Digital Commons Network^™

Utilizing A Culture System For Horizontal Cells To Study Neural Circuit Assembly In The Developing Mouse Retina, Ross M Perez, Yong H Park, Ajeet Singh, Collin Todora, Marlon F Mattos, Daniela Becerril, Rajashree Venkatraman, Arlene A Hirano, Nicholas C Brecha, Rinki Ratnapriya, Benjamin J Frankfort, Elizabeth Zuniga-Sanchez

Faculty, Staff and Students Publications

The precise wiring of the nervous system relies on neurons extending their processes at the right time and place to find their appropriate synaptic partner. The mechanisms that determine when and where neurons extend their neurites during synaptogenesis remains a central question in the field. In the present study, we used a cell culture system coupled with live imaging to investigate the wiring mechanisms in the developing mouse retina. We focused on horizontal cells which are a class of interneurons in the outer mouse retina known to synapse selectively to the distinct types of photoreceptors. Previous research has shown horizontal …

Using Lotilaner Ophthalmic Solution, 0.25% To Treat Demodex Blepharitis In Patients Who Were Initially Misdiagnosed: A Case Series, Laura M Periman, Richard Lindstrom, Paul Karpecki, Brandon Ayres, Eric Donnenfeld, Marjan Farid, Ian Benjamin Gaddie, Preeya K Gupta, Selina Mcgee, Kelly K Nichols, Stephen Pflugfelder, Christopher E Starr, Nandini Venkateswaran, Elizabeth Yeu, Cecelia Koetting

Faculty, Staff and Students Publications

Introduction: Demodex blepharitis (DB) is a chronic ocular inflammation caused by Demodex mite infestation of the eyelid. DB is often misdiagnosed, as some of its clinical findings and patient-reported outcomes overlap with those of other ocular surface diseases. The Demodex Expert Panel on Treatment and Eyelid Health (DEPTH) has reached consensus on the symptomatology, diagnosis, and treatment of DB. Consensus findings from the DEPTH group include that collarettes are pathognomonic for DB and that lotilaner ophthalmic solution, 0.25%, the first and only FDA-approved treatment for DB, should be the first-line treatment for the disease. This case series highlights two instances …

Evolving Burden Of Metabolic Dysfunction-Associated Steatotic Liver Disease And Its Complications In A Us Nationwide Healthcare System, Basim Ali, Ronald Samuel, Jennifer R Kramer, Liang Li, Xian Yu, Yumei Cao, Roxanne Desiderio, George Cholankeril, Steven M Asch, Hashem B El-Serag, Fasiha Kanwal

Faculty, Staff and Students Publications

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health problem. Measuring the burden of cirrhosis and its complications in people with MASLD is important to inform health care delivery.

Methods: We aimed to quantify the changes in the burden of MASLD-related cirrhosis and hepatocellular carcinoma (HCC) in a nationwide U.S. healthcare system. We used data from the Veterans Health Administration to examine temporal trends between 2010 and 2021 in the annual incidence and prevalence of cirrhosis and HCC in a large cohort of patients with MASLD, and to compare them to those in patients with hepatitis C …

Survodutide For Treatment Of Obesity: Baseline Characteristics Of Participants In A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (Synchronize™-1), Carel W Le Roux, Sean Wharton, Biykem Bozkurt, Elke Platz, Gabriele Bleckert, Samina Ajaz Hussain, Martina Brueckmann, Elena Startseva, Isabel M Kloer, Lee M Kaplan

Faculty, Staff and Students Publications

Aims: Survodutide, a novel glucagon receptor and glucagon-like peptide-1 (GLP-1) receptor dual agonist, elicited significant weight loss in a phase 2 trial in individuals with obesity without type 2 diabetes (T2D). Two multinational phase 3 trials are investigating survodutide for obesity management in individuals with or without T2D. We report the baseline characteristics of participants in the SYNCHRONIZE-1 trial in adults with obesity without T2D (ClinicalTrials.gov: NCT06066515).

