Digital Commons Network^™

The Effect Of Sex On A-To-I Editing In Skeletal Muscle During Inflammation, Skyler Lee

Graduate Theses/Dissertations

Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional mechanism mediated by ADAR enzymes that can alter RNA sequence, protein function, and gene regulation. Because ADAR1 is upregulated during inflammation and plays a critical role in innate immunity, previous studies investigated the effects of acute inflammation on RNA editing in male and female mice. Lipopolysaccharide (LPS) was used to induce inflammation, and RNA editing levels were examined in the heart, brain, and skeletal muscle. While editing levels in the heart and brain remained unchanged, skeletal muscle exhibited tissue- and sex-specific differences in editing. In this thesis, LPS treatment affected selective editing, increasing …

Climate Change In Gilgit-Baltistan: Satellite-Based Land Use/Land Cover Change Detection, Socio-Economic Dimensions, And Adaptation Strategies, Ali Muhammad

Graduate Theses/Dissertations

Climate change is increasingly transforming the cryosphere, hydrology, and human landscape of Gilgit-Baltistan, a highly climate-sensitive mountain region in northern Pakistan. This thesis investigates these transformations through satellite-based land use/land cover (LULC) change detection in four representative tehsils of Gilgit-Baltistan—Ali Abad, Gilgit, Nagar, and Sikander Abad—selected to span a gradient of human pressure and cryospheric exposure within the region. Using summer, cloud-free (< 10%) imagery from USGS Landsat 7 (2000) and Landsat 8 (2025), it conducts a multi-temporal comparison of environmental and socio-spatial change. After atmospheric correction and band compositing, the imagery is classified in ArcGIS Pro into six classes—Water, Barren land, Vegetation, Snow, Glacier, and Built-up—using a Support Vector Machine (SVM) classifier, with Maximum Likelihood Classification and Random Forest also tested but found less suitable for the final workflow. The analysis detects a pronounced reduction in mapped glacier-class area alongside a comparatively stable snow class, together with built-up expansion, while examining how temperature, precipitation, tourism, and population dynamics relate to observed LULC transitions. The results reveal a pattern of cryospheric decline and urban growth, with implications for water availability, ecological stability, hazard exposure, and settlement pressure. By integrating geospatial change detection with climatic and socio-economic interpretation, the thesis moves beyond mapping to explain interacting environmental and human drivers of landscape transformation and provides a reproducible remote-sensing baseline for monitoring land-surface change in heterogeneous mountainous terrain. It recommends integrated water-resource management, climate-resilient land-use planning, watershed and glacier monitoring, and sustainable tourism governance, supporting evidence-based decision-making by the Government of Gilgit-Baltistan and organizations working on climate adaptation, disaster risk reduction, and sustainable regional development.

Student Perspectives Of A Rubric-Based Performance Assessment In A Secondary Large Ensemble Classroom: Fairness, Clarity And Learning, Jeffrey S. Payne

Graduate Theses/Dissertations

The purpose of this study was to investigate student perceptions of a rubric-based performance assessment within a secondary large ensemble music program.  Seventy high school students enrolled in a high school band class completed a rubric-based performance assessment that featured personalized feedback and opportunities for resubmission  Using a mixed-methods approach, 17 students in the class voluntarily participated in a survey, the results of which I used to study my own use of assessment.  The survey consisted of eight Likert-scale questions and four open-response questions which were used alongside data regarding the resubmission rate and teacher documentation of instruction. Results indicated …

Advancing Hate Speech Detection: Binary And Multiclass Approaches From Traditional Methods To Parameter-Efficient And Ontology-Guided Language Models, Mahmoud Abusaqer

Graduate Theses/Dissertations

The widespread proliferation of hate speech on social media platforms poses significant challenges for content moderation and user safety, requiring automated systems that are simultaneously accurate, efficient, and capable of fine-grained distinctions. This thesis investigates hate speech detection through five published manuscripts organized into two complementary threads: binary detection (hateful vs. non-hateful) and multiclass detection across demographic targeting categories. The binary thread progresses from a broad 38-model baseline spanning traditional machine learning, deep learning, and transformer architectures (where RoBERTa reaches 91.48% accuracy and CatBoost remains competitive at 88.60%) to parameter-efficient adaptation, in which Low-Rank Adaptation (LoRA) of large language models …

