Digital Commons Network^™

Markov Chain Wave Generative Adversarial Network For Bee Bioacoustic Signal Synthesis, Kumudu Samarappuli, Iman Ardekani, Mahsa Mohaghegh, Abdolhossein Sarrafzadeh

Electrical & Computer Engineering Faculty Publications

This paper presents a framework for synthesizing bee bioacoustic signals associated with hive events. While existing approaches like WaveGAN have shown promise in audio generation, they often fail to preserve the subtle temporal and spectral features of bioacoustic signals critical for event-specific classification. The proposed method, MCWaveGAN, extends WaveGAN with a Markov Chain refinement stage, producing synthetic signals that more closely match the distribution of real bioacoustic data. Experimental results show that this method captures signal characteristics more effectively than WaveGAN alone. Furthermore, when integrated into a classifier, synthesized signals improved hive status prediction accuracy. These results highlight the potential …

An Explainable Cs-Mitigation Triangular (Ecsmt) Framework To Secure Graph Neural Networks, Sabah Ettahri, Sergio Pallas Enguita, Chung-Hao Chen, Wen-Chao Yang

Electrical & Computer Engineering Faculty Publications

This research addresses cyber risk by defending against backdoor attacks on Graph Neural Networks (GNNs). We propose the Explainable Complex System-Mitigation Triangular (ECSMT) Framework, which integrates Robust Training, Graph Regularization, and Data Sanitization into a lightweight, hardware-efficient defense layer. To evaluate structural generalizability, we conducted empirical evaluations across three distinct benchmark domains (AIDS, MUTAG, and PROTEINS) using a Graph Isomorphism Network (GIN) backbone. Under a baseline 5% backdoor subgraph trigger injection ratio, ECSMT achieves excellent utility retention, securing a Clean Accuracy (CA) of 97.33% (±0.62%) while reducing the Attack Success Rate (ASR) from 97.00% down to 69.45% on the primary …

Dynamic Direct Voltage Control Under Maximum Torque Per Ampere For Interior Pmsms, Mohamad Alzayed, Hicham Chaoui, Alaref Elhaj

Electrical & Computer Engineering Faculty Publications

A novel method for controlling the speed of interior permanent magnet synchronous motors (IPMSMs), known as the current-sensing-based dynamic direct voltage control method under the maximum torque per ampere (MTPA) concept, is introduced. This technique achieves precise tracking of machine velocity by determining the optimal combination of voltage amplitude and angle for each specific motor velocity and current/load condition. Unlike previous studies, this approach takes into account the transient model of the machine, resulting in improved accuracy during dynamic operating conditions compared with existing methods in the literature. Moreover, a comparative analysis is conducted involving different direct voltage MTPA speed …

Generative Ai-Driven Optimization In Flexible And Reconfigurable Manufacturing Systems, Salah Hammedi, Hicham Chaoui, Lotfi Nabli

Electrical & Computer Engineering Faculty Publications

Flexible and Reconfigurable Manufacturing Systems (FRMSs) are essential for coping with variability in modern production environments; however, efficient scheduling and rapid reconfiguration remain challenging. This paper presents a hybrid optimization framework that integrates Colored Petri Net (CPN) modeling with Generative Artificial Intelligence (GenAI) to enhance scheduling performance and system adaptability. The CPN formalism ensures verifiable modeling of system dynamics, while a transformer-based generative model produces candidate scheduling and reconfiguration strategies. Simulation experiments were conducted under static, dynamic, and adaptive scenarios, including machine breakdowns and dynamic job arrivals. Performance was evaluated using makespan, mean flow time, machine utilization, and reconfiguration latency. …

Generalized Inverter Fault Detection Using Normalized Current Features And A Lightweight Bilstm Network, Mohammad Zamani Khaneghah, Mohamad Alzayed, Hicham Chaoui

Electrical & Computer Engineering Faculty Publications

Fault detection and diagnosis of three-phase inverter-fed motor drives is essential for ensuring system reliability, safety, and continuous operation in applications such as electric vehicles and industrial automation. This paper proposes a data-driven fault detection framework based on normalized current features and a lightweight bidirectional long short-term memory (BiLSTM) network which can be generalized to different motor power rating in the same controller system. A compact set of six time-domain features, consisting of the mean and root-mean-square (RMS) values of the phase currents, is extracted and normalized with respect to the average RMS value. This normalization effectively removes dependency on …

