Digital Commons Network^™

The People’S Liberation Army In A New Era: Individuals, Ideas, And Influence, Joel Wuthnow, Derek Grossman, Phillip C. Saunders, Andrew Scobell, Andrew N.D. Yang

Books

The People’s Liberation Army in a New Era: Individuals, Ideas, and Influence assesses how China’s military has changed under Xi Jinping and the extent to which those changes reflect his leadership versus longer-term institutional trends. The volume addresses PLA modernization, organizational reform, political control, joint operations, deterrence, artificial intelligence, officer careers and training, Taiwan, China-Russia military exercises, military aid, and overseas security activities. It argues that while Xi has played a major role in shaping the PLA, many developments build on earlier reforms, enduring strategic priorities, and institutional practices.

Facevalue: Exploring Real-Time Self-View Overlays To Prompt Meaning-Oriented Self-Awareness In Remote Meetings, Gun Woo (Warren) Park, Anthony Tang, Fanny Chevalier

Research Collection School Of Computing and Information Systems

In remote video meetings, visual non-verbal cues, such as facial expressions or head movements, are seen continuously but often only partially. This increases ambiguity compared to in-person settings and can cause misinterpretation or misalignment between intended and perceived meaning. Motivated by communication theories, we designed FaceValue, a technology probe that augments the self-view with private, real-time overlays. These overlays are subtle, suggestive prompts intended to help attendees reflect on how their cues might be interpreted by others. To invite personal interpretation, FaceValue avoids behavioral labeling and instead aims to support meaning-oriented self-awareness: recognizing when visible cues may unintentionally (mis)communicate intent. …

Social Prescribing For People In Vulnerable Situations In Europe: Protocol For A Process Evaluation Of An Rct In Eight Countries, Kerryn Husk, Elizabeth Gilmour, Stephanie Tierney, Debra Westlake, Anuschka Arni, Hendrik Napierala, Farhad Rezvani, Marius Dierks, Wolfram J. Herrmann

Peninsula Medical School

Objective Social prescribing is a pathway that connects individuals to non-clinical services. It supports and addresses social needs, such as those related to loneliness, housing instability and mental health. Social Prescribing Europe (SP-EU), a European Union funded project, seeks to co-create an adaptation of the social prescribing pathway based on the needs of the following target groups: LGBTIQ+ people, refugees and first-generation immigrants, older people living alone. This adapted social prescribing pathway will be tested in a pragmatic randomised controlled trial (RCT) in ten hubs, covering eight countries, across Europe. The aim of this process evaluation is to explore the …

Pda (Privacy-Preserving Distributed Algorithms) In Action: Ten Principles For High-Quality Multi-Site Clinical Evidence Generation, Yong Chen, Chongliang Luo, Et Al.

2020-Current year OA Pubs

BACKGROUND: Distributed Research Networks (DRNs) offer significant opportunities for collaborative multi-site research and have significantly advanced healthcare research based on clinical observational data. However, generating high-quality real-world evidence using fit-for-use data from multi-site studies faces important challenges, including biases associated with various types of heterogeneity within and across sites and data sharing difficulties. Over the last 10 years, Privacy-Preserving Distributed Algorithms (PDA) have been developed and utilized in numerous national and international real-world studies spanning diverse domains, from comparative effectiveness research, target trial emulation, to healthcare delivery, policy evaluation, and system performance assessment. Despite these advances, there remains a lack …

Irs: Iterative Reference Selection Improves Normalization Of Microbiome Sequencing Data, Yiming Shi, Lili Liu, Jun Chen, Kristine M Wylie, Todd N Wylie, Sung Hee Park, Ruiwen Zhou, Yin Cao, Stephanie A Fritz, Molly J Stout, Maria Cristina Vazquez Guillamet, Lei Liu

2020-Current year OA Pubs

Microbiome studies often seek to determine how the absolute abundances of individual taxa change across biological conditions, yet sequencing read counts are sample-specific scaled representations of those abundances. Because sampling depth can differ across samples, fold changes calculated directly from sequencing read counts do not generally represent absolute-abundance fold changes. Normalization methods attempt to account for these between-sample differences in sampling depth, but their accuracy depends on the reference used. In particular, total-sum scaling uses all taxa as the reference and can introduce compositional bias. Reference-based methods instead rely on taxa that are stable across conditions, but contamination of the …