Knowledge And Attitudes Of Medical Students About Research Methodology, Statistics, And Statistical Inference: An Assessment For Clinical Research Comprehension Skills, Laith Ashour, Lama Al-Mehaisen, Afnan Rababa, Osama Alrjoob, Moutaz Amayrh, Malak Al-Rabe'e, Qusai Al-Anasweh, Hala Al-Miqdadi, Nada Freihat, Mohammad Al Khreisha, Ala' Al Doaikat, Al-Mo'tasem Bellah Al-Rahamneh, Hamzeh Hatamleh, Fayez Zedat

Health Professions Education

Objectives: Medical students require a solid understanding of statistics in research papers. However, literature lacks sufficient studies on their proficiency, especially on Jordanian aspect. Methods: We performed a cross-sectional study on 361 medical students to evaluate their attitudes toward statistics, their knowledge in research methodology, and their ability to correctly interpret commonly used statistics in medical research. Statistical attitudes were assessed using three scales (value, difficulty, and interest) from the SATS-36 scale. Additionally, a novel author's-validated scale was created to measure students' research methodology knowledge. The scale validity was assessed using Confirmatory Factor Analysis (CFA). Multiple linear regression analysis was …

Healthcare Students' Perspective On The Clinical Placement Learning Environment: A Cross-Sectional Study Of Third- And Fourth-Year Students At A College Of Health Sciences In The Uae., Wuni Abdul Razak, Fatima Alrayssi, Arwa Alkarbi, Latifa Al Saedi, Suliman Salih, Ajnas Alkatheeri, Mohamed Hassaneen, Mohd Nazmi Nordin, Mbambo Collen, Emne Hammoud, Shaik Balkhis Banu, Monika Sachdeva, Noon Kamil

Health Professions Education

Purpose: This study evaluates the clinical placement learning environment from the standpoint of Year 3 and Year 4 healthcare students in the UAE. Methods: The perspectives of healthcare students on clinical learning environments were studied using the validated Undergraduate Clinical Education Environment Measure (UCEEM). Third- and fourth-year (fifth-year pharmacy students inclusive) undergraduate healthcare students (radiography and medical imaging, emergency health, midwifery, nursing, pharmacy, physiotherapy, and psychology) (n=647) at a United Arab Emirates university were invited to participate in the study. The UCEEM contains 25 items under two overarching aspects, experiential learning and social engagement, with four subscales: learning opportunities at …

Effectiveness Of 3d-Printed Models In Undergraduate Dental Endodontic Education: A Systematic Review., Razi Jalali, Shankargouda Patil, Frank W Licari, Kamran H Awan, Shilpa Bhandi

Health Professions Education

Purpose: With the development of flexible polymers and stereolithography, 3D printed models have been proposed for dental education to overcome the shortcomings of extracted natural teeth and artificial resin blocks. This review aimed to systematically review the literature available for the effectiveness of the use of 3D printed tooth models for undergraduate endodontic education. Methods: Based on the inclusion and exclusion criteria, PubMed, Scopus, Web of Science, and Google Scholar electronic databases were searched. Clinical studies with full-text articles available in the English language were selected. Data extraction, risk of bias assessment using the ROBINS-I tool, and assessment of the …

Professional Identity Development Among Nursing Students: The Impact Of Structured Reflective Practice, Abdelmonim El Fadely, Kamal Takhdat, Charaf-Eddine Ahraiba, Rahma Bouali, Sabah Selmaoui, Boujemaa Agorram

