Digital Commons Network^™

Rituximab For The Treatment Of Immune Checkpoint Inhibitor-Induced Glomerulonephritis, Yazen Alasadi, Juan Cintron Garcia, Naszrin Arani, Valda Page, Yimin Geng, Clark R Andersen, Amanda Tchakarov, Abhijat Kitchlu, Omar Mamlouk, Ala Abudayyeh

Faculty, Staff and Student Publications

Background: Among patients receiving immune checkpoint inhibitor (ICI) therapy, the most common renal immune-related adverse event is interstitial nephritis, which is caused by severe T-cell infiltration and is typically responsive to steroids; although rarer, autoimmune induction in the kidney has also been reported. There is a paucity of data regarding ICI-induced autoimmune disease in the kidney and the challenges associated with continuing ICI therapy. Here, we present a single center case series of ICI-induced glomerulonephritis with data on treatment rechallenge.

Methods: We retrospectively reviewed 241 patients who underwent kidney biopsies at our institution between 2015 and 2024 and identified those …

Collision Tumors Involving Metastatic Carcinoma And Plasma Cell Myeloma: Report Of Two Cases, Ahmed A Ahmed, Muhammad Hassaan Khalid, Asad Ur Rehman, Nghia D Nguyen, Xinhai Robert Zhang

Faculty, Staff and Student Publications

Synchronous coexistence of plasma cell neoplasms (PCNs) and metastatic carcinoma is not a common phenomenon and poses a significant diagnostic challenge requiring meticulous histopathological and immunophenotypic analysis for accurate lineage assignment. We report two cases of collision tumors comprising PCN and metastatic lung carcinoma. Case 1 involved a 68-year-old male with metastatic non-small cell lung adenocarcinoma who developed intracranial lesions; resection revealed metastatic adenocarcinoma intermingled with clonal plasma cells. Case 2 was a 73-year-old woman with a lytic iliac crest lesion whose bone marrow and lesion biopsies showed diffuse infiltration by both carcinoma and atypical plasma cells. Comprehensive immunohistochemical profiling, …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Endogenous Processes Underlying Clock-Like Mutational Signatures, Teresa Druck, Rami I Aqeilan, C Marcelo Aldaz, Nicola Zanesi, Kay Huebner

Faculty, Staff and Student Publications

Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging and present in normal tissues. SBS1 results from cytosine demethylation, whereas SBS5 and SBS40 arise from unknown endogenous mechanisms. We hypothesized that loss of fragile‐site genes drives these two signatures. FHIT, located at FRA3B, is frequently deleted in cancers, and Fhit‐deficient mouse tissues exhibit a mutation profile resembling human SBS5. Data mining of …

Reply To: Late Nonrelapse Mortality: A Hidden Risk In Triplet Therapy For Idh-Mutated Aml?, Jennifer Marvin-Peek, Courtney D Dinardo

Faculty, Staff and Student Publications

No abstract provided.

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell

Faculty, Staff and Student Publications

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …

‘Male Victims Of ‘Honour Crimes’: A Critical Examination Of The Concepts Of ‘Honour’ And The Wider Debates Surrounding ‘So-Called Honour-Based Violence’ And ‘Hate Crime’, Narissa Maclennan-Matthews

School of Law, Humanities and Social Sciences Theses

This thesis critically interrogates the experiences of male victims of ‘so-called honour-based violence and abuse’ (SCHBVA) through an intersectional criminological framework. It draws primarily on Barbara Perry’s theories of ‘Doing Difference’ (2001; 2003) and the ‘in terrorem effects’ of hate crime (Perry & Alvi, 2012), alongside insights from Structural Criminology (Hartjen, 1978; Kramer, 1985) and Humanistic Criminology (Hagan, 1986). Drawing on semi-structured interviews with male survivors and criminal justice professionals, and employing thematic and case study analysis, the study examines how violence is produced and legitimised across intersecting axes of gender, sexuality, ethnicity, and religion.Building on Perry’s conceptualisation of ‘Doing …

