Digital Commons Network^™

Inaccurate Interpretation Of Hypoxia Signatures From Transcriptomic Analyses In Neuro-Oncology, Rebecca K Simmons, Pratima Raut, Subhi Talal Younes, Marco Gallo

Faculty, Staff and Students Publications

We aim to highlight problems with the biological interpretation of computationally-derived hypoxia signatures for neuro-oncology research. By reviewing important experimental work in the field, we discuss common misinterpretations of the concepts of normoxia and hypoxia. In fact, the concentration of oxygen in the adult brain is in the range of 1-7%. Unfortunately, this oxygen concentration range is often mistakenly considered hypoxic in neuro-oncology experiments, although it should be considered physioxic. Further, given the lack of a universal hypoxic signature, we stress the importance of deriving cell type-specific hypoxic signatures using carefully-executed experiments.

Cerebellar Atrophy In Pediatric-Onset Opsoclonus-Myoclonus-Ataxia Syndrome: A Large International Cohort Study, Rebecca Macrae, Kierstin Hederstedt, Christopher Cortina, Kumaran Deiva, Andrea Klein, Ming Lim, Thomas Rossor, Elizabeth A Sokol, Yasmin Khakoo, Nikita Malani Shukla, Timothy E Lotze, Wendy G Mitchell, Sarah Hopkins, Bo Zhang, Mark P Gorman

Faculty, Staff and Students Publications

Background and objectives: Pediatric-onset opsoclonus-myoclonus-ataxia syndrome (POOMAS) is a rare, neuroinflammatory syndrome that targets the cerebellum and can cause irreversible cerebellar structural changes, namely cerebellar atrophy. We investigated the frequency of cerebellar atrophy, as well as associated risk factors and functional outcome measures, using the largest active POOMAS registry.

Methods: This was a retrospective observational study of participants with POOMAS with disease onset from 1995 to 2025 using data from the multinational, multicenter POOMAS registry. Variables were compared between the cerebellar atrophy subgroups using the Fisher exact test or Wilcoxon rank-sum test.

Results: Of participants with follow-up imaging, cerebellar atrophy …

Parent-Child Neural Dynamics During A Stressful Task: Probing Associations With Temperament And Anxiety, Joscelin Rocha-Hidalgo, Harmony Nguyen, Dakota Reis, Denny Schaedig, Kahlil I Thompson, Susan B Perlman, Koraly E Pérez-Edgar

2020-Current year OA Pubs

Dynamic social interactions between parents and children can contribute to anxiety risk, amplifying shared genetic risk. Research has focused on observed behaviors to explain intergenerational transmission. Neural synchrony may contribute as a biological conduit for behavioral transmission of risk. We examined 109 parent-child dyads (

Genomic Analysis Of Oesophageal Carcinoma (Ec) Identifies Recurrent Mutations In Histone Methyltransferases As A Distinctive Subset, Jingyuan Wang, Moh'd Khushman, Et Al.

2020-Current year OA Pubs

Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility. We aimed to identify the molecular profile of KMT2-MT oesophageal cancer (EC) and associations with patient outcomes. In our study, KMT2 mutations were significantly associated with longer immunotherapy-related overall survival (OS) in the esophageal adenocarcinoma (EA) (21.42 vs 13.42 months, HR = 0.66, 95% CI: 0.50-0.88, P = 0.004), but not in the esophageal squamous cell carcinoma (ESCC). KMT2 mutations were significantly associated with microsatellite instability-high and …

Girls’ Education Roadmap: 2026 Report, Meredith Kozak, Miriam Temin, Lina López-Lalinde, Amaranta Martinez Martinez

Adolescents and Young People

This Roadmap highlights where the gender and education field can align on coordinated action and investment to close critical gender gaps in education and improve learning for all. Building on findings from the original 2021 Girls’ Education Roadmap, it brings together data on the greatest gender and education needs, evidence on evaluated approaches, and where current practice reaches or misses vulnerable learners. From this foundation, the Roadmap organizes insights around 18 gender-related barriers to education, giving decision makers a framework for diagnosing context specific challenges and identifying proven approaches to address them.