Materials and methods: Participants aged ≥18 years with BMI ≥30 or ≥27 kg/m2 with ≥1 obesity complication without T2D were randomized 1:1:1 to double-blind, once-weekly, subcutaneous injections of survodutide (up-titrated to 3.6 …

The Lived Experience Of Pediatric Pain Management: Insights From Families And Providers, Samrithaa Balakrishnan, Annesha Dey, Aarti Bavare, Paul Checchia, Katherine Shwetz, Natasha Afonso

Faculty, Staff and Students Publications

Pain represents a subjective experience that manifests with emotional and physical discomfort. In pediatric care, pain management is especially complex due to communicative limitations, which creates a unique point of entry for parents to contribute to their child's treatment process. In this study, we explored whether families' perceptions of their child's pain and preferences for treatment were aligned with healthcare providers' pain management decisions. Using narrative-informed techniques in interviews with families and healthcare providers in pediatric care settings, we analyzed areas of concordance and discordance in pain assessment and treatment priorities. Our findings show that trust is built over time …

Updates In The Management Of Peanut Allergy, S Shahzad Mustafa, Aikaterini Anagnostou, Matthew Greenhawt

Faculty, Staff and Students Publications

Peanut allergy is a significant rising public health problem affecting both children and adults. Early peanut introduction has been adopted in multiple westernized nations as a preventative strategic measure to reduce the risk of developing peanut allergy, although implementation faces barriers. Multiple therapies to treat peanut allergy have been developed, including oral immunotherapy and omalizumab as approved treatments to provide protection against reactions from accidental exposure and reduce the risk of anaphylaxis, offering options beyond strict avoidance. Strategies in the developmental pipeline include epicutaneous immunotherapy and sublingual immunotherapy. The future is bright for individuals with peanut allergy, as these breakthroughs …

Alpacas: An Evaluation Methodology For No- Or Low-Cost Course Materials, Heather Leonard

Publications

Evaluating no- or low-cost course materials is a key concern for those supporting affordable learning initiatives. This article will review the current needs of researchers in no- or low-cost course material, the methods currently available to guide them, and a new method I have designed to specifically address needs that current methods cannot. This method, ALPACAS (Apt, License, Provenance, Accurate, Currency, Authority, and Sources), combines insights from several other well-known methods to assist librarians, course designers, and instructors in finding appropriate no- or low-cost course materials. For each item in ALPACAS, I will break down why it is important and …

Hester’S Dubious Roots And Legacy: Open Fields Doctrine Under Scrutiny, Laura K. Donohue

Georgetown Law Faculty Publications and Other Works

For over a century, open fields doctrine has shaped Fourth Amendment law, denying people the right to be secure on their own property. Its application has steadily expanded, with the result that, by some estimates, the Government can now engage in warrantless surveillance of some ninety-six percent of private land and buildings regardless of fences, postings, the distance from public roads or byways, or the use to which the property is put. An originalist approach throws the doctrine into disarray: at the time of the Founding, common law protected the curtilage, which extended to the fields, barns, storehouses, and other …

Religious Freedom, Jesuit Mission, And Dei, William M. Treanor, Amelia J. Uelmen

Georgetown Law Faculty Publications and Other Works

The ability of Jesuit educational institutions to pursue a central part of their mission – that of fostering diverse, equitable and inclusive educational environments – is under attack. This essay outlines several dimensions of their religiously-grounded mission and the reasons to strongly protect from government interference the rights of Jesuit universities to implement programs and practices that align with DEI values. First, for Jesuit universities, these programs and practices are rooted in a much deeper culture of the more than 2,000-year old Catholic intellectual tradition and the now 500-year old tradition of Jesuit spirituality. Second, drawing on the classic work …

