Digital Commons Network^™

Predictors Of Inpatient Rn Turnover In Rural And Urban Vha Hospitals, Katherine G Bay, Chase S Eck, Melissa K Knox, Paras Mehta, Laura A Petersen

Faculty, Staff and Students Publications

Background: The rising demand for health care delivery and an aging workforce is of particular concern in rural areas, where health care access depends upon an adequate nursing workforce. To address this shortage and optimize care, it is essential to measure when registered nurses (RN) leave inpatient direct care positions (ie, inpatient RN turnover) and identify modifiable factors correlated with RN turnover.

Objectives: Apply a novel method for characterizing inpatient RN turnover to understand factors associated with variation in RNs leaving inpatient positions at rural and urban Veterans Health Administration (VHA) hospitals.

Project design: Retrospective cohort study.

Subjects: Direct care …

Esophageal Myotomy And Risk Of Esophageal Cancer And Mortality In Achalasia: Real-World Cohort Study, Fouad Jaber, Mohamad Ali Ibrahim, Mohammed Jaber, Youssef Soliman, Mai A Khalaf, Tara Keihanian, Fares Ayoub, Mohamed O Othman, Salmaan Jawaid

Faculty, Staff and Students Publications

Background and study aims: Achalasia is associated with increased risk of esophageal cancer, particularly squamous cell carcinoma. Although esophageal myotomy improves dysphagia, its impact on cancer risk and mortality remains unclear.

Patients and methods: We conducted a retrospective cohort study using the TriNetX research network, including adults (≥ 18 years) with achalasia confirmed by esophageal manometry. Patients were categorized based on treatment of those undergoing esophageal myotomy (peroral endoscopic myotomy [POEM] or laparoscopic Heller myotomy [LHM]) and those managed without myotomy. Patients with prior esophagectomy or malignancies associated with increased esophageal cancer risk were excluded. The primary outcome was incident …

Relationship Between Number Of Assigned Patients And Rn Time To Administer Medications During The Peak-Time Medication Pass, Chase S Eck, Melissa K Knox, Paras D Mehta, Christine Yang, Laura A Petersen

Faculty, Staff and Students Publications

Background: Inpatient nurse staffing affects patient outcomes. Less is known about the mechanism of this relationship and how lower overall staffing in a unit affects individual RN activities at the bedside.

Objectives: Estimate the relationship between the number of patients assigned to an RN and time spent on medication administration at the peak-time medication pass (PTM), a common nursing task.

Research design: Estimate the association using multivariable linear regression to adjust for patient severity and staff and unit fixed effects.

Subjects: All 9272 RNs administering medications during the PTM on 243 inpatient units in 113 VHA hospitals in 2019.

Measures: …

Long Covid And Cardiovascular Diseases Among U.S. Adults: Results From The U.S. Medical Expenditure Panel Survey, Geoffrey Y Zhang, John C Lin, Dang Nguyen, Sameed Ahmed M Khatana, Thomas P Giordano

Faculty, Staff and Students Publications

Objective: Long COVID is associated with persistent symptoms including cardiovascular complications; however, the epidemiology and directionality of this association remain unclear.

Methods: Utilizing a retrospective cohort study design with cross-sectional analyses, 8,332 respondents aged 18 and older from the 2022 Medical Expenditure Panel Survey (MEPS) who had a prior COVID-19 infection, were analyzed to determine the temporal association between long COVID and cardiovascular disease (CVD), modeling each as both outcome and exposure in separate analyses.

Results: Long COVID was associated with any CVD diagnosis (OR 1.37; 95% CI: 1.05-1.80), specifically angina (OR 1.81; 95% CI: 1.18-2.77) and myocardial infarction (OR …

Hypothyroidism Is Associated With Higher Healthcare Utilisation And Higher Need For Blood Transfusion After Primary Total Knee Arthroplasty (Tka) In Patients With Osteoarthritis: A National Inpatient Sample Analysis, Sumanth R Chandrupatla, Kranti C Rumalla, Jasvinder A Singh

Faculty, Staff and Students Publications

Purpose: To examine the association of hypothyroidism with primary total knee arthroplasty (TKA) outcomes in adults with primary underlying diagnosis of osteoarthritis (OA).