The Cross-Section Of Empirical Evidence And Personal Experience: A Deeper Look At School Resource Officers Through The Lens Of Demarcus A. Jenkins' Research On The Public Opinion Of Their Potential Removal From Public Schools, Quin Armstrong

University Honors Theses

Following the 2020 Black Lives Matter and Anti-Police movements, there were many discussions across the nation about possible changes to law enforcement operations. Among these discussions included specific discussions about what to do about law enforcement officers stationed in schools. These law enforcement officers are known as school resource officers, or SROs.

The focus of this thesis is specifically on Portland, Oregon's Portland Public School (PPS) district's decision to sever ties with the Portland Police Bureau, and what may have contributed to that ultimate decision. This is accomplished through an analysis of a research paper written by fellow Criminal Justice …

Research Priorities For Robust Climate Assessments In The United States, Melissa A. Kenney, Robert E. Kopp, Constantine Samaras, Marina Alberti, Sonia Y. Angell, Jennifer Burney, Colin Cunliff, Elliott T. Gall, J. T. Duffy-Anderson, Multiple Additional Authors

Mechanical and Materials Engineering Faculty Publications and Presentations

Scientific assessments play a critical role in synthesizing evidence to support evidence-based decision-making in many sectors and topics. For climate change, large-scale assessments like the Intergovernmental Panel on Climate Change (IPCC) and the United States (U.S.) National Climate Assessment (NCA) reports help many different users—from national government to local governments, Indigenous Peoples and communities, the private sector, the social sector, and the scientific community itself—navigate the complex field of climate risks, impacts, and integrated solutions. While co-creation with users is essential to developing actionable assessments, this paper lays the groundwork for future processes by identifying many advancing and emerging areas …

Energy Conservation In Mri: Sequence Selection And Operational Strategies, Nathan Scherer, Felicia Wang, Andrew L Chang, Mariam Malik, Anna Schroeder, Heather Craig, Benjamin E Northrup

2020-Current year OA Pubs

RATIONALE AND OBJECTIVES: The healthcare system accounts for approximately 9.8% of the United States' (U.S.) greenhouse gas emissions, much of which is due to imaging, particularly magnetic resonance imaging (MRI). This study investigates the components of MRI energy consumption and compares sequences that may be interchangeable in clinical practice. Although the greatest potential for decreasing energy expenditure lies in reduction of inappropriate imaging and optimizing energy consumption of idle MRI equipment, sequence substitution offers an underexplored solution that can potentially be implemented without changing practice patterns or capital expenditure.

MATERIALS AND METHODS: MRI energy expenditure of one machine was monitored …

Pediatric Hypertension Prevalence With 1 Vs. 2 Vs. 3 Within-Visit Blood Pressure Readings (Nhanes 2013-2020), Sandeep K Riar, Donald L Batisky, Scott Gillespie, Andrew M South

2020-Current year OA Pubs

To compare hypertension prevalence using 'initial' blood pressure (BP), 'subsequent' BP (averaged second and third readings) and 'total' BP (averaged three readings), we included 8-17-year-old youth with three BP readings from NHANES 2013-2020. From 2013-2016, BP was obtained using auscultation (manual protocol, MP) and subsequently, using oscillometry (automated protocol, AP). We excluded subjects with 'zero' diastolic blood pressure (DBP). In 5656 subjects, clinical hypertension (high systolic blood pressure [SBP] and/or DBP) prevalence was highest with 'initial' BP (350/5 642, 6.2% [95% CI 5.6-6.9%]), lower with 'subsequent' BP (289/5 642, 5.1% [4.6-5.7%], p <  0.001), and lowest with 'total' BP (251/5 642, 4.4% [3.9-5.0%], p <  0.001). Both MP and AP groups maintained this trend with a significantly lower hypertension prevalence with 'total' vs. 'subsequent' BP. An exception to the trend occurred in the AP group for three conditions: diastolic hypertension, hypertension in high BMI and Hispanic subjects. Diastolic hypertension prevalence with 'subsequent' DBP (86/2 285, 3.8% [3.1-4.6%]) exceeded that with 'initial' DBP (83/2 285, 3.6% [2.9-4.5%]) and was lowest with 'total' DBP (59/2 285, 2.6% [2.0-3.3%]). Diastolic hypertension prevalence was higher (126/5 642, 2.2% [1.9 - 2.7%]) with the 2016 European guidelines (same as 'subsequent' DBP) than with 'total' DBP (94/5 642, 1.7% [1.4 - 2.0%]). Our findings support the inclusion of the first BP reading in BP categorization, as 'total BP' leads to lower hypertension classification than 'subsequent' BP.

