, board readiness, …

The Impact Of Patent Forfeiture On Consumer Protection In The Pharmaceutical Sector, Ghizlane El Hamidi

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

The article examines how the forfeiture or loss of patent protection affects consumer protection in the pharmaceutical field. It reviews the role of pharmaceutical patents as mechanisms that secure inventors’ rights while shaping access to medicines and market dynamics. By discussing the evolution of Morocco’s industrial property framework and the balance between public health considerations and private monopoly rights, the paper analyzes the legal consequences of patent termination on consumer interests and regulatory choices.

Evaluating The Dispensing Of Non-Prescription Antibiotics In Baghdad's Community Pharmacies: A Public Health Concern., Ali Azeez Ali Al-Jumaili, Yusr Burhan Ahmed, Hasan Ali Hasan Shubbar, Mina Mohammed Jabbar

Maaen Journal for Medical Sciences

Background: Despite existing regulatory restrictions from the Iraqi Ministry of Health and global guidance from the World Health Organization, the practice of dispensing antibiotics without prescriptions remains prevalent.

Objectives: This study aimed to assess the prevalence of non-prescription antibiotic dispensing in community pharmacies across Iraq and to evaluate pharmacy personnel’s perceptions and practices concerning antimicrobial use.

Methods: A cross-sectional survey was conducted between January and February 2025, targeting 63 pharmacists working in independent pharmacies across Baghdad and other Iraqi governorates. Data were obtained through a predefined questionnaire administered both in person and online. Descriptive statistics summarized participant demographics and responses, …

The Implications Of Integrating Naturalised Refugees On National Security In Tanzania: Insights From Katumba Old Settlement, Adventina Lauren

Tanzania Journal of Sociology

The threats of flight-related factors of the integrated refugees on Tanzania’s national security have not been given serious attention. The article examined the effect of the 162,156 integrated refugee who fled their country of origin due to ethnic, economic, political, and religious conflicts. The study adopted a case study design mixing both qualitative and quantitative approaches. The data were collected through; a survey, in-depth interviews, direct observation, focus group discussion, and document review. It drew data from a sample of 397 involving both naturalised refugees (IRs) and native Tanzanians (NTs) who have been living in the study area and 31 …

Teachers’ Perceptions Towards Disruptive Behaviours Among Students In Public Secondary Schools In Tanzania, Jonas Kinanda

Tanzania Journal of Sociology

Disruptive behaviours among secondary school students adversely affect students, teachers, parents and community members. This study explores teachers’ perceptions towards disruptive behaviours among students in public secondary schools in Tanzania. This qualitative study involved 50 teachers selected from four public secondary schools from two councils, namely Mwanza City and Ukerewe District, both found in Mwanza Region, Tanzania. Data collection was done through interviews, focus group discussions, and document reviews. The analysis was thematic and MAXQDA. The findings showed that teachers perceived students’ disruptive behaviours as problematic to the teachers, peers, school administrators, parents, and the community at large. This is …

Capitalist Social Relations And The Environment: A Hyena—Baby Gazelle Acquaintance, Nelson Mwesiga Ishengoma

Tanzania Journal of Sociology

Despite playing a critical role in the survival of living beings, several empirical findings all around the world suggest that the planet Earth is now in a perilous state. Whilst acknowledging the influence of several superficial humanistic factors upon which the conventional discourses on the current environmental concerns have long been affixed, this analytical paper contends that such aspects are deficient in comprehending and remedying the problem. Contrarily, attempts to identify the underlying causes and cures of the environmental problem should recognise the modus vivendi of the prevailing capitalistic social relations, which serve as the basis for existing exploitative and …