Participation, Danielle M. Pillet-Shore

Faculty Publications

What does it take to participate in direct, naturally occurring social interaction? Conversation analytic (CA) studies reveal that “participation”—who participates, when, and how—is dynamic and locally, multimodally achieved by the people involved. Particularly in social situations when people are concurrently accessible to one another’s naked senses (Goffman, 1964), co-participation is enabled and performed through embodied and vocal resources including talk, gaze, facial displays, body orientation/posture, proximity, and gestures (e.g., M. H. Goodwin, 1999; C. Goodwin & M. H. Goodwin, 2005; Pillet-Shore, 2010; Sidnell, 2009). Using a multimodal CA lens, this chapter illuminates how “participation” is achieved in real-time, naturally occurring …

Amalie Joachim: Reminiscences Of Childhood, Robert W. Eshbach

Faculty Publications

This bilingual edition presents Reminiscences of Childhood, the autobiographical narrative of the Austrian operatic singer Amalie Joachim (née Schneeweiss), in Nina Joachim’s English translation together with the original German text. Written for her daughters, the memoir recounts Joachim’s family background in Carinthia and Styria; her early musical training and exposure to domestic chamber music; the political and personal upheavals of the revolutions of 1848; the death of her father and the family’s subsequent poverty; and her first theatrical engagements in Troppau and Hermannstadt. The narrative offers a vivid first-person account of musical life, female artistic formation, family survival, provincial theatre, …

Audiovisual Motion Onset Asynchrony As Expectation Violation: Effects On Memory And Liking In Media Contexts, Sijia Song

Electronic Theses & Dissertations (2024 - present)

This research presents the first systematic investigation of motion-onset asynchrony (MOA) as a form of audiovisual temporal incongruency grounded in contemporary spatial audio and extended reality (xR) systems. MOA—the delay between the onset of visual and auditory motion—was manipulated at three levels (0 s, 1.1 s, 3 s) to test its effects on cognitive (memory) and affective (liking) outcomes during short 2D animated video viewing. Guided by inverted-U models of expectation violation, it was hypothesized that moderate MOA would be associated with the highest memory performance and liking ratings and that liking would mediate MOA’s effects on memory. Across two …

Understanding The Syphilis Resurgence Among Females Of Childbearing Age: Informing Prevention Efforts In New York State, Salvatore Currenti

Electronic Theses & Dissertations (2024 - present)

Syphilis is caused by Treponema pallidum and transmitted through direct contact with infected mucosal lesions and via vertical transmission during pregnancy (i.e., congenital). Transmission of syphilis to an infant during pregnancy (i.e., congenital syphilis [CS]) can lead to early fetal death, stillbirth, neonatal death, preterm birth, low birthweight, and congenital infection in infants. The United States (U.S.) is experiencing epidemic increases in both females of reproductive age with syphilis and infants with CS. In New York State (NYS), these trends have also occurred, especially after COVID-19 emergence, and increases in reported cases and incidence rates are comparable to national statistics. …

Providers' Perceptions Of Barriers And Facilitators To Implementing Non-Pharmacological Treatment For Adults With Chronic Pain: A Meta-Synthesis, Mikhaela Mcfarlin

Electronic Theses & Dissertations (2024 - present)

Background. Chronic pain is a public health concern impacting approximately 20% of adults in the U.S. Nonpharmacological interventions are considered first-line treatments for patients with chronic pain, yet nonpharmacological interventions remain significantly underutilized. While previous research has explored barriers from the patient’s perspective, limited attention has been paid to providers’ experiences implementing these treatments. This qualitative meta-synthesis aimed to examine provider-perceived barriers and facilitators to implementing nonpharmacolgical treatments for adults with chronic pain. Methods. Independent reviewers conducted systematic searches across PubMed, PsycInfo, CINAHL, and ProQuest Dissertations using relevant (e.g., “mental health provider”, “nonpharmacological”) and applied inclusion criteria to …

The Maxima Method For Identification Of Principal Periodic Components In Time Series Analysis, Megan Di Maio

Electronic Theses & Dissertations (2024 - present)