Unlocking Cis-Regulatory Landscapes Across 500 Million Years Of Evolution And Disease Mechanisms, Tássia Mangetti Gonçalves, Casey L Stewart, Samantha D Baxley, Jason Xu, Kevin Boyer, Bijesh George, Daofeng Li, Chengran Yang, Harrison W Gabel, Xianhua Piao, Carlos Cruchaga, Yang E Li, Ting Wang, Oshri Avraham, Guoyan Zhao

2020-Current year OA Pubs

Genomic DNA encodes regulatory information that determines where, when, and to what extent genes are expressed. Theoretically, we should be able to identify these transcriptional "instructions" by examining genomic DNA sequence alone, yet this has remained challenging. Here we present the Vertebrate Regulatory MOdule Detector (VRMOD), a method that accurately predicts gene regulatory sequences using only the query genomic sequences. We applied VRMOD to 309 Ensembl genomes, generating a compendium of high-resolution, genome-position-fixed

Modular In Vivo Antibody-Adc Click To Reverse Drug Resistance In Tumours, Cristina Simó, Alexander C Vanover, Ricardo D'Oliveira Albanus, Sandeep Surendra Panikar, Shayla Shmuel, Alex Benton, Jader Giraldo-Guzman, José M Luna, Yifei Xu, Na-Keysha Berry, Nai Keltee, Jingxia Liu, Farrokh Dehdashti, Patrícia M R Pereira

2020-Current year OA Pubs

Antibody-drug conjugates (ADCs) have significantly advanced cancer therapy by enabling the selective delivery of cytotoxic agents to tumour cells. However, ADC efficacy remains constrained by its dependence on a single target antigen, which limits tumour targeting and promotes resistance in heterogeneous tumours with variable and low antigen expression

Characteristics Of Individuals With Cerebral Palsy Across The Us, Bhooma R Aravamuthan, Et Al.

2020-Current year OA Pubs

No abstract provided.

Implementation Of A New Mri Contrast Policy At A Large Hospital System: Access To Contrast-Enhanced Mri And Development Of Nsf In Patients With Renal Insufficiency, Daniel R Ludwig, Fan Zhang, Brittany Minor, Tammie L S Benzinger, Anup S Shetty

2020-Current year OA Pubs

RATIONALE AND OBJECTIVES: To evaluate access to contrast-enhanced MRI among patients with acute or chronic renal failure after implementation of a more permissive contrast policy and determine whether any patients developed nephrogenic systemic fibrosis (NSF).

MATERIALS AND METHODS: This retrospective study included all patients who had an order for contrast-enhanced MRI in our healthcare system between July 1st, 2023 and June 30th, 2025. Each exam was categorized as completed or cancelled, and multivariable analysis was performed to identify factors associated with exam cancellation. Potential diagnoses of NSF were identified by searching the problem list and encounter diagnoses using ICD-10 codes. …

Perioperative Depression And Anxiety Care In Older Patients: A Randomized Clinical Trial, Joanna Abraham, Katherine J Holzer, Simon Haroutounian, Bethany Pennington, Ana Baumann, Ryan Calfee, Theresa Cordner, Kenneth E Freedland, Thomas Kannampallil, Benjamin Kozower, Emily Lenard, J Philip Miller, Mary Politi, Michael Yingling, Michael S Avidan, Eric J Lenze

2020-Current year OA Pubs

IMPORTANCE: Depression and anxiety are common among older adults undergoing surgery and are associated with adverse postoperative outcomes. However, effective tailored perioperative mental health interventions are lacking.

OBJECTIVE: To evaluate a perioperative intervention to optimize mental health.

DESIGN, SETTING, AND PARTICIPANTS: A single-blind, hybrid, type 1, effectiveness-implementation randomized clinical trial was conducted (November 1, 2022, to March 31, 2025), with 3-month postoperative follow-up, at a US academic and community practice hospital network. Participants were 60 years or older; scheduled for cardiac, oncologic, or orthopedic surgery; and had clinically meaningful symptoms of depression and/or anxiety based on the Patient Health Questionnaire-Anxiety …

Comparison Of Safety And Efficacy Of Lower-Intensity Versus Standard Unfractionated Heparin Infusion Nomograms For Extracranial Venous Thromboembolism In The Neurological Intensive Care Unit, Abdullah M Hakoun, Megha Gupta, Rajat Dhar, Mahta Mardani, Fatih Koc, Salah G Keyrouz

2020-Current year OA Pubs

BACKGROUND: Anticoagulation for acute venous thromboembolism (VTE) in the neurological intensive care unit is challenging because patients with acute brain injury or recent neurosurgery are at high risk for hemorrhagic complications. Unfractionated heparin infusions are commonly used, sometimes with lower activated partial thromboplastin time targets, but the safety and effectiveness of lower-intensity UFH nomograms remain poorly defined.