Methods: We identified a prospective cohort of patients in the 2016-2020 national inpatient sample (NIS) that received primary TKA with an underlying diagnosis of OA, identified using International Classification of Diseases, Tenth Revision, Common Modification (ICD-10-CM) and Procedure Coding System (ICD-10-PCS) codes in the primary procedure and diagnosis positions, respectively. We performed multivariable-adjusted regression analyses for healthcare utilisation (length of hospital stay, hospital charges and discharge destination) and clinical outcomes (blood transfusion; prosthetic fracture, dislocation or infection; …

Healthcare Transition In Spina Bifida: A National Mixed Method Study, Betsy Hopson, Kathy H Huen, Molly B Richardson, Rhonda G Cady, Jennifer T Queally, Judy Thibadeau, Ellen Fremion

Faculty, Staff and Students Publications

Introduction: Adolescents and young adults (AYA) with spina bifida (SB) face substantial challenges during the transition from pediatric to adult healthcare, including fragmented systems, limited adult provider availability, and gaps in self-management readiness. Despite national guidelines, little is known about how transition practices are implemented across the Spina Bifida Association (SBA) Clinical Care Partner (CCP) network. This study examined clinician perspectives on current practices, barriers, facilitators, and definitions of successful healthcare transition (HCT).

Methods: Using an explanatory sequential mixed methods design, we first conducted a 47-item survey with clinicians from SBA CCP clinics (n = 20/32; 62.5 % response rate). …

Safety And Efficacy Of Vadadustat Versus Darbepoetin Alfa For Chronic Kidney Disease-Related Anemia In Patients Receiving Dialysis By Baseline Erythropoiesis-Stimulating Agent Dose, Alan Jardine, Steven K Burke, Wenli Luo, Todd Minga, Mark J Sarnak, Wolfgang C Winkelmayer, Rajiv Agarwal, Glenn M Chertow, Kai-Uwe Eckardt, Mark J Koury

Faculty, Staff and Students Publications

Introduction: Erythropoiesis-stimulating agents (ESAs) and iron supplementation are standard treatments for chronic kidney disease (CKD)-related anemia. Targeting higher hemoglobin values in CKD increases cardiovascular risk. Whether the increased risk is from higher ESA doses or higher hemoglobin levels is uncertain, but alternative therapies are sought for patients requiring high ESA doses. Phase 3 INNO2VATE trials in patients with dialysis-dependent CKD (DD-CKD) demonstrated vadadustat's noninferiority compared with darbepoetin alfa. To determine vadadustat's potential to treat anemia, including in patients requiring high ESA doses, its safety and efficacy were compared with those of darbepoetin alfa across prespecified baseline ESA dose subgroups in …

Ptpn1 Regulation Via Ybx1-Ptbp1 Interaction Promotes Fibroblast Activation And Fibrotic Remodeling In The Lung, Huibing Liu, Cong Xia, Yingying Zhang, Yulong Gan, Lianhui Cheng, Xuqian Wang, Airu Chang, Wenyu Zhao, Bin Li, Yaxuan Wang, Yajun Li, Ivan Rosas, Juntang Yang, Guoying Yu, Lan Wang

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial pneumonia of unknown etiology. Its pathogenesis involves complex multicellular interactions and signaling pathways, with fibroblast-to-myofibroblast transition (FMT) being critical for fibrogenesis. Although the transcription factor Y-box binding protein 1 (YBX1) regulates processes such as cell proliferation, transcription, translation, and DNA repair, its role in IPF remains undefined. Here, we demonstrate that YBX1 overexpression significantly promotes transforming growth factor-β1 (TGF-β1)-induced pulmonary FMT, leading to substantially increased extracellular matrix (ECM) deposition in primary human (PHLFs) and mouse (PMLFs) lung fibroblasts. Conversely, YBX1 inhibition markedly suppresses TGF-β1-driven aberrant fibroblast migration and activation. Mechanistically, YBX1 …

Editorial: New Insights On Vascular And Metabolic Diabetic Complications, Hua Mao, John D Imig, Ricardo Espinosa-Tanguma

Faculty, Staff and Students Publications

No abstract provided.

Comparing Rotational Thromboelastometry And Standard Coagulation Assays For Predicting Intraoperative Bleeding In Pediatric Liver Transplantation, Kirby Deshotels, Trung Nguyen, Jun Teruya, Muhammed Umair M Mian, Kelby Fuller, Sanjiv Harpavat, Anna Banc-Husu, Amir Navaei, John Goss, Moreshwar Desai, Arun Saini

Faculty, Staff and Students Publications

Background: Utility of preoperative rotational thromboelastometry (ROTEM) over standard coagulation assays (SCAs) in predicting intraoperative bleeding during orthotopic liver transplantation (OLT) in children with liver failure (LF) remains unclear.

