Digital Commons Network^™

Inflammation In Early Borrelia Burgdorferi Skin Infection, Ariana Nobles

Electronic Theses & Dissertations (2024 - present)

Borrelia burgdorferi (Bb) is the causative agent of approximately 476,000 cases of Lyme disease in the United States and rising. Bb is spread through infected saliva of the black-legged tick, Ixodes scapularis, to the host. Patients infected with Bb experience short-term symptoms, such as erythema migrans (EMs), fatigue, pain, and cognitive impairment. If left untreated, Bb infection will cause long-term health complications, like Lyme neuroborreliosis and Lyme arthritis. It is postulated that symptoms associated with Lyme disease are driven in part by inflammation.

My thesis focuses on the skin as it holds significant immunological importance in the …

A Moderated Mediation Analysis Of Mental Health Literacy, Personal Stigma, And Gender On Help-Seeking Intentions In College Students, Anna M. Gentile

Electronic Theses & Dissertations (2024 - present)

Although many college students experience mental health challenges, help-seeking rates remain disproportionately low relative to reported need (Abelson et al., 2022). Identifying factors that facilitate help-seeking is critical for improving access to mental health support in this population. Prior research has identified mental health literacy as a significant predictor of help-seeking behavior and intentions among college students (Gorczynski et al., 2017; Smith & Shochet, 2011), whereas personal stigma, which is defined as a person’s negative attitude towards people with mental health concerns (Griffiths et al., 2006), has been consistently associated with reduced help-seeking (Abelson et al., 2022). Grounded in the …

Intermittent Phrenic Afferent Activation Induces Phrenic Motor Plasticity, Nicole M. Popp, Taylor C. Holmes, Elizabeth A. Rozycki, Kristi A. Streeter

Physical Therapy Faculty Research and Publications

Approaches such as electrical stimulation of the phrenic neuromuscular system are currently used in humans to manage breathing impairments. We recently showed that electrical stimulation of the diaphragm muscle induces phrenic afferent-dependent plasticity. These findings highlight the need to better understand the mechanisms of afferent-mediated plasticity to guide and improve the development of novel therapies using electrical stimulation. Here, we tested the hypothesis that intermittent activation of large-diameter phrenic afferents induces phrenic motor plasticity, which, like other forms of plasticity, is pattern sensitive. We delivered inspiratory-triggered electrical stimulation using a narrow pulse width (0.1 ms) to preferentially activate large-diameter afferents, …

Sport Training Day Affects Adolescent Athletes’ Sleep Schedules, Abigail Larson, Jena Heck Street, Roman De Guia, Jacob J. Capin

Physical Therapy Faculty Research and Publications

Introduction: Sufficient sleep is integral to overall health whereas suboptimal sleep puts athletes at greater risk for injury, lengthens their recovery time, and decreases their performance. Our purpose was to compare sleep across training days (i.e., competition, practice, and rest) in adolescent athletes, specifically identifying differences between nights before and after training.

Methods: Participants [n = 33 (14 male, 19 female), aged 15.6 ± 1.0 years] wore an activPAL accelerometer continuously for 14 consecutive days and completed a sleep log noting training day status (i.e., competition, practice, rest).

Results: Athletes slept less on the day after competition compared to …