Towards Human-Centered Digital Health Interventions, Kristin M Kostick-Quenet, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

This article discusses the potential of digital health interventions (DHIs) in mental health care, emphasizing the importance of designing them to foster genuine humanistic care. It highlights current challenges in measuring engagement and outcomes, advocating for integrating human-centered endpoints such as dignity, autonomy, and therapeutic alliance into evaluation frameworks. The authors call for mechanistic research to identify effective engagement strategies and context-specific implementation approaches. Ultimately, successful DHIs should demonstrate both clinical efficacy and the preservation of humane, person-centered care, ensuring ethical and meaningful mental health support through technology.

Legal Geographies Of The Public Trust Doctrine, Alida Cantor, John P. Casellas Connors, Elizabeth Carlino

Geography Faculty Publications and Presentations

The Public Trust Doctrine (PTD) is a legal principle that recognizes a duty of the government to hold certain natural resources in trust for public benefit. The doctrine has been extended within the United States to address issues of water, coastal access, wildlife conservation, and climate change. Its implementation is spatially uneven and subjective, however, raising geographic questions around scale, power, and political economy. This article uses a legal geographic approach to understand the PTD. Focusing on water, wildlife, and atmospheric resources, we analyze themes of scale and jurisdiction, property and commons, and legal and environmental subjectivity. We argue that …

Nf1 Loss In Estrogen Receptor-Positive Breast Cancer Induces Osteoclast Formation And Immunosuppression To Promote Bone Metastasis, Zifan Zhao, Ze-Yi Zheng, Jonathan T Lei, Matthew J Baik, Yi-Hsuan Wu, Lauren K Somes, Andres F Mosquera Paternina, Omar A Harb, Owen A Chang, Fengshuo Liu, Matthew V Holt, Junkai Wang, Igor Bado, Hai Wang, George Miles, Zbigniew Gugala, Meenakshi Anurag, Ahmed Elkhanany, Yi Li, Valentina Hoyos, Xiang H-F Zhang, Eric C Chang

Faculty, Staff and Students Publications

Estrogen receptor-positive (ER+) breast cancer exhibits a marked propensity for skeletal metastasis; however, the molecular drivers of bone colonization remain incompletely defined. We investigated the tumor suppressor neurofibromin (NF1), a dual repressor for RAS and ER signaling, whose inactivation promotes endocrine therapy (ET) resistance and is associated with inferior relapse-free survival. NF1 copy number loss was detected in 62% of ER+ patients who subsequently developed metastases and was associated with an increased likelihood of bone metastases at initial diagnosis. In mouse xenograft models, NF1-depleted ER+ breast cancer cells demonstrated enhanced dissemination to skeletal sites following surgical resection of primary tumors. …

Bivip: A Competitive Neural Network For Bilateral Visuo-Haptic Processing, Eleonore Federica Di Rosa, Aaisha Sheth, Jeffrey Min-In Yau, Laura Astolfi, Cristiano Cuppini

Faculty, Staff and Students Publications

Visuo-haptic interactions are gaining interest in perception research because of their relevance to robotics and rehabilitation. While the benefits of integrating concurrent visuo-tactile cues are well-documented, the temporal dynamics of competitive interactions between vision and touch remain less understood. Building on extant empirical evidence of unilateral intersensory switching, we ask whether bilateral detection of visual and tactile stimuli can be explained by cross-sensory competition and explore the underlying sensorineural dynamics via a multi-level neural network model. Tested against results from a speeded reaction time task to unilateral and bilateral visual, tactile, and visuo-tactile targets, the network successfully predicts higher switch …

Assessment Of Glycemic Control Among Patients With Type 2 Diabetes Mellitus Attending A Tertiary Diabetes And Endocrinology Center In Sulaymania City/ Iraq, Lina Ali Al-Khafaji, Bahjat Abdulridha Alsaeedy