This dissertation investigates methods for mean estimation in periodically correlated time series, focusing on the Variable Bandpass Periodic Block Bootstrap (VBPBB) and a novel data-driven maxima method. Time series require specific methods because of the temporal correlation in the data. Traditional methods like the General Seasonal Block Bootstrap (GSBB) account for this correlation but often produce wide confidence intervals because they cannot isolate multiple periodicities, allowing noise and other frequencies to interfere with analysis. The VBPBB method addresses this by applying a Kolmogorov-Zurbenko Fourier Transform (KZFT) filter to the data before bootstrapping, which suppresses interfering frequencies and results in narrower, …

Time Series Decomposition And Forecasting Of Alzheimer’S Disease Mortality Using A Kolmogorov-Zurbenko Filter, Jack D. Farrell

Electronic Theses & Dissertations (2024 - present)

Alzheimer’s disease mortality has substantially risen in recent history, placing a significant burden on public health infrastructure and highlighting the need for improved analytical methods to better understand mortality data patterns and offer reliable predictions. Time series methods often struggle to balance both accuracy and interpretability, which hinders the ability to gather meaningful insights from time series data. To address these limitations, this study applies the Kolmogorov-Zurbenko (KZ) filter to monthly U.S. Alzheimer’s mortality data spanning from 1999 to 2023 and decomposes the series into long-term trend, seasonal, and noise components on a logarithmic scale. Long-term trend accounts for 86.49% …

The Instruments Of Chinese Economic Statecraft, Wilson Han

Electronic Theses & Dissertations (2024 - present)

The global economic order is undergoing a profound transformation as China increasingly leverages its vast commercial resources not merely for market expansion, but as strategic instruments to reshape global governance and secure its national interests. Moving beyond traditional analyses that rely on aggregate macroeconomic indicators, this dissertation investigates the targeted, highly asymmetrical mechanisms of Beijing’s economic statecraft. It systematically examines three specific instruments – institutional, financial, and trade – through which China projects structural power and constructs an alternative economic order.

The first empirical study explores China’s institutional statecraft by analyzing its bid to join the Comprehensive and Progressive Agreement …

Assigning Library E-Books As Textbooks: An Examination Of Collection Development Policies And User Education Practices At Minority-Serving Institutions, Michelle Ehrenpreis

Publications and Research

Assigning library e-books as course textbooks can help to alleviate the financial burden of college for many students. Accordingly, libraries include e-books in their collection development policies and strive to educate users on the availability of these texts via the use of library research guides. Previous studies discuss library collection strategies and intentions to use e-books as textbooks, but do not discuss continuous or permanent plans. This study examined library policies at Hispanic Service Institutions (HSI’s) and Historically Black Colleges and Universities (HBCU’s) to evaluate how these libraries approach and document their acquisitions of library e-books. Research guides at the …

Weighing The Costs: Understanding How Eating Disorder History And Motivation For Use Impacts Experience On A Glucagon-Like Peptide-1 Receptor Agonist And Interest In Future Use, Kimberly M. Gauert

Electronic Theses & Dissertations (2024 - present)

Glucagon-Like Peptide-1 receptor agonist (GLP-1 RA) medications have become popular tools due to their effectiveness regarding weight loss and chronic disease management. The drastic increase in demand for these medications has led to widespread availability and an increase in “off-label” use for cosmetic purposes. Although GLP-1 RA medications have the potential to positively impact overall health and wellbeing, there is also concern regarding potential misuse of these medications by those with a history of eating disorder behaviors. However, few studies to date have examined the relationship between a history of eating disorder pathology, reason for GLP-1 RA use, and current …

The Spectrum Of Limited Jurisdictions Courts: Exploring The City And Justice Courts In New York State, Alyssa Clark

Electronic Theses & Dissertations (2024 - present)