Health Professions Education

Purpose This study aimed to assess the impact of a structured reflective practice intervention on the development of professional identity among nursing students. Method A mixed-methods design was adopted. The intervention, based on guided reflective practice, was implemented with a voluntary sample of 58 participants. The evaluation relied on a quasi-experimental quantitative approach using the Macleod Clark Professional Identity Scale, with a comparison group and both pre-test and post-test measurements. A qualitative component was also included to explore the dimensions of the studied concept in greater depth. Results Quantitative findings showed a statistically significant difference between the post-test means (p < 0.001), indicating that the reflective practice intervention had a positive effect on the experimental group compared to the control group. The qualitative results further illuminated students’ reflections, which were organized into ten themes corresponding to the study’s conceptual framework: professional knowledge and skills, values and ethics, the nursing role, leadership, professional self-image, social image of the profession, sense of belonging, identification with role models, theory–practice integration, and career choice. These dimensions provided a comprehensive and nuanced understanding of professional identity, capturing the complexity of the concept. Conclusion These results support the integration of reflective practice as a pedagogical approach to fostering the construction and development of a positive professional identity. Professional identity, as a rich and multidimensional concept, goes beyond the process of professionalization—it represents its ultimate achievement.

Nursing Education In Indonesia And The Global Demand For Quality Healthcare: A Systematic Review, Evelyn Hemme Tambunan

Health Professions Education

Purpose: This study systematically reviewed evidence (2019–2025) on Indonesian nursing education, focusing on accreditation, competency based curricula, and workforce readiness in relation to global standards

Methods: Following PRISMA 2020 guidelines, a systematic search was conducted across Scopus, PubMed/MEDLINE, DOAJ/PMC, and policy repositories. Eligible sources included peer reviewed studies, systematic reviews, and policy reports related to nursing education in Indonesia quality assurance, competency based learning, and workforce demand.

Results: Twelve studies and reports were included, producing three themes: accreditation and quality assurance, competency based education and curriculum innovation, and workforce readiness and global alignment. Accreditation reforms, particularly Indonesia’s 2025 outcomes based …

Clay Modeling As An Effective Method Of Teaching-Learning Among Second-Year Medical Students In Pathology, Seema Umarji, Padmapriya K, Sulata Kamath

Health Professions Education

Introduction: Pathology is a core subject in undergraduate medical education, but students find it challenging to understand and retain microscopic concepts through lectures alone. Clay modeling, multisensory learning strategy, is shown to enhance comprehension in other subjects but remains understudied in pathology.

Purpose: To assess augmentation of learning using clay modeling, evaluate retention of knowledge after one month and explore student perceptions of clay modeling as a teaching method.

Methods: This interventional study involved 60 second-year MBBS students in the Department of Pathology over six months. Students were randomized into study and control groups. The study group used clay modelling …

Beyond The Numbers: A Mixed-Method Evaluation Of Faculty, Peer, And Self-Assessment Using Rubrics In Blood Pressure Determination Among Phase 1 Mbbs Students, Abeetha S, Chitra M, Suba A, B. Dharani, Sadhana S

Health Professions Education

Background: Competency-Based Medical Education (CBME) emphasizes formative, learner-centred assessment. Blood pressure (BP) measurement, a core clinical skill, integrates knowledge, skills, communication, ethics, and attitude. While rubrics are widely used to standardize evaluation, their utility in triangulating faculty, peer, and self-assessment in BP measurement remains underexplored.

Aim: To evaluate the reliability and educational value of rubric-based faculty, peer, and self-assessment in BP determination among Phase 1 MBBS students using a mixed-methods approach.

Methods: A cross-sectional mixed-methods study was conducted among 98 Phase 1 MBBS students in a South Indian medical college. Forty-nine students performed BP measurement, assessed simultaneously by 5 faculty …

Assessing The Effectiveness Of The Well-Being Through Occupational Participation (Wbop) Intervention In Promoting Well-Being In Occupational Therapy Students From A Philippine University: A Convergent Mixed-Methods Study, Elena Wong Espiritu, Maria Concepcion Dc. Cabatan, Guia Allyza D. Rabacca, Marlowe Eriberto P. Acuña Jr, Jay Allen B. Villon, Peñafrancia E. Ching

Health Professions Education

Purpose: Filipino occupational therapy students experience decreased well-being during their educational experience. However, there is a limited amount of literature describing their well-being and a scarcity of culturally specific interventions to promote student well-being. The Well-Being Through Occupational Participation intervention is an evidence-based, manualized program consisting of a variety of occupation-based activities. The objective of this study aimed to assess the effectiveness of a modified version of the intervention in promoting undergraduate Filipino occupational therapy student well-being.

