Digital Commons Network^™

Development Of Colonic Polyposis In A Woman With Chronic Myeloid Leukemia Treated With Dasatinib, Guido Pelaez, Behram Suha Yildiz, Mert Candan, Mohammad Ismail, Francesca Vacca, Marianna B Ruzinova, Samuel Ballentine, Kathleen Byrnes, Armin Ghobadi

2020-Current year OA Pubs

INTRODUCTION: Chronic myeloid leukemia (CML) is a hematopoietic malignancy driven by constitutive tyrosine kinase activity. Dasatinib, a second-generation (2G) tyrosine kinase inhibitor (TKI), is a preferred treatment due to its superior, durable, and rapid response rates. While dasatinib has known gastrointestinal (GI) side effects, colonic polyposis is a rare complication, not well described in the literature.

CASE PRESENTATION: Upon routine colonoscopy, a 66-year-old woman with chronic-phase CML was incidentally discovered to have asymptomatic colonic polyposis after 11 months of dasatinib therapy. Histopathology revealed reactive inflammatory changes without evidence of dysplasia or neoplasia. The polyposis resolved completely after cessation of dasatinib. …

Excellent Survival Following Low-Intensity Approaches Prior To Allo-Hsct In Ph+ All: A Comprehensive Meta-Analysis, Lacey S. Williams, Wenners Ballard Iii, Deniz Ozisik, Charles Scott Dorris, Kepher Makambi, Scott Rowley, Kieron Dunleavy, John Dipersio, Alaa Ali

2020-Current year OA Pubs

No abstract provided.

Psychological And Clinical Risk Factors For Substance Use In People With And Without Hiv, Joanna M Hobson, Shameka L Cody, Shannon R Gilstrap, Michael A Owens, Myles D Moody, Dyan M White-Gilliam, Stephen Justin Thomas, Emily J Bartley, Burel R Goodin

2020-Current year OA Pubs

BackgroundDespite growing concerns, limited research has demonstrated how psychological factors influence substance use in people with HIV (PWH). Therefore, we examined the association between heightened vigilance and substance use outcomes in people with (PWH) and without HIV (PWoH), while accounting for key risk factors.MethodsParticipants (n = 138) were recruited from an HIV clinic and the surrounding community, completing a urine drug screener (UDS) and questionnaires.ResultsPWH reported greater insomnia (

Subcutaneous Infliximab For Inflammatory Bowel Disease: Clinical Evidence, Pharmacokinetics, And Implementation Challenges, Mir Zulqarnain, Parakkal Deepak, Andres J. Yarur

2020-Current year OA Pubs

No abstract provided.

"Using Theories" And "Doing Theory": Tool And Action Orientations To Theory At The Interface Of Public Health And Anthropology, Peter Taber, Eileen M Dryden, Jean M Hunleth, Linda S Kahn, Lance Laird, Teresa Winstead, Genevra F Murray

2020-Current year OA Pubs

The use of "theory" is a common concern in public health and anthropology. However, the term can have quite distinct meanings. In this piece, we seek to name and characterize some tendencies in anthropological theorizing that contribute to potential misunderstandings when communicating with non-anthropologist colleagues in public health. In particular, we highlight differences between the use of recognizable, named "theories" that often explicitly frame public health research and interventions, and the open-ended and context-specific work of "doing theory" sometimes referenced in anthropology. Observing the linguistic shifts entailed to refer to theory in each of these cases-"using theories" versus "doing theory"-we …

Analysis Of Volatility Between Macroeconomic Variables And Busan Port Cargo Throughput According To Global Risks, Sang Ho Cho

Plymouth Business School Theses

This study investigates how container (BPC) and non-container (BPB) cargo throughput at Busan Port responds to structural shocks in global and domestic macroeconomic variables, and how their relative importance changes over time. The selection of variables was based on a combination of a Systematic Literature Review (SLR) and semi-structured interviews (SSI). The econometric analysis applied a stepwise framework, employing cumulative Impulse Response Functions (IRF) and Forecast Error Variance Decomposition (FEVD) based on Vector Error Correction Model (VECM) estimations, as well as Historical Decomposition (HD) for specific crisis periods. While IRF and FEVD were used to capture dynamic properties under general …

Tools Used To Measure Fear Avoidance Behaviour In The Management Of Mild Traumatic Brain Injury (Concussion), Liam Sherwood

Theses: Doctorates and Masters

Concussion can present challenges with respect to diagnosis and management. Fear avoidance behaviour and beliefs may be perpetuating factors in the clinical course of concussion. Understanding which patients may adopt such behaviours and beliefs can offer important information to allow tailoring of clinical management and implementing strategies to minimise the risk of progression to persisting post-concussion symptoms.