Fault Tolerance Of Accelerated Asynchronous Fixed-Point Iterations On Flexible Computing Infrastructure, Evan Coleman, Masha Sosonkina

Electrical & Computer Engineering Faculty Publications

Asynchronous iterative methods tolerate straggling processors by allowing workers to proceed with stale data, but at a cost: the iterates become inconsistent, potentially degrading convergence. We investigate whether convergence accelerators such as Anderson acceleration compensate for this degradation. We experimentally study three fixed-point iterations: the Jacobi method for sparse linear systems, value iteration for the Bellman equation, and the Hartree–Fock self-consistent field (SCF) iteration. The experiments are conducted using a high-performance execution framework, Ray, which abstracts the complexity of distributed systems and enables code parallelization and fault injection with minimal changes.

We establish two main results. First, straggler tolerance is …

On Distribution Matching For Probabilistic Constellation Shaping, Dimitrie C. Popescu, Cameron Kowski

Electrical & Computer Engineering Faculty Publications

Distribution matching (DM) transforms a stream of equally likely bits into digital symbols that correspond to a specific digital modulation scheme with probabilities of occurrence following a specified statistical distribution. This technique is referred to as probabilistic constellation shaping (PCS), and using the Maxwell–Boltzmann (MB) distribution improves spectral and energy efficiency of digital modulation schemes by enabling more frequent transmissions of lower energy digital symbols. The background behind PCS is presented in the paper and the two main DM methods widely used in practice are discussed, outlining scenarios in which one DM method may be preferable over the other. For …

Just Okay Is Not Okay, Cam Torrens

Mighty Pen Project Anthology & Archive

A career Air Force commander who's spent thirty years teaching decisive leadership avoids the one confrontation that would complicate his retirement.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.

Dysregulation Of Alternative Splicing Patterns In The Ovaries Of Reproductively Aged Mice, Adnan T. Alsamaraee, Vanessa L. Correll, Julius O. Nyalwidhe, Pavla Brachova, Nehemiah S. Alvarez

Department of Biomedical and Translational Sciences Faculty Publications

Female reproductive aging is characterized by progressive deterioration of ovarian function, yet the molecular mechanisms driving these changes remain incompletely understood. Here, we used long-read direct RNA-sequencing to map transcript isoform changes in mouse ovaries across reproductive age. Comparing young and aged mice after controlled gonadotropin stimulation, we identified widespread alternative splicing changes, including shifts in exon usage, splice site selection, and transcript boundaries. Aged ovaries exhibited increased isoform diversity, favoring distal start and end sites, and a significant rise in exon skipping and intron retention events. Many of these age-biased splicing events altered open reading frames, introduced premature stop …

Brief Pulses Of High-Level Fluid Shear Stress Enhance Metastatic Potential And Rapidly Alter The Metabolism Of Cancer Cells, Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henry

Department of Biomedical and Translational Sciences Faculty Publications

Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironment of the circulation on the outcome of the metastatic cascade is not well understood. Here, we find that cancer cells exposed to brief pulses of high-level fluid shear stress (FSS) exhibit enhanced invasiveness and anchorage-independent proliferation in vitro and enhanced metastatic colonization/tumor formation in vivo. Cancer cells exposed to FSS rapidly alter their metabolism in a manner that promotes survival by providing energy for cytoskeletal remodeling …

Stat4-Dependent Regulation Of Neuroinflammation In Atherosclerosis, Natalie Stahr, Alina K. Moriarty, Shelby D. Ma, W. Coles Keeter, Woong-Ki Kim, Larry D. Sanford, Elena V. Galkina

Department of Biomedical and Translational Sciences Faculty Publications

Atherosclerosis is linked to an increased risk of cognitive decline, with chronic inflammation being a common feature of both pathologies. IL-12 activates STAT4 to regulate myeloid cell functions, and blockade of this pathway alleviates cognitive impairment in Alzheimer's models. However, the mechanisms connecting vascular pathology to neuroinflammation remain unclear. Here, we examine whether STAT4 functions as a common mediator of neuroinflammation in atherosclerosis. We demonstrate that LysM^Cre-specific STAT4 deficiency ameliorates deficits in long-term memory in low-density lipoprotein-deficient (Ldlr^-/-) mice fed a high-fat diet (HFD-C). STAT4 deficiency moderately reduces Ser199-phosphorylated Tau burden. Atherosclerosis alters brain immune …