Methods: A convergent mixed-methods approach was used, specifically longitudinal survey for the quantitative design and qualitative descriptive for the qualitative design. Data was …

Development Of A Faculty-Led Program To Improve Npte Readiness, Yaqiong Wang, Marlon Addison, Michael Hauber, Rachel Mcgraw, Karen Bock, Brendon Stewart

Health Professions Education

Purpose. The National Physical Therapy Examination (NPTE) is a multiple-choice examination that Doctor of Physical Therapy (DPT) students must pass to obtain licensure as physical therapists in the United States. Recent national data show a concerning decline in first-time pass rates, dropping from 91% in 2020 to 82% in 2025.¹ This downward trend is also reflected at our university. These findings underscore the need for effective strategies to enhance NPTE preparation. Therefore, the purpose of this study is to: 1) Describe a scaffolded model of faculty-guided exam preparation, designed to enhance students’ success on the NPTE during the months …

Attitudes Toward Dementia Among Nursing Students: A Cross-Sectional Study, Ngoc Ha Vo Thi, Thuy Nga Tran Thi, Ngoc Sen Hoang Thi

Health Professions Education

Purpose: Dementia is the loss of cognitive function, including thinking, memory, and communication, due to brain disorders. The global prevalence of dementia is increasing, affecting younger populations. Caring for individuals with dementia requires preparedness to manage behavioral and psychological symptoms. As future healthcare providers, nursing students are expected to have the necessary knowledge and attitudes to support dementia patients. To describe nursing students' attitudes toward dementia and explore related factors.

Methods: A cross-sectional study was conducted on 520 nursing students at Da Nang University of Medical Technology and Pharmacy. A structured questionnaire assessed demographic characteristics, academic information, knowledge, and attitudes …

Health Students’ Knowledge, Perceptions, And Willingness Toward Artificial Intelligence In Tackling Antimicrobial Resistance: A Cross-Sectional Study, Ikhwan Yuda Kusuma, Fauziah Fauziah, Afriza Pujiati, Dhiya Zulayta, Septi Nurkhasanah, Khamdiyah Indah Kurniasih

Health Professions Education

Background: Antimicrobial resistance (AMR) causes approximately 4.95 million deaths annually. Although artificial intelligence (AI) may enhance AMR detection, surveillance, and antimicrobial use, evidence remains limited regarding how health students’ knowledge, perception, and willingness influence AI adoption for AMR control.

Purpose: This study aimed to examine the direct and mediating relationships between health students’ knowledge, perception, and willingness toward AI-based approaches for combating antimicrobial resistance in Indonesia using structural equation modeling.

Methods: A cross-sectional study involving 4,369 health students across Indonesia was conducted using a validated questionnaire. Data on knowledge, perception, and willingness were analyzed using Structural Equation Modeling (SEM), SmartPLS, …

The Role Of Participant–Clinician Relationality And Intervention Source In A Violence Reduction Trial: A Qualitative Study, Paul Leslie Simpson, Freya Stephenson, Patricia Morgan, Emaediong I. Akpanekpo, Jocelyn Jones, Peter William Schofield, Lee Knight, Tony Butler

Research outputs 2022 to 2026

Violence and domestic violence are global public health problems with prevention programs showing limited effectiveness. The form of delivery of such programs can influence their utility yet delivery characteristics are often poorly described. We analysed interviews with clinicians (n = 5) and participants (n = 12) involved in ReINVEST, a violence reduction clinical trial, to identify key elements of delivery. Three themes were identified: (1) clinician accessibility; (2) clinicians as participant advocates; and (3) humane care, reflecting participant–clinician ‘relationality’ as a central component of program delivery. We propose that this relationality is more likely to emerge in interventions delivered independently …

Exploratory Study Of The Relationship Among Religiousness, Resilience, Grit, Calling, And Differentiation Of Self In Nursing Students, Christine L. Sommers, Yonathan Aditya, Grace Solely Houghty, Ihan Martoyo

Health Professions Education

Purpose: To explore the relationships between resilience, religiousness, grit, calling, and differentiation of self in nursing students.

