A Bibliometric Evolution Of Molecular Mechanisms And Emerging Research Trends Of Therapeutic Resistance In Oral Cancer, Chu-Yen Chien, Ying-Chen Chen, Jia-Rong Wu, Hsu-Hua Chu, Yi-Jen Hung, Yi-Shing Shieh

Journal of Dental Sciences

Background/purpose: Drug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.

Materials and methods: A comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional …

Do Anatomy, Physiology And Biochemistry Subject Scores Predict Future Academic Performance? A Longitudinal Analysis Of Undergraduate Dental Students Across All Professional Years., Shahid Akhtar Akhund, Hassan Shaibah

Journal of Dental Sciences

Background/purpose: Basic sciences subjects including anatomy, physiology and biochemistry form the foundation of the Bachelor of Dental Surgery (BDS) programme. However, empirical evidence linking the basic science academic performance to sustained academic achievement across subsequent clinical years remains limited. This is true for low and medium sized economies like Pakistan.

Materials and methods: A retrospective, quantitative, and longitudinal cohort study was conducted.  The deidentified data from a representative dental college was used. Basic science examination scores from the 1^st professional year examination served as predictor variables. The examination scores across 14 subjects served as outcome variables. Pearson product-moment correlations …

Deer Antler Tip Cell Culture Supernatant Restores Endothelial Barrier Function And Angiotensin Converting Enzyme 2/Endothelial Nitric Oxide Synthase Nitric Oxide Signaling Impaired By Porphyromonas Gingivalis Lipopolysaccharide, Ming-Shou Hsieh, Ya-Ting Yang, Chin-Sheng Huang, Ting-Yi Renn, Chuen-Kai Wang, Chia-Chen Hsu, Wei Jen Chang, Yu-Sheng Chang

Journal of Dental Sciences

Background/purpose:

Periodontal inflammation contributes to endothelial dysfunction, but effective biologically active strategies for vascular protection remain limited. This study investigated whether deer antler tip cell culture supernatant could rescue Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) induced endothelial injury and restore endothelial homeostasis.

Materials and methods:

Velvet antler tissues from the tip, shaft, and burr regions were examined histologically and used for primary cell isolation. Human umbilical vein endothelial cells were exposed to Pg-LPS or indirectly co-cultured with LPS-stimulated THP-1-derived macrophages. Deer antler tip cell culture supernatant was subsequently applied to these endothelial inflammatory models, and its protective effects were …

Usable Authentication: Are We There Yet?, Nathan Clarke, Steven Furnell

School of Engineering, Computing and Mathematics

With technology increasingly embedded in everyday life, the demand for secure and usable authentication methods has never been greater. Traditional password-based systems continue to dominate, despite well-known usability and security challenges. This paper explores the evolution of user authentication technologies, from secret knowledge and tokens to biometrics and emerging approaches such as Passkeys. It critically evaluates the extent to which usability has been achieved, identifying both successes—such as biometrics integrated into smartphones—and persistent issues, including inconsistent guidance, ecosystem dependence, and accessibility barriers. Drawing on academic and commercial developments, the discussion highlights the growing burden on users who must authenticate across …

01.01.14. Mallard Hybrids, K. M. Mcbride, A. Auger, A. T. Fanning, Ann Hodgson, Florida Ornithological Society

01.01. <em>Anatidae</em> - Ducks, Geese, and Waterfowl

The Mallard complex of ducks is a suite of 14 closely related species found throughout the world whose genetics are just beginning to be understood. Within the complex, the wild-type mallard (Anas platyrhynchos) is the sole ancestor to most domesticated ducks.

Children And Adults Across 15 Countries Believe In Human Uniqueness Of Mind: A Cross-Cultural Investigation Of Cross-Species Mind Perception, Karri Neldner, Luke Maurits, Magie Junker, Lara Abbas, Nayrouz Abbas, Arianna Abis, Federica Amici, Bernardo Arroyo-Garcia, Negar Asghari, Giovanna Barragán Pardo, Zhen Zhang, Junior Peña Chumacero, Ardain Dzabatou, Dustin Eirdosh, Susan Hanisch, Tom Herrnsdorf, Tom Hovehne, Alicia Junker, Patricia Kanngiesser, Felipe Villa Larens, Safaa Mahmoud, Sandra Masaquiza, Iino Masato, Risma Illa Maulany, Tongtong Meng, Kardelen Mutlu, Putu Oka Ngakan, Ebru Peközer, Ljubica Petrović, Mirella Christy Rehatalanit