This dissertation is an investigation of decisions and outcomes in an important but seldom studied sector of the criminal justice system, the lower tiers of criminal courts (hereinafter referred to as LJCs). The LJCs in New York State (the subject of this dissertation) vary across two dimensions. The first dimension is court characteristics, which includes integration into a statewide court system (i.e., Justice Court vs. City Court). The second dimension is geodemographic characteristics (i.e., rural, suburban, and urban demographic characteristics). Recognizing this gap in literature, this dissertation provides an exploratory examination of the LJC’s patterns of case disposition and sentencing …

Studies Towards Chemical Synthesis Of Homogeneous Prion Glycoprotein, Baotong Tian

Electronic Theses & Dissertations (2024 - present)

Prion diseases are fatal neurodegenerative disorders initiated by conformational misfolding of the prion protein (PrP), which generates pathogenic conformers that propagate via templated conversion and accumulate as aggregates. Glycosylation can modulate the PrP folding energy landscape, thereby biasing folding trajectories and the distribution of resulting conformational states. Bank vole PrP contains two N-linked glycosylation sites, and disentangling the contributions of site occupancy versus glycan structure requires homogeneous, site-defined glycoforms. In contrast, biosynthetic expression typically produces heterogeneous glycoform ensembles due to multistep Golgi processing, precluding independent control of glycan identity at each site. Here we report a chemical synthesis strategy of …

Graph-Based And Graph-Transformer Representation Learning For Healthcare Data, Rui Wang

Electronic Theses & Dissertations (2024 - present)

Healthcare data exhibit complex structures, including heterogeneous clinical entities, sparse observations, and longitudinal patient trajectories. Effectively modeling such data remains a fundamental challenge in computational healthcare research. Traditional machine learning approaches often rely on flat feature representations that fail to capture relationships among clinical events, limiting their ability to model complex healthcare processes. These challenges motivate structured learning frameworks that capture both relational structure and temporal dynamics in healthcare data. This dissertation develops a series of graph-based representation learning approaches, extended through graph-transformer architectures for modeling complex healthcare data. Such data can be represented as graphs, where nodes correspond to …

The Relationship Between State-Level Career And Technical Education (Cte) Policies And Secondary Student Enrollment In Construction, Manufacturing, And Health Sciences Cte Programs, Brittany A. Kitterman

Electronic Theses & Dissertations (2024 - present)

Across the United States, employers in construction, manufacturing, and healthcare report ongoing difficulty filling positions. These shortages have been driven by an aging workforce, increased demand, and high rates of retirement. Compounding these shortages, Federal investments such as the Infrastructure Investment and Jobs Act and the CHIPS Act have further increased demand. Career and Technical Education programs are well positioned to support workforce development and help close workforce shortages, but access and participation remain limited. Supported by Federal Perkins funding, states have enacted CTE policies to increase access and enrollment in CTE programs aligned with high-demand industries such as construction, …

An Exploratory Mixed-Method Study Of Systems For Adhd Accommodation Implementation In New York State Middle Schools, Stacie Fenn Smith

Electronic Theses & Dissertations (2024 - present)

This mixed-method study examined organizational structures for ADHD accommodation implementation in New York State middle schools. While extensive research documents the effectiveness of specific ADHD accommodations, limited scholarly attention has focused on how educators organize themselves to deliver these supports consistently across multiple classroom settings. This study addressed that gap by investigating how educational leaders, teachers, and support staff structure systems for accommodation implementation. Grounded in Ecological Systems Theory (Bronfenbrenner, 1979) and Organizational Behavior Theory (Robbins & Judge, 2017), the study examined implementation across three organizational levels: building leaders, coordinators, and classroom teachers and support staff.

Data collection included a …

The Role Of The Coach In Student-Athlete Engagement, Christina Cobb

Electronic Theses & Dissertations (2024 - present)

Student engagement has long been recognized as a key indicator of student success in higher education, but limited research has examined engagement within the context of intercollegiate athletics. This qualitative case study explored how college coaches influence student-athlete engagement and how student-athletes utilize athletic department support services designed to promote engagement practices. Guided by Kuh et al.’s (2006) theory of student engagement, this study examined engagement through the lens of time and effort invested in educationally purposeful activities and the institutional environments that support or constrain participation.