Methods: A cross-sectional design with a questionnaire was used. A total of 434 nursing students currently enrolled in a nursing degree program completed the online questionnaire, for a response rate of 32.3%. The study used the Indonesian version of the following instruments: 1) CD-RISC 10; 2) Four Basic Dimensions of Religiousness; 3) 12-Item Grit Scale; 4) Brief Calling Scale; 5) Differentiation of Self.

Results: Most of the participants were female, enrolled in a Bachelor of Nursing program, and desired to be nurses to …

Clinical Spanish Instruction In Physical Therapist Education: A Quasi-Experimental Comparison Of Instructional Schedules, Rose M. Vallejo, Eric Kruger

Health Professions Education

Purpose: As the U.S. Hispanic population grows, patients with limited English proficiency encounter health disparities that compromise their care. As a result, clinical Spanish instruction in health professions education has become increasingly necessary to address these disparities. This study compared the effects of two instructional schedules: condensed (8-week) versus distributed (2-year), for a required clinical Spanish course in a physical therapist education program. A secondary aim was to implement a Spanish-language OSCE to assess functional communication proficiency.

Methods: Forty-eight students (mean age 25.0 ± 3.3 years; 54% female) from two consecutive cohorts received 16 hours of flipped classroom Spanish instruction. …

Centring The Audience: Attitudes And Behaviours In Australian Arts Organisations, Katya Johanson, Abbie Trott, Mark Taylor, Anne Kershaw, Hilary Glow, Tracy Margieson

Research outputs 2022 to 2026

Many arts organisations seek to increase the diversity of their audiences. Recent literature suggests that this requires organisations to interrogate and change their ways of operating. This is a fundamental shift for a sector that has long considered the goal of diversifying audiences as a problem external to the organisation. Responding to this discrepancy, this article compares attitudes and behaviours among workers in arts organisations, to identify whether staff see the need to make change and practise the behaviours required. It identifies and uses three organisational capabilities–‘dynamic capabilities’, ‘social networks’ and ‘business improvement processes’–to frame an analysis of a national …

Toward Urban-Scale Liquefaction Hazard Analysis: Evaluation And Optimization Of Cpt-Based Lateral Displacement Assessment, Varun M. Singh

Graduate Studies Theses and Dissertations 2026

Liquefaction-induced lateral spreading is a major type of earthquake-induced ground failure hazard and poses a significant threat to infrastructure systems. While semi-empirical methods, such as Lateral Displacement Index (LDI), have been developed to estimate lateral spreading displacement (LSD), their efficacy for regional-scale liquefaction hazard assessment remains unknown. This study evaluates and improves the LDI method for urban-scale seismic hazard assessments using a comprehensive dataset consisting of 1,713 Cone Penetration Test (CPT) case histories from the 2011 Christchurch, New Zealand earthquake, and high-resolution topographic data. Comparing the predicted LSDs and ground-truth observations from both field investigations and remote-sensing surveys reveals that …

Assessing The Implementation Of National Sodium Reduction Policies In Nigeria: An Interim Qualitative Evaluation Of Stakeholder Perspectives, Chisom Obiezu-Umeh, Erica L Jamro, Guhan Iyer, Mark D Huffman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Population-wide dietary sodium reduction is a global priority and a highly cost-effective strategy to lower blood pressure and reduce cardiovascular disease risk. In response, the Nigerian government launched the National Multi-sectoral Action Plan (NMSAP) in 2019, recommending evidence-based policy actions including limiting sodium in processed foods, restricting food advertising especially for children, promoting public awareness, integrating nutrition education in schools, and front-of-package labeling. We conducted a qualitative study to examine progress, barriers, and facilitators in implementing these policy actions 3 years post-launch.