Methods: In this single-center retrospective cohort of pediatric OLT recipients, we compared the predictive values of preoperative ROTEM parameters (intrinsic pathway (INTEM) maximum clot firmness (MCF), extrinsic pathway (EXTEM) clotting time (CT), INTEM CT, and fibrinogen-based (FIBTEM) MCF) and the corresponding SCAs (platelet count, international normalized ratio (INR), activated partial thromboplastin time (aPTT), and fibrinogen level, respectively) for significant intraoperative bleeding (blood loss of > 22 mL/kg; i.e., ≥ 85th percentile for …

Definitions Of Arginine Availability: A Critical Metabolic Marker Of Physiological Processes, Mustafa Tosur, Farook Jahoor, Ashok Balasubramanyam

Faculty, Staff and Students Publications

No abstract provided.

Modulation Of Corneal Sensory Processing And Pain Responses By Dry Eye And Corneal Wounding, Ebru Yaman, Yangluowa Qu, Kaylin C Arpaia, Fairouz Elsaeidi, Uma Lakshmi Balakrishnan, Lance He, Henry Skrehot, Jehan Alam, Rui Chen, Mary Ann Stepp, Cintia S De Paiva, Stephen C Pflugfelder

Faculty, Staff and Students Publications

Background: Dry eye disease (DED) is a multifactorial disorder of the ocular surface in which tear film instability, epithelial barrier disruption, and neurosensory dysfunction contribute to symptom generation. Although several contributing factors have been identified, how different forms of ocular surface stress affect sensory pathways and behavioral responses remains unclear.

Purpose: This study aimed to evaluate corneal barrier function, sensory responses, and pain-related behaviors across acute and chronic dry eye and corneal injury models, and to assess stimulus-specific responses associated with TRPV1 and TRPM8 mediated pathways.

Methods: Female C57BL/6 J wild type and Mmp9KO mice were evaluated in acute desiccating …

Eng 4850, Clas

Executive Actions

No abstract provided.

Enhancing Stroke Recovery: A Proposal To Implement Self-Efficacy Strategies In Rehabilitation, Ariana M. Allen, Elliott P. Mcneely

Williams Honors College, Honors Research Projects

Self-efficacy is a critical predictor of rehabilitation success in stroke survivors, influencing motivation, therapy adherence, and functional recovery. This study will investigate the current use of structured self-efficacy enhancement programs (SEEPs) by healthcare professionals in post-stroke rehabilitation settings. Guided by Bandura's Self-Efficacy Theory, this proposal outlines a study that will include a comprehensive literature review and suggestions for further research. It will explore the frequency and methods of SEEP use, including goal setting, motivational feedback, and graded task planning. Data would be analyzed through descriptive statistics and thematic analysis. Findings are expected to identify usage patterns, barriers, and opportunities to …

Magnifying Mental Health In The Perinatal Population: A Systematic Review, Kasey E. Arnold, Alyssa M. Maki

Williams Honors College, Honors Research Projects

Pregnant individuals often experience significant anxiety, which can negatively affect both pregnancy and fetal outcomes. This systematic review evaluates the effectiveness of pharmacologic versus non-pharmacologic anxiety-relieving interventions, primarily focusing on the labor period. The PICOT question is: In perinatal patients, do non-pharmacologic anxiety-relieving measures, compared to pharmacologic anxiety-relieving measures, have a greater impact on ease of delivery and overall mental health during pregnancy and the perinatal period? PRISMA (2020) guidelines were used with inclusion criteria of human subjects, English language, and published within the last six years. Databases included PubMed, CINAHL, and Cochrane Library. Twenty-three studies were analyzed to examine …

High School Students’ Uses Of Ai In The Writing Process: A Qualitative Study, Sydney S. Thomas

Williams Honors College, Honors Research Projects

The purpose of this Honors Research Project was to examine how Artificial Intelligence (AI) impacts the quality of student writing and to provide educators with insight into how AI-assisted work may differ from independently produced writing. This study includes a review of current literature on the growing use of AI in education, along with concerns related to student dependence and the limitations of AI-detection software. Anonymous archived student writing samples were then analyzed using a researcher-developed rubric that measured grammatical accuracy, sentence complexity, vocabulary, organization, use of evidence, and voice/originality. Results showed that AI-assisted writing consistently performed strongly in grammatical …