Participants included six student-athletes, four coaches, and two athletic department administrators at a …

Rethinking Theories Of Political Discourse: The Limitations Of The Deliberative-Agonistic Split, Connor Moran

Electronic Theses & Dissertations (2024 - present)

What are “theories of political discourse,” why do they matter to political theory, and where do current ones fall short? This dissertation mines the existing resources availed by contemporary democratic theory in order to respond to the discursive challenge of “pernicious polarization,” particularly in the United States. The most comprehensive and influential theories of political discourse today have been furnished by the almost 40-year debate between deliberative democracy and agonism, both of which offer normative models centered on ameliorating the quality of political discourse.

The key finding of the dissertation is that the foundational works of the deliberative-agonistic split lack …

Academic Satisfaction Of Graduate Students In Mental Health Professions: Mediating Roles Of Burnout And Engagement, Yu Ying Li

Electronic Theses & Dissertations (2024 - present)

Academic satisfaction for students is as critical to their retention and well-being as job satisfaction for working adults; however, it has received limited empirical attention particularly among graduate students in mental health-related programs. One of the barriers to mental health trainees’ satisfaction with their academic training is burnout. The current study evaluated the applicability of Study Demands-Resources (SD-R) framework (Lesener et al., 2020) to trainees. Specifically, this study examined the relations between study demands (i.e., perceived stress), study resources (i.e., supervisory alliance and social support), student burnout, student engagement, and academic satisfaction. It also tested if student burnout and engagement …

Corannulene: Optimized Synthesis And Four-Fold Reduction, Guy Rozenman

Electronic Theses & Dissertations (2024 - present)

Corannulene is a bowl-shaped π-conjugated fragment of the ball-shaped C₆₀-fullerene that undergoes stepwise multielectron reduction and can accept four electrons to form the aromatic tetraanion, C₂₀H₁₀⁴⁻. Prior literature has established this charge state in donor-solvated alkali-metal assemblies: early solution studies identified the formation of the tetraanion under lithium reduction in THF, and later X-ray diffraction crystallography demonstrated a triple-decker lithium sandwich in which two corannulene tetraanion decks encapsulate five Li⁺ ions. The central objective of this thesis is to determine whether the corannulene tetraanion can instead be isolated as a bulk solvent-free alkali-metal salt containing only corannulene and …

Constructing The Political “Other”: Affective Polarization And Cross-Ideological Portrayals On Instagram, Amanda M. Novellin

Electronic Theses & Dissertations (2024 - present)

Instagram has frequently been characterized by users as a platform that permits the circulation of hostile and adversarial political content due to comparatively limited moderation practices. In January 2025, Meta CEO Mark Zuckerberg announced changes to content moderation policies on Facebook and Instagram, including the removal of third-party fact-checking mechanisms. These platform-level changes further reshaped the political information environment in which online discourse occurs. However, even prior to these policy changes, Instagram had established itself as a prominent space for highly polarized political expression across the ideological spectrum.

This thesis examines how political polarization in the United States is reflected …

Inflammation In Early Borrelia Burgdorferi Skin Infection, Ariana Nobles

Electronic Theses & Dissertations (2024 - present)

Borrelia burgdorferi (Bb) is the causative agent of approximately 476,000 cases of Lyme disease in the United States and rising. Bb is spread through infected saliva of the black-legged tick, Ixodes scapularis, to the host. Patients infected with Bb experience short-term symptoms, such as erythema migrans (EMs), fatigue, pain, and cognitive impairment. If left untreated, Bb infection will cause long-term health complications, like Lyme neuroborreliosis and Lyme arthritis. It is postulated that symptoms associated with Lyme disease are driven in part by inflammation.

My thesis focuses on the skin as it holds significant immunological importance in the …