In this thesis, I:

-       systematically reviewed the current measurement tools used to assess fear avoidance behaviours and beliefs associated with concussion;

-       explored the experience of clinicians, researchers and people with lived experience of concussion in relation to fear avoidance behaviours;

- …

Development Of Virtual Reality Learning Environments In Science To Engage Secondary Students In Hazardous Activities, Luke Spartalis

Theses: Doctorates and Masters

This research examines the need for change in including hazardous activities in education. As different learning technologies develop, platforms that retain authentic outcomes via virtual reality are needed. The main objective of this research is to examine the inclusion of Virtual Reality Learning Environments (VRLEs) to determine their value in areas that include hazardous conditions. The research considered the ways that VR tools could be optimised to support these activities, as well as considering the challenges of VRLE implementation. The study examined whether VRLE’s allowed for authentic experiences to sufficiently drive an acceptance of VR to complement existing teaching and …

The Development Of A Midwifery Specific Tool To Identify The Barriers And Enablers To Change Within The Midwifery Setting, Sara Davis

Theses: Doctorates and Masters

Despite being well-positioned to identify service gaps and propose improvements, many midwives lack the knowledge, skills, confidence, or tools to effect practice change. Implementation science (IS) offers a structured approach to moving evidence-based innovations into practice; however, existing IS theories, models, and frameworks do not reflect the unique context of midwifery practice. The first step in the intentional implementation of an evidence-based practice innovation is to conduct a context assessment to identify factors that may facilitate or impede its uptake. There are numerous evidence-based checklists for this, but none capture all the influences on midwifery practice environments.

In this study, …

The Experience Of Homelessness Among Older Adults In Bhutan - A Narrative Inquiry Study, Phuntsho Om

Theses: Doctorates and Masters

A shift in the demographics of homelessness started to occur in the 1900s, with a significant increase in the number of middle-aged or elderly men and women being recognised as a part of the homeless population. The rising urgent global concern of homelessness of older adults necessitates a deeper understanding of the lived experience and holistic well-being of these marginalised adults. This thesis aimed to explore the phenomenon of homelessness of older adults in Bhutan, which is an often neglected topic in both national and international gerontological research.

Employing narrative inquiry within the constructivist approach as articulated by Pino Gravidia …

Patient Experiences Of Receiving Home-Based Immunotherapy Infusions - A Constructivist Grounded Theory Study, Patricia Ann Cook

Theses: Doctorates and Masters

Context: The treatment of cancer and chronic health conditions has been greatly revolutionised via intravenous immunotherapy infusions. Demand, both globally and in Australia, is increasing due to several factors including aging and increased populations, subsequent increases of cancer cases, new immunotherapy indications and increased survival rates.

In Perth, Western Australia, a private service provider commenced delivering a home based immunotherapy infusions model of care as a hospital substitution service provider in 2013 and the service has now been extended across Australia. The safety and efficacy of home-based infusions have been well documented in research, and an increasing number of patients …

How Educational Leaders At A Type C International School In China Understand Educational Leadership, Peter Pagett

Theses: Doctorates and Masters

This study examined how educational leaders at a Type C international school in China understand educational leadership. The extensive knowledge on educational leaders identifies many important facets of this phenomenon, such as the importance of leaders focussing on mission and vision and building relationships. Current understanding also highlights the role of personal identity in influencing a leaders’ work and understandings. However, literature on educational leadership in the context of international schools is scant. Given the challenges specific to international education such as culture shock, transience and isolation there is a need to conduct more research into these types of schools. …

Beyond Restless Sleep: A Cross-Sectional Study Of Obstructive Sleep Apnea Risk, Aging Biomarkers, And Chronic Low Back Pain, Khalid W Freij, Fiona Bat Agbor, Philemon Domoyeri, Kiari R Kinnie, Asia M Wiggins, Demario S Overstreet, Tammie L Quinn, Shivraj S Grewal, S Justin Thomas, Walid W Freij, Shameka L Cody, Michael A Owens, Robert E Sorge, Burel R Goodin, Edwin N Aroke

