Digital Commons Network^™

Investigating The Reliability And Validity Of The Social Connectedness Instrument Among U.S. Adults, Blake A. Fraser

Doctoral Dissertations and Projects

Growing evidence shows that poor social connectedness is becoming a public health threat, with rising prevalence and connections to poor mental and physical health across the lifespan. Therefore, there is an urgent need to develop feasible and effective social connectedness interventions. There is limited evidence for the effectiveness of current interventions, with studies recommending tailoring the intervention to an individual’s specific social connection needs. However, previous measures of social connectedness provide little information about potentially modifiable contributors of poor connection. Thus, the Social Connectedness Instrument (SCI) was developed to fill in this gap by proposing two novel latent constructs of …

Women, Religion, And Education In North Carolina: How The Feminization Theory Applies From The Nineteenth Century To Present Day, Jennifer Lauren Walker

Doctoral Dissertations and Projects

In the state of North Carolina southern traditions run deep. The strong foundation of religion and family have been a constant in this state. However, not everything about this state’s history has been equal or fair, especially in the case of women and education. It would take the Progressive era for the feminization of southern life and culture to work its way into the lifestyle found amongst North Carolina residents. Women across the state would lay witness to the changes that both feminization and religion brought into their lives. Education would be one major factor that played into the equation …

Cultural Superimposition In Humanitarian Protection, Jocelyn B. Cazares Willingham

Seton Hall Law Review

No abstract provided.

Perceptions Of Stigma Of Pregnant Individuals Experiencing Substance Use Disorder Receiving Prenatal Care At Magdalene Clinic: A Cross-Sectional Study, Hannah F. Mckinnon, Melissa L. Fair, Jody Teel, Courtney Lubaczewski, Alison Kimura, Kimbley Smith, Kacey Eichelberger

Open Access Fund Publications

Background

Substance use disorder (SUD) is highly stigmatized with pregnant individuals experiencing substance-related stigma at greater levels than the general population due to perceived deviance from societal norms. Pregnant individuals experiencing stigma may be more likely to delay or receive inadequate prenatal care. The purpose of this cross-sectional study was to understand self-reported enacted, anticipated, and internalized stigma of pregnant individuals experiencing SUD receiving prenatal care at Magdalene Clinic, a collaborative, trauma-informed OB-GYN clinic.

Methods

The Substance Use Stigma Mechanism Scale was administered to 226 individuals to measure past, present, and anticipated future experiences of substance use related stigma from …

Improving Mathematical Problem-Solving Performance Through The Use Of Reading Comprehension Strategies, Rebecca Yonan

Masters Projects

Research shows that math problem solving relies on more than arithmetic computation. Word problem solving is a combination of text comprehension and word memory. Being able to successfully solve word problems at the elementary level helps prepare students for algebra, and higher academics. Learning to solve word problems teaches students problem solving techniques that can be applied in their adult lives. This project creates an instructional routine where lessons are built around teaching primarily through word problem solving. Students will receive instruction on text comprehension, math vocabulary building, word memory, and arithmetic computation in order to simultaneously increase their math …

Diet-Responsive Genetic Determinants Of Intestinal Colonization In The Yeast Candida Albicans, Musfirat Shubaita, Mazen Oneissi, Elena Lindemann-Pérez, Cecilia Fadhel Alvarez, Anne-Marie Krachler, Diana M Proctor, J Christian Pérez

Faculty, Staff and Student Publications

Dietary components influence microbial composition in the digestive tract. Although often viewed as energy sources, dietary components are likely to shape microbial determinants of intestinal colonization beyond metabolism. Here, we report that a dietary long-chain fatty acid enhances the yeast Candida albicans colonization of the murine gut partly by eliciting modifications to the fungal cell surface. Mice fed an oleic acid-rich diet were readily colonized by C. albicans and exhibited higher fungal load in feces compared with rodents fed an isocaloric control diet. Surprisingly, β-oxidation, a catabolic process to break down fatty acids for energy production, was dispensable for C. …

Cattle Drives To Coal Cars: Norfolk & Western And The New South Industrialization Of Tazewell County, Virginia, 1880-1930, Hannah Beth Hensley

