Digital Commons Network^™

A Comparative Analysis Of The Efficacy, Safety And Mechanism Of Action Of Flebogamma Dif, Fostamatinib And Romiplostim In Immune Thrombocytopenia, Mary Akinyemi, Kamna Ravi, Furong Tian, Baljit Singh

Research Outputs: 2025-Present

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated platelet destruction, resulting in a platelet count below 100 × 10⁹/L and an increased risk of bleeding complications that significantly impair quality of life. Despite advances in ITP management, the unpredictable and heterogeneous nature of the disease continues to challenge treatment selection. This review compares the efficacy, safety, and mechanisms of action of Fostamatinib, Flebogamma DIF, and Romiplostim in adult and pediatric ITP patients. Peer-reviewed studies published over the past 20 years, including randomized and non-randomized clinical trials, observational studies, and real-world evidence, were screened for relevance, with …

Warm Mix Asphalt: Key Issues, Performance Challenges, And Modeling Advances, Mahmoud Owais, Marwa Awad

Mansoura Engineering Journal

Warm Mix Asphalt (WMA) has emerged as a sustainable alternative to conventional Hot Mix Asphalt by enabling asphalt production and compaction at reduced temperatures, thereby lowering energy consumption, emissions, and worker exposure to heat and fumes. Despite these advantages, the field performance of WMA remains influenced by technology-specific mechanisms, additive–binder compatibility, aggregate characteristics, moisture susceptibility, compaction quality, recycled material content, and climatic conditions. This review provides a critical synthesis of major WMA technologies, including foamed systems, chemical additives, organic waxes, hybrid additives, bio-based modifiers, and WMA mixtures incorporating reclaimed asphalt pavement. Particular attention is given to how these technologies affect …

Preserving The Identity Of Historic Coptic Orthodox Monasteries In Egypt Under Contemporary Pressures: Case Studies Of St. Bishoy And St. Anthony Monasteries, George Medhat Adeeb, Mohamed Khairy Amin, Mohamed Ahmed Al-Sherbiny

Mansoura Engineering Journal

Historic Coptic Orthodox monasteries in Egypt (HCOMEs) represent an important component of Christian heritage, integrating architectural value with enduring spiritual traditions that reflect both tangible and intangible dimensions. However, contemporary development and changing functional demands are generating transformations that may affect their identity if not carefully managed. Despite extensive scholarship, limited research has systematically examined these transformations through a structured evaluative approach. This study addresses this gap by developing and applying an analytical and evaluation framework to examine how contemporary pressures influence the historical, architectural-spatial, and spiritual identity of HCOMEs, and to assess the effectiveness of monastic responses. The framework …

The Desecration Of Sacred Spaces In The Dead Sea Scrolls And Pre-Nicene Latin Christianity: A History Of Interpretation Of The Eschatological Motif Of The Defiling Enemy In Apocalypticism, Rodrigo De Galiza Barbosa

Dissertations

Problem

The motif of the polluting enemy in the sanctuary is an important point of departure in the articulation of community boundaries in Hebraic-Christian culture. This particular motif has the potential to explain, at least in part, how Jewish and Christian communities would have understood the apocalyptic evil other and, from this understanding, set boundaries for their holy communities. Texts such as Dan 8 and 2 Thess 2 have been the locus classicus of the so-called antichrist, and ever since their interpretation has shaped how Christians and Jews have understood the enemy to their respective communities. In the history of …

Structured Interactions With Llms To Support Ltl: Supplemental Information, Karenna Kung, Maanas Punuru, Alicia M. Grubb, Paola Spoletini

Computer Science: Faculty Publications

This repository contains the supplemental information for the paper: "Structured Interactions with LLMs to Support LTL", which investigates how students interact with and can be supported by LLM explanations while translating linear temporal logic formulae into English natural language.

Cross-Cultural Communication Challenges In Multicultural Hospitality Teams: A Case Study Of The Arlington Hotel, Dublin, Lorrana Rosendo Da Silva

Business ETD Collections

This study investigates intercultural communication challenges within multicultural teams in the hospitality sector in Dublin, focusing on how linguistic barriers, cultural expectations and the dynamics of subgroups influence staff collaboration and day-to-day coordination. The research employs a qualitative case study at the Arlington Hotel, utilizing four semi-structured interviews—two with managers and two with employees—analyzed using thematic analysis. The findings indicate that, particularly during periods of high operational pressure, differences in English proficiency and understanding of accents can affect the clarity of instructions and the confidence to seek clarification. Furthermore, subgroups based on language or nationalities were described as useful in …