2020-Current year OA Pubs

This secondary data analysis aimed to determine the nature of the relationship between obstructive sleep apnea (OSA) risk, biological age acceleration, and nonspecific chronic low back pain (CLBP). In total, 199 adults aged 18-82 years who filled both STOPBANG and pain questionnaires subsetted for secondary analysis. Based on the STOPBANG questionnaire, 104 had a low OSA risk and 95 had an intermediate or high OSA risk. Dunedin Pace of Aging Computed from the Epigenome (DunedinPACE), Horvath's, Hannum's, PhenoAge, and GrimAge clocks were used to determine biological age and pace of biological aging. Individuals with low OSA risk reported increased DunedinPACE …

Persistence Of Contested Value Cocreation Practices, Kim Feddema, Kaisa Koskela-Huotari, Paul Harrigan

Research outputs 2022 to 2026

The climate crisis and other global challenges make it clear that not only are new value cocreation practices (VCPs) needed, but some current VCPs must be discontinued. Prior service literature assumes that VCPs can be disrupted by reforming the institutions that govern them. However, empirical observations show that VCPs may persist even when targeted by institutional work, and recent organizational research points to contested practices that continue to be enacted even when challenged or criticized. To understand this phenomenon in value cocreation, we conducted an embedded case study of exotic pet-keeping—a set of VCPs that continue despite intervention efforts. Our …

Music Learning And School-Aged Children’S And Adolescents’ Wellbeing: A Scoping Review, Jason Goopy, Stephanie L.R. Macarthur

Research outputs 2022 to 2026

There is compelling evidence that music can support young people’s wellbeing, particularly through music listening to and making. In this article we report a systematic review of music learning and wellbeing literature to offer a new perspective on learning music as a wellbeing strategy. In this review, we investigated (a) what definitions and theories of wellbeing have been used; (b) what methodologies have been employed, particularly measurement tools; (c) what learning contexts and participant demographics have been examined; and (d) what is known about music learning and the wellbeing of school-aged children and adolescents. This review was conducted using the …

A Critical Review Of The Theory Of Planned Behaviour In Tourism Research, Kourosh Esfandiar, Arghavan Hadinejad

Research outputs 2022 to 2026

The Theory of Planned Behaviour (TPB) has received considerable attention across various academic disciplines and remains one of the most widely applied–yet increasingly critiqued–theoretical frameworks in tourism research. Despite its widespread use, there is a notable lack of critical reflection on its adequacy in capturing the complexity of tourist behaviour and a limited exploration of alternative theoretical pathways. This paper addresses this gap by critically evaluating the appropriateness and limitations of the TPB in tourism research. Special attention is given to the Theory of Reasoned Goal Pursuit (TRGP), a recent extension of the TPB, alongside complementary frameworks from parent disciplines …

Pathways To Prosperity: How Tourism Industry Training Reduces Poverty, Panpan Sun, Songshan Huang, Ghialy Yap, Zhibin Lin, Lei Zhao

Research outputs 2022 to 2026

This study investigates the effects of tourism industry training (TIT) on poverty alleviation, considering both direct and indirect pathways. Integrating labour mobility theory, human capital theory, and the tourism-led growth (TLG) hypothesis, we propose a new theoretical framework. Based on panel data from 29 Chinese provinces between 2000 and 2019, the empirical results show that TIT has a significant negative effect on poverty level, depth, and severity, with a larger direct impact than the indirect effect through tourism development. We also find significant regional differences in the impact of TIT on poverty reduction, with TIT having a more substantial impact …

The Nurse's Role In Curative-To-Palliative Transitions In Advanced Cancer: A Theory Synthesis Using Turner's Method, Geya George, Deborah Kirk, Davina Porock

Research outputs 2022 to 2026

Aim: This paper aims to explain the process of formulating a robust theory that comprehensively explains the nurse's role during the transition from curative to the palliative phase in advanced cancer care. Design: A qualitative theory synthesis approach was applied, utilising Turner's 9-step theory synthesis method to integrate five grounded theories and 10 qualitative studies. The Walker and Avant method of concept development and analysis further ensured rigour. Methods: Turner's theory synthesis was used to formulate a more comprehensive, testable theory from five existing grounded theories and 10 other qualitative studies that explain the nurse's role in supporting and facilitating …

It Makes You Nervous When You Start Talking About Racism: Shining Light On Teacher Educators’ Experiences Of Anti-Racist Pedagogy In Australian Teacher Education, Sasha Janes