Doctoral Dissertations and Projects

Addressing the impact of the New South gospel of industrialization on Tazewell County, Virginia, this research seeks to examine the county’s shift from a primarily agricultural, barter economy prior to 1880 to one of both industry and agriculture by 1930. It traces Virginia’s early railroads and coal mines, following the creation and collapse of the Atlantic, Mississippi & Ohio Railroad and subsequent birth of the Norfolk & Western Railroad, and details early geographic studies indicating the presence of coal in Southwest Virginia’s mountains. Tazewell County became the gateway to the rich Pocahontas coal fields of West Virginia with the boom …

Clear Cell Hidradenoma: A Review Of Reported Cases, George Ladas, Christopher Stewart, Peter A. Khoury, Adam Kramer, Charles Harper, Pear Sukarom, Niritta Patel, Patricia Palanca, Gursuraj Grewal, Suporn Sukpraprut-Braaten

Student Publications

Clear cell hidradenoma (CCH) is an extremely rare benign adnexal skin tumor originating from eccrine sweat glands. The purpose of this systematic review is to analyze and demonstrate trends in the location, occurrence, and presentation of CCH as well as its ability to present in advanced disease states. This study identified 460 case reports published from 1979 through 2022 through PubMed searches. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were tightly adhered to. The search keywords were “acrospiroma” and “clear cell hidradenoma.” Investigators reviewed the articles and extracted the following information: demographics; medical history and medications; anatomic …

Progress And Challenges In Profiling Protein-Rna And Protein-Associated Rna-Rna Interactions, Zhuoyi Song, Eric L Van Nostrand

Faculty, Staff and Students Publications

RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-RNA interactions that include both well-studied examples of small regulatory RNAs (e.g. microRNAs, snRNAs, snoRNAs, piRNAs) guiding ribonucleoprotein complexes to their targets as well as structured RNA elements defining the interaction landscape for an RBP. To elucidate the full scope of RBP-RNA interactions, CLIP ( crosslinking and immunoprecipitation)-based methods have emerged as powerful tools. Even with the wide application …

Resolution Of A Human Chromosomal Mystery: Evolutionary Complexity Revealed, Jeffrey Rogers

Faculty, Staff and Students Publications

The human complement of chromosomes differs from our closest primate relatives by virtue of a unique chromosome fusion event. In this issue of Cell Genomics, Yang et al. provide the first detailed analysis of the site of chromosome fusion and reconstruct the complex evolutionary relationships among the genomic elements within the human fusion site and their related sequences in our great ape relatives.

Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood

Faculty, Staff and Students Publications

Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613. Systematic proteomic, functional genomic, and biochemical studies revealed that MCB-613 binds KEAP1 in a covalent, cysteine-independent fashion, acting as a divalent molecular bridge that relies upon lysine residues in the KEAP1 dimerization domain to join monomers of KEAP1 together. Oligomerization of KEAP1 by MCB-613 sets into motion a fatal cascade of KEAP1 …

Ophiobolin A Impacts Mitochondrial Redox Biology In An Epithelial-Mesenchymal Transition (Emt)-Specific Manner, Haleigh N Parker, Yongfeng Tao, Jenna Tobin, Kayla L Haberman, Samantha Davis, Emily York, Alysia Martinez, Nobuyuki Matsumoto, Jaquelin Aroujo, Jun Hyoung Park, Bernd Zechmann, Benny Abraham Kaipparettu, Angela Boari, Christie M Sayes, Antonio Evidente, Alexander Kornienko, Benjamin Cravatt, Daniel Romo, Joseph H Taube

Faculty, Staff and Students Publications

Breast cancer progression is facilitated by the epithelial to mesenchymal transition (EMT), generating cancer cells with enhanced metastatic capacity and resistance to chemotherapeutics. The fungus-derived sesterterpenoid natural produce compound, ophiobolin A (OpA), possesses nanomolar cytotoxic activity and a high therapeutic index, although its molecular targets and mechanism of action are not well characterized. Herein, we utilized a model of mammary epithelial cells and breast cancer cell lines with and without EMT features to characterize the mechanism of selectivity towards EMT(+) cells by OpA. Proteins interacting with OpA in EMT(+) cells, including mitochondrial glutathione transporter SLC25A40, were identified through via mass …