A Child On Stand: The Impact Of Experiencing Trauma On Children’S Testimonial Efficacy In Legal Proceedings, Morgan Sweger

Williams Honors College, Honors Research Projects

Children who are victims of physical, sexual, emotional, or verbal abuse are nearly always left deeply traumatized by such events. In extreme cases, abused children may be asked to testify against their abuser(s) in legal proceedings, recounting their trauma in front of a room full of strangers. For some, the trauma of abuse may influence a child’s ability to effectively recall and describe their experiences and for others, the process of participating in legal proceedings creates deeper wounds. Research has aimed to understand whether children lack the ability to contribute sufficient testimonies during investigations of abuse and how these investigations …

Galician Culture Through The Lens Of Sargadelos, Rosella J. Messaros

Williams Honors College, Honors Research Projects

This research project covers the history and significance of the Sargadelos ceramics brand in Galicia, Spain. I then relate my research to my own personal experiences, tying into my family's Spanish heritage.

An Exploration Of The Status And Legacy Of The Latin Language, Jean M. Allison

Williams Honors College, Honors Research Projects

The Latin language, widely referred to as a "dead language," has historically held a great influence throughout various cultures and dialects, still holding some of this importance in the contemporary world. This project intends to explore these influences, both modern and historical, as well as how the language is now considered dead. A variety of written material spanning several centuries will be utilized to examine these aspects of the project posed within the presented overarching theme. All of the relevant information from these texts will ultimately be summarized and critically detailed within a written report that displays the findings of …

Locked And Loaded: The Truth Behind Gun Violence, Alana N. Shroyer

Williams Honors College, Honors Research Projects

Gun control remains one of the most controversial policy issues in the United States. While gun reform advocates argue for stricter firearm regulations to reduce gun violence, pro-gun advocates contend that crime is driven more by individual behavior, socioeconomic conditions, and mental health than by gun availability alone. This research project examines gun control laws in the United States, analyzes gun violence data, explores illegal firearm trade markets, compares international approaches, and evaluates whether gun control laws effectively reduce violence while preserving constitutional rights.

Effect Of Jet Lag And Nighttime Shifts On The Circadian Rhythm Of Humans, Mahd Adrees

Williams Honors College, Honors Research Projects

This project reviews the circadian rhythm and its disruption by jet lag and nighttime shifts. It discusses the effects on melatonin, sleep quality, and physiological symptoms using articles from Google Scholar. Key studies, mechanisms, and statistics will support these points. A discussion follows, comparing and contrasting the various literature sources. This review aims to raise awareness and summarize strategies to reduce jet lag and nighttime shift effects, improving wellbeing.

Automated Pill Dispenser, Ryan Oderkirk, Connor Beaven, Rachelle Labrie, Josue Panchana

Williams Honors College, Honors Research Projects

The project we propose is an automated system for dispensing dosages of medication throughout the day. It will be able to alert a user when their pills need to be taken and give them the correct dosages of up to four different medications. These dosages are configurable as well as the scheduled time they are to be taken. In addition, the pill dispenser will alert users when they are low on medications and need to refill the machine.

Honors Project In Business Admin Group 2, Matt R. Howell, Richard W. Black, Kale R. Kochman, Anthony J. Mast

Williams Honors College, Honors Research Projects

Our team is performing a strategic analysis on Project Learn, Summit County's non-profit that provides resources to adult learners to complete their GED. Our goal is to provide recommendations for them to expand their market and improve the product that they currently offer. This includes exploring new partnerships, adding additional services, and various other initiatives that we hope will improve the organization's wellbeing.