Muthanna Medical Journal

Introduction: The sociodemographic and clinical factors play a role in type 2 Diabetes Mellitus (T2DM) glycemic control.
Objectives: To assess glycemic control among T2DM patients and its association with sociodemographic and clinical factors.
Materials and methods: A prospective observational study of 210 patients with T2DM at a tertiary diabetes and endocrinology center in Sulaymania city/ Iraq, from April to November 2024. The study involved sociodemographic data, body mass index, blood pressure, and blood tests for HbA1c, fasting blood sugar, total cholesterol, LDL, HDL, triglycerides, blood urea and creatinine. The performed HbA1c tests were compared with baseline results to identify differences, …

Molecular Detection Of Staphylococcus Aureus: A Performance Comparison Of Colony Pcr And Conventional Pcr Targeting The Icab Gene, Farah Badri Abed, Shahrazad Hazim Muhi, Sahar Mustafa Ibrahim, Riyam Alaa Mohammed

Muthanna Medical Journal

Background: Staphylococcus aureus is an important nursing disease that requires a prompt and effective diagnosis to implement a strategy to curb its transmission and spread. Although the gold standard is the conventional PCR using column-purified genomic DNA, Colony PCR with crude cell lysates saves a lot of time and cost of the test and its performance features have not been well established.
Objectives: This paper will compare Colony PCR (boiling method) and Conventional PCR (ABIOpuretm kit extraction) to amplify icaB gene (141 bp), which is a major determinant of biofilm formation in S. aureus and then assess their application with …

An Investigative Approach Leveraging Digital Twin Technology For A Cnc Machine, Anand Valiavalappil

Yanbu Journal of Engineering and Science

Digital twin technology has emerged as an effective approach for improving the monitoring, validation, and optimization of Computer Numerical Control (CNC) machining operations. This study presents an investigative framework integrating Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM), Software-in-the-Loop (SIL), and Hardware-in-the-Loop (HIL) methodologies for diagnosing and rectifying machining defects in CNC systems using the digital twin - virtual model (component and asset twins). Four machining experiments were conducted using Aluminum 6061-T6, Polytetrafluoroethylene (PTFE), Brass, and Stainless Steel (AISI 304) on an EMCO CNC machine integrated with Siemens 840D controls. The first two experiments, involving turning and drilling operations, are presented in detail; the …

Investigating How Personal Values Shape Tourism Experiences: A Case Study Of The Irish National Stud And Gardens, Amy Monahan, Ann T. Conway

International Journal of Tour Guiding and Visitor Attraction Research

This Paper explores the relationship between personal values and tourism experiences  that are  satisfying. A case study of the Irish National Stud and Gardens was undertaken in order to explore this concept. Interviews were conducted to investigate how qualities of the attraction appealed to the visitors’ personal values, thereby enhancing the overall visitor experience. A set of personal values were identified which were specific to the destination. The research demonstrated how an understanding of personal values can assist attractions with various aspects of their operations, with context specific recommendations provided at the end. This approach was taken was taken to …

Exploring The Backgrounds, Experiences, Motivations, And Development Of School-Based Wheelchair Sport Coaches, Deborah Shapiro, Scott Douglas, Jp Barfield, Laurie A. Malone

Journal of Coach Development

Coaching in adapted sport is a complex and demanding practice that requires both specialized technical expertise and a deep understanding of disability. This study explored the motivations, backgrounds, and developmental pathways of interscholastic school-based wheelchair sport coaches. We examined how coaches are introduced to wheelchair sport coaching, their initial and ongoing development, and their perspectives on effective coaching and training practices. A total of 17 coaches (10 men, 7 women) with 1 to 17 years of experience in wheelchair sports coaching from 7 interscholastic wheelchair sports teams participated in one 60-minute mini focus group discussion and responded to a set …

Coming Soon To A Cellar Near You: Novel Range Expansion Of A Short-Bodied Cellar Spider, Physocyclus Enaulus (Araneae: Pholcidae), In A Building In Central Illinois, Usa, Ricky Gieser, Mark Davis

The Great Lakes Entomologist

A reproductive population of Physocyclus enaulus Crosby, 1926 (Pholcidae: Araneae), a short-bodied cellar spider native to the American southwest and Mexico, is documented for the first time in a single building in Illinois, far outside of their known native range. The means of introduction is unknown but is likely influenced by either accidental hitchhiking spiders or a deliberate introduction to control brown recluse populations. Cellar spiders were purchased and released in the same building to predate on brown recluse spiders, but the first P. enaulus individual was found a year prior to the release. These cellar spiders have a wide-ranging …