Medulloblastoma Stem Cell Programs: Molecular Roadmaps Of Disease Progression, Jamie Zagozewski, Parthiv Haldipur, Kathleen J Millen, Tamra E Werbowetski-Ogilvie

Faculty, Staff and Students Publications

Over the last decade, an unprecedented number of sequencing studies have characterized the molecular landscape of pediatric brain cancers, including the highly heterogeneous tumor medulloblastoma (MB). Extensive MB profiling has enabled a much deeper understanding of the primitive neurodevelopmental programs that are hijacked during tumor progression. However, we have yet to successfully target and fully eradicate the putative stem and early progenitor cells that drive MB tumorigenesis. This goal will require better human models that faithfully recapitulate oncogenic events, a deeper understanding of the mechanisms governing cell fate decisions in the primary and metastatic compartments, and comprehensive validation studies of …

A Case Comment On Cryogas Equipment V. Inox India, Eashan Ghosh

Indian Journal of Law and Technology

Composite claims for copyright and design have long posed conceptual difficulties under Indian law. A pointed attempt by the Supreme Court in Cryogas Equipment v Inox India (‘Cryogas’) to resolve these difficulties, therefore, is of considerable interest.

In this Comment, I examine Cryogas in detail. I find that, despite adopting a schematic approach that is promising on the surface, Cryogas offers little assistance in untangling the constituent portions of copyright-design claims. For one, its test for telling apart artistic works from designs is entirely self-referential and requires a pre-existing understanding of what outputs statutorily constitute ‘artistic works’ and …

Chatgpt Goes To (National)Law School, Rahul Hemrajani, Vedant Gupta, R Srivatsan, Radhika Singhal, Krishne Tanneerbavi, Shristy Chhaparia, Siddharth Johar, Srujan Sangai, Suvanssh Mahajan, Priyansh Dixit, V Sreedharan, Dhruv Holla, Gunjan Modi, Kajal Jamdare, Pratyay Amrit, Sannah Mudbidri, Ishaan Goel, Akshit Singla, Arjun Mehta, Madhav Mitruka, Mannat Mahaey, Nathaniel Warjri, Swapnil Das, Ojas Chandaniha, Yash Ahirwar, Animesh Tiwari, Aman Meena

Indian Journal of Law and Technology

This paper presents the first comprehensive empirical evaluation of Large Language Models’ (‘LLMs’) performance in Indian legal education. We compare six Artificial Intelligence (‘AI’) chatbots with law students at the National Law School of India University, Bengaluru, across four subjects: Contract Law, Corporate Law, Criminal Procedure, and Jurisprudence. Our findings show that LLMs achieve performance comparable to human students (B+ grade), with newer commercial models consistently outperforming older and open-source alternatives. We also find that while LLMs excel in theoretical subjects and structured legal analysis, they show limitations in handling jurisdiction-specific knowledge and complex scenario-based reasoning. These findings have important …

Ever Onward: The Frontier Myth And The Information Age, Jack Shuler

Fast Capitalism

No abstract provided.

E-Mail: Connections, Contexts, And Another Space, Terry Caesar

Fast Capitalism

No abstract provided.

Media Culture And The Triumph Of The Spectacle, Douglas Kellner

Fast Capitalism

No abstract provided.