METHODS: Between March and September 2024, we conducted 47 key informant interviews and 5 focus group discussions …

Effects Of Anti-Parkinsonian Medication On Gait During Internal And External Rhythmic Auditory Cueing In Pd, Sidney T Baudendistel, Lauren E Tueth, Ryan P Duncan, Allison M Haussler, Liza Birov, Gammon M Earhart

2020-Current year OA Pubs

INTRODUCTION: External and internal auditory cueing strategies improve gait function, including velocity and stride length, in people with Parkinson disease (PD). Further, internal cueing can reduce gait variability, a measure associated with falls. In the present study, we asked whether the efficacy of external and internal rhythmic cues depends on dopaminergic status, i.e., OFF vs. ON medication. This question is relevant to the real-world use of cueing, as dopaminergic medication responsiveness fluctuates for individuals. We measured gait while participants with PD walked with an external cue (music playing aloud) and with an internal cue (mentally singing) in both OFF and …

Left Atrial Appendage Closure Devices: A Contemporary Review Of Techniques, Tips And Tricks, Kamran Namjouyan, Hafeez Ul Hassan Virk, Affan Rizwan, Muzamil Khawaja, Mahboob Alam, Markus Strauss, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Atrial fibrillation (AF) affects approximately 3%-5% of adults and is projected to double in prevalence by 2060, significantly increasing the burden of thromboembolic stroke. This risk is largely attributed to thrombus formation within the left atrial appendage (LAA), particularly in nonvalvular AF, where the LAA's trabeculated anatomy, diverse morphologies (e.g., chicken wing, windsock, cactus, cauliflower), and impaired contractility allows for blood stasis and thrombogenesis. As a result, the LAA has become a focus for stroke prevention strategies. This review demonstrates current evidence on LAA closure by discussing patient selection, anatomical feasibility, procedural workflow, imaging guidance (transesophageal echocardiography vs. intracardiac echocardiography), …

A Practical Approach To The Management Of Percutaneous Coronary Intervention Complications, Tanawat Attachaipanich, Hafeez Ul Hassan Virk, Muzamil Khawaja, Mahboob Alam, Ravi S Hira, Jacob A Doll, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Introduction: Despite advances in stent design, pharmacotherapy, and procedural techniques that have improved percutaneous coronary intervention (PCI) outcomes and reduced PCI-related complications, these events still occur and are associated with adverse outcomes. Moreover, complex PCI procedures, which predispose to increased risk of complications, are increasingly performed. Understanding risk factors, underlying mechanisms, evidence-based management, and preventive strategies are essential to optimize procedural outcomes. This review aims to summarize current evidence and highlight gaps in knowledge related to PCI-associated complications.

Methods: This narrative review used a focused PubMed search through October 2025, prioritizing randomized trials, large observational studies, guidelines, and consensus statements. …

Comparing Rotational Thromboelastometry And Standard Coagulation Assays For Predicting Intraoperative Bleeding In Pediatric Liver Transplantation, Kirby Deshotels, Trung Nguyen, Jun Teruya, Muhammed Umair M Mian, Kelby Fuller, Sanjiv Harpavat, Anna Banc-Husu, Amir Navaei, John Goss, Moreshwar Desai, Arun Saini

Faculty, Staff and Students Publications

Background: Utility of preoperative rotational thromboelastometry (ROTEM) over standard coagulation assays (SCAs) in predicting intraoperative bleeding during orthotopic liver transplantation (OLT) in children with liver failure (LF) remains unclear.