METHODS: We performed a retrospective single-center study of patients diagnosed with acute extracranial VTE, including deep venous thrombosis and/or pulmonary embolism, between June 2018 and April 2024. Patients were grouped by treatment strategy: standard-intensity UFH targeting aPTT 60-100 s, lower-intensity UFH targeting aPTT …

Cracking The Code: Genotype-Phenotype Correlation Models In Sarcoglycanopathies, Leonela Luce, Conrad C Weihl, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Sarcoglycanopathies are among the most severe limb-girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype-phenotype correlations. This study aimed to establish accurate genotype-phenotype correlations for LGMDR3, LGMDR4, and LGMDR5.

METHODS: We analyzed the largest sarcoglycanopathy cohort to date (n = 541). Clinical data, including age at symptom onset and loss of ambulation, were collected and used to define phenotype severity. Predictive models were developed considering the impact of non-truncating variants on secondary …

Opioid Dispensing Volume And Per-Patient Intensity In Sickle Cell Disease, Kevin Y Xu, Brandon K Attell, Joanna L Buss, Tashalee R Brown, Charles R Jonassaint, Richard A Grucza, Allison A King, Max Jordan Nguemeni Tiako

2020-Current year OA Pubs

IMPORTANCE: Opioids remain central to management of acute and chronic pain in sickle cell disease (SCD). Opioid dispensing declined over the 2010s amid opioid stewardship efforts, but patterns since 2020 are less clear. Analyses aggregating opioids into morphine milligram equivalents (MME) may obscure agent-specific patterns.

OBJECTIVE: To characterize opioid dispensing volume and per-recipient frequency, duration, and dose among individuals with SCD.

DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study of commercially insured and Medicaid-enrolled patients with SCD using the Merative MarketScan databases across 3 periods from January 2011 to February 2016, March 2016 to December 2020, and January 2021 to …

Spinal Cord Imaging For Multiple Sclerosis: Advances, Priorities, And Opportunities, Cornelia Laule, Matthew R Brier, Et Al.

2020-Current year OA Pubs

The spinal cord plays a central role in the pathophysiology and clinical manifestations of multiple sclerosis (MS), yet remains under-studied compared with the brain. This review summarizes key insights from the 2025 North American Imaging in MS Spinal Cord Imaging Workshop, highlighting recent advances, ongoing challenges, and future opportunities in MS spinal cord imaging. We review pathological studies and outline the clinical relevance of spinal cord lesions and atrophy for diagnosis, prognosis, and disease monitoring, highlighting emerging biomarkers of progression independent of relapse activity. Correlations between magnetic resonance imaging, histopathology, and clinical outcomes support the validation and translational potential of …

Supporting English Language Learners: Evaluating Bilingual Education Policies In Boston Area High Schools, Valentina A. Tolentino

Undergraduate Theses and Capstone Projects

This study examines how the evolution of bilingual education policies and instruction has affected non-English speaking and bilingual high school students. Especially in Boston/Lynn Public School, bilingual and non-English speaking students are rapidly growing in population, yet questions still remain whether the existing educational policies adequately support their academic and emotional well -being. Using a demographic survey and interviews, I connected with high school graduates  ranging from 18 year olds to 22 years olds and asked questions to assess their language support, classroom experience, emotional well-being, and academic engagement. Analysis of the data demonstrates the influence that their bilingual education …

Abundance And Balance Of Circulating Leukocyte Subsets And Colorectal Cancer Survival, Alicia R Richards, Maria F Gomez, Bianca I Dowling, Catherine M Bulka, Biljana Gigic, Jane C Figueiredo, Christopher I Li, David Shibata, Adetunji T Toriola, Doratha A Byrd, Cornelia M Ulrich, Mingxiang Teng, Paul A Stewart, Erin M Siegel, Jacob K Kresovich

2020-Current year OA Pubs

BACKGROUND: Cancer immunology research has traditionally focused on tumor-infiltrating leukocytes, but the role of the peripheral leukocytes remains understudied. Since tumor-infiltrating leukocytes are recruited from the blood, circulating immune profiles may provide prognostic insights obtainable before surgery, reflecting overall immune competence.