Timescapes Of The Network Society, Robert Hassan

Fast Capitalism

Since the late ‘70s, the mutually reinforcing interaction between neoliberal economics and the revolution in information and communication technologies (ICTs) has transformed the world in many ways. “Globalization” is what we have come to call this process, and many aspects of its profound effect have been analyzed from a range of perspectives (e.g. Appadurai 1990; Robertson 1993; Omahe 1993; Waters 1995; Bauman 1998; Steger 2003). This paper discusses a central element of this change through globalization that has so far received relatively little attention—our relationship with time and how this is changing, in turn, the nature of power and politics. …

About The Authors, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

C. Wright Mills: A New Left For A New Day, Charles Lemert

Fast Capitalism

Thomas Paine, during a crucial moment in the American war against its colonizers, said famously: “These are times that try men’s souls.” Many think, I among them, that these too are times that try men’s souls. At such a time, one must look back for clues as to what to think and do. One from not that long ago who lends us wisdom of a sort is C. Wright Mills, who in the 1950s, tried to make sense of America’s changing culture. However, a bad heart killed him in 1962, just after he wrote of the possibility of a New …

Of The Enemy: Scalping As Culture And Commodity On The North American Frontier, James Sandy

Fast Capitalism

In a February 1711 letter home, John Barnwell recounted his campaign’s recent victories in the raging Tuscarora War. Fighting in the western reaches of colonial North Carolina, Barnwell and a group of South Carolina militiamen marched from one Tuscarora village to the next in search of Native American warriors to kill and civilians to harass, enslave, or otherwise brutalize. John “Tuscarora” Barnwell was thorough in his recollection of their campaign, going to great lengths to describe their “valient” task. Barnwell, like many other frontiersmen and militia commanders of his generation, added a flair for the dramatic to his retelling of …

Fighting For Justice In The Neoliberal University: The Promise Of Reflexive And Flexible Solidarity, Timothy Gibson, Bethany Letiecq

Fast Capitalism

In the neoliberal university, faculty are encouraged to build strong connections in virtually every way except one: as workers. In this paper, we will discuss our experiences as leaders of the XXX chapter of the American Association of University Professors, with a focus on our campaign to build across-campus labor coalition connecting faculty, students, staff, and contract workers in the struggle for economic and social justice. We will begin by examining the constellation of structural forces and professional hierarchies that amplify labor exploitation on campus, subvert shared governance and academic freedom, and cultivate a campus culture of disconnection, competition, and …

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

“Rise Of The Resistance” And The Demise Of Social Being: The Autolysis Of Subjectivity In The Twenty-First Century, Reha Kadakal

Fast Capitalism

Structural transformations in the 21st century necessitate radical rethinking of the category of subject that underlie the notions of autonomy, agency and individuality. This paper depicts an onto-genetic transformation of the subject— its autolysis—in the historical present by building on representations and the mediation of categories of social life. The paper first delineates the notion of representation as a central element of critical ontology as a form of social theory by building on Hegel and Durkheim. It then draws on a recent product from the culture industry, namely The Disneyland theme-park ride called “Rise of the Resistance,” which involves a …

The Artificiality Of Digital Scarcity: Contradictions Between Code, Law, Norms, And Value(S), Anthony Jack Knowles

Fast Capitalism

The rise and fall of Napster represented a major turning point in the history of the internet as it simultaneously paved the way for peer-to-peer filesharing as well as ushered in a backlash from incumbent media companies backed by an army of lawyers. This essay grapples with the ramifications of this struggle against filesharing and piracy that forever changed the internet. Much of how and why the internet is structured as it is can be explained through recognizing that this contradictory state of affairs is due to the inherent properties of the internet and digital files when "forced" to fit …

Napster's Mediations, Gavin Mueller

Fast Capitalism

While Napster has often been understood as a force for disintermediation, this essay examines three possible levels that Napster could be theorized as engaged in mediation: the level of protocol, the level of interface, and the level of culture. Each has implications for how we understand the politics of Napster, and peer-to-peer more generally.

Napster "Freedom" At Northeastern University: A Distanced Ethnography, Marcus Breen

Fast Capitalism

This article offers a critical first hand account, from an academic at Northeastern University after Napster's creator Sean Fanniong left the campus in 1999. Reflecting on the impact of Fanning on the campus, drawing on the history of community computer innovation in Boston as a means of activism, the article identifies through Marx, the way monopoly capitalism destroyed Napster's capacity for free music culture. The impact of Intellectual Property law in shutting down digital innovations such as Napster, is considered for the impact it had on the ideals of the liberal university in the United States.

The Shadows Of Wealth, David Mcclough

The Journal of Economics and Politics

No abstract provided.