Member Engagement And Retention Challenges In The Latin Cycling Club Dublin, Sarideth Ailin Solis Lopez

Business ETD Collections

This study investigates participant engagement and retention challenges at Latin Cycling Club Dublin, a volunteer-run, non-profit community cycling group based in Dublin, Ireland. The group brings together Spanish-speaking people and others interested in Latin culture who ride together for hobby, social connection, and health improvement. Despite having 259 Instagram followers, 125 Strava participants, and 112 WhatsApp group members, only 8 to 12 people join rides on a regular basis, representing a drop-off of approximately 90 to 93%. The same small core group attends most rides, while the majority of followers remain inactive. Female participation is below 10%, and non-Spanish speakers …

Social Drivers Of Healthcare Access In Pediatric Autoimmune Disease: A U.S. Analysis (2022–2023), Kevin Okifo

Yale Medicine Thesis Digital Library

Background: Prior studies in adults have demonstrated that social drivers of health contribute to disparities in disease burden, management, and healthcare access among individuals with autoimmune disease (AD). There is emerging pediatric evidence suggesting similar patterns, but national-level data describing how social and structural factors shape healthcare access for children with AD remain limited. The aim of this study is to identify the sociodemographic and structural factors associated with healthcare access among children and adolescents with AD in the United States. Understanding these factors can support meaningful advances that will optimize patient-centered care and wraparound services for pediatric AD.Study Design: …

Health Communication Challenges In The Digital Era: Two Empirical Investigations, Neeraj Gautam Patel

Yale Medicine Thesis Digital Library

Background: The quality and availability of health information consumed by the general public have undergone dramatic changes in the 21st century with the rise of digitization and the internet. These include the growth of direct-to-consumer (DTC) advertising of prescription drugs on television and online media, changes in health content on traditional news media platforms, and the propagation of health misinformation and disinformation on social media and other websites. Understanding the nature and sources of these changes can inform efforts and interventions aimed at improving the general public’s understanding of health information. One area of interest within regulated health communication is …

Should Judicial Opinions Be Read Like Statutes?, Margaret H. Lemos

Faculty Scholarship

Should judicial opinions be interpreted with an eye to their purpose, context, or the intent of their authors, or should interpreters focus on the ordinary meaning of the text? Opinions present the same sorts of interpretive puzzles as other legal texts, and yet they have been omitted from the debates over interpretive methodology that dominate the fields of constitutional and statutory interpretation. The omission is no accident: the Supreme Court has stated repeatedly—and with increasing frequency in recent years—that judicial opinions are not to be read like statutes. Yet neither courts nor commentators have explained why the principles that ground …

The Ywca Goes To The Countryside: The Rural Work Of The Chinese Young Women’S Christian Association, 1926-1947, Elizabeth Littell-Lamb Phd

Asia Pacific Perspectives

This is the first study of the Chinese YWCA’s rural work. The decision to “go to the countryside” in part grew out of a critique by Chinese YWCA women of its Westerninfluenced agenda. That critique led the YWCA national committee to establish rural work as a first step toward a China-centered agenda. Key aspects of that agenda were the empowerment of rural secretaries in the field and the inclusion of rural women as members. The empowerment of rural secretaries contributed to the democratization of professional relationships within the association. The inclusion of rural women as members allowed the YWCA to …

Legal Semiotics, Political Ontology, & Merging Chronotopes Of Identity Through The Federation Of Aboriginal Nations Of The Americas, Kevin T. Inglesby

Graduate Student Theses, Dissertations, & Professional Papers

This dissertation studies the concept of self-determination related to a confederation known as the Federation of Aboriginal Nations of the Americas. It addresses three main questions: How does FANA represent an institution of legal cooperation? In what ways does cultural capital become reproduced? And what are key principles for the Federations’ code of unity? Self-determination is a core principle of international law and may be identified through treaties and social conventions like Wunnandry. The study explores an interdisciplinary approach to American Indian selfdetermination through a focus on applied anthropology, cultural heritage, and Peircean legal semiotics to problematize some historical approaches …

Advancing Understanding Of Lived Experience Of Unhoused People To Reduce Social Stigma And Promote Community Health: A Theoretically-Guided Photovoice Study, B-Rad Stephen Applegate

Graduate Student Theses, Dissertations, & Professional Papers

Homelessness is a persistent public health challenge shaped by structural inequities, stigma, and exclusion from social and health systems. Community-Based Participatory Research (CBPR) has increasingly been used to center the knowledge of people who are unhoused, yet limited attention has been given to the theoretical frameworks guiding this work across disciplines. The purpose of this dissertation was to examine theories and methods used in CBPR with unhoused populations and to explore the extension of Margaret Newman’s Theory of Health as Expanding Consciousness from a nursing-focused theory to a public health framework for understanding lived experience.