METHODS: We analyzed treatment-naïve blood samples from 134 stage I-III colorectal cancer (CRC) patients using a nested case-control design (33 recurrences, 45 deaths; median follow-up: 7.4 years). Circulating leukocyte subsets were estimated using methylation cytometry applied to genome-wide methylation profiles. Cox regression models estimated associations between leukocyte metrics and disease-free and overall survival, adjusting for clinical factors.

RESULTS: Higher …

Parallel Failures: The Recurring Logic Of Interventionist Blunders From Ukraine To Mexico, Jerjes Aguirre Ochoa, Jorge Alejandro Vázquez Valdez

Journal of Strategic Security

This article argues that a potential US military intervention in Mexico, predicated on securitizing cartels as terrorist threats, would replicate strategic failures seen in interventions like Russia’s in Ukraine. Through a comparative framework of three variables—securitization, underestimated nationalist resistance, and neglected co-responsibility—the analysis shows how external force applied to structural crises provokes nationalist backlash. In Mexico, any intervention would reactivate historical memory of US interference, triggering broad institutional and social resistance. The core security challenge is not the cartels but Mexico's institutional fragility: systemic impunity, subnational governance deficits, and weak checks and balances. Therefore, militarized approaches are counterproductive. As a …

Was The Us Invasion Of Iraq A Mistake, Or Are We Missing The Emergence Of A Promising Democracy?, Robert Burrell, Arman Mahmoudian, John Pennell

Journal of Strategic Security

This study evaluates the long-term impact of the 2003 US invasion of Iraq on its democratic development, social stability, and regional geopolitics. Utilizing a comprehensive data-driven approach, including metrics on governance resilience, national morale, political dynamics, economic indicators, and security sector reforms, the research assesses progress over two decades. Findings indicate gradual improvements in Iraq’s democratic institutions, public confidence, and economic resilience, despite persistent challenges such as corruption, sectarian divisions, and regional influence from Iran and neighboring states. The analysis suggests that Iraq’s resilience and evolving political landscape could foster a nascent democracy capable of regional influence if key reforms …

International Competency And Regulatory Standards In Osteopathic Practice: A Comparative Documentary Analysis Of Regulated And Formally Recognised Jurisdictions, Lee Muddle, Gopi Anne Mcleod, Loïc Treffel, Oliver P. Thomson, Ana Paula A. Ferreira, Brett Vaughan

Research outputs 2022 to 2026

Objective: To compare competency standards and regulatory expectations for osteopathic practice across jurisdictions where the profession is formally regulated or recognised as a healthcare profession. Methods: A documentary analysis was undertaken across regulated and formally recognised jurisdictions. National competency frameworks, regulatory standards and professional guidance documents were identified through regulatory and professional body websites and direct contact with relevant organisations. Nineteen national competency, regulatory or professional framework documents from 17 jurisdictions were included. The World Health Organization Benchmarks for Training in Osteopathy and EN16686 Osteopathic Healthcare Provision were included as international comparison points. Data were extracted using a structured template …

Neonatal Assessment And Vr: Designing 3d Simulation Training For Prehospital Clinicians, Michella G. Hill, Luke Hopper, Belinda Flanagan, Sara Hansen, Alecka Miles, Jess Watson, Sean Cashman, Kirstie Balding, Peggy Dysktra, Joshua Johnson, Brennen Mills

Research outputs 2022 to 2026

Prehospital emergency care requires clinicians to manage a vast array of medical and trauma incidents, including rare events such as obstetrics (i.e., childbirth) emergencies. Emergency births can have life-threatening complications such as neonatal respiratory distress potentially leading to cardiopulmonary resuscitation. Management of low-frequency high-risk (LFHR) events such as birthing and immediate neonatal care occurring outside the planned place of birth require expert clinical management. Underutilised skill and knowledge of LFHR events decay within 12-months of being taught. LFHR events are often overlooked for refresher training due to the low occurrence of such cases, putting LFHR patients at even greater risk …

Nurses' Perspectives Of Dysphagia Screening Practices In Irish Residential Long-Term Care Settings: A Qualitative Descriptive Study, Constantino Estupiñán Artiles, Claire Donnellan, Julie Regan, Mary Mooney