Lipid And Foam Cell Accumulation As Novel Pathological Features Of Benign Prostatic Hyperplasia, Dita Julianingsih, Samara V. Silver, Thaissa Horne, Kasun Gunawardena, Savannah Ward, Alicia Malewska, Douglas Strand, Julius Nyalwidhe, Ilya Sobol, Petra Popovics

Department of Biomedical and Translational Sciences Faculty Publications

Background

Benign prostatic hyperplasia (BPH) encompasses a heterogeneous set of pathological processes that instigate lower urinary tract symptoms (LUTS). Using a mouse model of steroid hormone imbalance-induced lower urinary tract dysfunction, we identified luminal lipid-laden foamy macrophages, although their presence and contribution to human pathology have not yet been established. The objective of this study was to determine whether luminal macrophages are associated with human BPH and to assess how lipid accumulation relates to underlying pathological features and clinical parameters.

Methods

Whole-mount tissue sections from simple prostatectomy specimens and prostates from healthy donors were used to evaluate the association of …

The Structure Of The Native Cardiac Crossbridge In The Rigor State, Cristina M. Risi, Tyler Nguyen, Betty Belknap, Howard D. White, Jose R. Pinto, Prescott B. Chase, Vitold E. Galkin

Department of Biomedical and Translational Sciences Faculty Publications

Cardiac contraction is driven by double-headed myosin cycling on cardiac thin filaments, where troponin-tropomyosin regulates myosin access to actin. Prior high-resolution structural studies used a single-headed myosin bound to bare actin, thereby limiting insight into coordination between myosin heads and the influence of troponin-tropomyosin on actomyosin interactions. Here, we report a high-resolution structure of the native cardiac rigor cross-bridge formed by heavy meromyosin bound to the thin filament. We show that direct communication between the two bound heads, uneven interactions between the heads and tropomyosin, and spatial constraints imposed by troponin govern myosin placement along the thin filament. Additionally, the …

Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton

Department of Biomedical and Translational Sciences Faculty Publications

We report the first crystal structure of the telmisartan-tempol conjugate 2,2,6,6-tetramethyl-1-(λ'-oxidaneyl)piperidin-4-yl 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl]-[1,1'-biphenyl]-2-carboxylate free radical (YK-4-250, C₄₂H₄₆N₅O₃), a dual-function inhibitor designed to target both the angiotensin II type 1 receptor (AT₁R) and reactive oxygen species (ROS). Structural analysis reveals a unique crystal architecture in which the nitroxide radical is stabilized within a sterically protected environment while preserving the telmisartan pharmacophore essential for high-affinity receptor antagonism. YK-4-250 is a novel small-molecule conjugate of telmisartan and tempol that incorporates a catalytic stabilized nitroxide radical and was rationally designed to mitigate gastrointestinal acute radiation syndrome (GI-ARS).

Medical Students Report Coherent Ethical Orientations Towards Ai Across Academic And Clinical Domains, With No Clear Association With Perceived Technical Readiness: A Cross-Sectional Pilot Study, Ismail El Moudden, Madison Baldauf, John Millerhagen, Anca Dana Dobrian

Department of Obstetrics & Gynecology Faculty Publications

Background

Whether perceived technical AI competency is associated with greater ethical openness to AI integration, a relationship often assumed in curricular design, remains empirically untested. This pilot study examined relationships between perceived AI readiness, ethical perspectives toward AI integration, and curricular needs among medical students.

Methods

A cross-sectional survey was administered to medical students at a single U.S. institution from September through November 2025. The survey assessed self-reported AI readiness, ethical perspectives across academic and clinical domains, and responses to 22 scenario-based ethical items; all measures were student self-reports, and findings reflect student perceptions. Composite indices were created for Perceived …

Association Between Neighborhood Social Determinants Of Health And Stillbirth, Tetsuya Kawakita, Misa Hayasaka, Ann M. Harper, John Brush, George Saade

Department of Obstetrics & Gynecology Faculty Publications

OBJECTIVE:

To examine the association between neighborhood-level social determinants of health and stillbirth.