Methods: In this single-center retrospective cohort of pediatric OLT recipients, we compared the predictive values of preoperative ROTEM parameters (intrinsic pathway (INTEM) maximum clot firmness (MCF), extrinsic pathway (EXTEM) clotting time (CT), INTEM CT, and fibrinogen-based (FIBTEM) MCF) and the corresponding SCAs (platelet count, international normalized ratio (INR), activated partial thromboplastin time (aPTT), and fibrinogen level, respectively) for significant intraoperative bleeding (blood loss of > 22 mL/kg; i.e., ≥ 85th percentile for …

Modulation Of Corneal Sensory Processing And Pain Responses By Dry Eye And Corneal Wounding, Ebru Yaman, Yangluowa Qu, Kaylin C Arpaia, Fairouz Elsaeidi, Uma Lakshmi Balakrishnan, Lance He, Henry Skrehot, Jehan Alam, Rui Chen, Mary Ann Stepp, Cintia S De Paiva, Stephen C Pflugfelder

Faculty, Staff and Students Publications

Background: Dry eye disease (DED) is a multifactorial disorder of the ocular surface in which tear film instability, epithelial barrier disruption, and neurosensory dysfunction contribute to symptom generation. Although several contributing factors have been identified, how different forms of ocular surface stress affect sensory pathways and behavioral responses remains unclear.

Purpose: This study aimed to evaluate corneal barrier function, sensory responses, and pain-related behaviors across acute and chronic dry eye and corneal injury models, and to assess stimulus-specific responses associated with TRPV1 and TRPM8 mediated pathways.

Methods: Female C57BL/6 J wild type and Mmp9KO mice were evaluated in acute desiccating …

A Rare Case Of Eosinophilic Granulomatosis With Polyangiitis Following Development Of Central Diabetes Insipidus: A Case Report And Literature Review, Tatsuaki Kosaka, Shinya Yamamoto, Naoko Yasugi, Sayaka Sugioka, Takuro Hakata, Rintaro Saito, Ryosuke Hiwa, Sho Koyasu, Yuki Teramoto, Motoko Yanagita

Faculty, Staff and Students Publications

Central diabetes insipidus (CDI) can develop as an acquired systemic disease. However, cases of eosinophilic granulomatosis with polyangiitis (EGPA) with concurrent CDI are rare. We herein report a case of EGPA following CDI. A 68-year-old woman with a 30-year history of sinusitis and asthma developed CDI, followed by severe renal dysfunction with eosinophilia and elevated myeloperoxidase-antineutrophil cytoplasmic antibody levels. A renal biopsy confirmed EGPA. Intensive treatment resulted in dialysis discontinuation, while partial improvement in arginine vasopressin secretion suggested a potential link between EGPA and CDI. We also conducted a literature review on concurrent EGPA and CDI. Clinicians should be aware …

Amino Acids And Lean Mass Accretion In Preterm Neonates, Antonio C Ramos Dos Santos, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

Purpose of review: This review evaluates recent evidence on how total protein and energy intake, amino acid composition, and nutrient delivery modality influence protein synthesis in preterm neonates, with the goal of informing nutritional strategies to support optimal lean mass accretion and growth.

Recent findings: Preterm neonates exhibit anabolic resistance to feeding due to impaired insulin and amino acid signaling in skeletal muscle. Enteral nutrition, especially fortified human milk, supports better lean mass accretion and neurodevelopment than parenteral nutrition. Intermittent bolus feeding and pulsatile leucine supplementation during continuous feeding further enhance mTORC1-dependent translation initiation signaling and protein synthesis efficiency in …

The Constitutional Significance Of The First American Pope: The Promise Of Listening In An Era Of Mutual Suspicion, Derek A. Webb

Scholarly Articles

Pope Leo XIV has focused a good deal of writing and speaking in the first year of his pontificate on the theme of listening, dialogue, and bridgebuilding. For Leo, listening, dialogue, and creating harmony across diverse perspectives where possible are at the heart of the Christian life. But his reflections on these themes, while rooted in theology, are aimed at a wider audience, going well beyond the church community, and addressing philosophical issues of universal human concern. Indeed, the first American pope happens to be highlighting certain ideals regarding dialogue that, while perhaps forgotten today, are central to the American …

Disparate (Algorithmic) Advantage, Yunsieg P. Kim, Jacob Eisler

Hofstra Law Faculty Scholarship

No abstract provided.