Aquatic Habitat Use By Western Toads And American Bullfrogs In California’S Central Valley: Effects Of Local Habitat Characteristics And Landscape Composition, Kaitlyn Breana Hernandez

Cal Poly Humboldt theses and projects

Drastic losses of historic wetland habitat in the California Central Valley have caused widespread population declines and extirpations of aquatic breeding amphibians. Efforts to restore wetland habitat have included private land, which represents 70% of land tenure in the Central Valley. Management of these restored wetlands is focused on waterfowl with the assumption that they will provide habitat for native herpetofauna. This study used combined surveys to test the assumption that restored wetlands on private land provide habitat for native amphibians with the western toad (Anaxyrus boreas) as a case study. The objectives were to use environmental DNA …

A Critical Toponymy Of Humboldt County: Ethics And Tensions Within Efforts To Change Place Names, Serenity Aleta Wood

Cal Poly Humboldt theses and projects

This project explores how Humboldt regional placenames enact toponymic silencing and how Indigenous activists challenge colonial names and geographies, advancing un-settled interpretations that position language revitalization/regeneration as a means of revitalizing relationships with the land. Mobilizing Dr. Cutcha Risling Baldy’s concept of (re)naming, I analyze two case studies, the Baduwa’t documentary and the Tolowa Dee-ni' Nation’s film A'-t'i Xwee-ghayt-nish: Still, We Live On, as well as three additional artistic works: Sarah Biscarra Dilley’s every pattern needs a passage, Sasha taqwšəblu LaPointe’s Thunder Song, and Jaune Quick-to-See Smith’s painting, State Names. In tandem with film and poetry analysis, I survey local …

Amplifying Counterstories And Testimonios About Latine Rural Youth: A Case Study Of The Educational Experience Of Oaxacan-American Youth In Rural Humboldt County, Lorena Cortez

Cal Poly Humboldt theses and projects

As the Latine community has increased in rural Humboldt County and in rural regions across the country, educators and researchers have struggled to address the needs of this student population. These challenges are reinforced by deficit perspectives that frame multicultural and multilingual student populations as “culturally lacking” or as “English learners”. Such narratives continue to drive policy in the K-12 education system and contribute to persistent inequities; Latine students represent the lowest educational attainment across other rural student populations (Sansone, 2023, p.60). To challenge these deficit narratives, this research applies a LatCrit methodological framework to create testimonios, a form of …

Decolonizing Restorative Justice: A Teaching Development Project, Lacy Felice Mitchell

Cal Poly Humboldt theses and projects

The coloniality of power serves as a central axis within the matrix of domination that characterizes global capitalist modernity, as Anibal Quijano famously argued. This power is rooted in particular ways of looking, seeing, and understanding social reality, anchored in Eurocentrism as an epistemological paradigm for the hegemonic discourse produced by the West against both internal and external categories of “other.” Such categories still inform the production of knowledge in educational settings. In this project, I engage in a critique of the coloniality of power to explore its implications and potential for critical pedagogical practice within the context of sociology …

“Twist But Don’T Break:” Constellating Past And Present Barriers In Black Queer Multimodal Publishing That Shift Text Into Subtext; Addressing Acceptance Into Queer Creative Communities And The Void Of Black Voices Within, Kae Ann Dennert-Frederick

Cal Poly Humboldt theses and projects

What does it look like to reframe our understanding of intersectional work? Looking at multimodality I will walk through the multiple frameworks by asking how Black Queer publishing of Young Adult fiction uses visuals to describe what cannot be said and what choices are made to show community structure and language, while also having to adapt for publication standards. I have researched this by looking into examples of Queer publishing (any representation of queerness in a form of publishing—in the text and sometimes in the authors' identity), as well as authors’ use of visuals to say what cannot be said …

Queering Poetry Workshops, Dobby Morse

Cal Poly Humboldt theses and projects

To what extent do participants report that a poetry workshop builds connections between poets and strengthen their confidence in writing? What do participants want or expect from a poetry workshop?

Through this project I hope to attend and host poetry workshops with an emphasis on the queer community. I will collaborate with campus and community organizations like Queer Humboldt and other organizations that are interested in exploring queer experiences through writing, connection, and meditation. This project will serve as a how-to guide for those seeking to conduct their own workshops.

Weaponized Borders: A Contrapuntal Analysis Of Uneven Humanitarian Aid And Comparative Landscapes, Alex Orla-Bukowski

Cal Poly Humboldt theses and projects

The proliferation of global border regimes has caused an increased level of state violence against humans and the environment. In this thesis I explore how contemporary border regimes propagate myths on human mobility, obstruct humanitarian policy, and weaponize environmental landscapes to sustain state violence while obscuring political responsibility. Building on this, I argue that borders are the source of violence and create systems of vulnerability as a core-function of state making. My research primarily utilizes semi-structured interviews with humanitarian actors and secondary data analysis to trace the testimonies of those subject to state-based harm and explore the gaps in aid …