School of Psychology

The way humans relate to other animals is fundamentally shaped by whether we perceive ourselves as unique, with feelings and thoughts not shared by other animals. How beliefs about animals’ ability to feel and think develop across cultures remains largely unexplored. We asked children and adolescents (4–17 years, N = 1025) and adults (N = 190) from 33 urban and rural communities across 15 countries whether animals have thoughts or feelings (judgments of presence), and whether those thoughts or feelings are human-like (judgments of similarity). Bayesian analyses revealed that participants generally ascribed non-human animals the ability for thoughts and feelings. …

Others’ Requests May Dampen The Desire To Do Good: The Effect Of Requests On Children's Prosocial Motivation Across Five Cultures., Anneliese Skrobanek, Patricia Kanngiesser, Jahnavi Sunderarajan, Jorge David Mantilla Salgado, Saiwa Sisa Quimbo Yacelga, Shoji Itakura, Marie M. Morita, Masanori Yamaguchi, Nadia Chernyak, Lucy M. Stowe, Joscha Kärtner

School of Psychology

There exists cultural variation in how people react to prosocial obligations, but we still know little about when these differences emerge in development and how they can be explained. We investigated this in a study with 6- to 11-year-old children (N = 686) in five cultural contexts. Children listened to scenarios about spontaneous and requested (within-subjects) helping and sharing. They rated requested scenarios as less desirable and less satisfying, but there was significant cross-cultural variation in the magnitude of this effect, which was mostly stable with age. We also measured children's sense of individual agency and internalization of prosocial norms …

Front Matter For The Florida Breeding Bird Atlas Ii, Ann Hodgson, Florida Ornithological Society

Breeding Bird Atlas II Front Matter

The front matter from the Florida Breeding Bird Atlas II from the Florida Ornithological Society. Included are introductions, methods, results, discussion, appendices, and references.

The table of contents will be updated with page numbers as more accounts are added.

Operationalizing Mtss: A Case Study Of Principal Leadership Practices In Guiding School-Based Leadership Teams Through Inquiry And Improvement Science, Heather M. Teto

UNF Graduate Theses and Dissertations

The COVID-19 pandemic widened academic achievement gaps, creating an urgent mandate for school leaders to implement systemic, data-driven frameworks to support student academic recovery. While the Multi-Tiered System of Supports (MTSS) is a widely adopted framework for addressing these disparities, its success is dependent on the strategic involvement and instructional leadership of the school principal. This qualitative case study explores the lived experiences and leadership characteristics of elementary school principals as they lead School-Based Leadership Teams in implementing a district-developed MTSS framework.

Guided by the principles of Improvement Science and the Plan-Do-Study-Act (PDSA) inquiry cycle, this research examines the specific …

Novice Teachers' Perceptions Of Clinical Experience And Their Preparedness To Teach In High-Need Urban Schools, Robin D. Renelus

UNF Graduate Theses and Dissertations

This hermeneutic phenomenological study examined novice teachers’ perceptions of how clinical experiences in a teacher preparation program prepared them to teach in high-need urban schools. The study included 12 novice teachers with three or fewer years of teaching experience who completed their clinical experience at the same university in Northeast Florida. Data were collected using Seidman’s (2019) three-interview approach, which explored participants’ backgrounds, day-to-day teaching experiences, and reflections on their sense of preparedness. Data were analyzed to develop textural descriptions of what participants experienced and structural descriptions of how those experiences were shaped (Moustakas, 1994).

Participants described clinical experiences as …

From Preparation To Practice: A Study Of Assistant Principals After Completion Of An Aspiring Assistant Principal Preparation Program, Mallory L. Mcconnell

UNF Graduate Theses and Dissertations

Leadership programs and readiness in schools, particularly those in Florida, is well studied. However, few studies have investigated how current assistant principals who have completed Clay County District School’s Aspiring Assistant Principal Program describe their experiences, believe the program has prepared them for the realities of school leadership, or identify the most impactful elements that have supported their leadership development. This case study seeks to collect foundational research knowledge by analyzing data from the program, participants, and key facilitators. Using a sampling of current assistant principals who have completed the Aspiring Assistant Principal Program, this research examines the results in …

Fostering Reading: Review Of A College Bridge Program For Deaf And Hard Of Hearing High School Students, Cara Wilmot

UNF Graduate Theses and Dissertations

This mixed-methods formative program evaluation examined the reading component of a summer College Bridge Program (CBP) designed for high school students who are deaf and hard of hearing (d/Dhh). Persistent disparities in reading outcomes among d/Dhh students have been linked to differences in language access, communication access, and opportunities to receive specialized instruction. Using the Context, Input, Process, Product (CIPP) evaluation model, this study evaluated how the CBP identified and addressed students' reading needs, implemented evidence-based instructional practices, and supported reading development through a three-week summer program.