Exploring Mathematics Texts In A Further Education College, Rajdulari Pettitt

School of Law, Humanities and Social Sciences Theses

Learning mathematics is a challenge for many learners in Further Education. It is also a requirement since Government policy stipulates that Further Education (FE) learners in England, who have achieved a General Certificate of Secondary Education (GCSE) Mathematics grade 3 or lower, are required to continue studying this subject alongside their vocational courses. As a core subject, mathematics includes numbers, shapes, patterns and statistics with progression generally from concrete to abstract form; mathematics texts include specific vocabulary such as probability trees and procedures such as calculations using decimals. Engagement with mathematics has been shown to be related to motivation, confidence …

‘The Limits Of The Landscape: A Critical Examination Of Outdoor Learning, Self-Regulation, And Semh Within Neoliberal Schooling’, Nicola Clayton

School of Law, Humanities and Social Sciences Theses

This doctoral thesis critically examines a specialised outdoor learning intervention for primary pupils with significant Social, Emotional, and Mental Health (SEMH) needs who are at risk of exclusion. It assesses the intervention’s implementation and its efficacy in supporting these pupils' capacity for self-regulation and stress management.The study is situated amidst escalating global child mental health concerns and recent English educational policy shifts that mandate schools to actively foster pupil well-being. Exploring outdoor education as a widely cited approach for promoting positive mental health, this research engages with established social theories, particularly those of Bernstein and Bourdieu, to critique the wider …

Safe Family Therapy Activities And The Emotional Well-Being Of Parents Of Autistic Children, Gamze Camci

School of Law, Humanities and Social Sciences Theses

This thesis addresses a critical gap in the existing literature on the emotional well-being of parents of autistic children by applying SAFE family therapy activities grounded in the Narrative Attachment Therapy approach through a three-cycle action research design. Stage 1 involved 3 parents as primary participants, with their children present during selected sessions. Stage 2 included 2 families; the primary focus was on 3 parents across these families. Stage 3 engaged 5 therapists. Data were collected through interviews, diaries, questionnaires and therapy recordings. Data from interviews and journals were analysed thematically, whereas questionnaires were analysed idiographically. The first and second …

Navigating The Digital Shift In Mozambique: Teacher Agency And Digital Learning In Schools, Clive Ruraca

School of Law, Humanities and Social Sciences Theses

The educational technology industry frequently promotes the idea of a significant paradigm shift, proposing that technology can supplant traditional, transmission-based pedagogies such as ‘tell and practice’ approaches. In theory, this perspective positions digital tools as catalysts for systemic educational reform, capable of replacing rote learning with dynamic, technology-supported models (Voogt et al., 2013; Wang et al., 2024; Casilli & Posada, 2019). Employing an interpretative, empirical methodology, involving questionnaires and interviews with secondary school teachers. Data from this study are used to explore teachers’ experiences with digital learning tools through the lens of Activity Theory. This study examines the digital shift …

What Were Teaching Assistants' Perceptions Of Their Role While Working During The Covid-19 Global Pandemic And What Motivated Them To Fulfil Their Role?, Sarah Holt

School of Law, Humanities and Social Sciences Theses

This thesis considers Teaching Assistants’ perceptions of their role during the Covid-19 pandemic and their motivation to fulfil their role. Existing literature regarding Teaching Assistants’ work during the pandemic has focused on their role largely in terms of teaching responsibilities. In addition to this, the research draws out original observations of how Teaching Assistants worked in this highly unusual context. It explores their specific experiences and the changes experienced to their role, ways of working within their schools and to existing power structures in schools. This thesis seeks to understand these changes in identity and relationships through the theoretical framework …

Educational Interventions To Prepare Undergraduate Students For Out-Of-Hours Practice As A Newly Qualified Doctor In The United Kingdom: A Scoping Review, Alex Gordon, Molly Parkinson, Rosanna Watts, Kamal El-Badawi, Erin Dawson, Rohan Chiktara, Lorna Burns, Nicola Brennan

Peninsula Dental School

Background: In the United Kingdom (UK), newly qualified doctors are routinely responsible for out-of-hours (OOH) care, often managing acutely unwell patients with limited supervision. Despite national recommendations encouraging OOH experience during medical school training, there is no formal curriculum for OOH practice. Objectives: This scoping review aimed to identify the range of educational interventions designed to prepare UK medical students for OOH clinical responsibilities and assess their reported effects on perceived and actual preparedness. Methods: Following Joanna Briggs Institute methodology, a systematic search of seven databases and grey literature sources was conducted. Eligible studies involved UK-based medical students and reported …