Research outputs 2022 to 2026

Objectives To examine nurses’ perspectives on current dysphagia screening practices in Irish residential long-term care settings (RLTCS), and to investigate barriers and facilitators to nursing-led dysphagia screening within this healthcare context. Methods This study employed a qualitative descriptive design and was reported in accordance with the Consolidated Criteria for Reporting Qualitative Research checklist. Participants were recruited through purposive sampling from RLTCS located in the northeast of the Republic of Ireland. Eleven in-person focus group interviews were conducted with thirty-four nurses working in clinical and managerial roles. A semi-structured interview guide was utilised, and the data were subsequently analysed using reflexive …

Neurochemical Impact Of Psychostimulants: Longitudinal Mri Analysis Of Brain Iron Content In Children With Adhd, Hugo A.E. Morandini, Sjoerd B. Vos, Paola Chivers, Tim J. Silk, Pradeep Rao

Research outputs 2022 to 2026

Background: Attention Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in school-aged children and has been associated with impaired brain iron homeostasis. Evidence has shown that psychostimulant treatment may affect brain iron content in children with ADHD, however, longitudinal evidence remains limited. The present longitudinal study investigated the effect of psychostimulant treatment duration and age at treatment onset on brain iron content in children with ADHD. Methods: Neuroimaging and phenotypical data were collected from the publicly available Oregon ADHD-1000 dataset. After screening, data from 29 psychostimulant-medicated children with ADHD and 38 neurotypical children were included. Individual General Estimating Equation (GEE) …

Underfunded And Undervalued: Community-Based Health Promotion Practitioners’ Experiences Of Western Australia’S Prevention Sector, Ruth M. Wallace, Leesa N. Costello, Elizabeth J. Cook

Research outputs 2022 to 2026

Prevention is a central policy focus of contemporary health promotion, offering cost-effective strategies to reduce disease burden and improve population well-being. Despite this, Australia allocates a small proportion of its health budget to prevention, with funding models characterized by short-term cycles and competitive tendering. While the consequences for public health are well documented, the impact on the health promotion workforce remains underexplored. Workforce health and stability are critical for program delivery, ethical practice, continuity of relationships with communities, and the capacity to sustain long-term prevention efforts. This qualitative study examined the experience of 19 community-based health promotion practitioners in Western …

Characterising The Beyond 50 Cohort: Preliminary Exploration Of Physical And Psychosocial Health Factors And Substance Use Among A Cohort Of Community Dwelling Adults Aged 50–70 Years, Rose Laing, Tina Lam, Bosco Rowland, Paul Dietze, Aislinn Lalor, Keith D. Hill, Laura Alfrey, Nadine E. Andrew, Shalini Arunogiri, Stephen Bright, Louisa Picco, Suzanne Nielsen

Research outputs 2022 to 2026

Introduction: Older adults exhibit unique risks associated with poor mental health and substance use. The Beyond 50 study is a longitudinal cohort investigating the determinants of healthy ageing, including relationships between physical and psychosocial health and substance use. We aim to characterise the Beyond 50 cohort and explore patterns of physical and psychosocial health and substance use. Methods: Baseline data collection was completed between September 2023 and August 2024. Annual follow-up data collection commenced in September 2024. Descriptive statistics will be used to characterise the cohort at the time of baseline survey completion. Results: Of the 1059 participants, the mean …

Culturally Safe Nursing: Transformative Learning Experiences Through Critical Reflection Assessment, Lesley Andrew, Michelle Pedlow, Bev Ewens

Research outputs 2022 to 2026

Aim: To explore the transformative learning experiences of postgraduate nursing students engaging in an Aboriginal culture and history module, through an analysis of a critical reflection assessment, in particular the student development of cultural awareness and culturally safe practice.

Background: Despite mandated inclusion of Aboriginal cultural content in Australian nursing curricula, culturally unsafe practices and racism persist. Transformative learning, underpinned by critical reflection, can challenge fixed assumptions and promote cultural awareness and culturally safe care.

Design: A qualitative descriptive study using thematic analysis. Methods: Written critical reflections from 15 consenting postgraduate nursing students who completed the Ngany Kalyakal Katatjiny Boordawan …

Metabolomics In Renal Cystic Disease: Links To Mechanisms And Identification Of Pathways For Potential Prediagnosis, Liyan Chen, David Broadhurst, Armaghan Shafaei, Jacqueline K. Phillips, Shijie Tang, Hayley Abbiss