Participants included 45 d/Dhh high school students from 12 southeastern states, as well …

Teacher Judgment In The Age Of Artificial Intelligence: Collaborative Inquiry Into Generative Ai For Udl-Aligned Instructional Planning In Elementary English Language Arts, Melissa G. Metz

UNF Graduate Theses and Dissertations

This action research study explores how teacher-facing generative artificial intelligence (GAI), specifically Google Gemini, can support educators in UDL-aligned instructional planning within a Title I elementary school. Although AI is often discussed in terms of student-facing applications, less is known about how GAI can assist teachers with lesson planning, differentiation, and the demands of sustaining inclusive Tier I instruction. Guided by a conceptual framework integrating Universal Design for Learning (UDL) and technology integration perspectives, the study engaged four educators in collaborative inquiry through AI Visioning Workshops, reflections, interviews, and planning artifacts.

Data were analyzed through iterative coding, analytic memoing, and …

The Composition Of Gases From A Diffusion Flame Above Longleaf Pine Needle Fuel Beds, David R. Weise, Thomas H. Fletcher, Timothy J. Johnson, Weimin Hao, Russell G. Tonkyn, Catherine A. Banach, Javier Palarea-Albaladejo, Mahsa Alizadeh, Stephen Baker

Faculty Publications

The gas and tar composition of a wildland fire diffusion flame from longleaf pine needles is currently relatively unmeasured and more data are needed to fill in the gap between pyrolysis data and smoke plume data, thus improving physical and chemical modeling of wildland smoke formation. A pilot experiment to measure light gas and tar composition of such a flame is described for three flame zones: persistent flame (flame base), intermittent flame, and smoke plume. Flame gases from 24 experimental fires were collected in canisters and analyzed for CO2, CO, H2, CH4, and C2 to C7 hydrocarbon gases. Other light …

Out Of The Office: Market Impacts Of Institutional Investor Distraction, S. Owen Davidson, Michael S. Drake, James R. Moon Jr., James D. Warren

Faculty Publications

Research has long recognized that institutional investors possess significant information processing advantages. Yet even these investors face limited attention constraints, implying that periods of distraction may attenuate their advantage. We examine the effects of a plausibly exogenous shock to institutional attention arising from the annual buy-side focused Equity Research and Valuation (ERV) conference for Chartered Financial Analysts on institutions’ information processing. Validation tests using conference call data indicate that fewer buy-side analysts are present on calls during ERV conferences and that questions are shorter, consistent with the presence of substitute or backup analysts. In our main analyses, we find that …

Do Audit Partner And Audit Committee Member Ideologies Influence Engagement Partner Selection And Financial Reporting Oversight Effectiveness?, Robert Felix, Sattar Mansi, Mikhail Pevzner, Timothy Seidel

Faculty Publications

This study examines whether the ideological orientation of the audit partner and audit committee members— defined as their personal belief systems and inclinations, including their attitude toward risk, ambiguity, and novelty—has an impact on engagement partner selection and the effectiveness of oversight in the financial reporting process. Drawing on prior evidence that the two main US political parties reflect different ideologies, we hand-collect political donation data to construct ideological scores for audit partners and audit committee members. Our findings highlight several intriguing relationships. First, audit committees are more likely to select an ideologically dissimilar partner. Second, greater ideological dissimilarity between …

Do Cohort Restatements Generate Contagion? A Re-Examination, Melissa F. Lewis-Western, Timothy Seidel, Michael S. Wilkins

Faculty Publications

Gleason, Jenkins, and Johnson (2008) provide evidence that restatements lead to stock price declines among non-restating industry peer firms, suggesting that investors perceive contemporaneous manipulation within the industry. In contrast, Kedia, Koh, and Rajgopal (2015) find that restatements—especially less severe ones—encourage peer firms to initiate earnings manipulation. These divergent findings, together with the rising prevalence of less severe restatements and advances in monitoring technologies, motivate a re-examination of manipulation contagion. Although we are able to replicate the results of both seminal studies, we find that the results in Kedia, Koh, and Rajgopal (2015) are sensitive to design choices that affect …