Seasonal Emergence, Egg Gallery Characteristics, And Natural Enemies Of The Eastern Ash Bark Beetle, Hylesinus Aculeatus (Coleoptera: Curculionidae: Scolytinae), In Michigan, Robert A. Haack

The Great Lakes Entomologist

Hylesinus aculeatus Say (Coleoptera: Curculionidae: Scolytinae) commonly infests the trunks and limbs of recently dead, dying, or cut ash (Fraxinus spp.) trees in eastern North America. In the Great Lakes region, H. aculeatus is univoltine, overwinters as adults, breeds in late spring and early summer, and constructs transverse biramous egg galleries. I sampled trunk and branch sections from three small-diameter white ash (F. americana L.) trees that were cut in April 1986 in Ingham County, Michigan, and then naturally infested by H. aculeatus and associates. Bolts cut from these trees and placed in an outdoor rearing cage in …

Paper Wasp Species Polistes Fuscatus (Hymenoptera: Vespidae) Tracks Urban Lead (Pb) Levels More Than Polistes Dominula, Lindsey R. Kemmerling, Anna L. Lovat, Allison A. Hanka, Emilie C. Snell-Rood

The Great Lakes Entomologist

Lead (Pb) is a persistent, toxic pollutant with widespread but inequitably distributed impacts, especially for humans in urban areas. The impacts of lead pollution on other organisms is largely unknown, even as they commonly experience exposure to lead alongside humans. We tested hypotheses regarding the lead concentrations of paper wasps across a gradient of pollution relative to soil and human lead levels, and correlations with wasp body condition. We collected two species of paper wasp across an urban gradient of lead pollution: Polistes fuscatus (Fabricius) (Hymenoptera: Vespidae), native to our study location, and Polistes dominula (Christ), nonnative to our study …

Could The European Thanasimus Formicarius Outcompete The North American Thanasimus Dubius (Coleoptera: Cleridae) If Introduced To North America?, Robert A. Haack, Robert K. Lawrence

The Great Lakes Entomologist

A federal quarantine was enacted in the United States (US) in the fall of 1992 in response to discovery of the Eurasian pine shoot beetle, Tomicus piniperda (L.) (Coleoptera: Scolytinae), in July 1992 in Ohio. The quarantine regulated movement of pine products (e.g., Christmas trees, nursery stock, and logs) at the county level from infested to uninfested US states. A classical biological program was considered for T. piniperda starting in 1995, focusing on the Eurasian clerid beetle Thanasimus formicarius (L.), an important predator of T. piniperda. Concerns were raised in 1996 that if T. formicarius were released in the …

Fecundity Of Thanasimus Dubius (Coleoptera: Cleridae) Rebounds After A Period Of Prey Scarcity, Robert A. Haack, Robert K. Lawrence

The Great Lakes Entomologist

We field-collected Thanasimus dubius (Fabricius) (Coleoptera: Cleridae) adults during spring, maintained them separately in the laboratory, and initially gave them four bark beetle adults [Ips grandicollis (Eichhoff) or Tomicus piniperda (L.) (Coleoptera: Curculionidae: Scolytinae)] daily as prey. Using a subset of the female clerids (N = 41), we assigned them to one of four feeding groups that varied in the number of prey provided daily. For the first four weeks of a 12–week study, the four diets were: four prey daily, two prey daily, one prey daily, and one prey every 2 days. After four weeks, all females were …

Ukrainian Theology, War, And Human Transformation: Reflections On The International Conference ‘Transfiguration: Tradition And Eschatology, Vladyslav Fulmes

Occasional Papers on Religion in Eastern Europe

On June 11, 2026, the Volyn Orthodox Theological Academy (Lutsk, Ukraine) hosted the international theological conference “Transfiguration: Tradition and Eschatology”, bringing together scholars, clergy, philosophers, chaplains, psychologists, and researchers from several countries. This report examines the conference’s principal theological and interdisciplinary themes, including deification, eschatology, ecclesiology, ecological responsibility, pastoral care, military and medical chaplaincy, digital technologies, and the Church’s response to war and post-war reconstruction.