METHODS:

We performed a retrospective cohort study of deliveries that occurred at a gestational age of at least 20 weeks within a five-hospital system (2012-2022). Electronic health record data mapped to the Observational Medical Outcomes Partnership Common Data Model were geocoded using addresses at the time of delivery and linked to neighborhood health indices, which included the Area Deprivation Index (ADI), Maternal Vulnerability Index (MVI), and Social Vulnerability Index (SVI) at the Census tract level. Stillbirths were adjudicated by medical record review. Modified Poisson regression generated relative …

Longitudinal Patterns Of Urinary Biomarkers Of Placental And Renal Function In Pregnancy And Associations With Early Pregnancy Exposure To Phthalates And Replacements, Erin E. Mcnell, Danielle R. Stevens, Barrett M. Welch, Suzanne Fenton, Antonia M. Calafat, Julianne Cook Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson

Department of Obstetrics & Gynecology Faculty Publications

Phthalates and replacements are endocrine-disrupting chemicals that may interfere with early pregnancy processes such as placentation and renal adaptation. Placental and renal biomarkers may help examine these toxicologic mechanisms. This study aims to characterize longitudinal changes in urinary protein biomarkers of placental angiogenesis (sFlt-1, PlGF, sEng) and renal function (KIM-1, NGAL, nephrin), and investigate associations with early pregnancy exposure to phthalates and replacements. Among 291 participants from the Human Placenta and Phthalates prospective cohort, urinary metabolites of eight phthalates and two replacements were quantified at up to 2 time points from 12 to 15 weeks gestation. Repeated measures were averaged …

The Association Between The Degree Of Social Vulnerability And Maternal Anemia And Other Adverse Perinatal Outcomes, Rubymel J. Knupp, Christina T. Blanchard, Ariann Nassel, Ashley Shea, Lindsay S. Robbins, Jeff M. Szychowski, Ashley N. Battarbee, Akila Subramaniam

Department of Obstetrics & Gynecology Faculty Publications

Objective

Maternal anemia in pregnancy is associated with many adverse maternal, fetal, and neonatal outcomes. The role of social determinants of health (SDOH) in the development of maternal anemia and other adverse outcomes is continually evolving. One such newer tool, the Social Vulnerability Index (SVI), measures an individual's community-level SDOH, with higher SVI denoting higher vulnerability. Our objective was to evaluate the association between SVI, maternal anemia, and other adverse perinatal outcomes.

Methods

Retrospective cohort study of pregnant individuals delivering singletons at a gestational age ≥23 weeks at a single center from 2014 to 2018. Patients with sickle cell disease, …

Evaluating The Mediating Role Of Gestational Phthalate And Replacement Biomarkers In The Associations Between Race/Ethnicity And Birthweight, Amir J. Lueth, Danielle R. Stevens, Sarahna A. Moyd, Elena Sinkovskaya, Ann Przybylska, Antonia M. Calafat, Julianne C. Botelho, George Saade, Alfred Abuhamad, Kelly K. Ferguson

Department of Obstetrics & Gynecology Faculty Publications

Background

Gestational exposure to phthalates is higher among non-Hispanic black (NHB) women than non-Hispanic white (NHW) women and may contribute to racial/ethnic differences in birthweight z-scores.

Objective

We aimed to investigate whether gestational phthalate and replacement biomarkers mediate the association between race/ethnicity and birthweight z-scores.

Methods

We analyzed data from 271 pregnancies in the Human Placenta and Phthalates study, a prospective cohort recruited from 2017 to 2020. Urinary phthalate metabolite concentrations were measured at up to eight time points during pregnancy and averaged to represent gestational exposure. Metabolites were grouped by parent compound. Linear regression models estimated associations in phthalate …

The American Anomaly: Feasibility Of Universal Healthcare, William Bernstein

Student Research and Publications

No abstract provided.

Vicarious Liability In Sexual Misconduct Cases In Minnesota, Mike Steenson

Mitchell Hamline Law Review

Employers are vicariously liable for torts committed by their employees acting within the course and scope of their employment. The predominant test turns on whether the employee acted, at least in part, out of a desire to serve the employer’s interests. That test is problematic in cases involving intentional torts committed by an employee, particularly in sexual assault cases. Existing vicarious liability rules have been heavily criticized for the motive rule’s limiting effect, even where the nature of the employment may facilitate the tort. A minority of jurisdictions impose vicarious liability in cases where the tort is a characteristic risk …

Justice For The Accomplice: Minnesota's 2023 Accomplice Liability Amendment And Its Shortcomings, John M. Thompson

Mitchell Hamline Law Review

No abstract provided.