Psychological Distance And Auditor Assessment Of The Severity Of An Internal Control Deficiency, Scott C. Jackson, John D. Keyser, Douglas F. Prawitt

Faculty Publications

Auditors often underestimate the severity of internal control deficiencies, particularly when associated misstatements are immaterial. We find that auditors are more likely to correctly classify a material weakness when no misstatement information is provided than when misstatement information is available, and that this finding may unconsciously arise from auditors’ construal level in judging control deficiency severity. Through a series of experiments, we manipulate misstatement information related to an internal control deficiency designed to represent a material weakness. We hold the size of potential misstatement constant and find that auditors and graduate auditing students are less likely to correctly assess the …

Who Invests In Crypto? Revealed Types And Economic Drivers Of Retail Investment, Darren Aiello, Scott R. Baker, Tetyana Balyuk, Marco Di Maggio, Mark J. Johnson, Jason Kotter

Faculty Publications

Using transaction-level data from millions of U.S. households, we provide the first comprehensive characterization of retail cryptocurrency investment. Crypto investors are distinguished not by demographics but by a latent behavioral type revealed through consumption patterns—one that also predicts higher participation in traditional equity brokerages. The economic forces driving crypto investment, including income shocks, workplace peer effects, and inflation exposure, mirror those driving traditional investment. Crucially, households whose consumption matches the crypto-investor profile are more responsive to all these drivers across both asset classes, suggesting that investor type is a more relevant distinction than asset class.

Influence Of Surface Features On Heat Transfer During Dropwise Condensation Over Superhydrophobic Surfaces In Shear Flow, Shaur Humayun, R. Daniel Maynes, Julie Crocket, Brian D. Iverson

Faculty Publications

This study investigates heat transfer during dropwise condensation (DWC) on superhydrophobic (SH) surfaces in humid air shear flow, emphasizing the effect of increased drop mobility and the influence of surface micro/nanostructure on heat transfer rates. Experiments were conducted on smooth hydrophobic, microstructured SH, nanostructured carbon-infiltrated carbon nanotube (CICNT) surfaces, and two-tiered SH surfaces with both micro and nanostructures. Heat transfer rates were measured under humid air flow rates in the range of 2–4 CFM. Experimental results demonstrate that surfaces with nanostructure (including two-tiered structures) exhibit increased drop mobility and coalescence-induced drop jumping, enhancing drop removal rates and overall heat transfer …

Efficiently Stowed Flashers With Uniform-Thickness Panels Based On Non-Developable Origami, Larry L. Howell, Robert J. Lang, Specer P. Magleby, Davis Wing

Faculty Publications

We present the mathematical construction of a deployable flasher pattern with near-uniform nonzero thickness in the deployed form and efficient face-to-face packing in the stowed form. We demonstrate its fabrication, deployment, and stowage. The results facilitate the design and manufacture of deployable systems with panels whose substantial thickness is dictated by the end application, with particular utility for space systems.

Adherence And Compliance With Exercise Training In Progressive Multiple Sclerosis: Rates And Correlates From The Cogex Trial, Cogex Research Team, Robert W. Motl, Andrew Argie, Roberto S. Hernandez, Brian M. Sandroff, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein

School of Health Professions

Background: There is limited understanding of adherence and compliance rates for exercise training(ET) in people with progressive multiple sclerosis(PMS).Objectives: This secondary, exploratory data analysis examined rates of adherence and compliance for continuous, moderate intensity training and high-intensity intervaltraining(HIIT) and possible correlates among people with PMS from the CogEx trial.Methods: CogEx was a multi-site, multi-arm, randomized, double-blinded, and shamcontrolled trial undertaken by 11 sites in six di8erent countries. Participants(N=311) wererandomized into one of four conditions with di8erent combinations of ET and cognitive rehabilitation, including respective sham conditions, delivered twice weekly over 12 weeks.The analysis focused on adherence and compliance rates and …

Mapping The Role Of Occupational Therapy Within Primary Care Services: A Scoping Review, Katie-Mai Davies, Alison Warren, Sam Wakley

School of Health Professions

Introduction:Occupational therapy is named a key profession within primary care, with growing demand due to an ageing population and increase of people living with long-term conditions. Despite this, occupational therapy within primary care remains an evolving, under researched area of practice. This scoping review explored the role of occupational therapy within primary care including the populations and interventions currently provided.Methods:The Joanna Briggs Institute (JBI) methodology for scoping reviews was followed with systematic searches conducted across CINAHL, PubMED and AMED databases with grey literature also sourced. The findings are presented in tabular format and analysed using descriptive statistics and frequency counts …