Religion And Economics: The Economic Views Of Catholicos-Patriarch Ilia Ii Of Georgia, Giuli Giguashvili

Occasional Papers on Religion in Eastern Europe

The paper examines the impact of religion on a country’s economic development, analyzing how religious values and institutions influence economic behavior. The research employs a qualitative, comparative, and historical approach based on the systematic analysis of primary and secondary sources. Religion can promote economic growth by strengthening work ethics, education, and social order. Still, it may also hinder development through inefficient resource allocation and regulatory influence. In the context of the 1700th anniversary of Christianity in Georgia, the study highlights the relationship between Orthodox teaching and economic thought. Drawing on the epistles and sermons of the Catholicos-Patriarch of All Georgia, …

Practical Aspects Of Religious Social Work In Modern Ukraine, Inna Vladislavivna Kovalchuk

Occasional Papers on Religion in Eastern Europe

This work analyzes the current state and specifics of the activity of religious organizations in the social sphere of Ukraine. Special attention is paid to the transformation of religious social work in the conditions of a full-scale war, where religious communities have become key agents of humanitarian, psychological and spiritual assistance. The article examines the mechanisms of interaction between the church, the state and non-governmental organizations in solving social problems. The findings are based on the practical experiences of those working with internally displaced persons (IDPs), veterans, large families, and individuals facing difficult life circumstances. Unique methods of denominational assistance …

The Church’S Social Vocation In World War I And Postwar Recovery: Theodor Zöckler’S Pastoral Ministry In Stanislaviv And Its Relevance For Contemporary Ukraine, Liudmyla Tymchuk, Yurii Klonovskyi

Occasional Papers on Religion in Eastern Europe

This article examines Theodor Zöckler’s pastoral ministry in Stanislaviv during the First World War and the difficult years of postwar reconstruction, and assesses the relevance of that experience for churches in contemporary Ukraine. Drawing on archival records, institutional reports, church periodicals, correspondence, and historical scholarship, the study analyzes how Zöckler combined spiritual care with evacuation, humanitarian relief, medical service, child protection, education, vocational training, and institutional advocacy. Historical-genetic, problem-chronological, hermeneutic, and comparative methods are used to reconstruct the transformation of his ministry under conditions of occupation, forced displacement, political transition, and economic collapse. The findings show that Zöckler’s response moved …

Solidarity In Action: Social Service Of Caritas Organizations In Ukraine In Wartime, Andrii Marchenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to the analysis of the activities of Caritas charitable organizations in Ukraine, which are affiliated with the Ukrainian Greek Catholic Church (Caritas Ukraine) and the Roman Catholic Church (Caritas-Spes Ukraine), in the realities of the Russian-Ukrainian war. Particular attention is focused on considering how the fundamental ideas of Christian love, mercy, common good, and solidarity are embodied in the various practices of humanitarian, spiritual, and other support that these institutions provide to different categories of the population of Ukraine, especially those who have suffered from the destructive consequences of the war. Types of such support include, …

Imperial Pedagogy And Religious Constraint: The Politics Of Islamic Education In The Kazakh Steppe Under Tsarist Rule, Kunduzay Yerimbetova, Bekmurat Naimanbayev

Occasional Papers on Religion in Eastern Europe

This article examines the evolution of the Russian Empire’s educational policies toward Islamic schools in the Kazakh Steppe from the mid-nineteenth century to the 1917 Revolution. While the early imperial administration initially tolerated Islamic institutions for pragmatic governance, the latter half of the nineteenth century witnessed a decisive paradigm shift toward systematic surveillance and restriction. Drawing on archival records and colonial administrative decrees, the study analyzes the implementation of the "Ilminsky system" and the compulsory introduction of the Cyrillic alphabet as tools for cultural assimilation and Russification. The research highlights the dual nature of colonial education: while the Tsarist authorities …

Volume 9 (2026) Climate And Responsibility

International Journal on Responsibility

This issue focuses on the various ways responsibility affects environmental justice. Specifically, this volume urges us to think about how societal and individual (in)action influences ecological crises and what informs this behavior, with a specific focus on religious and Indigenous beliefs and values.