A Multifaceted Innovation To Support Student Nurse Writing Self-Efficacy, Lila De Tantillo, Lauren Holloway

Faculty Publications

Background: Supporting academic writing is a critical pathway for professional development in nursing. More knowledge is needed about fostering student confidence in writing and self-efficacy in the writing process. Innovation: The purpose was to implement a multifaceted program to expand writing resources and support writing self-efficacy among nursing students. Course-specific instruction and an online learning platform were provided to support student writing and critical thinking. Implications: Students noted the need for additional preparation in the initial stages or prewriting components of writing-based assignments. We determined that building academic literacy and confidence in writing is vital to support critical thinking in …

Making Unsafe Sequences Unexecutable: Formal Protocol Enforcement For Cyber-Physical Systems, Arthur Amorim

Graduate Studies Theses and Dissertations 2026

Cyber-physical systems execute physical actions in response to software commands, making their communication protocols a primary attack surface. A stealthy attack is a sequence of individually valid messages that violates a required ordering, driving the system into an unsafe state without malware or protocol violation. Existing defenses examine messages or physical state in isolation, not protocol level sequences, and cannot prevent them. Preventing them requires enforcement that makes unsafe sequences unexecutable at the communication boundary.

Formal methods offer a principled path to enforcement, but no tool spans specification to safe deployed hardware. Model checking automates proofs but has no certified …

Non-Destructive Hhxrf Archaeometry For Grouping Individuals Via Trace Element Analysis Of Dental Remains, Griffon G. Binkowski

Graduate Studies Theses and Dissertations 2026

Handheld X-ray fluorescence (HHXRF) spectrometry has been validated as an accurate, non-destructive method for analyzing archaeological osseous materials. This study utilizes HHXRF to address key bioarchaeological questions, including population differentiation, individuation, and the interpretation of bioaccumulated trace elements versus diagenetic impacts. Using dental enamel from the Maya site of Altun Ha, Belize (n=20) and several Roman-Christian sites in the Dakhleh Oasis in Egypt (n=6), the occlusal surface of molar crowns was assayed in air using a Bruker Tracer III- equipped with a 12 mil Al, 1 mil Ti, 6 mil Cu filter. Semi-quantitative trace element ratios (Sr/Ca, Fe/Ca, and Zn/Ca) …

Non-Gaussian Phenomena In Light Scattering And Applications, Shubham Atul Dawda

Graduate Studies Theses and Dissertations 2026

Physical reality is rarely deterministic; which, when probed by electromagnetic fields that also fluctuate, leads to observables that are most efficiently modelled as statistical processes. At equilibrium, this is usually achieved by invoking the Gaussian statistics of underlying physical processes, however, in practice, one often encounters out-of-equilibrium conditions where Gaussian descriptions may not suffice. Such situations are plentiful in nature– from biology to astronomy. This dissertation addresses several non-Gaussian phenomena associated with light scattering, and includes specific models’ derivations, experimental techniques developments, and demonstrations of potential applications. The systematic presentation will consider circumstances that infringe upon specific assumptions of the …

Minimizing Performance Overheads For Crash-Consistency In Disaggregated Persistent Memory, Khan Shaikhul Hadi

Graduate Studies Theses and Dissertations 2026

Compute express link (CXL) enables persistent memory disaggregation with memory pooling and hardware managed multi-host memory sharing capability, resulting in better resource utilization, increased scalability. Persistency-aware applications need to manage crash consistency across the system which results in significant performance overhead. This dissertation systematically investigates performance overhead to achieve crash consistency in disaggregated persistent memory and proposes solutions to enable persistency-aware application scaling for distributed system. First, we study persistent parallel programming to scale computation capability beyond single processor and determine the underlying hardware limitation to adopt lock-free data structure. We propose hardware support to design durable atomic instruction (DAI) …

Stolen Childhood: Picture Book Stories Of Indian Residential Schools, Maughn Rollins Gregory

Picture Books

In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …

Shin-Chi’S Canoe (2008) By Nicola Campbell, Maughn Rollins Gregory

Picture Books

In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …

The Effects Of Systematic Instructional Interventions On Functional Communication, Vocational Independence, And Academic Performance For High School Students With Autism In A Self-Contained Special Education Setting, Sarah O. Shalash

University of Kentucky Master's Theses

This project evaluated the effects of systematic instruction on functional communication, vocational independence, and functional mathematics for three high school students with autism in a self-contained special education classroom using three A–B single-case designs. Interventions included a system of least prompts for AAC requesting and vocational task completion and constant time delay for a functional timer-setting task. Student performance was measured as the percentage of independently completed responses across instructional sessions. Student T demonstrated meaningful improvement in independent AAC requesting and reached 75% independence in the final session. Student B demonstrated emerging improvement in timer-setting performance and reached 60% independence …