Research outputs 2022 to 2026

Teacher educators have a significant responsibility in promoting anti-racist pedagogy and guiding preservice teachers to engage in critical self-examination regarding dominant narratives. However, many teacher education programmes fall short of adequately equipping aspiring teachers for diverse classrooms as they often perpetuate a predominantly white system and curricula. Informed by Critical Pedagogy and underpinned by a lens of Culturally Sustaining Pedagogies, this paper discusses the experiences of teacher educators facilitating anti-racist pedagogy within teacher education programmes at Australian universities. Semi-structured interviews were held with 23 experienced teacher educators employed at universities across Australia. Data reveal teacher educators’ efforts to promote anti-racist …

Invisible Innovation: Intellectual Labour On Regional University Campuses In Australia, Merete Schmidt, Lucinda Aberdeen, Colleen Carlon, Robyn Eversole

Research outputs 2022 to 2026

In Australia, regional university campuses occupy a geographically and institutionally peripheral position in a metrocentric higher education system. We argue that the concentration of research funding and capabilities at metropolitan campuses devalues the intellectual labour of academics working on regional university campuses. The authors use collaborative autoethnography to explore a common theme of ‘gap filling’, that is, mobilising scarce resources to create unique solutions for local issues, and draw on Southern Theory to theorise the implications for our work in the location-based power relations of the Australian knowledge production economy. In this context, we utilise Eversole's concept of ‘invisible innovation’ …

Educating The Next Generation Of Engineers: Spatial Thinking Is Key To Their Success, Sheryl Sorby, Gavin Duffy, Jack Parkinson, Gibin Raju, John Lynch, Muhammad Asghar

Research Outputs: 2025-Present

This paper attempts to answer questions regarding the link between engineering success and spatial skills through three themes. The previous research of the authors in examining the questions surrounding each theme is the focus of this paper; we acknowledge that others around the world may have conducted similar research, but the specific findings of the authors are the main focus of this paper. In the first theme, we examine data from several author-led studies where positive correlations have been found between spatial skill levels and proficiency in tasks that are a part of what it means to be an engineer. …

Sustainable Development And Faith, Tony Kealy

Research Outputs: 2025-Present

The contribution of faith-based input to the broader idea of sustainable development has not been widely acknowledged in the traditional sense; however, recent global events suggest it may warrant further exploration. This qualitative study examines how faith-based activities, such as missionary work, have historically and can continue to contribute significantly to the environmental, economic, and human/social aspects of organizational decision-making. The focus is on the Catholic faith, specifically the role played by the Irish-based Medical Missionaries of Mary religious congregation in the mid-to-late twentieth century. An initial literature review was conducted to gather information from various sources to define sustainable …

Diffusion-Enhanced Nat-Bart Vision Language Transformer For Unified Urdu Word Recognition, Wahid Hussain, Shahbaz Hassan, Isma Ul Hassan, Ahmad Raza Shahid, Asif Naeem, Muhammad Usman Yaseen, Nouman Ashraf

Research Outputs: 2025-Present

Handwritten Urdu text recognition remains a very challenging problem due to the cursive and complex nature of the Nastaliq script. Each writer has a unique style, and there is a severe lack of large, well-labeled datasets. These challenges make Urdu text recognition much harder than for many other languages. Here we propose a novel and effective approach for handwritten Urdu word recognition that addresses both data scarcity and feature complexity. We utilized conditional diffusion models to generate synthetic handwritten Urdu word images. These models produce realistic word samples covering a wide range of variations, such as stroke thickness, curves, and …

School Library Professionals’ Perspectives On Current And Future Workforce Challenges, Margaret Kristin Merga, Saiyidi Mat Roni

Research outputs 2022 to 2026

While school library professionals work across many nations, supporting student learning and wellbeing, there is limited current research capturing shared issues faced by this educational workforce. The International School Library Workforce Survey collected insights from 971 respondents across 63 countries derived from analysis of both quantitative and qualitative data. Findings suggest that in an international context, school library professionals are experiencing notable issues that impact upon their morale and their ability to enact their professional roles. Respondents were more likely to disagree then agree that school library professionals were typically valued in their country. While the vast majority of respondents …

Driving Factors And Spatio-Temporal Evolution Of Tourist Accident Clusters In Chinese Outbound Tourism, Chaowu Xie, Kun Zhang, Jiangchi Zhang, Songshan Huang

Research outputs 2022 to 2026

The clustering of tourist accidents is a critical yet underexplored area of research. This study employs cluster theory and safety system theory to develop a comprehensive measurement tool for analysing tourist accident clusters, examining their spatiotemporal evolution patterns, and identifying the driving mechanisms from a holistic destination perspective. By analysing accident records of Chinese outbound tourists across 48 countries from 2011 to 2019, the findings reveal a reduction in disparities among tourist accident clusters (α-convergence effect) and a fluctuating trend over time. Spatial autocorrelation analysis identifies four distinct spatial distribution patterns: low-low (L-L), high-low (H-L), high-high (H-H), and low-high (L-H). …