Clinical Informatics Education To Advance Learning Health Systems: A Scoping Review, Alexandra Zingg, L Ida Tovar, Laura Witte, Kelsey L Koym, Kyler Godwin

Library Staff Publications

Introduction: Learning health systems leverage clinical data and knowledge to advance healthcare quality. Effective training in informatics concepts and tools is essential for medical trainees to become health system experts and contributors to positive organizational change. The objective of this study is to summarize characteristics of existing clinical informatics training programs and map these to recommended Learning Health System informatics competencies. We aim to answer the following research questions: (1) How are academic medical institutions implementing informatics education initiatives for medical trainees? (2) Are these initiatives implementing recommended informatics competencies? and (3) How effective are these initiatives according to established …

Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci In 732,564 Participants, Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, Heming Wang, Michael R Brown, Amy R Bentley, Qin Hui, Aldi T Kraja, John L Morrison, Jeffrey R O'Connel, Songmi Lee, Karen Schwander, Traci M Bartz, Lisa De Las Fuentes, Mary F Feitosa, Xiuqing Guo, Xu Hanfei, Sarah E Harris, Zhijie Huang, Mart Kals, Christophe Lefevre, Massimo Mangino, Yuri Milaneschi, Peter J Van Der Most, Natasha L Pacheco, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Quan Sun, Yasuharu Tabara, Dina Vojinovic, Yujie Wang, Stefan Weiss, Qian Yang, Wei Zhao, Wanying Zhu, Md Abu Yusuf Ansari, Hugues Aschard, Pramod Anugu, Themistocles L Assimes, John Attia, Laura D Baker, Christie Ballantyne, Lydia Bazzano, Eric Boerwinkle, Brain Cade, Hung-Hsin Chen, Wei Chen, Yii-Der Ida Chen, Zekai Chen, Kelly Cho, Ileana De Anda-Duran, Latchezar Dimitrov, Anh Do, Todd Edwards, Tariq Faquih, Aroon Hingorani, Susan P Fisher-Hoch, J Michael Gaziano, Sina A Gharib, Ayush Giri, Mohsen Ghanbari, Hans Jörgen Grabe, Mariaelisa Graff, C Charles Gu, Jiang He, Sami Heikkinen, James Hixson, Yuk-Lam Ho, Michelle M Hood, Serena C Houghton, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Tuomas O Kilpeläinen, Pirjo Komulainen, Henry J Lin, Gregorio V Linchangco, Annemarie I Luik, Jintao Ma, James B Meigs, Joseph B Mccormick, Cristina Menni, Ilja M Nolte, Jill M Norris, Lauren E Petty, Hannah G Polikowsky, Laura M Raffield, Stephen S Rich, Renata L Riha, Thomas C Russ, Edward A Ruiz-Narvaez, Colleen M Sitlani, Jennifer A Smith, Harold Snieder, Tamar Sofer, Botong Shen, Jingxian Tang, Kent D Taylor, Maris Teder-Laving, Rima Triatin, Michael Y Tsai, Henry Völzke, Kenneth E Westerman, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Alan B Zonderman, Xiaofeng Zhu, Jennifer E Below, Simon R Cox, Michelle Evans, Myriam Fornage, Ervin R Fox, Nora Franceschini, Sioban D Harlow, Elizabeth Holliday, M Arfan Ikram, Tanika Kelly, Timo A Lakka, Deborah A Lawlor, Changwei Li, Ching-Ti Liu, Reedik Mägi, Alisa K Manning, Fumihiko Matsuda, Alanna C Morrison, Matthias Nauck, Kari E North, Brenda Wjh Penninx, Michael A Province, Bruce M Psaty, Jerome I Rotter, Tim D Spector, Lynne E Wagenknecht, Ko Willems Van Dijk, Lifelines Cohort Study, Million Veteran Program, Cashell E Jaquish, Peter Wf Wilson, Patricia A Peyser, Patricia B Munroe, Paul S De Vries, W James Gauderman, Yan V Sun, Han Chen, Clint L Miller, Thomas W Winkler, Dabeeru C Rao, Susan Redline, Diana Van Heemst

Faculty, Staff and Student Publications

Background and aims: Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.