Using a scoping review methodology …

Oxytocin Dosing During Trial Of Labor After Cesarean To Minimize The Risk Of Uterine Rupture: A Systematic Review And Meta-Analysis, Pierpaolo Nicolì, Moti Gulersen, Jordan Beacham, Hila Hochler, Alessandra Familiari, Anna Locatelli, Cynthia Abraham, Ettore Cicinelli, Amerigo Vitagliano, Vincenzo Berghella

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: Oxytocin remains the mainstay for induction and for the management of labor arrest during trial of labor after cesarean (TOLAC). Therefore, the clinical question should be not whether to use oxytocin, but how to optimize its administration. This meta-analysis aimed to assess which oxytocin protocol, in terms of initial dose, amount of increase, timing to next increase, and maximum dose, may minimize the risk of uterine rupture (UR) during TOLAC.

DATA SOURCES: PubMed, Embase and Clinicaltrials.gov were searched up to September 21, 2024.

STUDY ELIGIBILITY CRITERIA: Randomized and nonrandomized studies evaluating the association between induction and/or augmentation with oxytocin …

Impact Of Prophylactic Oral Azithromycin During Labor On Azithromycin Resistance (Amr) In Nasal Staphylococcus Aureus And Streptococcus Pneumoniae In Women And Infants In The Multi-Country Azithromycin Prevention In Labor Use Study (A-Plus)., Patricia L. Hibberd, Jean H. Kim, Marissa Trotta, Sixto M. Leal, Anna Aceituno, Doyle V. Ward, Archana Patel, Akila Subramaniam, Waldemar A. Carlo, Imran Ahmed, Sarah Saleem, Sk Masum Billah, Rashidun Haque, Manolo Mazariegos, Fabian Esamai, Manjunath S. Somannavar, Shivaprasad S. Goudar, Elwyn Chomba, Muska Mwenchanya, Adrien Lokangaka, Antoinette Tshefu, Robert L. Goldenberg, Melissa Bauserman, Nancy F. Krebs, Sherri Bucher, Richard J. Derman, William A. Petri, Marion Koso-Thomas, Denise C. Babineau, Elizabeth M. Mcclure, Alan T. N. Tita

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Prophylactic oral azithromycin vs. placebo reduced maternal, but not neonatal, mortality/sepsis in the A-PLUS Randomized Trial. While prophylactic intrapartum azithromycin reduces maternal mortality/sepsis, it may promote antimicrobial resistance (AMR) in commensal bacteria,.

METHODS: Randomly selected women and their infants participating in A-PLUS were enrolled in a longitudinal cross-sectional sub-study to assess the presence of azithromycin resistance in selected bacteria in nasal cultures. Staphylococcus aureus and Streptococcus pneumoniae were cultured on selective agar, then azithromycin-containing agar to select for azithromycin resistant bacteria, identified biochemically. Azithromycin susceptibility was assessed by E-test. Nasal cultures were collected from women and infants between August …

Predictive Analytics For Optimising Delivery Performance In Supply Chain Management, Vishwanath Sai Krishna Teja

ICT

Supply chain management has always been a challenging area where delivery delays stand as one of its main ongoing issues. Many companies continue to use outdated data collection systems despite the advancements in data collection tools. This study investigates how predictive analytics can help companies to prevent their operational problems from reaching their customers.

In this study, two datasets were used. The first is the Data Co Smart Supply Chain dataset which covers order level operations from 2015 to 2018, and the second is the World Bank Logistics Performance Index, which covers logistics quality across more than 160 countries. After …

The Role Of Dromedary Camels In The Pprv Epidemiology: Episystem Possibility And Evidence Supporting Global Eradication., Reham Karam, Mahmoud S. Safwat

Mansoura Veterinary Medical Journal

Background: Peste des petits ruminants (PPR) is a notifiable, highly contagious and transboundary viral disease infecting a wide range of domestic and wild ruminant species and is caused by a morbillivirus. The disease represents a major predisposing factor of poverty in many endemic regions. Although global eradication of PPR is an internationally endorsed objective, achieving this goal has become increasingly challenging due to the expanding host range of the virus. Methods: Narrative review methodology was used and SANRA criteria to access reliability and quality of the methodology. focuses on PPR infection in camels, which has been reported in some instances …

Rigidity And Risk: A State Space Grid Analysis Of Parent-Child Interactions, Sleep, And Early Internalizing Symptoms, Brianna Trudeau

Master's Theses and Doctoral Dissertations

Background. Internalizing problems in preschoolers are prevalent, cause significant impairment, and often persist into later development. Emerging research uses state space grid (SSG) methodology to examine dynamic parent-child interaction processes that may contribute to these difficulties. While affective rigidity has been linked to maladaptive outcomes, less is known about behavioral rigidity and its association with child internalizing symptoms.