Reflections From A Community Capacity Building Forum To Support People Bereaved By Suicide, Colleen Carlon, Jacquie Tarrant, Marie Eckersley, Priscilla Vindin

Research outputs 2022 to 2026

An estimated half the population may be impacted by suicide loss. The combination of grief and trauma makes the experience particularly complex. Recognised as the most stigmatised of all sudden losses people bereaved by suicide are in sociocultural contexts that disrupt constructive grief processes and create barriers for help seeking and supportive responses. Effecting change in this context poses a significant health promotion challenge. Social workers in the South West Region of Western Australia sought to develop and deliver a unique postvention approach aimed at strengthening the self-support capacity of people bereaved by suicide while building broader community capacity for …

How Does Pre-Registration Child Specific Education Prepare Newly Qualified Nurses’ To Care For Children, Young People, And Their Families? An Empty Narrative Review, Matt Carey, Danielle Edge, Julie Blamires, Mandie Foster, Sarah Neill

School of Nursing and Midwifery

This narrative review investigates the influence of child-specific content within pre-registration nursing programs on newly qualified nurses’ perceptions of preparedness to care for children, young people, and their families. Despite international recognition of the specialised competencies required for pediatric nursing, the proportion and quality of child-focused education across Higher Education Institutions is not clear. The Population, Exposure, Outcome framework provided a comprehensive search strategy applied across eight databases to identify relevant studies that met the inclusion and exclusion criteria. Of 663 records identified, 451 were screened and 25 full texts wereassessed for eligibility by two reviewers. No studies met the …

A Figurational Analysis Of Health And/Or Physical Education Teacher Educators’ Conceptualisations Of Policy, And Their Sociogenesis, Laura Alfrey, Dylan Scanlon, David Aldous, Jenna Lorusso, Kellie Baker, Christopher Clark, Mo Jafar

Research outputs 2022 to 2026

Policy engagement is key to promoting quality physical education yet it has been identified as a ‘grand challenge’ for Health and/or Physical Education (H/PE) internationally. All H/PE professionals, including teacher educators, have a collective responsibility to engage with policy but existing research tells us little about how H/PE teacher educators (H/PETEs) understand and engage with policy. It is important to examine H/PETEs conceptualisations of policy for a few reasons, not least because teacher educators play a crucial role in supporting future generations of teachers who themselves will need to engage with policy as a core feature of their professional lives. …

The “Green Persuasion Effect” Of Negative Messages: How And When Message Framing Influences Tourists’ Environmentally Responsible Behavior, Xuehuan He, Chengzhi Ye, Songshan Huang, Lujun Su

Research outputs 2022 to 2026

Tourist activities may harm the environment, making tourists’ environmentally responsible behavior particularly important in tourism research. This research investigates the persuasion effect of message framing in environmental protection reminders on environmentally responsible behavior. Through five studies employing both field and controlled experiments and different measures of environmentally responsible behavior across varied tourism scenarios, we demonstrate that negatively (vs. positively) framed messages more effectively increase environmentally responsible behavior. Specifically, negatively framed messages are more effective in enhancing tourists’ environmental awareness, which triggers more environmentally responsible behavior. Furthermore, we identify social class as a moderator of message framing effectiveness, showing that negatively …

Can Environmentally Friendly Hotels Lead Customers To Green Behaviors? Evidence From The Stimulus–Organism–Response Model And Social Cognitive Theory, Saeid Nosrati, Mohtaram Rabbani, Razieh Sharifipur Shirazi, Ilkay Yorganci, Niusha Talebzadeh, Negin Bassirat

Research outputs 2022 to 2026

Purpose Using the stimulus–organism–response model and social cognitive theory, this study aims to examine how environmentally friendly hotels influence customers’ green patronage intention and green word-of-mouth. The study explored the mediating effects of hedonic value and utilitarian value and the moderating role of environmental concern. Design/methodology/approach Data were collected from 200 customers of environmentally friendly hotels in Iran and analyzed using structural equation modeling (SEM) with Mplus (version 8.3) software. Findings The results indicate that environmentally friendly hotels positively influence hedonic and utilitarian values, as well as green patronage intention and green word-of-mouth. Additionally, hedonic and utilitarian values partially mediate …