Methods: We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) …

Spatial Evolution In Temporal Dynamics Of Hemodynamic Response Function In Human Superior Colliculi With Ultra-High-Resolution Mri At 9.4t, Nooshin J Fesharaki, Artemy Vinogradov, David Ress, Jung Hwan Kim

Faculty, Staff and Student Publications

The superior colliculus (SC) plays a crucial role in multisensory integration, visual information processing, saccadic target selection, visual selective attention, and decision making. In particular, the SC has a key role in oculomotor coordination, following a rostro-caudal organization. The rostral SC, which corresponds to foveal representation, is linked to fixation, microsaccades, smooth pursuit, and vergence adjustments. In contrast, the caudal SC, representing more peripheral visual field, is associated with the large gaze shifts (saccades). However, evidence regarding whether this functional gradient is preserved in the human SC remains limited. In this study, we employed a sequence-following visual-motor task to specifically …

Limosilactobacillus Reuteri Alleviates Proinflammatory T-Cell-Mediated Liver Injury And Transcriptomic Changes In Immunocompromised Mice, Ana Fadhel Alvarez, Zheng Yin, Beanna Okeugo, Alexander Banerjee, Meng Luo, Christopher M Taylor, Salomea Giorgberidze, Vaishali Harne, Rambabu Majji, Melissa N Munroe, Ji Ho Suh, Stephen T C Wong, Kang Ho Kim, Hari Krishna Yalamanchili, Suhair Al Salihi, Jon Marc Rhoads, Yuying Liu

Children’s Nutrition Research Center Staff Publications

Background: A deficiency of immunosuppressive regulatory T cells, as seen in scurfy (SF) mice or in IPEX syndrome in humans, can lead to multiorgan inflammation. Oral administration of the probiotic Limosilactobacillus reuteri Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM) 17938 prolongs survival and reduces Th1- and Th2-associated inflammation in SF mice. It remains unclear how DSM 17938-educated SF-CD4+ T cells modulate T-cell-liver communication.

Methods: To characterize CD4+ T cells from SF mice orally administered DSM 17938 (Prob-SF-CD4+ T cells) and to compare them with CD4+ T cells from SF mice (SF-CD4+ T cells), cells isolated from SF spleens were …

Polyfluoroalkyl Substances And Altered Glucose Homeostasis In Adolescents Following Bariatric Surgery, Elizabeth Costello, Brittney O Baumert, Zhenjiang Li, Vishal Midya, Shudi Pan, Justin R Ryder, Thomas H Inge, Todd M Jenkins, Stephanie Sisley, Stavra A Xanthakos, Anita Courcoulas, Douglas I Walker, Nikos Stratakis, Damaskini Valvi, Scott M Bartell, Angela L Slitt, Rohit Kohli, Sarah Rock, Michele A La Merrill, Sandrah P Eckel, Max T Aung, Rob Mcconnell, David V Conti, Lida Chatzi

Children’s Nutrition Research Center Staff Publications

Objectives: Bariatric surgery is an effective treatment for severe obesity and associated metabolic comorbidities. Exposure to polyfluoroalkyl substance (PFAS) before bariatric surgery may attenuate improvements in glucose metabolism and explain some of the heterogeneity in post-surgery outcomes.

Design: This is an observational cohort study.

Methods: Adolescents (n = 186) enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery study were included. Eight-PFAS congeners were measured in plasma before surgery. Linear and logistic regressions were used to examine cross-sectional associations between log2-transformed PFAS (ng/mL) and fasting glucose, insulin, hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR). Linear mixed …

Corticotropin-Releasing Factor Neurons In The Bed Nucleus Of The Stria Terminalis Modulate Avoidance Behaviors And Feeding, Juan Manuel Romero, Shae-Marie Stafford-Trujillo, Mitzy Mendoza, Pey-Shyuan Chin, Snigdha Srivastava, Mikhail Kochukov, Qingchun Tong, Benjamin Russell Arenkiel

The Brown Foundation: Institute of Molecular Medicine

Introduction: Animals rely on defensive avoidance of exposed or potentially threatening environments as a fundamental survival strategy, often expressing this behavior as thigmotaxis, or a preference for the periphery of an open space. However, researchers still do not understand how neural circuits coordinate avoidance behavior with competing physiological drives such as feeding. In this study, we investigate how corticotropin-releasing factor (CRF)-expressing neurons in the bed nucleus of the stria terminalis (BNST) integrate environmental avoidance and feeding behavior.

Methods: We used adult male and female mice and applied fiber photometry to monitor BNST CRF neuronal activity in vivo. We performed both …

The Southeastern Librarian 73(4) Winter 2026 (Full Issue)

The Southeastern Librarian

No abstract provided.