Research outputs 2022 to 2026

Polycystic kidney disease (PKD) is a common hereditary kidney disorder with an insidious onset and complex mechanisms, making early diagnosis challenging. Current diagnostic methods, including imaging and genetic testing, have limitations. Imaging detects cysts only once formed, and genetic testing is costly, labor-intensive, and unable to guarantee complete diagnostic accuracy or predict onset and progression. Metabolomics may offer an approach to uncover PKD mechanisms by detecting metabolic alterations that precede clinical manifestations, enabling identification of disease-specific biomarkers, and providing earlier and more practical detection than imaging or genetic testing. This review synthesizes existing metabolomics studies of human PKD and renal …

Rank, Degrading Treatment, And The Italy-Albania Agreement, Jamal Barnes, Obed Adonteng-Kissi

Research outputs 2022 to 2026

In November 2023, Italy signed a five-year agreement with Albania to transfer asylum seekers intercepted in international waters by Italian vessels to Italian-run detention centres in Albania for asylum processing and deportation. The agreement has been controversial and raises several human rights issues. This article examines these human rights concerns and argues that the agreement is degrading by design. Analysing policy documents, legal cases, speeches, international human rights and refugee law, and philosophical and legal scholarship on the concept of degrading treatment, this article argues that the cumulative effect of subjecting people to unnecessary suffering, discrimination, and dehumanisation creates a …

Study Designs For Interpath-002 And Interpath-009 Of Adjuvant Intismeran Autogene Plus Pembrolizumab For Non-Small Cell Lung Cancer, Jonathan D. Spicer, Solange Peters, Justin F. Gainor, Jamie E. Chaft, Christine M. Bestvina, Jay M. Lee, Thomas U. Marron, Muhammad A. Khattak, Laureen S. Ojalvo, Joydeep K. Banerjee, Zheng Wang, Xuan Deng, Nazly Shariati, Steven M. Keller, Tina Cascone

Research outputs 2022 to 2026

Background: Neoantigens are immunogenic molecules arising from patient-specific tumor mutations. Intismeran autogene (intismeran; formerly V940, mRNA-4157), an mRNA-based individualized neoantigen therapy (INT) encoding ≤34 neoantigens unique to each patient's tumor, is designed to promote an antitumor immune response. In early-phase studies, adjuvant intismeran plus pembrolizumab showed antitumor activity with solid tumors. Standard-of-care therapy for non-small cell lung cancer (NSCLC) tumors ≥4 cm includes platinum-based chemotherapy and pembrolizumab given after (adjuvant) or both before and after (perioperative) surgical resection. We describe study designs for the INTerpath-002 and INTerpath-009 studies evaluating the addition of intismeran to adjuvant pembrolizumab-based therapy in stage II-IIIB …

Trx Suspension Vs Swiss-Ball Core Training For Core-Muscle Endurance And Static/Dynamic Balance In Overweight Inactive Women: A Randomized Trial, Siavash Naddafha, Mona Sarhadi, Maryam Taherkhani, Abbas Biniaz

Research outputs 2022 to 2026

Purpose: Prolonged sitting and physical inactivity are key risk factors for trunk-muscle weakness, impaired balance, and low-back pain in overweight women. Although unstable-surface training is widely prescribed, head-to-head comparisons between TRX suspension and Swiss-ball exercise are limited. We compared these modalities for effects on core-muscle endurance and balance.

Methods: Thirty overweight, inactive women (30 ± 5 years; BMI 27.3 ± 1.6 kg·m⁻2) were block-randomized (1:1) to 8 weeks (3 sessions/week) of TRX or Swiss-ball training using five matched exercises at Borg RPE 13–15 on the 6–20 scale. Outcomes were trunk-extensor (Biering-Sørensen), trunk-flexor (60° curl-up), and trunk-lateral (side-bridge) endurance; static balance …

Integration Of Lipidomic And Polygenic Risk Scores Within Contemporary Clinical Cardiovascular Risk Assessment Pathways: A Multi-Cohort Development And Validation Study, Aleksandar Dakic, Jingqin Wu, Tingting Wang, Thomas G. Meikle, Kevin Huynh, Changyu Yi, Habtamu B. Beyene, Agus Salim, Michelle Cinel, Nat Mellett, John Blangero

Human Genetics Publications

Background: Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is most consequential in the intermediate-risk group, where treatment decisions are uncertain and additional risk refinement could alter management. Circulating lipid species and inherited genetic variation capture complementary molecular aspects of atherosclerotic risk that are not fully reflected by conventional clinical variables, but are not routinely incorporated into primary-care risk assessment. We investigated whether selective integration of lipidomic and genomic risk signals into AusCVDRisk …