Objective. This study examined whether dyadic behavioral rigidity could be represented as a latent construct across tasks, whether behavioral rigidity predicted preschool internalizing symptoms, and whether rigidity mediated the relationship between parent and child sleep problems and child internalizing symptoms.

Method. Participants …

Bio-Orthogonal Chemistry-Based Strategy To Turn-On And Turn-Off Crispr-Cas9 Gene Editing In Solution And In Live Cells, Bhoomika Pandit

Electronic Theses & Dissertations (2024 - present)

The CRISPR–Cas9 system is a widely popular tool for genome engineering. There is a strong interest in developing tools for temporal control of CRISPR-Cas9 activity to address some of the challenges and to broaden the scope of potential applications. In this thesis I describe two biorthogonal based approaches to either Turn-ON and Turn-OFF CRISPR-Cas9 gene editing.

In first project work I describe a bio-orthogonal chemistry-based approach to Turn-ON Cas9 nuclease activity with temporal precision. We report a TCO-acylimidazole reagent that acylates 2′-OH groups of RNA. Poly-acylation (“cloaking”) of RNA was optimized in vitro using a model 18-nt oligonucleotide, as well …

Performance Of Foamed Concrete Before And After Fire Conditions: A Review, Poles Bahgat, Mohamed Kohail, A. Fathy, A. Afifi

Mansoura Engineering Journal

Foamed concrete is defined as a type of concrete distinguished by its workability, low density, and insulating properties. It is used as building material. The objective of this review is to discuss the physical and mechanical characteristics and fire sensitivity of foamed concrete. Density influences the strength of concrete. The strength of concrete is between 2 and 3.5 MPa, which increased with the addition of gold mining waste, reaching approximately 35 MPa at optimal replacement levels.  There is a 60-70% reduction in strength for lightweight concrete with a density of 400-1200 kg/m³ compared to conventional concrete. The fire sensitivity of …

Hope For The Drowned: Baptism, Faith, And The Open Community Of Grace In Marilynne Robinson’S Housekeeping And Lila, Mackenzie M. Miller

Graduate Student Theses, Dissertations, & Professional Papers

This thesis explores the baptismal imagery across two of Marilynne Robinson’s novels, Housekeeping and Lila. The hermeneutic used to understand baptism is based on some of the works of Rowan Williams, Mircea Eliade, and Northrop Frye. In its death and rebirth function, baptism is understood for its connection to the formation of self and identity. Baptism is also explored as a means of community initiation. Further, connecting these two baptismal functions, this thesis also looks at the role community plays in the formation of that identity. In this process, I compare Housekeeping’s Ruth and Lila’s titular character; …

Heart Of Stone: Geomorphization Through Stone-Oriented Affects, Grace F. Foster

Graduate Student Theses, Dissertations, & Professional Papers

This thesis draws from the work of geologist Marcia Bjornerud to bring a scientific (specifically geologic) understanding of humanity’s relationship to our home planet to bear in a literary context. I employ Bjornerud’s term “geomorphization” to expand from inter-species kinship to inter-substance kinship and to establish stone as an active, lively subject without relying on anthropomorphization. Geomorphization as I define it refers to recognizing similarity between ourselves and stone/Earth on the basis of our stoniness rather than stone’s human-ness. Geomorphizing ourselves entails what Bjornerud calls “timefulness,” a geologic perspective on temporality that sees the past as continually acting in the …

The Middle School Transition: Exploring Student Perceptions On The Transition From Elementary To Middle School, Cody T. Weed

Education Dissertations

The purpose of this study was to understand middle school students’ perceptions of their transition from elementary school to better learn the interactions and dynamics that unfold between them and their immediate environment. The middle school transition is a pivotal developmental phase marked by significant logistical, academic, and social–emotional challenges. Grounded in transition theory, the 4S framework, and stage-environment fit theory, this research explores the interactions between students and their new environment. Utilizing an embedded design mixed-methods approach, this study surveyed sixth-grade students at a public middle school in Eastern Washington. The goal was to illuminate students’ needs and concerns …

2026-2027 Graduate Catalog, Morehead State University. Registrar's Office.

Morehead State Catalog Archive

2026-2027 graduate catalog for Morehead State University.

Teresa Murphy Papers - Accession 1466, Teresa Harlem Murphy, Virgeson Family

Manuscript Collection

The Teresa Murphy Papers consists of a scrapbook, Winthrop yearbook (The Tatler), and family photographs belonging to 1929 Winthrop graduate, Teresa Harlem Murphy (b. 1908. The scrapbook details her life and experience while a student at Winthrop from 1925 to 1929. The Tatler contains many notes from classmates including their married names. Also of interest is a Victorian era calendar listing the birth and death dates of members of the Virgeson Family which includes the family of Joseph Cahoon Virgeson (1875-1941) and Katherine Elizabeth Whitley Virgeson (1879-1958).

Lindsay Pettus–J. Marion Sims Research Papers - Accession 1733, David Lindsay Pettus, James Marion Sims

Manuscript Collection

The Lindsay Pettus–J. Marion Sims Research Papers document historical research conducted by historian and conservationist Lindsay Pettus (1940–2020) on Dr. James Marion Sims (1813–1883), a native of Lancaster County, South Carolina, who is historically recognized for his role in the development of modern gynecology. The collection reflects Pettus’s sustained interest in documenting Sims’s life, medical career, legacy, and public commemoration, particularly within South Carolina.

The collection consists of research files, correspondence, printed materials, photographs, postcards, and reference notes compiled during Pettus’s research activities. Research materials include internet articles, photocopies of published writings, a photocopy of Sims’s autobiography, bibliographies, book lists …

National Master Farm Homemakers Guild Record - Accession 1734, National Master Farm Homemakers Guild

Manuscript Collection

The National Master Farm Homemaker’s Guild Records document the activities, governance, and programs of the National Master Farm Homemaker’s Guild, an organization founded in 1929 to promote the highest possible standard of living in the farmhouse and to emphasize the positive aspects of farm life. The collection reflects the Guild’s efforts to support farm homemakers through leadership, education, and national and state-level coordination.

The collection consists primarily of administrative records, including presidents’ reports, national convention materials, and meeting minutes. Presidents’ reports provide insight into organizational priorities, initiatives, and communications between the national leadership and state guilds during the early 1980s. …

Kathryn Summers Powell Papers - Accession 1741, Kathryn Summers Powell

Manuscript Collection

The Kathryn Summers Powell Papers document the professional career and administrative work of Dr. Kathryn Summers Powell (1920–2000), Professor of Home Economics at Winthrop College from 1960 to 1976. The collection primarily reflects Dr. Powell’s leadership in program development, departmental administration, and applied family and community education initiatives during her tenure at Winthrop.

Materials in the collection consist of faculty manuals, interoffice memoranda, accounting and reimbursement records, calendars, and internal policy documents that illustrate the operational and administrative functions of the Home Economics Department. Of particular significance are records related to curriculum planning and program development, including notes and drafts …

Pat Conroy First Edition Book Collection - Accession 1747, Donald Patrick Conroy

Manuscript Collection

The Pat Conroy First Edition Book Collection consists of first edition publications authored by Donald Patrick “Pat” Conroy (1945–2016), an acclaimed American novelist whose work is closely associated with the cultural, social, and physical landscapes of the South Carolina Lowcountry. Many of the volumes in this collection are signed by the author, enhancing their research and evidentiary value.

The collection spans Conroy’s literary career from his debut memoir The Boo (1970) through The Death of Santini (2013), a reflective work that revisits characters and themes central to his earlier writings. Included are major novels, memoirs, and nonfiction works such as …

Jordan Panoramic Photograph Collection - Accession 1767, Carol Mcwhorter Jordan

Manuscript Collection

The Jordan Panoramic Photograph Collection consists of two early twentieth-century panoramic photographs that document large-scale institutional and organizational gatherings in the American South. The images are dated 1905 and 1912 and reflect the use of panoramic photography to capture expansive scenes, collective identity, and public activity during this period.

The first photograph, taken in 1912 by the Russell Bros. photographic studio and labeled “Panorama no. 871,” depicts Camp Pettus, a military training camp located in Anniston, Alabama. The image provides a wide view of the camp’s layout, personnel, and infrastructure, offering visual evidence of early twentieth-century military preparedness and training …